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Journal Articles

Abstract 1673: Establishment and characterization of pediatric brain tumor models in an orthotopic mouse model

Eva Oswald, Kanstantsin Lashuk, Johannes Gojo, Dorothee Lenhard, Norman Mack, Sonja Krausert, Daniela Lötsch, David Jones, Marcel Kool, Till Milde, Walter Berger, Stefan M. Pfister, Julia Schüler
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1673.
DOI: https://doi.org/10.1158/1538-7445.AM2022-1673
Published: 15 June 2022
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Journal Articles

Abstract 5221: The first-in-class ERK inhibitor ulixertinib (BVD-523) shows activity in MAPK-driven pediatric low-grade glioma models as single agent and in combination with MEK inhibitors or senolytics

Romain Sigaud, Lisa Rösch, Charlotte Gatzweiler, Julia Benzel, Laura von Soosten, Heike Peterziel, Sara Najafi, Simay Ayhan, Nina Hofmann, Kathrin I. Förster, Jürgen Burhenne, Rémi Longuespée, Cornelis M. van Tilburg, David T. Jones, Stefan M. Pfister, Deborah Knoerzer, Brent Kreider, Max Sauter, Kristian W. Pajtler, Marc Zuckermann, Ina Oehme, Olaf Witt, Till Milde
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5221.
DOI: https://doi.org/10.1158/1538-7445.AM2022-5221
Published: 15 June 2022
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Journal Articles

Functional Precision Medicine Identifies New Therapeutic Candidates for Medulloblastoma

Jessica M. Rusert, Edwin F. Juarez, Sebastian Brabetz, James Jensen, Alexandra Garancher, Lianne Q. Chau, Silvia K. Tacheva-Grigorova, Sameerah Wahab, Yoko T. Udaka, Darren Finlay, Huriye Seker-Cin, Brendan Reardon, Susanne Gröbner, Jonathan Serrano, Jonas Ecker, Lin Qi, Mari Kogiso, Yuchen Du, Patricia A. Baxter, Jacob J. Henderson, Michael E. Berens, Kristiina Vuori, Till Milde, Yoon-Jae Cho, Xiao-Nan Li, James M. Olson, Iris Reyes, Matija Snuderl, Terence C. Wong, David P. Dimmock, Shareef A. Nahas, Denise Malicki, John R. Crawford, Michael L. Levy, Eliezer M. Van Allen, Stefan M. Pfister, Pablo Tamayo, Marcel Kool, Jill P. Mesirov, Robert J. Wechsler-Reya
Journal: Cancer Research
Cancer Res (2020) 80 (23): 5393–5407.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-1655
Published: 02 December 2020
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Includes: Supplementary data
Journal Articles

Abstract A53: Synergistic interaction of HDACi and PLK1i in Group 3 MYC-amplified medulloblastoma

Gintvile Valinciute, Jonas Ecker, Thomas Hielscher, Christin Schmidt, Marc Remke, Gianluca Sigismondo, Jeroen Krijgsveld, Stefan M. Pfister, Olaf Witt, Till Milde
Journal: Cancer Research
Cancer Res (2020) 80 (14_Supplement): A53.
DOI: https://doi.org/10.1158/1538-7445.PEDCA19-A53
Published: 15 July 2020
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Journal Articles

Abstract 509: Genomic profiling of acute lymphoblastic leukemia in ataxia telangiectasia patients reveals tight link between ATM mutations and chromothripsis

Manasi Ratnaparkhe, Mario Hlevnjak, Thorsten Kolb, Anna Jauch, Kendra Maass, Frauke Devens, Agata Rode, Volker Hovestadt, Andrey Korshunov, Agata Pastorczak, Wojciech Mlynarski, Stephanie Sungalee, Jan Korbel, Jessica Hoell, Ute Fischer, Till Milde, Christof Kramm, Michaela Nathrath, Krystyna Chrzanowska, Eugen Tausch, Masatoshi Takagi, Takashi Taga, Shlomi Constantini, Jan Loeffen, Jules Meijerink, Stefan Zielen, Gudrun Goehring, Brigitte Schlegelberger, Eberhard Maass, Reiner Siebert, Joachim Kunz, Andreas Kulozik, Barbara Worst, David Jones, Stefan Pfister, Marc Zapatka, Peter Lichter, Aurelie Ernst
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 509.
DOI: https://doi.org/10.1158/1538-7445.AM2017-509
Published: 01 July 2017
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Journal Articles

Abstract 1935: Molecular characterization of orthotopic patient-derived xenograft models of pediatric brain tumors

Sebastian Brabetz, Susanne N. Gröbner, Huriye Seker-Cin, Florian Selt, Till Milde, David T. Jones, Madison T. Wise, Jessica M. Rusert, Kyle Pedro, Andy Strand, Olaf Witt, Sarah E. Leary, Xiao-Nan Li, Robert J. Wechsler-Reya, James M. Olson, Stefan M. Pfister, Marcel Kool
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1935.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1935
Published: 01 July 2017
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Journal Articles

Abstract 3094: Epigenetic classification of ependymal brain tumors across age groups

Hendrik Witt, Martin Sill, Khalida Wani, Steve Mack, David Capper, Stephanie Heim, Pascal Johann, Sally Lambert, Marina Rhyzova, Volker Hovestadt, Theophilos Tzaridis, Kristian Pajtler, Sebastian Bender, Till Milde, Paul A. Northcott, Andreas E. Kulozik, Olaf Witt, Peter Lichter, V Peter Collins, Andreas von Deimling, Marcel Kool, Michael D. Taylor, Martin Hasselblatt, David T. Jones, Andrey Korshunov, Ken Aldape, Stefan Pfister
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3094.
DOI: https://doi.org/10.1158/1538-7445.AM2014-3094
Published: 01 October 2014
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Journal Articles

GRHL1 Acts as Tumor Suppressor in Neuroblastoma and Is Negatively Regulated by MYCN and HDAC3

Johannes Fabian, Marco Lodrini, Ina Oehme, Marie C. Schier, Theresa M. Thole, Thomas Hielscher, Annette Kopp-Schneider, Lennart Opitz, David Capper, Andreas von Deimling, Inga Wiegand, Till Milde, Ulrich Mahlknecht, Frank Westermann, Odilia Popanda, Frederik Roels, Barbara Hero, Frank Berthold, Matthias Fischer, Andreas E. Kulozik, Olaf Witt, Hedwig E. Deubzer
Journal: Cancer Research
Cancer Res (2014) 74 (9): 2604–2616.
DOI: https://doi.org/10.1158/0008-5472.CAN-13-1904
Published: 30 April 2014
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Includes: Supplementary data
Journal Articles

Abstract 3687: An integrative genomics approach identifies distinct molecular and epigenetic subgroups of pediatric glioblastoma

Dominik Sturm, Hendrik Witt, Karine Jacob, Carolin Konermann, David TW Jones, Elke Pfaff, Andrey Korshunov, Marina Rizhova, Volker Hovestadt, Marc Remke, Timothy van Meter, Michael Frühwald, Christoph Kramm, Andreas E. Kulozik, Andreas von Deimling, Christian Hartmann, Till Milde, Olaf Witt, Guido Reifenberger, Peter Lichter, Christoph Plass, Nada Jabado, Stefan M. Pfister
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3687.
DOI: https://doi.org/10.1158/1538-7445.AM2012-3687
Published: 15 April 2012
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Journal Articles

Abstract 3458: Activated BRAF induces pilocytic astrocytomas in mice

Jan Gronych, Andrey Korshunov, Josephine Bageritz, Till Milde, Manfred Jugold, David T. Jones, Dolores Hambardzumyan, Marc Remke, Christian Hartmann, Hendrik Witt, Olaf Witt, Sabine Heiland, Martin Bendszus, Eric C. Holland, Stefan Pfister, Peter Lichter
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3458.
DOI: https://doi.org/10.1158/1538-7445.AM2011-3458
Published: 15 April 2011
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Journal Articles

Abstract 3453: Induction of differentiation in high-risk ependymoma stem-like cells by treatment with the HDAC inhibitor Vorinostat

Till Milde, Susanne Kleber, Andrey Korshunov, Hendrik Witt, Thomas Hielscher, Philipp Koch, Hans-Georg Kopp, Manfred Jugold, Hedwig E. Deubzer, Ina Oehme, Marco Lodrini, Axel Benner, Oliver Bruestle, Andreas von Deimling, Andreas E. Kulozik, Stefan Pfister, Ana Martin-Villalba, Olaf Witt
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 3453.
DOI: https://doi.org/10.1158/1538-7445.AM2011-3453
Published: 15 April 2011
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Journal Articles

Abstract 31: Subgroup-specific molecular alterations may explain the tremendous clinical heterogeneity of intracranial ependymoma

Hendrik Witt, Andrey Korshunov, Thomas Hielscher, Axel Benner, Sebastian Bender, Till Milde, Marc Remke, Andreas von Deimling, Andreas E. Kulozik, Olaf Witt, Peter Lichter, Stefan Pfister
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 31.
DOI: https://doi.org/10.1158/1538-7445.AM10-31
Published: 15 April 2010
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