1-20 of 26
Thomas Seufferlein
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Abstract C053: Pancreatic cancer patient-derived organoids, preclinical tools for therapeutic profiling, patient response prediction, and tumor evolution

Free
Johann Gout, Yazid J Resheq, Jessica Lindenmayer, Julian D Schwab, Elodie Roger, Johann M Kraus, Thomas Ettrich, Alica K Beutel, Lukas Perkhofer, Hans A Kestler, Thomas Seufferlein, Alexander Kleger
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C053.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C053
Published: 15 September 2024
View articletitled, Abstract C053: Pancreatic cancer patient-derived organoids, preclinical tools for therapeutic profiling, patient response prediction, and tumor evolution
Journal Articles

Abstract C052: Repurposing Statins to Target Gemcitabine Resistance in Pancreatic Cancer

Free
Sabrina Calderon, Alica K. Beutel, Ethan Nghiem, Rima Singh, Natalie Yousefian, Cecily Anaraki, Kevin Gulay, Dennis Juarez, Alexander Kleger, Thomas Seufferlein, Alexander Muir, Cholsoon Jang, Herve Tiriac, David Fruman, Christopher Halbrook
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C052.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C052
Published: 15 September 2024
View articletitled, Abstract C052: Repurposing Statins to Target Gemcitabine Resistance in Pancreatic Cancer
Journal Articles

Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer

Free
Alica K. Beutel, Sabrina Calderon, Ethan Nghiem, Rima Singh, Cecily Anaraki, Kevin Gulay, Herve Tiriac, Alexander Kleger, Thomas Seufferlein, Alexander Muir, Cholsoon Jang, Dennis Juarez, David Fruman, Christopher Halbrook
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): A056.
https://doi.org/10.1158/1538-7445.PANCA2023-A056
Published: 16 January 2024
View articletitled, Abstract A056: Targeting the mevalonate biosynthesis pathway in gemcitabine resistant pancreatic cancer
Journal Articles

Abstract C061: Therapeutic profiling, patient response prediction, and tumor evolution in pancreatic cancer organoids

Free
Johann Gout, Yazid J. Resheq, Jessica Lindenmayer, Thomas Ettrich, Lukas Perkhofer, Thomas Seufferlein, Alexander Kleger
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C061.
https://doi.org/10.1158/1538-7445.PANCA2023-C061
Published: 16 January 2024
View articletitled, Abstract C061: Therapeutic profiling, patient response prediction, and tumor evolution in pancreatic cancer organoids
Journal Articles

Abstract CT195: Interim safety results from SEPION/AIO-PAK-0118: A multicenter, Phase I/II study of sequential epigenetic and immune targeting in combination with nab-paclitaxel/gemcitabine in patients with advanced pancreatic ductal adenocarcinoma

Free
Jens T. Siveke, Marianne Sinn, Stefan Boeck, Gabriele Siegler, Thomas Seufferlein, Joerg Trojan, Dirk Waldschmidt, Alexander Koenig, Dorothea Schipp, Ines Winkler, Sven Thorsten Liffers, Volker Kunzmann
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT195.
https://doi.org/10.1158/1538-7445.AM2023-CT195
Published: 14 April 2023
View articletitled, Abstract CT195: Interim safety results from SEPION/AIO-PAK-0118: A multicenter, Phase I/II study of sequential epigenetic and immune targeting in combination with nab-paclitaxel/gemcitabine in patients with advanced pancreatic ductal adenocarcinoma
Journal Articles

Abstract B034: CXCR4 targeting endogenous human peptides eliminate migrating cancer stem cells by disrupting tumor-stroma crosstalk in pancreatic ductal adenocarcinomas

Free
Kanishka Tiwary, Mirja Harms, Bastian Beitzinger, Roman Schmid, Syeda Inaas, Karolin Walter, Alexander Kleger, Mika Lindén, Thomas Seufferlein, Jan Münch, Patrick Christian Hermann
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): B034.
https://doi.org/10.1158/1538-7445.METASTASIS22-B034
Published: 15 January 2023
View articletitled, Abstract B034: CXCR4 targeting endogenous human peptides eliminate migrating cancer stem cells by disrupting tumor-stroma crosstalk in pancreatic ductal adenocarcinomas
Journal Articles

Abstract B035: CXCL12 / CXCR4 signaling enhances and sustains migrating cancer stem cells via BMI1 in pancreatic ductal adenocarcinomas

Free
Kanishka Tiwary, Anton Lahusen, Syeda Inaas, Stefanie Hauff, Karolin Walter, Alexander Kleger, Thomas Seufferlein, Bruno Sainz, Jr., Patrick Christian Hermann
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_2): B035.
https://doi.org/10.1158/1538-7445.METASTASIS22-B035
Published: 15 January 2023
View articletitled, Abstract B035: CXCL12 / CXCR4 signaling enhances and sustains migrating cancer stem cells via BMI1 in pancreatic ductal adenocarcinomas
Journal Articles

Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types

Free
Jan Budczies, Klaus Kluck, Susanne Beck, Iordanis Ouralidis, Michael Allgäuer, Michael Menzel, Eugen Rempel, Daniel Kazdal, Lukas Perkhofer, Alexander Kleger, Peter Schirmacher, Thomas Seufferlein, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 810.
https://doi.org/10.1158/1538-7445.AM2022-810
Published: 15 June 2022
View articletitled, Abstract 810: HRD is inversely correlated with MSI and identifies immunologically cold tumors in most cancer types
Journal Articles

RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer

Available to Purchase
Frank Arnold, Johann Gout, Heike Wiese, Stephanie E. Weissinger, Elodie Roger, Lukas Perkhofer, Karolin Walter, Jeanette Scheible, Caterina Prelli Bozzo, André Lechel, Thomas J. Ettrich, Ninel Azoitei, Li Hao, Axel Fürstberger, Ewa K. Kaminska, Konstantin M.J. Sparrer, Volker Rasche, Sebastian Wiese, Hans A. Kestler, Peter Möller, Thomas Seufferlein, Pierre-Olivier Frappart, Alexander Kleger
Journal: Cancer Research
Cancer Res (2021) 81 (7): 1758–1774.
https://doi.org/10.1158/0008-5472.CAN-20-2633
Published: 01 April 2021
View articletitled, RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer
Open the PDF for RINT1 Regulates SUMOylation and the DNA Damage Response to Preserve Cellular Homeostasis in Pancreatic Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract B22: Trybeca-1: A randomized, phase 3 study of eryaspase in combination with chemotherapy versus chemotherapy alone as second-line treatment in patients with pancreatic adenocarcinoma (NCT03665441)

Free
Pascal Hammel, Rosanna Berardi, Eric Van Cutsem, Jaime Feliu, Richard Greil, Harpreet Wasan, Jean-Philippe Metges, Peter Nygren, Pia Österlund, Marcus Noel, Thomas Seufferlein, Geert-Jan Creemers, Anu Gupta, Sophie Salesse, Nigel Biswas-Baldwin, Hedy Dion, Hagop Youssoufian, Iman El-Hariry, Manuel Hidalgo
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B22.
https://doi.org/10.1158/1538-7445.PANCA19-B22
Published: 13 December 2019
View articletitled, Abstract B22: Trybeca-1: A randomized, phase 3 study of eryaspase in combination with chemotherapy versus chemotherapy alone as second-line treatment in patients with pancreatic adenocarcinoma (NCT03665441)
Journal Articles

ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage

Available to Purchase
Lukas Perkhofer, Anna Schmitt, Maria Carolina Romero Carrasco, Michaela Ihle, Stephanie Hampp, Dietrich Alexander Ruess, Elisabeth Hessmann, Ronan Russell, André Lechel, Ninel Azoitei, Qiong Lin, Stefan Liebau, Meike Hohwieler, Hanibal Bohnenberger, Marina Lesina, Hana Algül, Laura Gieldon, Evelin Schröck, Jochen Gaedcke, Martin Wagner, Lisa Wiesmüller, Bence Sipos, Thomas Seufferlein, Hans Christian Reinhardt, Pierre-Olivier Frappart, Alexander Kleger
Journal: Cancer Research
Cancer Res (2017) 77 (20): 5576–5590.
https://doi.org/10.1158/0008-5472.CAN-17-0634
Published: 15 October 2017
View articletitled, ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage
Open the PDF for ATM Deficiency Generating Genomic Instability Sensitizes Pancreatic Ductal Adenocarcinoma Cells to Therapy-Induced DNA Damage in another window
Includes: Supplementary data
Journal Articles

Abstract 1809: PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation

Free
Ninel Azoitei, Alexander Becher, Konrad Steinestel, Arefeh Rouhi, Kristina Diepold, Susanne Bobrovich, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1809.
https://doi.org/10.1158/1538-7445.AM2017-1809
Published: 01 July 2017
View articletitled, Abstract 1809: PKM2 promotes tumor angiogenesis by regulating HIF-1alpha through NF-kappaB activation
Journal Articles

Abstract 1435: Role of PRKD2 in HSP90- and hypoxia-mediated epithelial-to-mesenchymal transition

Free
Ninel Azoitei, Alexander Becher, Kristina Diepold, Susanne Bobrovich, Cornelia Brunner, Gabriela Chiosis, Stefan Fröhling, van Lint Johan, Claudia Scholl, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1435.
https://doi.org/10.1158/1538-7445.AM2015-1435
Published: 01 August 2015
View articletitled, Abstract 1435: Role of PRKD2 in HSP90- and hypoxia-mediated epithelial-to-mesenchymal transition
Journal Articles

HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization

Available to Purchase
Ninel Azoitei, Kristina Diepold, Cornelia Brunner, Arefeh Rouhi, Felicitas Genze, Alexander Becher, Hans Kestler, Johan van Lint, Gabriela Chiosis, John Koren, III, Stefan Fröhling, Claudia Scholl, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2014) 74 (23): 7125–7136.
https://doi.org/10.1158/0008-5472.CAN-14-1017
Published: 30 November 2014
View articletitled, HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization
Open the PDF for HSP90 Supports Tumor Growth and Angiogenesis through PRKD2 Protein Stabilization in another window
Includes: Supplementary data
Journal Articles

Abstract 5129: Role of PRKD2 in HSP90 inhibition-mediated suppression of cancer growth

Free
Ninel Azoitei, Kristina Diepold, Felicitas Genze, Arefeh Rouhi, Susanne Brobovich, Stefan Froehling, Gabriela Chiosis, Cornelia Brunner, Johan van Lint, Marcus Cronauer, Claudia Scholl, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5129.
https://doi.org/10.1158/1538-7445.AM2014-5129
Published: 01 October 2014
View articletitled, Abstract 5129: Role of PRKD2 in HSP90 inhibition-mediated suppression of cancer growth
Journal Articles

Abstract LB-513: Abelson Interactor 1 is a novel substrate of protein kinase D2: potential implications in tumor cell migration

Free
Subbaiah Chary Nimmagadda, Tim Eiseler, Johan Van Lint, Peter Storz, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-513.
https://doi.org/10.1158/1538-7445.AM2012-LB-513
Published: 15 April 2012
View articletitled, Abstract LB-513: Abelson Interactor 1 is a novel substrate of protein kinase D2: potential implications in tumor cell migration
Journal Articles

Abstract 5506: Trabedersen (AP 12009) for the treatment of patients with advanced tumors: A phase I/II study

Free
Helmut Oettle, Andreas Hilbig, Thomas Seufferlein, Thomas Luger, Roland Schmid, Götz von Wichert, Esther Endlicher, Claus Garbe, Katharina C. Kaehler, Axel Hauschild, Peter Kiessling, Susanne Schmaus, Hubert Heinrichs, Karl-Hermann Schlingensiepen
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 5506.
https://doi.org/10.1158/1538-7445.AM2011-5506
Published: 15 April 2011
View articletitled, Abstract 5506: Trabedersen (AP 12009) for the treatment of patients with advanced tumors: A phase I/II study
Journal Articles

Abstract 296: Protein kinase D regulates Rho GTPase activity through rhotekin

Free
Ganesh Varma Pusapati, An Rykx, Sandy Vandoninck, Johan van Lint, Guido Adler, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 296.
https://doi.org/10.1158/1538-7445.AM10-296
Published: 15 April 2010
View articletitled, Abstract 296: Protein kinase D regulates Rho GTPase activity through rhotekin
Journal Articles

Protein Kinase D2 Mediates Activation of Nuclear Factor κB by Bcr-Abl in Bcr-Abl+ Human Myeloid Leukemia Cells

Available to Purchase
Tamara Mihailovic, Martin Marx, Alexandra Auer, Johan Van Lint, Mathias Schmid, Christoph Weber, Thomas Seufferlein
Journal: Cancer Research
Cancer Res (2004) 64 (24): 8939–8944.
https://doi.org/10.1158/0008-5472.CAN-04-0981
Published: 16 December 2004
View articletitled, Protein Kinase D2 Mediates Activation of Nuclear Factor κB by Bcr-Abl in Bcr-Abl+ Human Myeloid Leukemia Cells
Open the PDF for Protein Kinase D2 Mediates Activation of Nuclear Factor κB by Bcr-Abl in Bcr-Abl+ Human Myeloid Leukemia Cells in another window
Journal Articles

Transforming Growth Factor β1 Treatment Leads to an Epithelial-Mesenchymal Transdifferentiation of Pancreatic Cancer Cells Requiring Extracellular Signal-regulated Kinase 2 Activation

Available to Purchase
Volker Ellenrieder, Sandra F. Hendler, Wolfgang Boeck, Thomas Seufferlein, Andre Menke, Claudia Ruhland, Guido Adler, Thomas M. Gress
Journal: Cancer Research
Cancer Res (2001) 61 (10): 4222–4228.
Published: 01 May 2001
View articletitled, Transforming Growth Factor β1 Treatment Leads to an Epithelial-Mesenchymal Transdifferentiation of Pancreatic Cancer Cells Requiring Extracellular Signal-regulated Kinase 2 Activation
Open the PDF for Transforming Growth Factor β1 Treatment Leads to an Epithelial-Mesenchymal Transdifferentiation of Pancreatic Cancer Cells Requiring Extracellular Signal-regulated Kinase 2 Activation in another window