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Thomas P. Loughran
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Journal Articles

Abstract 5832: Sphingolipid metabolism determines the efficacy of nanoliposomal ceramide in acute myeloid leukemia

Charyguly Annageldiyev, Arati Sharma, Brian M. Barth, Todd E. Fox, Tye Deering, Viola Devine, Nicole R. Keasey, Stephan T. Stern, Megan M. Young, Hong-Gang Wan Wang, Jason Liao, Junjia Zhu, Aaron D. Viny, Ross L. Levine, Thomas P. Loughran, Mark Kester, David F. Claxton
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5832.
https://doi.org/10.1158/1538-7445.AM2018-5832
Published: 01 July 2018
View article titled, Abstract 5832: Sphingolipid metabolism determines the efficacy of nanoliposomal ceramide in acute myeloid leukemia
Journal Articles

Abstract 323: SKI-178, a single agent co-targeting sphingosine kinase 1 and microtubule dynamics, as a therapeutic strategy for treatment of acute myeloid leukemia

Taryn E. Dick, Jeremy A. Hengst, Laura M. Geffert, Robert F. Paulson, Hong-Gang Wang, David F. Claxton, Mark Kester, Thomas P. Loughran, Jong K. Yun
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 323.
https://doi.org/10.1158/1538-7445.AM2016-323
Published: 15 July 2016
View article titled, Abstract 323: SKI-178, a single agent co-targeting sphingosine kinase 1 and microtubule dynamics, as a therapeutic strategy for treatment of acute myeloid leukemia
Journal Articles

Abstract 2613: STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia via the MEK/ERK and PKC pathway

Ushma Atul Doshi, Thomas P. Loughran, Mark Kester
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2613.
https://doi.org/10.1158/1538-7445.AM2015-2613
Published: 01 August 2015
View article titled, Abstract 2613: STAT3 mediates C6-ceramide-induced cell death in chronic lymphocytic leukemia via the MEK/ERK and PKC pathway
Journal Articles

Abstract 606: Novel somatic mutations in the DNA-binding and coiled-coil domain of the STAT3 gene in LGL-leukemia

Emma I. Andersson, Hanna Rajala, Heikki Kuusanmäki, Arjan van Adrichem, Samuli Eldfors, Sonja Lagström, Thomas Olson, Michael Clemente, Pekka Ellonen, Caroline Heckman, Thomas P. Loughran, Jaroslaw P. Maciejewski, Satu Mustjoki
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 606.
https://doi.org/10.1158/1538-7445.AM2015-606
Published: 01 August 2015
View article titled, Abstract 606: Novel somatic mutations in the DNA-binding and coiled-coil domain of the STAT3 gene in LGL-leukemia
Journal Articles

Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation

Steven Nathaniel Steinway, Jorge G.T. Zañudo, Wei Ding, Carl Bart Rountree, David J. Feith, Thomas P. Loughran, Jr, Reka Albert
Journal: Cancer Research
Cancer Res (2014) 74 (21): 5963–5977.
https://doi.org/10.1158/0008-5472.CAN-14-0225
Published: 30 October 2014
View article titled, Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation
Open the PDF for Network Modeling of TGFβ Signaling in Hepatocellular Carcinoma Epithelial-to-Mesenchymal Transition Reveals Joint Sonic Hedgehog and Wnt Pathway Activation in another window
Includes: Supplementary data
Journal Articles

Abstract 1807: Pre-clinical evaluation of Mcl-1 inhibition through maritoclax in acute myeloid leukemia

Qiang Liu, Kenichiro Doi, Krishne Gowda, Brian M. Barth, David Claxton, Shantu Amin, Thomas P. Loughran, Hong-Gang Wang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1807.
https://doi.org/10.1158/1538-7445.AM2014-1807
Published: 01 October 2014
View article titled, Abstract 1807: Pre-clinical evaluation of Mcl-1 inhibition through maritoclax in acute myeloid leukemia
Journal Articles

Abstract 1805: Characterization of pyoluteorin derivatives as Mcl-1 antagonists

Kenichiro Doi, Krishne Gowda, Qiang Liu, Shen-Shu Sung, Jyh Ming Lin, Shantu Amin, Thomas P. Loughran, Hong-Gang Wang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1805.
https://doi.org/10.1158/1538-7445.AM2014-1805
Published: 01 October 2014
View article titled, Abstract 1805: Characterization of pyoluteorin derivatives as Mcl-1 antagonists
Journal Articles

Abstract 761: Acid ceramidase promotes drug resistance in acute myeloid leukemia through P-gp upregulation mediated by NF- kB activation

Su-Fern Tan, Xin Liu, Kenichiro Doi, Hong-Gang Wang, Myles Cabot, David Feith, Thomas P. Loughran
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 761.
https://doi.org/10.1158/1538-7445.AM2014-761
Published: 01 October 2014
View article titled, Abstract 761: Acid ceramidase promotes drug resistance in acute myeloid leukemia through P-gp upregulation mediated by NF- kB activation
Journal Articles

Abstract 1067: HTLV-1 Tax deregulates autophagy in promoting T-cell survival and proliferation.

Tong Ren, Wen Dong, Yoshinori Takahashi, Thomas P. Loughran, Shao-Cong Sun, Hong-gang Wang, Hua Cheng
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1067.
https://doi.org/10.1158/1538-7445.AM2013-1067
Published: 15 April 2013
View article titled, Abstract 1067: HTLV-1 Tax deregulates autophagy in promoting T-cell survival and proliferation.
Journal Articles

Abstract LB-66: Oncogenic properties of tax protein from human T cell leukemia virus type 2

Tong Ren, Wen Dong, Yoshinori Takahashi, Di Xiang, Yunsheng Yuan, Xin Liu, Thomas P. Loughran, Shao-Cong Sun, Hong-Gang Wang, Hua Cheng
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): LB-66.
https://doi.org/10.1158/1538-7445.AM2012-LB-66
Published: 15 April 2012
View article titled, Abstract LB-66: Oncogenic properties of tax protein from human T cell leukemia virus type 2
Journal Articles

Abstract 5417: Expansion of effector regulatory T-cells represents a novel and independent prognostic factor marking escape from immune surveillance in Myleodysplastic Syndrome

Adam W. Mailloux, Chiharu Sugimori, Rami S. Komrokji, Jaroslaw P. Maciejewski, Mikkael A. Sekeres, Ronald Paquette, Thomas P. Loughran, Alan F. List, Pearlie K. Epling-Burnette
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5417.
https://doi.org/10.1158/1538-7445.AM2012-5417
Published: 15 April 2012
View article titled, Abstract 5417: Expansion of effector regulatory T-cells represents a novel and independent prognostic factor marking escape from immune surveillance in Myleodysplastic Syndrome
Journal Articles

Abstract 4304: Developing T-LGL leukemia model for targeted therapy

Tong Ren, Xin Liu, Thomas P. Loughran, Hua Cheng
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4304.
https://doi.org/10.1158/1538-7445.AM2011-4304
Published: 15 April 2011
View article titled, Abstract 4304: Developing T-LGL leukemia model for targeted therapy
Journal Articles

Abstract 4302: Targeting the sphingolipid pathway in NK large granular lymphocyte leukemia

Rebecca J. Watters, Xin Liu, Todd E. Fox, Mark Kester, Thomas P. Loughran
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4302.
https://doi.org/10.1158/1538-7445.AM2011-4302
Published: 15 April 2011
View article titled, Abstract 4302: Targeting the sphingolipid pathway in NK large granular lymphocyte leukemia
Journal Articles

Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias

Deborah L. Hodge, Jun Yang, Matthew D. Buschman, Paul M. Schaughency, Hong Dang, William Bere, Yili Yang, Ram Savan, Jeff J. Subleski, Xiao-Ming Yin, Thomas P. Loughran, Jr., Howard A. Young
Journal: Cancer Research
Cancer Res (2009) 69 (9): 3986–3994.
https://doi.org/10.1158/0008-5472.CAN-08-3735
Published: 30 April 2009
View article titled, Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias
Open the PDF for Interleukin-15 Enhances Proteasomal Degradation of Bid in Normal Lymphocytes: Implications for Large Granular Lymphocyte Leukemias in another window
Includes: Supplementary data