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Thomas P. Brent
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Journal Articles

Methylation Hot Spots in the 5′ Flanking Region Denote Silencing of the O6-Methylguanine-DNA Methyltransferase Gene

Xilin C. Qian, Thomas P. Brent
Journal: Cancer Research
Cancer Res (1997) 57 (17): 3672–3677.
Published: 01 September 1997
View article titled, Methylation Hot Spots in the 5′ Flanking Region Denote Silencing of the <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase Gene
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Journal Articles

Glial Cell-specific Differences in Repair of O6-Methylguanine

Susan P. LeDoux, Betty A. Williams, B. Scott Hollensworth, Chuen-cheh Shen, Jürgen Thomale, Manfred F. Rajewsky, Thomas P. Brent, Glenn L. Wilson
Journal: Cancer Research
Cancer Res (1996) 56 (24): 5615–5619.
Published: 01 December 1996
View article titled, Glial Cell-specific Differences in Repair of <em>O</em><sup>6</sup>-Methylguanine
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Journal Articles

Wild-Type p53 Suppresses Transcription of the Human O6-Methylguanine-DNA Methyltransferase Gene

Linda C. Harris, Joanna S. Remack, Peter J. Houghton, Thomas P. Brent
Journal: Cancer Research
Cancer Res (1996) 56 (9): 2029–2032.
Published: 01 May 1996
View article titled, Wild-Type p53 Suppresses Transcription of the Human <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase Gene
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Journal Articles

Ribozyme-mediated Modulation of Human O6-Methylguanine-DNA Methyltransferase Expression

Philip M. Potter, Linda C. Harris, Joanna S. Remack, Carol C. Edwards, Thomas P. Brent
Journal: Cancer Research
Cancer Res (1993) 53 (8): 1731–1734.
Published: 01 April 1993
View article titled, Ribozyme-mediated Modulation of Human <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase Expression
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Journal Articles

A Comparison of Human O6-Methylguanine-DNA Methyltransferase Promoter Activity in Mer+ and Mer- Cells

Linda C. Harris, Philip M. Potter, Joanna S. Remack, Thomas P. Brent
Journal: Cancer Research
Cancer Res (1992) 52 (22): 6404–6406.
Published: 01 November 1992
View article titled, A Comparison of Human <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase Promoter Activity in Mer<sup>+</sup> and Mer<sup>-</sup> Cells
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Journal Articles

Identification of the Cross-Link between Human O6-Methylguanine-DNA Methyltransferase and Chloroethylnitrosourea-treated DNA

Prescilla E. Gonzaga, Philip M. Potter, Tian-qi Niu, Dong Yu, David B. Ludlum, Joseph A. Rafferty, Geoffrey P. Margison, Thomas P. Brent
Journal: Cancer Research
Cancer Res (1992) 52 (21): 6052–6058.
Published: 01 November 1992
View article titled, Identification of the Cross-Link between Human <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase and Chloroethylnitrosourea-treated DNA
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Journal Articles

Expression of O6-Methylguanine-DNA Methyltransferase in Six Human Medulloblastoma Cell Lines

Xuanmin He, Lawrence E. Ostrowski, Mathew A. von Wronski, Henry S. Friedman, Carol J. Wikstrand, Sandra H. Bigner, Ahmed Rasheed, Surinder K. Batra, Sankar Mitra, Thomas P. Brent, Darell D. Bigner
Journal: Cancer Research
Cancer Res (1992) 52 (5): 1144–1148.
Published: 01 March 1992
View article titled, Expression of <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase in Six Human Medulloblastoma Cell Lines
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Journal Articles

Production and Characterization of Antipeptide Antibodies against Human O6-Methylguanine-DNA Methyltransferase

Lawrence E. Ostrowski, Charles N. Pegram, Mathew A. von Wronski, Peter A. Humphrey, Xuanmin He, Susumu Shiota, Sankar Mitra, Thomas P. Brent, Darell D. Bigner
Journal: Cancer Research
Cancer Res (1991) 51 (13): 3339–3344.
Published: 01 July 1991
View article titled, Production and Characterization of Antipeptide Antibodies against Human <em>O</em><sup>6</sup>-Methylguanine-DNA Methyltransferase
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Journal Articles

Immunoaffinity Purification of Human O6-Alkylguanine-DNA Alkyltransferase Using Newly Developed Monoclonal Antibodies

Thomas P. Brent, Mathew von Wronski, Charles N. Pegram, Darell D. Bigner
Journal: Cancer Research
Cancer Res (1990) 50 (1): 58–61.
Published: 01 January 1990
View article titled, Immunoaffinity Purification of Human <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferase Using Newly Developed Monoclonal Antibodies
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Journal Articles

Response of Cultured Human Cell Lines from Rhabdomyosarcoma Xenografts to Treatment with Chloroethylnitrosoureas

Debra G. Smith, Thomas P. Brent
Journal: Cancer Research
Cancer Res (1989) 49 (4): 883–886.
Published: 01 February 1989
View article titled, Response of Cultured Human Cell Lines from Rhabdomyosarcoma Xenografts to Treatment with Chloroethylnitrosoureas
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Journal Articles

Characterization of a Novel Reaction by Human O6-Alkylguanine-DNA Alkyltransferase with 1,3-Bis(2-chloroethyl)-1-nitrosourea-treated DNA

Thomas P. Brent, Joanna S. Remack, Debra G. Smith
Journal: Cancer Research
Cancer Res (1987) 47 (23): 6185–6188.
Published: 01 December 1987
View article titled, Characterization of a Novel Reaction by Human <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferase with 1,3-Bis(2-chloroethyl)-1-nitrosourea-treated DNA
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Journal Articles

Formation of DNA Interstrand Cross-Links by the Novel Chloroethylating Agent 2-Chloroethyl(methylsulfonyl)methanesulfonate: Suppression by O6-Alkylguanine-DNA Alkyltransferase Purified from Human Leukemic Lymphoblasts

Thomas P. Brent, Steven O. Lestrud, Debra G. Smith, Joanna S. Remack
Journal: Cancer Research
Cancer Res (1987) 47 (13): 3384–3387.
Published: 01 July 1987
View article titled, Formation of DNA Interstrand Cross-Links by the Novel Chloroethylating Agent 2-Chloroethyl(methylsulfonyl)methanesulfonate: Suppression by <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferase Purified from Human Leukemic Lymphoblasts
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Journal Articles

Inactivation of Purified Human O6-Alkylguanine-DNA Alkyltransferase by Alkylating Agents or Alkylated DNA

Thomas P. Brent
Journal: Cancer Research
Cancer Res (1986) 46 (5): 2320–2323.
Published: 01 May 1986
View article titled, Inactivation of Purified Human <em>O</em><sup>6</sup>-Alkylguanine-DNA Alkyltransferase by Alkylating Agents or Alkylated DNA
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Journal Articles

Suppression of Cross-Link Formation in Chloroethylnitrosourea-treated DNA by an Activity in Extracts of Human Leukemic Lymphoblasts

Thomas P. Brent
Journal: Cancer Research
Cancer Res (1984) 44 (5): 1887–1892.
Published: 01 May 1984
View article titled, Suppression of Cross-Link Formation in Chloroethylnitrosourea-treated DNA by an Activity in Extracts of Human Leukemic Lymphoblasts
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