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Thomas Kirchner
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Journal Articles

SMAD4 Loss Induces c-MYC–Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis

Leon P. Loevenich, Markus Tschurtschenthaler, Matjaz Rokavec, Miguel G. Silva, Moritz Jesinghaus, Thomas Kirchner, Frederick Klauschen, Dieter Saur, Jens Neumann, Heiko Hermeking, Peter Jung
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4604–4623.
https://doi.org/10.1158/0008-5472.CAN-22-1247
Published: 16 December 2022
View articletitled, SMAD4 Loss Induces c-MYC–Mediated NLE1 Upregulation to Support Protein Biosynthesis, Colorectal Cancer Growth, and Metastasis
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract A13: Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility

Mitchell J. Machiela, Thomas G.P. Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna González-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdett, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Uta Dirksen, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Andreas E. Kulozik, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen Chanock, Olivier Delattre
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): A13.
https://doi.org/10.1158/1538-7445.PEDCA17-A13
Published: 01 October 2018
View articletitled, Abstract A13: Genome-wide association study identifies multiple new loci associated with Ewing sarcoma susceptibility
Journal Articles

Abstract A069: Combination of immune status and tumor microvascularization provides strong prognostic markers for prostate cancer recurrence prediction

Nathalie Harder, Maria Athelogou, Harald Hessel, Alexander Buchner, Christian Stief, Thomas Kirchner, Günter Schmidt, Ralf Huss, Tze Heng Tan
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A069.
https://doi.org/10.1158/1538-7445.PRCA2017-A069
Published: 14 August 2018
View articletitled, Abstract A069: Combination of immune status and tumor microvascularization provides strong prognostic markers for prostate cancer recurrence prediction
Journal Articles

Abstract 2970: Multiple new susceptibility loci identified in genome-wide association study of Ewing sarcoma

Mitchell J. Machiela, Thomas G. Grünewald, Didier Surdez, Stephanie Reynaud, Olivier Mirabeau, Eric Karlins, Rebeca Alba Rubio, Sakina Zaidi, Sandrine Grossetete-Lalami, Stelly Ballet, Eve Lapouble, Valérie Laurence, Jean Michon, Gaelle Pierron, Heinrich Kovar, Nathalie Gaspar, Udo Kontny, Anna González-Neira, Piero Picci, Javier Alonso, Ana Patino-Garcia, Nadège Corradini, Neal D. Freedman, Nathaniel Rothman, Casey L. Dagnall, Laurie Burdette, Kristine Jones, Michelle Manning, Kathleen Wyatt, Weiyin Zhou, Meredith Yeager, David G. Cox, Robert N. Hoover, Javed Khan, Gregory T. Armstrong, Wendy M. Leisenring, Smita Bhatia, Leslie L. Robison, Uta Dirksen, Markus Metzler, Wolfgang Hartmann, Konstantin Strauch, Thomas Kirchner, Andreas E. Kulozik, Lindsay M. Morton, Lisa Mirabello, Margaret A. Tucker, Franck Tirode, Stephen J. Chanock, Olivier Delattre
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2970.
https://doi.org/10.1158/1538-7445.AM2018-2970
Published: 01 July 2018
View articletitled, Abstract 2970: Multiple new susceptibility loci identified in genome-wide association study of Ewing sarcoma
Journal Articles

Abstract 3605: Next generation sequencing from cerebral spine fluid yields actionable targets in leptomeningeal carcinomatosis

Louisa von Baumgarten, Anna Reischer, Jörg Kumbrink, Andreas Jung, Sibylle Liebmann, Steffen Ormanns, Klaus Metzeler, Julian Holch, Volker Heinemann, Thomas Kirchner, Benedikt Westphalen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3605.
https://doi.org/10.1158/1538-7445.AM2018-3605
Published: 01 July 2018
View articletitled, Abstract 3605: Next generation sequencing from cerebral spine fluid yields actionable targets in leptomeningeal carcinomatosis
Journal Articles

Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas?

Giuseppina Sannino, Aruna Marchetto, Thomas Kirchner, Thomas G.P. Grünewald
Journal: Cancer Research
Cancer Res (2017) 77 (17): 4556–4561.
https://doi.org/10.1158/0008-5472.CAN-17-0032
Published: 31 August 2017
View articletitled, Epithelial-to-Mesenchymal and Mesenchymal-to-Epithelial Transition in Mesenchymal Tumors: A Paradox in Sarcomas?
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Journal Articles

Abstract 692: Pappalysin-1 is a suitable target for T cell receptor transgenic T cells to kill Ewing sarcoma in vivo and in vitro

Uwe Thiel, Andreas Kirschner, Melanie Thiede, Thomas GP Grünewald, Rebeca Alba Rubio, Günther Richter, Thomas Kirchner, Dirk Busch, Poul Sorensen, Stefan Burdach
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 692.
https://doi.org/10.1158/1538-7445.AM2017-692
Published: 01 July 2017
View articletitled, Abstract 692: Pappalysin-1 is a suitable target for T cell receptor transgenic T cells to kill Ewing sarcoma in vivo and in vitro
Journal Articles

Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations

Cristina Blaj, Eva Marina Schmidt, Sebastian Lamprecht, Heiko Hermeking, Andreas Jung, Thomas Kirchner, David Horst
Journal: Cancer Research
Cancer Res (2017) 77 (7): 1763–1774.
https://doi.org/10.1158/0008-5472.CAN-16-2821
Published: 02 April 2017
View articletitled, Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations
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Includes: Supplementary data
Journal Articles

Abstract 1136: p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer

Lei Shi, Rene Jackstadt, Helge Siemens, Huihui Li, Thomas Kirchner, Heiko Hermeking
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1136.
https://doi.org/10.1158/1538-7445.AM2014-1136
Published: 01 October 2014
View articletitled, Abstract 1136: p53-induced miR-15a/16-1 and AP4 form a double-negative feedback loop to regulate epithelial-mesenchymal transition and metastasis in colorectal cancer
Journal Articles

p53-Induced miR-15a/16-1 and AP4 Form a Double-Negative Feedback Loop to Regulate Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer

Lei Shi, Rene Jackstadt, Helge Siemens, Huihui Li, Thomas Kirchner, Heiko Hermeking
Journal: Cancer Research
Cancer Res (2014) 74 (2): 532–542.
https://doi.org/10.1158/0008-5472.CAN-13-2203
Published: 16 January 2014
View articletitled, p53-Induced miR-15a/16-1 and AP4 Form a Double-Negative Feedback Loop to Regulate Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer
Open the PDF for p53-Induced miR-15a/16-1 and AP4 Form a Double-Negative Feedback Loop to Regulate Epithelial–Mesenchymal Transition and Metastasis in Colorectal Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 1795: Impact of ischemia time on mRNA and microRNA expression in surgical liver tissue.

Claudia Schuster, Wolfgang E. Thasler, Thomas Kirchner, Falk Hlubek
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1795.
https://doi.org/10.1158/1538-7445.AM2013-1795
Published: 15 April 2013
View articletitled, Abstract 1795: Impact of ischemia time on mRNA and microRNA expression in surgical liver tissue.
Journal Articles

Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling

David Horst, Justina Chen, Teppei Morikawa, Shuji Ogino, Thomas Kirchner, Ramesh A. Shivdasani
Journal: Cancer Research
Cancer Res (2012) 72 (6): 1547–1556.
https://doi.org/10.1158/0008-5472.CAN-11-3222
Published: 14 March 2012
View articletitled, Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling
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Includes: Supplementary data
Journal Articles

Abstract 4875: Combining immunohistochemistry and proteomics for improved antibody validation in complex FFPE tissues

Claudia Schuster, Falk Hlubek, Katharina Malinowsky, Sibylle Liebmann, Daniela Berg, Claudia Wolff, Simone Reu, Jens Neumann, Claudius Faber, Heinz Hoefler, Thomas Kirchner, Karl-Friedrich Becker
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4875.
https://doi.org/10.1158/1538-7445.AM2011-4875
Published: 15 April 2011
View articletitled, Abstract 4875: Combining immunohistochemistry and proteomics for improved antibody validation in complex FFPE tissues
Journal Articles

Abstract 3014: Robust microRNA expression profiling of specific cells in complex archival tissue stained by immunohistochemistry

Falk Hlubek, Claudia Schuster, Jan Budczies, Thomas Kirchner
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3014.
https://doi.org/10.1158/1538-7445.AM10-3014
Published: 15 April 2010
View articletitled, Abstract 3014: Robust microRNA expression profiling of specific cells in complex archival tissue stained by immunohistochemistry
Journal Articles

Abstract LB-252: Expression of FGF-2 is essential for the maintenance of cancer stem cell characteristics in human colorectal tumor cell lines

Silvio K. Scheel, Bikul Das, Lydia Kriegl, Reza B. Mukhthari, Micky Tsui, Herman Yeger, Thomas Kirchner, Andreas Jung
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-252.
https://doi.org/10.1158/1538-7445.AM10-LB-252
Published: 15 April 2010
View articletitled, Abstract LB-252: Expression of FGF-2 is essential for the maintenance of cancer stem cell characteristics in human colorectal tumor cell lines
Journal Articles

The β-catenin target gene bFGF is expressed in a small fraction of tumor cells with characteristics of cancer stem cells in human colorectal cancer

Silvio Scheel, Bikul Das, Micky Tsui, Thomas Brabletz, Angela Haynl, Herman Yeger, Thomas Kirchner, Andreas Jung
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 5002.
Published: 01 May 2008
View articletitled, The β-catenin target gene bFGF is expressed in a small fraction of tumor cells with characteristics of cancer stem cells in human colorectal cancer
Journal Articles

Expression of the pro-invasive protein SPARC is regulated by β-catenin/TCF4 in colorectal cancer

Falk Hlubek, Claudia Schuster, Silvio Scheel, Lydia Kriegel, Andreas Jung, Jan Budczies, Thomas Kirchner
Journal: Cancer Research
Cancer Res (2008) 68 (9_Supplement): 1956.
Published: 01 May 2008
View articletitled, Expression of the pro-invasive protein SPARC is regulated by β-catenin/TCF4 in colorectal cancer
Journal Articles

The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer

Simone Spaderna, Otto Schmalhofer, Mandy Wahlbuhl, Arno Dimmler, Katja Bauer, Aneesa Sultan, Falk Hlubek, Andreas Jung, Dennis Strand, Andreas Eger, Thomas Kirchner, Jürgen Behrens, Thomas Brabletz
Journal: Cancer Research
Cancer Res (2008) 68 (2): 537–544.
https://doi.org/10.1158/0008-5472.CAN-07-5682
Published: 15 January 2008
View articletitled, The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer
Open the PDF for The Transcriptional Repressor ZEB1 Promotes Metastasis and Loss of Cell Polarity in Cancer in another window
Includes: Supplementary data
Journal Articles

Wnt/β-catenin   target genes are differentially expressed within colorectal cancer

Falk Hlubek, Thomas Brabletz, Jan Budczies, Sabine Pfeiffer, Andreas Jung, Thomas Kirchner
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2152.
Published: 01 May 2007
View articletitled, Wnt/β-catenin   target genes are differentially expressed within colorectal cancer
Journal Articles

p16INK4A is a β-catenin target gene and its expression correlates with low survival in human colorectal cacner

Andreas Jung, Stella Wassermann, Silvio Scheel, Thomas Brabletz, Richard Palmqvist, Falk Hlubek, Angela Haynl, Susanne Merkel, Thomas Kirchner
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1259.
Published: 01 May 2007
View articletitled, p16INK4A is a β-catenin target gene and its expression correlates with low survival in human colorectal cacner