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Thomas Kindler
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Journal Articles

Abstract 6373: From genotype to phenotype: Adding phosphoproteomic analysis to molecularly-guided therapy recommendation in Cancer of Unknown Primary (CUP)

Free
Maximilian Werner, Tobias Mundt, Annika Schneider, Waqar Hussain, Jonas Arnold, Cecilia Bang Jensen, Martina Fröhlich, Barbara Hutter, Jennifer Hüllein, Nagarajan Paramasivam, Amirhossein Sakhteman, Matthew The, Daniela Richter, Simon Kreutzfeldt, Christoph E. Heilig, Maria-Veronica Teleanu, Daniel B. Lipka, Annika Baude, Katja Beck, Katrin Pfütze, Maren Knödler, Damian Rieke, Johanna Falkenhorst, Ilektra Antonia Mavroeidi, Christian Brandts, Anna L. Illert, Melanie Börries, Thomas Kindler, Tobias Marcus Herold, Nicole Pfarr, Albrecht Stenzinger, Christoph Heining, Irina Kerle, Evelin Schröck, Peter Horak, Daniel Hübschmann, Lino Möhrmann, Bernhard Küster, Stefan Fröhling, Hanno Glimm
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6373.
https://doi.org/10.1158/1538-7445.AM2025-6373
Published: 21 April 2025
View articletitled, Abstract 6373: From genotype to phenotype: Adding phosphoproteomic analysis to molecularly-guided therapy recommendation in Cancer of Unknown Primary (CUP)
Journal Articles

Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response

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Erik S. Blomain, Shaghayegh Soudi, Ziwei Wang, Anish Somani, Ajay Subramanian, Serey C.L. Nouth, Eniola Oladipo, Christin New, Deborah E. Kenney, Neda Nemat-Gorgani, Thomas Kindler, Raffi S. Avedian, Robert J. Steffner, David G. Mohler, Susan M. Hiniker, Alexander L. Chin, Anusha Kalbasi, Michael S. Binkley, Marius Fried, Matthias M. Gaida, Matt van de Rijn, Everett J. Moding
Journal: Cancer Research
Cancer Res (2025) 85 (6): 1162–1174.
https://doi.org/10.1158/0008-5472.CAN-24-3281
Published: 14 March 2025
View articletitled, Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response
Open the PDF for Evolutionary Pressures Shape Undifferentiated Pleomorphic Sarcoma Development and Radiotherapy Response in another window
Includes: Supplementary data
Journal Articles

Abstract 926: Genomics-based personalized oncology of advanced thymic epithelial tumors

Free
Lino Möhrmann, Lysann Rostock, Małgorzata Oleś, Arne Jahn, Marie Arlt, Nagarajan Paramasivam, Korinna Jöhrens, Luise Rupp, Marc Schmitz, Daniela Richter, Sebastian Uhrig, Martina Fröhlich, Barbara Hutter, Jennifer Hüllein, Elena E. Wolf, Dorothea Hanf, Laura Gieldon, Simon Kreutzfeldt, Christoph E. Heilig, Veronica Teleanu, Daniel B. Lipka, Andreas Mock, Ivan Jelas, Damian T. Rieke, Marcel Wiesweg, Melanie Boerries, Anna L. Illert, Alexander Desuki, Thomas Kindler, Angela M. Krackhardt, C. Benedikt Westphalen, Heidrun Grosch, Leonidas Apostolidis, Albrecht Stenzinger, Irina A. Kerle, Christoph Heining, Daniel Hübschmann, Evelin Schröck, Stefan Fröhling, Hanno Glimm
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 926.
https://doi.org/10.1158/1538-7445.AM2023-926
Published: 04 April 2023
View articletitled, Abstract 926: Genomics-based personalized oncology of advanced thymic epithelial tumors
Journal Articles

Abstract 4544: Genomic, transcriptomic, functional, and mechanistic characterization of rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusions

Free
Julia Schoepf, Sebastian Uhrig, Christoph E. Heilig, Kwang-Seok Lee, Tatjana Walther, Alexander Carazzato, Anna Maria Dobberkau, Dieter Weichenhan, Christoph Plass, Mark Hartmann, Gaurav Diwan, Zunamys Carrero, Claudia R. Ball, Tobias Hohl, Thomas Kindler, Patricia Rudolph-Hähnel, Anna Nilsson, Ingrid Øra, Roland Imle, Ana Banito, Robert Russell, Barbara C. Jones, Daniel B. Lipka, Hanno Glimm, Daniel Hübschmann, Wolfgang Hartmann, Stefan Fröhling, Claudia Scholl
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4544.
https://doi.org/10.1158/1538-7445.AM2023-4544
Published: 04 April 2023
View articletitled, Abstract 4544: Genomic, transcriptomic, functional, and mechanistic characterization of rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusions
Journal Articles

Abstract 2003: Oncogenic interplay of FUS-DDIT3 and YAP1 in myxoid liposarcoma

Free
Ruth Berthold, Ilka Isfort, Jonas Breuer, Lorena Heinst, Thomas Kindler, Pierre Åman, Inga Grünewald, Eva Wardelmann, Thomas G. Grünewald, Florencia Cidre-Aranaz, Claudia Scholl, Stefan Fröhling, Marcel Trautmann, Wolfgang Hartmann
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2003.
https://doi.org/10.1158/1538-7445.AM2021-2003
Published: 01 July 2021
View articletitled, Abstract 2003: Oncogenic interplay of FUS-DDIT3 and YAP1 in myxoid liposarcoma
Journal Articles

Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium

Free
Peter Horak, Christoph Heining, Andreas Mock, Simon Kreutzfeldt, Andreas Lassmann, Lino Möhrmann, Jennifer Hüllein, Dorothea Hanf, Arne Jahn, Leo Ruhnke, Laura Gieldon, Christoph E. Heilig, Veronica Teleanu, Martina Fröhlich, Sebastian Uhrig, Katja Beck, Daniela Richter, Stephan Wolf, Katrin Pfütze, Christina Geörg, Bettina Meissburger, Frederick Klauschen, Ulrich Keilholz, Sebastian Ochsenreither, Gunnar Folprecht, Jens Siveke, Sebastian Bauer, Thomas Kindler, Christian Brandts, Melanie Boerries, Anna L. Illert, Nikolas von Bubnoff, Karsten Spiekermann, Philipp J. Jost, Klaus Schulze-Osthoff, Michael Bitzer, Peter Schirmacher, Christof von Kalle, Richard F. Schlenk, Barbara Klink, Barbara Hutter, Daniel Hübschmann, Albrecht Stenzinger, Wilko Weichert, Evelin Schröck, Benedikt Brors, Hanno Glimm, Stefan Fröhling, German Cancer Consortium (DKTK)
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 821.
https://doi.org/10.1158/1538-7445.AM2020-821
Published: 15 August 2020
View articletitled, Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium
Journal Articles

Abstract 820: Genomics based personalized oncology of cancer of unknown primary

Free
Maximilian Werner, Lino Möhrmann, Małgorzata Oleś, Andreas Mock, Arne Jahn, Simon Kreutzfeldt, Sebastian Uhrig, Martina Fröhlich, Barbara Hutter, Daniela Richter, Gina Rüter, Ivan Jelas, Rainer Hamacher, Johanna Falkenhorst, Sebastian Wagner, Christian Brandts, Melanie Börries, Anna Illert, Klaus Metzeler, Benedikt Westphalen, Alexander Desuki, Thomas Kindler, Albrecht Stenzinger, Evelin Schröck, Benedikt Brors, Peter Horak, Christoph Heining, Stefan Fröhling, Hanno Glimm
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 820.
https://doi.org/10.1158/1538-7445.AM2020-820
Published: 15 August 2020
View articletitled, Abstract 820: Genomics based personalized oncology of cancer of unknown primary
Journal Articles

Abstract 3841: Therapeutic targeting of FLT3 mutations in AML via menin-MLL1 and FLT3 inhibition

Free
Margarita M. Dzama, Martha C. Taubert, Kerstin Kunz, Johanna Rausch, Chun-Wei Chen, Annalisa Mupo, Matthias Theobald, Thomas Kindler, Richard P. Koche, George S. Vassiliou, Scott A. Armstrong, Michael W. Kühn
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3841.
https://doi.org/10.1158/1538-7445.AM2019-3841
Published: 01 July 2019
View articletitled, Abstract 3841: Therapeutic targeting of FLT3 mutations in AML via menin-MLL1 and FLT3 inhibition
Journal Articles

Abstract 3437: Requirement for YAP1 signaling in myxoid liposarcoma

Free
Marcel Trautmann, Ya-Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki, Ilka Isfort, Magdalene Cyra, Eva Wardelmann, Sebastian Huss, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Anders Ståhlberg, Pierre Åman, Thorsten Zenz, Undine Lange, Thomas Kindler, Claudia Scholl, Wolfgang Hartmann, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3437.
https://doi.org/10.1158/1538-7445.AM2019-3437
Published: 01 July 2019
View articletitled, Abstract 3437: Requirement for YAP1 signaling in myxoid liposarcoma
Journal Articles

Abstract 1257: The transcription factor CREB is essential in myxoid liposarcoma

Free
Magdalene Cyra, Sebastian Huss, Miriam Schulte, Ilka Isfort, Susanne Hafner, Thomas Simmet, Thomas Kindler, Pierre Åman, Eva Wardelmann, Wolfgang Hartmann, Marcel Trautmann
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1257.
https://doi.org/10.1158/1538-7445.AM2019-1257
Published: 01 July 2019
View articletitled, Abstract 1257: The transcription factor CREB is essential in myxoid liposarcoma
Journal Articles

Abstract 468: Clinical relevance of comprehensive genomic analysis in advanced-stage cancers and rare malignancies: Results from the MASTER trial of the German Cancer Consortium

Free
Peter Horak, Christoph Heining, Simon Kreutzfeldt, Christoph E. Heilig, Lino Möhrmann, Laura Gieldon, Martina Fröhlich, Sebastian Uhrig, Daniel Hübschmann, Katja Beck, Daniela Richter, Stephan Wolf, Katrin Pfütze, Christina Geörg, Bettina Meißburger, Frederick Klauschen, Sebastian Ochsenreither, Gunnar Folprecht, Jens Siveke, Sebastian Bauer, Thomas Kindler, Christian Brandts, Melanie Börries, Nikolas von Bubnoff, Karsten Spiekermann, Philipp J. Jost, Klaus Schulze-Osthoff, Michael Bitzer, Peter Schirmacher, Christof von Kalle, Richard Schlenk, Barbara Klink, Barbara Hutter, Wilko Weichert, Albrecht Stenzinger, Evelin Schröck, Benedikt Brors, Hanno Glimm, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 468.
https://doi.org/10.1158/1538-7445.AM2019-468
Published: 01 July 2019
View articletitled, Abstract 468: Clinical relevance of comprehensive genomic analysis in advanced-stage cancers and rare malignancies: Results from the MASTER trial of the German Cancer Consortium
Journal Articles

Abstract 5223: Epigenetic silencing mediated by non-phosphorylated STAT5B prevents differentiation in acute myeloid leukemia

Free
Jakub Szybinski, Daniel Sasca, Jan Heidelberger, Karolin Klumb, Viral Shah, Anna Dolnik, Matthias Theobald, Lars Bullinger, Petra Beli, Thomas Kindler
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 5223.
https://doi.org/10.1158/1538-7445.AM2019-5223
Published: 01 July 2019
View articletitled, Abstract 5223: Epigenetic silencing mediated by non-phosphorylated STAT5B prevents differentiation in acute myeloid leukemia
Journal Articles

Abstract 267: Targeting the alt-NHEJ DNA repair pathway selectively sensitizes KRAS-mutant cancer cells to chemotherapy

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Patricia S. Haehnel, Sarah Swoboda, Nadine Lehmann, Sebastian Rosigkeit, Hernike Gothe, Danial I. Sasca, Dennis Strand, Matthias Theobald, Vassilis Roukos, Ernesto Bockamp, Thomas Kindler
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 267.
https://doi.org/10.1158/1538-7445.AM2019-267
Published: 01 July 2019
View articletitled, Abstract 267: Targeting the alt-NHEJ DNA repair pathway selectively sensitizes KRAS-mutant cancer cells to chemotherapy
Journal Articles

Abstract LB-287: Identification of patients at risk for tumor predisposition syndromes based on the evaluation of sporadic cancer exome sequencing data: experiences from the NCT/DKTK MASTER program

Free
Evelin Schrock, Barbara Hutter, Martina Fröhlich, Falk Zakrzewski, Sebastian Uhrig, Andreas Rump, Karl Hackmann, Joseph Porrmann, Laura Gieldon, Daniela Richter, Albrecht Stenzinger, Thomas Kindler, Wilko Weichert, Philipp J. Jost, Christian Brandts, Klaus Schulze-Osthoff, Johanna Falkenhorst, Sebastian Bauer, Frederick Klauschen, Konrad Klinghammer, Gunnar Folprecht, Martin Wermke, Karsten Spiekermann, Benedikt Brors, Stefan Gröschel, Christoph Heining, Peter Horak, Hanno Glimm, Stefan Fröhling, Barbara Klink
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-287.
https://doi.org/10.1158/1538-7445.AM2017-LB-287
Published: 01 July 2017
View articletitled, Abstract LB-287: Identification of patients at risk for tumor predisposition syndromes based on the evaluation of sporadic cancer exome sequencing data: experiences from the NCT/DKTK MASTER program
Journal Articles

STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2

Free
Winnie F. Tam, Patricia S. Hähnel, Andrea Schüler, Benjamin H. Lee, Rachel Okabe, Nan Zhu, Saskia V. Pante, Glen Raffel, Thomas Mercher, Gerlinde Wernig, Ernesto Bockamp, Daniel Sasca, Andreas Kreft, Gertraud W. Robinson, Lothar Hennighausen, D. Gary Gilliland, Thomas Kindler
Journal: Cancer Research
Cancer Res (2013) 73 (1): 373–384.
https://doi.org/10.1158/0008-5472.CAN-12-0255
Published: 02 January 2013
View articletitled, STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2
Open the PDF for STAT5 Is Crucial to Maintain Leukemic Stem Cells in Acute Myelogenous Leukemias Induced by MOZ-TIF2 in another window
Includes: Supplementary data
Journal Articles

Identification and characterization of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with AML.

Free
Thomas Kindler, Frank Breitenbuecher, Stefan Kasper, Kerstin Kunz, Birgit Carius, Thomas Meyer, Harald Gschaidmeier, Christoph Huber, Thomas Fischer
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 852.
Published: 01 April 2004
View articletitled, Identification and characterization of a novel activating mutation (Y842C) within the activation loop of FLT3 in patients with AML.