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Thomas Helleday
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Journal Articles

Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response

Louise Ramos, Martin Henriksson, Thomas Helleday, Alanna C. Green
Journal: Cancer Research
Cancer Res (2024) 84 (1): 9–16.
https://doi.org/10.1158/0008-5472.CAN-23-1290
Published: 02 January 2024
View article titled, Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response
Open the PDF for Targeting MTHFD2 to Exploit Cancer-Specific Metabolism and the DNA Damage Response in another window
Includes: Supplementary data
Journal Articles

Abstract A051: The spatial landscape of clonal somatic copy number alterations in benign and malignant prostate epithelia

Andrew Erickson, Mengxiao He, Emelie Berglund, Maja Marklund, Reza Mirzazadeh, Niklas Schultz, Linda Kvastad, Alma Andersson, Ludvig Bergenstråhle, Joseph Bergenstråhle, Ludvig Larsson, Leire Alonso Galicia, Alia Shamikh, Elisa Basmaci, Teresita Díaz De Ståhl, Timothy Rajakumar, Dimitrios Doultsinos, Kim Thrane, Andrew L. Ji, Paul A. Khavari, Firaz Tarish, Anna Tanoglidi, Jonas Maaskola, Richard Colling, Tuomas Mirtti, Freddie C. Hamdy, Dan J. Woodcock, Thomas Helleday, Ian G. Mills, Alastair D. Lamb, Joakim Lundeberg
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A051.
https://doi.org/10.1158/1538-7445.PRCA2023-A051
Published: 02 June 2023
View article titled, Abstract A051: The spatial landscape of clonal somatic copy number alterations in benign and malignant prostate epithelia
Journal Articles

Abstract CT182: OXC-101 shows favorable safety profile in first in human phase 1 trial in patients with advanced solid cancer

Jeffrey Yachnin, Lars Ny, Teresa Sandvall, Kumar Sanjiv, Martin Scobie, Björn Platzack, Pawel Barancewski, Olof Breuer, Vassilis Gorgoulis, Ioannis S. Pateras, Maria Klockare, Austin Smith, Ulrika Warpman Berglund, Thomas Helleday
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT182.
https://doi.org/10.1158/1538-7445.AM2023-CT182
Published: 14 April 2023
View article titled, Abstract CT182: OXC-101 shows favorable safety profile in first in human phase 1 trial in patients with advanced solid cancer
Journal Articles

Abstract 6204: DNA-PK inhibition augment the cancer specific cytotoxicity of mitotic MTH1 inhibitor OXC-101

Akhilesh Nagesh Danda, Helge Gad, Martin Scobie, Laura Martínez-López, Nuria Pastor Carrillo, Manuel Luis Orta, Thomas Helleday, Ulrika warpman berglund, Kumar Sanjiv
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6204.
https://doi.org/10.1158/1538-7445.AM2023-6204
Published: 04 April 2023
View article titled, Abstract 6204: DNA-PK inhibition augment the cancer specific cytotoxicity of mitotic MTH1 inhibitor OXC-101
Journal Articles

Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1

Ulrika Warpman Berglund, Helge Gad, Kumar Sanjiv, Ann-Sofie Jemth, Oliver Mortusewics, Lars Brautigam, Juha Rantala, Thomas Helleday
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1569.
https://doi.org/10.1158/1538-7445.AM2023-1569
Published: 04 April 2023
View article titled, Abstract 1569: OXC-101 kills cancer by disturbing microtubule polymerization and inhibiting MTH1
Journal Articles

Abstract 2171: The spatial landscape of clonal somatic mutations in benign and malignant tissue

Andrew Erickson, Emelie Berglund, Mengxiao He, Maja Marklund, Reza Mirzazadeh, Niklas Schultz, Linda Kvastad, Alma Andersson, Ludvig Bergenstråhle, Joseph Bergenstråhle, Ludvig Larsson, Alia Shamikh, Elisa Basmaci, Teresita Diaz De Ståhl, Timothy Rajakumar, Kim Thrane, Andrew L. Ji, Paul A. Khavari, Firaz Tarish, Anna Tanoglidi, Jonas Maaskola, Richard Colling, Tuomas Mirtti, Freddie Hamdy, Dan J. Woodcock, Thomas Helleday, Ian G. Mills, Alastair D. Lamb, Joakim Lundenberg
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2171.
https://doi.org/10.1158/1538-7445.AM2022-2171
Published: 15 June 2022
View article titled, Abstract 2171: The spatial landscape of clonal somatic mutations in benign and malignant tissue
Journal Articles

Abstract PR016: The spatial landscape of clonal somatic mutations in benign and malignant tissue

Andrew Erickson, Emelie Berglund, Mengxiao He, Maja Marklund, Reza Mirzazadeh, Niklas Schultz, Ludvig Bergenstråhle, Linda Kvastad, Alma Andersson, Joseph Bergenstråhle, Ludvig Larsson, Alia Shamikh, Elisa Basmaci, Teresita Diaz De Ståhl, Timothy Rajakumar, Kim Thrane, Andrew L. Ji, Paul A. Khavari, Firaz Tarish, Anna Tanoglidi, Jonas Maaskola, Richard Colling, Tuomas Mirtti, Freddie C. Hamdy, Dan J. Woodcock, Thomas Helleday, Ian G. Mills, Alastair D. Lamb, Joakim Lundeberg
Journal: Cancer Research
Cancer Res (2022) 82 (10_Supplement): PR016.
https://doi.org/10.1158/1538-7445.EVODYN22-PR016
Published: 15 May 2022
View article titled, Abstract PR016: The spatial landscape of clonal somatic mutations in benign and malignant tissue
Journal Articles

MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia

Kumar Sanjiv, José Manuel Calderón-Montaño, Therese M. Pham, Tom Erkers, Viktoriia Tsuber, Ingrid Almlöf, Andreas Höglund, Yaser Heshmati, Brinton Seashore-Ludlow, Akhilesh Nagesh Danda, Helge Gad, Elisee Wiita, Camilla Göktürk, Azita Rasti, Stefanie Friedrich, Anders Centio, Montserrat Estruch, Thea Kristin Våtsveen, Nona Struyf, Torkild Visnes, Martin Scobie, Tobias Koolmeister, Martin Henriksson, Olov Wallner, Teresa Sandvall, Sören Lehmann, Kim Theilgaard-Mönch, Mathew J. Garnett, Päivi Östling, Julian Walfridsson, Thomas Helleday, Ulrika Warpman Berglund
Journal: Cancer Research
Cancer Res (2021) 81 (22): 5733–5744.
https://doi.org/10.1158/0008-5472.CAN-21-0061
Published: 15 November 2021
View article titled, MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
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Includes: Supplementary data
Journal Articles

NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis

Zhenjun Zhao, Helge Gad, Carlos Benitez-Buelga, Kumar Sanjiv, Hua Xiangwei, He Kang, Mingxuan Feng, Zhicong Zhao, Ulrika Warpman Berglund, Qiang Xia, Thomas Helleday
Journal: Cancer Research
Cancer Res (2021) 81 (15): 4079–4093.
https://doi.org/10.1158/0008-5472.CAN-20-1028
Published: 01 August 2021
View article titled, NEIL3 Prevents Senescence in Hepatocellular Carcinoma by Repairing Oxidative Lesions at Telomeres during Mitosis
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Includes: Supplementary data
Journal Articles

MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG

Sean G. Rudd, Helge Gad, Kumar Sanjiv, Nuno Amaral, Anna Hagenkort, Petra Groth, Cecilia E. Ström, Oliver Mortusewicz, Ulrika Warpman Berglund, Thomas Helleday
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3530–3541.
https://doi.org/10.1158/0008-5472.CAN-19-0883
Published: 01 September 2020
View article titled, MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG
Open the PDF for MTH1 Inhibitor TH588 Disturbs Mitotic Progression and Induces Mitosis-Dependent Accumulation of Genomic 8-oxodG in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 1057: Targeting MTHFD2 using first-in-class inhibitors kills haematological and solid cancer through thymineless-induced replication stress

Thomas Helleday
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1057.
https://doi.org/10.1158/1538-7445.AM2020-1057
Published: 15 August 2020
View article titled, Abstract 1057: Targeting MTHFD2 using first-in-class inhibitors kills haematological and solid cancer through thymineless-induced replication stress
Journal Articles

Abstract 5204: Targeting OGG1 arrest cancer cell proliferationby mitochondrial dysfunction and replication stress

Carlos Benitez-Buelga, Torkild Visnes, Kumar Sanjiv, Oliver Mortusewicz, Ulrika Warpman Berglund, Thomas Helleday
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 5204.
https://doi.org/10.1158/1538-7445.AM2020-5204
Published: 15 August 2020
View article titled, Abstract 5204: Targeting OGG1 arrest cancer cell proliferationby mitochondrial dysfunction and replication stress
Journal Articles

Abstract 4799: OGG1 depleted cancer cells are sensitive to anti-malarial drug proguanil: Repurposing for cancer treatment

Varshni Rajagopal, Karthick Marimuthu, Carlos Benitez-Buelga, Olov Wallner, Evert Homan, Martin Scobie, Christina Kalderén, Thomas Helleday, Ulrika Warpman Berglund, Kumar Sanjiv
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4799.
https://doi.org/10.1158/1538-7445.AM2020-4799
Published: 15 August 2020
View article titled, Abstract 4799: OGG1 depleted cancer cells are sensitive to anti-malarial drug proguanil: Repurposing for cancer treatment
Journal Articles

Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds

Sylvain Peuget, Jiawei Zhu, Gema Sanz, Madhurendra Singh, Massimiliano Gaetani, Xinsong Chen, Yao Shi, Amir Ata Saei, Torkild Visnes, Mikael S. Lindström, Ali Rihani, Lidia Moyano-Galceran, Joseph W. Carlson, Elisabet Hjerpe, Ulrika Joneborg, Kaisa Lehti, Johan Hartman, Thomas Helleday, Roman Zubarev, Galina Selivanova
Journal: Cancer Research
Cancer Res (2020) 80 (7): 1538–1550.
https://doi.org/10.1158/0008-5472.CAN-19-2069
Published: 02 April 2020
View article titled, Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds
Open the PDF for Thermal Proteome Profiling Identifies Oxidative-Dependent Inhibition of the Transcription of Major Oncogenes as a New Therapeutic Mechanism for Select Anticancer Compounds in another window
Includes: Supplementary data
Journal Articles

Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells

Kumar Sanjiv, Helge gad, Sean G. Rudd, Oliver Mortusewicz, Ailine Stolz, Nuno Amaral, Lars Brautigham, Linda Pudelko, Christina Kaldéren, Ann-Sofie Jemth, Ingrid Almlöf, Torkild Visnes, Niklas Schultz, Johan Boström, José Manuel Calderon Montano1, Anna Hagenkort, Petra Groth, Camilla Gokturk, Tobias Koolmeister, Prasad Wakchaure, Evert Homan, Mikael Altun, Cecilia Ström, Martin Scobie, Holger Bastians, Ulrika Warpman Berglund, Thomas Helleday
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 105.
https://doi.org/10.1158/1538-7445.AM2019-105
Published: 01 July 2019
View article titled, Abstract 105: MTH1 promotes mitotic progression to avoid oxidative DNA damage in cancer cells
Journal Articles

Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor

Robert Gustafsson, Ann-Sofie Jemth, Nina M.S. Gustafsson, Katarina Färnegårdh, Olga Loseva, Elisée Wiita, Nadilly Bonagas, Leif Dahllund, Sabin Llona-Minguez, Maria Häggblad, Martin Henriksson, Yasmin Andersson, Evert Homan, Thomas Helleday, Pål Stenmark
Journal: Cancer Research
Cancer Res (2017) 77 (4): 937–948.
https://doi.org/10.1158/0008-5472.CAN-16-1476
Published: 14 February 2017
View article titled, Crystal Structure of the Emerging Cancer Target MTHFD2 in Complex with a Substrate-Based Inhibitor
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Includes: Supplementary data
Journal Articles

NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine

Nicholas C.K. Valerie, Anna Hagenkort, Brent D.G. Page, Geoffrey Masuyer, Daniel Rehling, Megan Carter, Luka Bevc, Patrick Herr, Evert Homan, Nina G. Sheppard, Pål Stenmark, Ann-Sofie Jemth, Thomas Helleday
Journal: Cancer Research
Cancer Res (2016) 76 (18): 5501–5511.
https://doi.org/10.1158/0008-5472.CAN-16-0584
Published: 15 September 2016
View article titled, NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine
Open the PDF for NUDT15 Hydrolyzes 6-Thio-DeoxyGTP to Mediate the Anticancer Efficacy of 6-Thioguanine in another window
Includes: Supplementary data
Journal Articles

Abstract 1260: Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell

Kumar Sanjiv, Helge Gad, Sean Rudd, Rachel Hurley, Patric Herr, José Manuel Calderón Montaño, Oliver Mortusewicz, Tobias Koolmeister, Sylvain Jaques, Estefanía Burgos Morón, Andreas Hoglund, Te-Chang Lee, Martin Scobie, Scott Kaufmann, John Weroha, Ulrika Warpman Berglund, Andrea Wahner Hendrickson, Thomas Helleday
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1260.
https://doi.org/10.1158/1538-7445.AM2016-1260
Published: 15 July 2016
View article titled, Abstract 1260: Polymerase kappa determines the sensitivity of MTH1 inhibitors to cisplatin-resistant cell
Journal Articles

Abstract LB-176: The human androgen receptor regulates DNA damage response (DDR) in prostate cancer

Mohammad Asim, Heather Zecchini, Firas Tarish, Charlie Massie, Ajoeb Baridi, Anne Warren, Wanfeng Zhao, Leigh-Anne McDuffus, Patrice Mascalchi, Greg Shaw, Harveer Dev, Karan Wadhwa, Paul Wijnhoven, Josep Forment, Scott Lyons, Andy Lynch, Cormac O’Neill, Vincent Zecchini, Paul Rennie, Aria Baniahmad, Simon Tavare, Ian Mills, Niklas Schulz, Yaron Galanty, Thomas Helleday, David Neal
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-176.
https://doi.org/10.1158/1538-7445.AM2016-LB-176
Published: 15 July 2016
View article titled, Abstract LB-176: The human androgen receptor regulates DNA damage response (DDR) in prostate cancer
Journal Articles

Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition

Lars Bräutigam, Linda Pudelko, Ann-Sofie Jemth, Helge Gad, Mohit Narwal, Robert Gustafsson, Stella Karsten, Jordi Carreras Puigvert, Evert Homan, Carsten Berndt, Ulrika Warpman Berglund, Pål Stenmark, Thomas Helleday
Journal: Cancer Research
Cancer Res (2016) 76 (8): 2366–2375.
https://doi.org/10.1158/0008-5472.CAN-15-2380
Published: 14 April 2016
View article titled, Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition
Open the PDF for Hypoxic Signaling and the Cellular Redox Tumor Environment Determine Sensitivity to MTH1 Inhibition in another window
Includes: Supplementary data