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Theodore S. Lawrence
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Journal Articles

Abstract 1801: Rewiring of cortical glucose metabolism fuels human brain cancer growth

Andrew J. Scott, Anjali Mittal, Baharan Meghdadi, Sravya Palavalasa, Abhinav Achreja, Alexandra O'Brien, Ayesha Kothari, Weihua Zhou, Jie Xu, Angelica Lin, Kari Wilder-Romans, Donna M. Edwards, Vijay Tarnal, Nathan Qi, Theodore S. Lawrence, Sriram Venneti, Nathalie Y. Agar, Costas A. Lyssiotis, Wajd N. Al-Holou, Deepak Nagrath, Daniel R. Wahl
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1801.
https://doi.org/10.1158/1538-7445.AM2024-1801
Published: 22 March 2024
View article titled, Abstract 1801: Rewiring of cortical glucose metabolism fuels human brain cancer growth
Journal Articles

Abstract B051: DNA damage signaling activates GTP synthesis to promote glioblastoma treatment resistance

Andrew J. Scott, Alexandra O'Brien, Weihua Zhou, Jie Xu, Sravya Palavalasa, Ayesha U. Kothari, Kari Wilder-Romans, Li Zhang, Anthony C. Andren, Sriram Chandrasekaran, Jason Heth, Yoshie Umemura, Nathan Qi, Theodore S. Lawrence, Wajd N. Al-Holou, Costas A. Lyssiotis, Daniel R Wahl
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_1): B051.
https://doi.org/10.1158/1538-7445.BRAIN23-B051
Published: 04 March 2024
View article titled, Abstract B051: DNA damage signaling activates GTP synthesis to promote glioblastoma treatment resistance
Journal Articles

Abstract A004: GTP signaling links metabolism, DNA repair, and responses to genotoxic stress

Weihua Zhou, Zitong Zhao, Angelica Lin, John Yang, Jie Xu, Kari Wilder-Romans, Annabel Yang, Andrew J. Scott, Jing Li, Sumeet Solanki, Jennifer Speth, Natalie Walker, Ayesha U. Kothari, Yangyang Yao, Erik R. Peterson, Navyateja Korimerla, Christian K. Werner, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra M Obrien, Ameer L Elaimy, Sean P. Ferris, Shuang G. Zhao, Jann N. Sarkaria, Balázs Győrffy, Shuqun Zhang, Wajd N. Al-Holou, Yoshie Umemura, Meredith A Morgan, Theodore S. Lawrence, Costas A. Lyssiotis, Marc Peters-Golden, Yatrik M. Shah, Daniel R. Wahl
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_1): A004.
https://doi.org/10.1158/1538-7445.BRAIN23-A004
Published: 04 March 2024
View article titled, Abstract A004: GTP signaling links metabolism, DNA repair, and responses to genotoxic stress
Journal Articles

Abstract CT151: A phase II study of optimized individualized adaptive radiation therapy for hepatocellular carcinoma

Daniel J. Herr, Chang Wang, Mishal Mendiratta-Lala, Martha Matuszak, Charles S. Mayo, Yue Cao, Neehar Parikh, Randy Ten Hanken, Dawn Owen, Teodor Stanescu, Michael Yan, Laura A. Dawson, Matthew Schipper, Theodore S. Lawrence, Kyle C. Cuneo
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): CT151.
https://doi.org/10.1158/1538-7445.AM2023-CT151
Published: 14 April 2023
View article titled, Abstract CT151: A phase II study of optimized individualized adaptive radiation therapy for hepatocellular carcinoma
Journal Articles

Abstract 1092: Targeting one-carbon metabolism radiosensitizes pancreatic ductal adenocarcinoma cells (PDAC)

Minal Nenwani, Abhinav Achreja, Olamide Animasahun, Itisam Sarangi, Jyotirmoy Roy, Srinadh Choppara, Fulei Wuchu, Miya Paserba, Anjali Mittal, Sergio Quispe, Aradhana Mohan, Meredith Morgan, Theodore S. Lawrence, Deepak Nagrath
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1092.
https://doi.org/10.1158/1538-7445.AM2023-1092
Published: 04 April 2023
View article titled, Abstract 1092: Targeting one-carbon metabolism radiosensitizes pancreatic ductal adenocarcinoma cells (PDAC)
Journal Articles

Abstract 3677: DNA damage signaling activates de novo GTP synthesis to promote chemoradiation resistance in glioblastoma

Andrew J. Scott, Alexandra M. O'Brien, Weihua Zhou, Vidhi Pareek, Zhou Sha, Sravya Palavalasa, Ayesha U. Kothari, Kari Wilder-Romans, Li Zhang, Anthony C. Andren, Sriram Chandrasekaran, Jason Heth, Yoshie Umemura, Nathan Qi, John Woulfe, Sriram Venneti, Meredith A. Morgan, Theodore S. Lawrence, Wajd N. Al-Holou, Costas A. Lyssiotis, Daniel R. Wahl
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3677.
https://doi.org/10.1158/1538-7445.AM2023-3677
Published: 04 April 2023
View article titled, Abstract 3677: DNA damage signaling activates <em>de novo</em> GTP synthesis to promote chemoradiation resistance in glioblastoma
Journal Articles

Abstract 3498: GTP-dependent signaling links metabolism, non-homologous end joining and treatment responses in cancer and normal tissues

Weihua Zhou, Angelica Lin, Zitong Zhao, John Yang, Kari Wilder-Romans, Jie Xu, Sumeet Solanki, Jing Li, Annabel Yang, Andrew Scott, Ayesha Kothari, Erik Peterson, Navyateja Korimerla, Jessica Liang, Janna Jacobson, Sravya Palavalasa, Alexandra Obrien, Sean Ferris, Shuang Zhao, Jann N. Sarkaria, Meredith Morgan, Theodore S. Lawrence, Costas A. Lyssiotis, Yatrik Shah, Daniel R. Wahl
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3498.
https://doi.org/10.1158/1538-7445.AM2023-3498
Published: 04 April 2023
View article titled, Abstract 3498: GTP-dependent signaling links metabolism, non-homologous end joining and treatment responses in cancer and normal tissues
Journal Articles

Abstract LB013: Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

Wajd N. Al-Holou, Hanxiao Wang, Visweswaran Ravikumar, Morgan Oneka, Roel G. Verhaak, Hoon Kim, Drew Pratt, Sandra Camelo-Piragua, Corey Speers, Daniel Wahl, Sunita Shankar, Todd Hollon, Oren Sagher, Jason Heth, Karin M. Muraszko, Theodore S. Lawrence, Ana C. deCarvalho, Tom Mikkelsen, Arvind Rao, Alnawaz Rehemtulla
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB013.
https://doi.org/10.1158/1538-7445.AM2022-LB013
Published: 15 June 2022
View article titled, Abstract LB013: Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma
Journal Articles

Abstract 6267: Repurposing antiandrogens to overcome therapy resistance in androgen receptor-positive glioblastoma

Christian K. Werner, Uchechi Nna, Hanshi Sun, Kari Wilder-Romans, Joseph Dresser, Ayesha Kothari, Weihua Zhou, Yangyang Yao, Arvind Rao, Stefanie Stallard, Carl Koschmann, Tarik Bor, Waldemar Debinski, Alexander Hegedus, Meredith Morgan, Sriram Venneti, Edwina Baskin-Bey, Daniel Spratt, Howard Colman, Jann Sarkaria, Arul Chinnayain, Joel Eisner, Corey Speers, Theodore S. Lawrence, Roy Strowd, Daniel R. Wahl
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6267.
https://doi.org/10.1158/1538-7445.AM2020-6267
Published: 15 August 2020
View article titled, Abstract 6267: Repurposing antiandrogens to overcome therapy resistance in androgen receptor-positive glioblastoma
Journal Articles

Abstract B19: Targeting ATM to sensitize pancreatic cancer to immunotherapy and radiotherapy

Michael Green, Qiang Zhang, Xueting Lang, Yu Lei, Theodore S. Lawrence, Weiping Zou, Meredith A. Morgan
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B19.
https://doi.org/10.1158/1538-7445.PANCA19-B19
Published: 13 December 2019
View article titled, Abstract B19: Targeting ATM to sensitize pancreatic cancer to immunotherapy and radiotherapy
Journal Articles

Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma

Mark Yarchoan, Parul Agarwal, Augusto Villanueva, Shuyun Rao, Laura A. Dawson, Thomas Karasic, Josep M. Llovet, Richard S. Finn, John D. Groopman, Hashem B. El-Serag, Satdarshan P. Monga, Xin Wei Wang, Michael Karin, Robert E. Schwartz, Kenneth K. Tanabe, Lewis R. Roberts, Preethi H. Gunaratne, Allan Tsung, Kimberly A. Brown, Theodore S. Lawrence, Riad Salem, Amit G. Singal, Amy K. Kim, Atoosa Rabiee, Linda Resar, Jeffrey Meyer, Yujin Hoshida, Aiwu Ruth He, Kalpana Ghoshal, Patrick B. Ryan, Elizabeth M. Jaffee, Chandan Guha, Lopa Mishra, C. Norman Coleman, Mansoor M. Ahmed
Journal: Cancer Research
Series: Author Choice
Cancer Res (2019) 79 (17): 4326–4330.
https://doi.org/10.1158/0008-5472.CAN-19-0803
Published: 03 September 2019
View article titled, Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma
Open the PDF for Recent Developments and Therapeutic Strategies against Hepatocellular Carcinoma in another window
Journal Articles

Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy

Qiang Zhang, Michael D. Green, Xueting Lang, Jenny Lazarus, Joshua D. Parsels, Shuang Wei, Leslie A. Parsels, Jiaqi Shi, Nithya Ramnath, Daniel R. Wahl, Marina Pasca di Magliano, Timothy L. Frankel, Ilona Kryczek, Yu L. Lei, Theodore S. Lawrence, Weiping Zou, Meredith A. Morgan
Journal: Cancer Research
Cancer Res (2019) 79 (15): 3940–3951.
https://doi.org/10.1158/0008-5472.CAN-19-0761
Published: 01 August 2019
View article titled, Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy
Open the PDF for Inhibition of ATM Increases Interferon Signaling and Sensitizes Pancreatic Cancer to Immune Checkpoint Blockade Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract CT235: A dose escalation trial of the Wee1 inhibitor AZD1775, in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer

Kyle C. Cuneo, Meredith A. Morgan, Mark M. Zalupski, Vaibhav Sahai, Matthew J. Schipper, Jonathan Maybaum, Theodore S. Lawrence
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT235.
https://doi.org/10.1158/1538-7445.AM2019-CT235
Published: 01 July 2019
View article titled, Abstract CT235: A dose escalation trial of the Wee1 inhibitor AZD1775, in combination with gemcitabine and radiation for patients with locally advanced pancreatic cancer
Journal Articles

Abstract 2539: Discovery of degradation pathway for maternal embryonic leucine zipper kinase (MELK): Implications for breast cancer therapy

Shyam Nyati, Benjamin Chandler, Anna Michmerhuizen, Andrea Pesch, Cassandra Ritter, Leah Moubadder, Meilan Liu, Meleah Cameron, Eric Olsson, Kari Wilder-Romans, Dipankar Ray, Theodore S. Lawrence, Felix Y. Feng, Lori J. Pierce, Corey Speers
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2539.
https://doi.org/10.1158/1538-7445.AM2019-2539
Published: 01 July 2019
View article titled, Abstract 2539: Discovery of degradation pathway for maternal embryonic leucine zipper kinase (MELK): Implications for breast cancer therapy
Journal Articles

Abstract 3218: Maternal embryonic leucine zipper kinase (MELK) confers radioresistance in triple-negative breast cancers (TNBC) through a nonhomologous end joining (NHEJ)-mediated pathway

Shyam Nyati, Ben Chandler, Eric Olsen, Leah Moubadder, Meilan Liu, Meleah Cameron, Kari Wilder-Romans, Theodore S. Lawrence, Powel H. Brown, Fellix Y. Fang, Lori J. Pierce, Corey Speers
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3218.
https://doi.org/10.1158/1538-7445.AM2018-3218
Published: 01 July 2018
View article titled, Abstract 3218: Maternal embryonic leucine zipper kinase (MELK) confers radioresistance in triple-negative breast cancers (TNBC) through a nonhomologous end joining (NHEJ)-mediated pathway
Journal Articles

Abstract 5840: Radiosensitization with the c-MET inhibitor crizotinib in KRAS mutant colorectal cancer

Kyle C. Cuneo, Himabindu Kurapati, Ranjit Mehta, Theodore S. Lawrence, Mukesh K. Nyati
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5840.
https://doi.org/10.1158/1538-7445.AM2017-5840
Published: 01 July 2017
View article titled, Abstract 5840: Radiosensitization with the c-MET inhibitor crizotinib in KRAS mutant colorectal cancer
Journal Articles

Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis

Daniel R. Wahl, Joseph Dresser, Kari Wilder-Romans, Joshua D. Parsels, Shuang G. Zhao, Mary Davis, Lili Zhao, Maureen Kachman, Stefanie Wernisch, Charles F. Burant, Meredith A. Morgan, Felix Y. Feng, Corey Speers, Costas A. Lyssiotis, Theodore S. Lawrence
Journal: Cancer Research
Cancer Res (2017) 77 (4): 960–970.
https://doi.org/10.1158/0008-5472.CAN-16-2008
Published: 14 February 2017
View article titled, Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis
Open the PDF for Glioblastoma Therapy Can Be Augmented by Targeting IDH1-Mediated NADPH Biosynthesis in another window
Includes: Supplementary data
Journal Articles

Abstract CT035: A dose escalation trial of the WEE1 inhibitor AZD1775, gemcitabine, and concurrent radiation in locally advanced pancreatic cancer

Kyle C. Cuneo, Meredith Morgan, Matthew J. Schipper, Jonathan Maybaum, Mary U. Feng, Mahmoud Al-Hawary, Diane M. Simeone, Leah D. Olson, Vaibhav Sahai, Mark Zalupski, Theodore S. Lawrence
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): CT035.
https://doi.org/10.1158/1538-7445.AM2016-CT035
Published: 15 July 2016
View article titled, Abstract CT035: A dose escalation trial of the WEE1 inhibitor AZD1775, gemcitabine, and concurrent radiation in locally advanced pancreatic cancer
Journal Articles

Abstract LB-010: Maternal embryonic leucine zipper kinase (MELK): A novel target for radiosensitization that is independently prognostic in triple-negative breast cancers

Corey Speers, Alyssa Santola, Shuang G. Zhao, Meilan Liu, Vishal Kothari, Kari Wilder-Romans, Theodore S. Lawrence, Powel H. Brown, Lori J. Pierce, Felix Y. Fang
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-010.
https://doi.org/10.1158/1538-7445.AM2016-LB-010
Published: 15 July 2016
View article titled, Abstract LB-010: Maternal embryonic leucine zipper kinase (MELK): A novel target for radiosensitization that is independently prognostic in triple-negative breast cancers
Journal Articles

Abstract 519: Combined inhibition of WEE1 and PARP1 radiosensitizes KRAS mutant non-small cell lung cancers via inhibition of DSB repair

Leslie A. Parsels, David Karnak, Joshua D. Parsels, Zachery Reichert, Jonathan Maybaum, Theodore S. Lawrence, Meredith Ann Morgan
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 519.
https://doi.org/10.1158/1538-7445.AM2016-519
Published: 15 July 2016
View article titled, Abstract 519: Combined inhibition of WEE1 and PARP1 radiosensitizes KRAS mutant non-small cell lung cancers via inhibition of DSB repair