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Theodore Nicolaides
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Journal Articles

Abstract 3401: Whole genome cell-free tumor DNA mutational signatures for noninvasive monitoring of pediatric brain cancers

Ivy Tran, Kristyn Galbraith, Guisheng Zhao, Robyn Borsuk, Joyce Varkey, Sharon Gardner, Jeffrey Allen, David Harter, Jeffrey Wisoff, Eveline T. Hidalgo, Sunil Deochand, Dillon Maloney, Danielle Afterman, Tomer Lauterman, Noah Friedman, Imane Bourzgui, Nidhi Ramaraj, Zohar Donenhirsh, Ronel Veksler, Jonathan Rosenfeld, Ravi Kandasamy, Iman Tavassoly, Boris Oklander, G. Praveen Raju, Theodore Nicolaides, Asaf Zviran, Matija Snuderl
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3401.
https://doi.org/10.1158/1538-7445.AM2022-3401
Published: 15 June 2022
View article titled, Abstract 3401: Whole genome cell-free tumor DNA mutational signatures for noninvasive monitoring of pediatric brain cancers
Journal Articles

Abstract LB140: CNS penetrant, irreversible inhibitors potently inhibit the family of allosteric oncogenic EGFR mutants expressed in GBM and demonstrate efficacy in patient-derived xenograft models

Matthew O'Connor, Matt Lucas, Darlene Romashko, Sara Rasmussen, Tai-An Lin, Nigel Waters, Raffaele Fiorenza, Iwona Wrona, Deborah Chen, Theodore Nicolaides, David R. Raleigh, Tomoko Ozawa, George Trainor, Luca Arista, Alexander Flohr, Giorgio Ottaviani, Chris Roberts, Elizabeth Buck
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB140.
https://doi.org/10.1158/1538-7445.AM2021-LB140
Published: 01 July 2021
View article titled, Abstract LB140: CNS penetrant, irreversible inhibitors potently inhibit the family of allosteric oncogenic EGFR mutants expressed in GBM and demonstrate efficacy in patient-derived xenograft models
Journal Articles

Abstract LB-111: Epidermal growth factor receptor oncogenes expressed in glioblastoma are activated as covalent dimers and exhibit unique pharmacology

Matthew O'Connor, Theodore Nicolaides, Jie Zhang, Alexander Flohr, Roberto Iacone, Alexander V. Mayweg, David M. Epstein, Elizabeth Buck
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-111.
https://doi.org/10.1158/1538-7445.AM2019-LB-111
Published: 01 July 2019
View article titled, Abstract LB-111: Epidermal growth factor receptor oncogenes expressed in glioblastoma are activated as covalent dimers and exhibit unique pharmacology
Journal Articles

Abstract 143: MAPK pathway blockade effects on glioma stem cells and immunotherapy in BRAFV600E mutant gliomas

Stefan Grossauer, Katharina Koeck, Malek Chouchane, Joanna J. Phillips, Claudia K. Petritsch, Theodore Nicolaides
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 143.
https://doi.org/10.1158/1538-7445.AM2018-143
Published: 01 July 2018
View article titled, Abstract 143: MAPK pathway blockade effects on glioma stem cells and immunotherapy in BRAF<sup>V600E</sup> mutant gliomas
Journal Articles

Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells

Robin G. Lerner, Stefan Grossauer, Banafsheh Kadkhodaei, Ian Meyers, Maxim Sidorov, Katharina Koeck, Rintaro Hashizume, Tomoko Ozawa, Joanna J. Phillips, Mitchel S. Berger, Theodore Nicolaides, C. David James, Claudia K. Petritsch
Journal: Cancer Research
Cancer Res (2015) 75 (24): 5355–5366.
https://doi.org/10.1158/0008-5472.CAN-14-3689
Published: 14 December 2015
View article titled, Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells
Open the PDF for Targeting a Plk1-Controlled Polarity Checkpoint in Therapy-Resistant Glioblastoma-Propagating Cells in another window
Includes: Supplementary data
Journal Articles

Abstract LB-208: Targeting resistance pathways in BRAF-mutant pediatric gliomas

Tsun-Wen (Sheena) Yao, Yasuyuki Yoshida, Jie Zhang, Tomoko Ozawa, David James, Theodore Nicolaides
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-208.
https://doi.org/10.1158/1538-7445.AM2014-LB-208
Published: 01 October 2014
View article titled, Abstract LB-208: Targeting resistance pathways in BRAF-mutant pediatric gliomas
Journal Articles

Sensitivity of Glioblastomas to Clinically Available MEK Inhibitors Is Defined by Neurofibromin 1 Deficiency

Wendy L. See, I-Li Tan, Joydeep Mukherjee, Theodore Nicolaides, Russell O. Pieper
Journal: Cancer Research
Cancer Res (2012) 72 (13): 3350–3359.
https://doi.org/10.1158/0008-5472.CAN-12-0334
Published: 01 July 2012
View article titled, Sensitivity of Glioblastomas to Clinically Available MEK Inhibitors Is Defined by Neurofibromin 1 Deficiency
Open the PDF for Sensitivity of Glioblastomas to Clinically Available MEK Inhibitors Is Defined by Neurofibromin 1 Deficiency in another window
Includes: Supplementary data
Journal Articles

Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy

Krister J. Barkovich, Theodore Nicolaides, Sujatmi Hariono, Adam Garske, Qi Wen Fan, Kevan Shokat, William A. Weiss
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2314.
https://doi.org/10.1158/1538-7445.AM2011-2314
Published: 15 April 2011
View article titled, Abstract 2314: Erlotinib response in lung- and glioma-derived EGFR alleles: Correlating kinase site occupancy with efficacy
Journal Articles

Abstract 552: Targeting brain tumors with PLX3397, an inhibitor of the CSF-1 receptor kinase

Brian L. West, James Tsai, Theodore Nicolaides, Bernice Wong, Hoa Nguyen, Adhirai Marimuthu, Prabha Ibrahim, Peter Hirth, Gideon Bollag
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 552.
https://doi.org/10.1158/1538-7445.AM2011-552
Published: 15 April 2011
View article titled, Abstract 552: Targeting brain tumors with PLX3397, an inhibitor of the CSF-1 receptor kinase
Journal Articles

Recovery of Map kinase signaling mediates resistance to EGFR inhibitor-based therapy in malignant glioma.

Theodore Nicolaides, Qi Wen Fan, C. James, William Weiss
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4006.
Published: 01 May 2007
View article titled, Recovery of Map kinase signaling mediates resistance to EGFR inhibitor-based therapy in malignant glioma.