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Journal Articles

Abstract 1566: DNA damage generated by transcription-replication conflicts explains the synthetic lethality of PARP inhibitors with homologous recombination deficiency

Thanos D. Halazonetis, Michalis Petropoulos, Giacomo G. Rossetti, Angeliki Karamichali, Alena Freudenmann, Luca Iacovino, Vasilis Dionellis, Sotirios K. Sotiriou

Cancer Res (2023) 83 (7_Supplement): 1566.

https://doi.org/10.1158/1538-7445.AM2023-1566

Published: 04 April 2023

View article titled, Abstract 1566: DNA damage generated by transcription-replication conflicts explains the synthetic lethality of PARP inhibitors with homologous recombination deficiency

Journal Articles

Remodeling Collapsed DNA Replication Forks for Cancer Development

Sotirios K. Sotiriou, Thanos D. Halazonetis

Cancer Res (2019) 79 (7): 1297–1298.

https://doi.org/10.1158/0008-5472.CAN-19-0216

Published: 01 April 2019

View article titled, Remodeling Collapsed DNA Replication Forks for Cancer Development

Journal Articles

A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas

Sergey I. Nikolaev, Sotirios K. Sotiriou, Ioannis S. Pateras, Federico Santoni, Stavros Sougioultzis, Henrik Edgren, Henrikki Almusa, Daniel Robyr, Michel Guipponi, Janna Saarela, Vassilis G. Gorgoulis, Stylianos E. Antonarakis, Thanos D. Halazonetis

Cancer Res (2012) 72 (23): 6279–6289.

https://doi.org/10.1158/0008-5472.CAN-12-3869

Published: 29 November 2012

View article titled, A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas

Includes: Supplementary data

Journal Articles

Abstract 3109: Correlation between genomic aberrations and the DNA damage response in bladder cancer

Troels Schepeler, Philippe Lamy, Jens Laurberg, Niels Fristrup, Jirina Bartkova, Vibeke Hvidbjerg, Laurence Tropia, Jiri Bartek, Thanos D. Halazonetis, Thomas Reinert, Michael Borre, Lars Dyrskjøt, Torben F. Ørntoft

Cancer Res (2012) 72 (8_Supplement): 3109.

https://doi.org/10.1158/1538-7445.AM2012-3109

Published: 15 April 2012

View article titled, Abstract 3109: Correlation between genomic aberrations and the DNA damage response in bladder cancer

Journal Articles

Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior

Michalis Liontos, Marilena Koutsami, Maria Sideridou, Konstantinos Evangelou, Dimitris Kletsas, Brynn Levy, Athanassios Kotsinas, Odelia Nahum, Vassilis Zoumpourlis, Mirsini Kouloukoussa, Zoi Lygerou, Stavros Taraviras, Christos Kittas, Jirina Bartkova, Athanasios G. Papavassiliou, Jiri Bartek, Thanos D. Halazonetis, Vassilis G. Gorgoulis

Cancer Res (2007) 67 (22): 10899–10909.

https://doi.org/10.1158/0008-5472.CAN-07-2837

Published: 15 November 2007

View article titled, Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior

Includes: Supplementary data

Journal Articles

Phosphorylation of ATR-Interacting Protein on Ser²³⁹ Mediates an Interaction with Breast-Ovarian Cancer Susceptibility 1 and Checkpoint Function

Monica Venere, Andrew Snyder, Omar Zgheib, Thanos D. Halazonetis

Cancer Res (2007) 67 (13): 6100–6105.

https://doi.org/10.1158/0008-5472.CAN-07-0369

Published: 06 July 2007

View article titled, Phosphorylation of ATR-Interacting Protein on Ser239 Mediates an Interaction with Breast-Ovarian Cancer Susceptibility 1 and Checkpoint Function

Journal Articles

Distinct pathways of upstream activation of p53 during hypoxia versus desferioxamine exposure

Joseph M. Ackermann, Thanos D. Halazonetis, Wafik S. El-Deiry

Cancer Res (2006) 66 (8_Supplement): 783.

Published: 15 April 2006

View article titled, Distinct pathways of upstream activation of p53 during hypoxia versus desferioxamine exposure

Journal Articles

Valosin-Containing Protein Phosphorylation at Ser⁷⁸⁴ in Response to DNA Damage

Mark Livingstone, Hong Ruan, Jessica Weiner, Karl R. Clauser, Peter Strack, Shengfang Jin, Amy Williams, Heidi Greulich, James Gardner, Monica Venere, Tamara A. Mochan, Richard A. DiTullio, Jr., Katarina Moravcevic, Vassilis G. Gorgoulis, Anne Burkhardt, Thanos D. Halazonetis

Cancer Res (2005) 65 (17): 7533–7540.

https://doi.org/10.1158/0008-5472.CAN-04-3729

Published: 01 September 2005

View article titled, Valosin-Containing Protein Phosphorylation at Ser784 in Response to DNA Damage

Journal Articles

Human LATS1 Is a Mitotic Exit Network Kinase

John Bothos, Robyn L. Tuttle, Michelle Ottey, Francis C. Luca, Thanos D. Halazonetis

Cancer Res (2005) 65 (15): 6568–6575.

https://doi.org/10.1158/0008-5472.CAN-05-0862

Published: 01 August 2005

View article titled, Human LATS1 Is a Mitotic Exit Network Kinase

Journal Articles

53BP1 and NFBD1/MDC1-Nbs1 Function in Parallel Interacting Pathways Activating Ataxia-Telangiectasia Mutated (ATM) in Response to DNA Damage

Tamara A. Mochan, Monica Venere, Richard A. DiTullio, Jr., Thanos D. Halazonetis

Cancer Res (2003) 63 (24): 8586–8591.

Published: 24 December 2003

View article titled, 53BP1 and NFBD1/MDC1-Nbs1 Function in Parallel Interacting Pathways Activating Ataxia-Telangiectasia Mutated (ATM) in Response to DNA Damage

Journal Articles

Inactivating Mutations Targeting the chfr Mitotic Checkpoint Gene in Human Lung Cancer

George Mariatos, John Bothos, Panayotis Zacharatos, Matthew K. Summers, Daniel M. Scolnick, Christos Kittas, Thanos D. Halazonetis, Vassilis G. Gorgoulis

Cancer Res (2003) 63 (21): 7185–7189.

Published: 11 November 2003

View article titled, Inactivating Mutations Targeting the chfr Mitotic Checkpoint Gene in Human Lung Cancer

Journal Articles

Substitutions That Compromise the Ionizing Radiation-induced Association of p53 with 14-3-3 Proteins Also Compromise the Ability of p53 to Induce Cell Cycle Arrest

Elena S. Stavridi, Nabil H. Chehab, Asra Malikzay, Thanos D. Halazonetis

Cancer Res (2001) 61 (19): 7030–7033.

Published: 01 October 2001

View article titled, Substitutions That Compromise the Ionizing Radiation-induced Association of p53 with 14-3-3 Proteins Also Compromise the Ability of p53 to Induce Cell Cycle Arrest

Journal Articles

CREB-binding Protein and p300/CBP-associated Factor Are Transcriptional Coactivators of the p53 Tumor Suppressor Protein

Daniel M. Scolnick, Nabil H. Chehab, Elena S. Stavridi, Marcus C. Lien, Loretta Caruso, Elizabeth Moran, Shelley L. Berger, Thanos D. Halazonetis

Cancer Res (1997) 57 (17): 3693–3696.

Published: 01 September 1997

View article titled, CREB-binding Protein and p300/CBP-associated Factor Are Transcriptional Coactivators of the p53 Tumor Suppressor Protein

Journal Articles

An Engineered Four-Stranded Coiled Coil Substitutes for the Tetramerization Domain of Wild-Type p53 and Alleviates Transdominant Inhibition by Tumor-derived p53 Mutants

Matthew J. F. Waterman, Jennifer L. F. Waterman, Thanos D. Halazonetis

Cancer Res (1996) 56 (1): 158–163.

Published: 01 January 1996

View article titled, An Engineered Four-Stranded Coiled Coil Substitutes for the Tetramerization Domain of Wild-Type p53 and Alleviates Transdominant Inhibition by Tumor-derived p53 Mutants

NARROW

Abstract 1566: DNA damage generated by transcription-replication conflicts explains the synthetic lethality of PARP inhibitors with homologous recombination deficiency

Remodeling Collapsed DNA Replication Forks for Cancer Development

A Single-Nucleotide Substitution Mutator Phenotype Revealed by Exome Sequencing of Human Colon Adenomas

Abstract 3109: Correlation between genomic aberrations and the DNA damage response in bladder cancer

Deregulated Overexpression of hCdt1 and hCdc6 Promotes Malignant Behavior

Phosphorylation of ATR-Interacting Protein on Ser²³⁹ Mediates an Interaction with Breast-Ovarian Cancer Susceptibility 1 and Checkpoint Function

Distinct pathways of upstream activation of p53 during hypoxia versus desferioxamine exposure

Valosin-Containing Protein Phosphorylation at Ser⁷⁸⁴ in Response to DNA Damage

Human LATS1 Is a Mitotic Exit Network Kinase

53BP1 and NFBD1/MDC1-Nbs1 Function in Parallel Interacting Pathways Activating Ataxia-Telangiectasia Mutated (ATM) in Response to DNA Damage

Inactivating Mutations Targeting the chfr Mitotic Checkpoint Gene in Human Lung Cancer

Substitutions That Compromise the Ionizing Radiation-induced Association of p53 with 14-3-3 Proteins Also Compromise the Ability of p53 to Induce Cell Cycle Arrest

CREB-binding Protein and p300/CBP-associated Factor Are Transcriptional Coactivators of the p53 Tumor Suppressor Protein

An Engineered Four-Stranded Coiled Coil Substitutes for the Tetramerization Domain of Wild-Type p53 and Alleviates Transdominant Inhibition by Tumor-derived p53 Mutants

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