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Tetsuo Takehara
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Journal Articles

Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non–Cell Autonomous Liver Carcinogenesis

Yuki Makino, Hayato Hikita, Kenji Fukumoto, Ji Hyun Sung, Yoshihiro Sakano, Kazuhiro Murai, Sadatsugu Sakane, Takahiro Kodama, Ryotaro Sakamori, Jumpei Kondo, Shogo Kobayashi, Tomohide Tatsumi, Tetsuo Takehara
Journal: Cancer Research
Cancer Res (2022) 82 (16): 2860–2873.
https://doi.org/10.1158/0008-5472.CAN-21-4390
Published: 16 August 2022
View article titled, Constitutive Activation of the Tumor Suppressor p53 in Hepatocytes Paradoxically Promotes Non–Cell Autonomous Liver Carcinogenesis
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Includes: Supplementary data
Journal Articles

Abstract 351: Serum ST6GAL1 is a novel biomarker for predicting efficacy of tyrosine kinase inhibitors in hepatocellular carcinoma by detecting FGF19 expressing tumor

Yuta Myojin, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Tetsuo Takehara
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 351.
https://doi.org/10.1158/1538-7445.AM2021-351
Published: 01 July 2021
View article titled, Abstract 351: Serum ST6GAL1 is a novel biomarker for predicting efficacy of tyrosine kinase inhibitors in hepatocellular carcinoma by detecting FGF19 expressing tumor
Journal Articles

Abstract 1756: The roles of Regnase-1 in pancreatic cancer development and progression

Junya Okabe, Takahiro Kodama, Tetsuo Takehara
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1756.
https://doi.org/10.1158/1538-7445.AM2021-1756
Published: 01 July 2021
View article titled, Abstract 1756: The roles of Regnase-1 in pancreatic cancer development and progression
Journal Articles

Abstract 2927: Inactivation of traf3 promotes intrahepatic cholangiocarcinoma development via hepatocyte trans-differentiation

Yuto Shiode, Takahiro Kodama, Hayato Hikita, Ryotaro Sakamori, Tomohide Tatsumi, Tetsuo Takehara
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2927.
https://doi.org/10.1158/1538-7445.AM2021-2927
Published: 01 July 2021
View article titled, Abstract 2927: Inactivation of traf3 promotes intrahepatic cholangiocarcinoma development via hepatocyte trans-differentiation
Journal Articles

p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4

Chihiro Kajiwara, Katsumi Fumoto, Hirokazu Kimura, Satoshi Nojima, Keita Asano, Kazuki Odagiri, Makoto Yamasaki, Hayato Hikita, Tetsuo Takehara, Yuichiro Doki, Eiichi Morii, Akira Kikuchi
Journal: Cancer Research
Cancer Res (2018) 78 (21): 6107–6120.
https://doi.org/10.1158/0008-5472.CAN-18-1749
Published: 01 November 2018
View article titled, p63-Dependent Dickkopf3 Expression Promotes Esophageal Cancer Cell Proliferation via CKAP4
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Includes: Supplementary data
Journal Articles

CTGF Mediates Tumor–Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression

Yuki Makino, Hayato Hikita, Takahiro Kodama, Minoru Shigekawa, Ryoko Yamada, Ryotaro Sakamori, Hidetoshi Eguchi, Eiichi Morii, Hideki Yokoi, Masashi Mukoyama, Suemizu Hiroshi, Tomohide Tatsumi, Tetsuo Takehara
Journal: Cancer Research
Cancer Res (2018) 78 (17): 4902–4914.
https://doi.org/10.1158/0008-5472.CAN-17-3844
Published: 04 September 2018
View article titled, CTGF Mediates Tumor–Stroma Interactions between Hepatoma Cells and Hepatic Stellate Cells to Accelerate HCC Progression
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Includes: Supplementary data
Journal Articles

Abstract 4797: Continuous hepatocyte apoptosis accelerates diethylnitrosamine-induced liver tumor development

Yasutoshi Nozaki, Hayato Hikita, Satoshi Tanaka, Yuta Myojin, Sadatsugu Sakane, Kazuhiro Murai, Yuto Shiode, Yugo Kai, Yuki Makino, Tasuku Nakabori, Yoshinobu Saito, Takahiro Kodama, Ryotaro Sakamori, Tomohide Tatsumi, Eiji Miyoshi, Tetsuo Takehara
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4797.
https://doi.org/10.1158/1538-7445.AM2017-4797
Published: 01 July 2017
View article titled, Abstract 4797: Continuous hepatocyte apoptosis accelerates diethylnitrosamine-induced liver tumor development
Journal Articles

Abstract 407: Whole-genome pooled CRISPR/Cas library screens to identify new hepatocellular carcinoma drivers and drug targets in combination with sorafenib

Takahiro Kodama, Justin Y. Newberg, Nancy A. Jenkins, Tetsuo Takehara, Neal G. Copeland
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 407.
https://doi.org/10.1158/1538-7445.AM2017-407
Published: 01 July 2017
View article titled, Abstract 407: Whole-genome pooled CRISPR/Cas library screens to identify new hepatocellular carcinoma drivers and drug targets in combination with sorafenib
Journal Articles

Anticancer Chemotherapy Inhibits MHC Class I–Related Chain A Ectodomain Shedding by Downregulating ADAM10 Expression in Hepatocellular Carcinoma

Keisuke Kohga, Tetsuo Takehara, Tomohide Tatsumi, Takuya Miyagi, Hisashi Ishida, Kazuyoshi Ohkawa, Tatsuya Kanto, Naoki Hiramatsu, Norio Hayashi
Journal: Cancer Research
Cancer Res (2009) 69 (20): 8050–8057.
https://doi.org/10.1158/0008-5472.CAN-09-0789
Published: 14 October 2009
View article titled, Anticancer Chemotherapy Inhibits MHC Class I–Related Chain A Ectodomain Shedding by Downregulating ADAM10 Expression in Hepatocellular Carcinoma
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Includes: Supplementary data
Journal Articles

Suppression of Bcl-xL Deamidation in Human Hepatocellular Carcinomas

Tetsuo Takehara, Hiroshi Takahashi
Journal: Cancer Research
Cancer Res (2003) 63 (12): 3054–3057.
Published: 15 June 2003
View article titled, Suppression of Bcl-xL Deamidation in Human Hepatocellular Carcinomas
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Journal Articles

Administration of Interleukin-12 Enhances the Therapeutic Efficacy of Dendritic Cell-based Tumor Vaccines in Mouse Hepatocellular Carcinoma

Tomohide Tatsumi, Tetsuo Takehara, Tatsuya Kanto, Takuya Miyagi, Noriyoshi Kuzushita, Yoshiko Sugimoto, Masahisa Jinushi, Akinori Kasahara, Yutaka Sasaki, Masatsugu Hori, Norio Hayashi
Journal: Cancer Research
Cancer Res (2001) 61 (20): 7563–7567.
Published: 01 October 2001
View article titled, Administration of Interleukin-12 Enhances the Therapeutic Efficacy of Dendritic Cell-based Tumor Vaccines in Mouse Hepatocellular Carcinoma
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