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Journal Articles

Abstract LB134: Mutational signatures in colorectal cancer from 11 countries reveal new insights in early-onset colorectal cancer

Free
Wellington dos Santos, Marcos Diaz-Gay, Sarah Moody, Sergey Senkin, Behnoush Abedi-Ardekani, Mariya Kazachkova, Stephen Fitzgerald, Saamin Cheema, Valerie Gaborieau, Jingwei Wang, Christine Carreira, Thomas Cattiaux, Priscilia Chopard, Calli Latimer, David Zaridze, Riley Cox, Reza Malekzadeh, Miodrag Ognjanovic, Suleeporn Sangrajrang, Maria P. Curado, Rui M. Reis, Ivana Holcatova, Carlos Vaccaro, Beata Swiatkowska, Jolanta Lissowska, Carolina Wiesner, Tatsuhiro Shibata, Surasak Sangkhathat, Patricia Ashton-Prolla, Laura Humphreys, Sandra Perdomo, Ana C. de Caravalho, Mike Stratton, Paul Brennan, Ludmil Alexandrov
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB134.
https://doi.org/10.1158/1538-7445.AM2024-LB134
Published: 05 April 2024
View articletitled, Abstract LB134: Mutational signatures in colorectal cancer from 11 countries reveal new insights in early-onset colorectal cancer
Journal Articles

Single-Cell Analysis Reveals a CD4+ T-cell Cluster That Correlates with PD-1 Blockade Efficacy

Open Access
Hiroshi Kagamu, Satoshi Yamasaki, Shigehisa Kitano, Ou Yamaguchi, Atsuto Mouri, Ayako Shiono, Fuyumi Nishihara, Yu Miura, Kosuke Hashimoto, Hisao Imai, Kyoichi Kaira, Kunihiko Kobayashi, Yae Kanai, Tatsuhiro Shibata, Katsuhisa Horimoto
Journal: Cancer Research
Cancer Res (2022) 82 (24): 4641–4653.
https://doi.org/10.1158/0008-5472.CAN-22-0112
Published: 16 December 2022
View articletitled, Single-Cell Analysis Reveals a CD4+ T-cell Cluster That Correlates with PD-1 Blockade Efficacy
Open the PDF for Single-Cell Analysis Reveals a CD4+ T-cell Cluster That Correlates with PD-1 Blockade Efficacy in another window
Includes: Supplementary data
Journal Articles

The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy

Available to Purchase
Hidenari Hirata, Atsushi Niida, Nobuyuki Kakiuchi, Ryutaro Uchi, Keishi Sugimachi, Takaaki Masuda, Tomoko Saito, Shun-Ichiro Kageyama, Yushi Motomura, Shuhei Ito, Tadamasa Yoshitake, Daisuke Tsurumaru, Yusuke Nishimuta, Akira Yokoyama, Takanori Hasegawa, Kenichi Chiba, Yuichi Shiraishi, Junyan Du, Fumihito Miura, Masaru Morita, Yasushi Toh, Masakazu Hirakawa, Yoshiyuki Shioyama, Takashi Ito, Tetsuo Akimoto, Satoru Miyano, Tatsuhiro Shibata, Masaki Mori, Yutaka Suzuki, Seishi Ogawa, Kousei Ishigami, Koshi Mimori
Journal: Cancer Research
Cancer Res (2021) 81 (19): 4926–4938.
https://doi.org/10.1158/0008-5472.CAN-21-0653
Published: 01 October 2021
View articletitled, The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy
Open the PDF for The Evolving Genomic Landscape of Esophageal Squamous Cell Carcinoma Under Chemoradiotherapy in another window
Includes: Supplementary data
Journal Articles

E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer

Available to Purchase
Masami Suzuki, Mihoko Saito-Adachi, Yasuhito Arai, Yuko Fujiwara, Erina Takai, Shinsuke Shibata, Masahide Seki, Hirofumi Rokutan, Daichi Maeda, Masafumi Horie, Yutaka Suzuki, Tatsuhiro Shibata, Tohru Kiyono, Shinichi Yachida
Journal: Cancer Research
Cancer Res (2021) 81 (2): 489–500.
https://doi.org/10.1158/0008-5472.CAN-19-2988
Published: 15 January 2021
View articletitled, E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer
Open the PDF for E74-Like Factor 3 Is a Key Regulator of Epithelial Integrity and Immune Response Genes in Biliary Tract Cancer in another window
Includes: Supplementary data
Journal Articles

Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression

Available to Purchase
Yutaka Midorikawa, Shogo Yamamoto, Kenji Tatsuno, Claire Renard-Guillet, Shingo Tsuji, Akimasa Hayashi, Hiroki Ueda, Shiro Fukuda, Takanori Fujita, Hiroto Katoh, Shumpei Ishikawa, Kyle R. Covington, Chad J. Creighton, Masahiko Sugitani, David A. Wheeler, Tatsuhiro Shibata, Genta Nagae, Tadatoshi Takayama, Hiroyuki Aburatani
Journal: Cancer Research
Cancer Res (2020) 80 (18): 3810–3819.
https://doi.org/10.1158/0008-5472.CAN-20-0225
Published: 15 September 2020
View articletitled, Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression
Open the PDF for Accumulation of Molecular Aberrations Distinctive to Hepatocellular Carcinoma Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 2506: Exploring the complex etiology of oncogenic fusions in childhood cancer

Free
Nathaniel D. Anderson, Richard de Borja, Matthew D. Young, Fabio Fuligni, Andrej Rosic, Nicola D. Roberts, Nischalan Pillay, Jeffrey A. Toretsky, Yoshida Akihiko, Tatsuhiro Shibata, Markus Metzler, Gino Somers, Stephen W. Scherer, Adrienne M. Flanagan, Peter J. Campbell, Joshua D. Schiffman, Mary Shago, Ludmil B. Alexandrov, Jay S. Wunder, Irene L. Andrulis, David Malkin, Sam Behjati, Adam Shlien
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2506.
https://doi.org/10.1158/1538-7445.AM2019-2506
Published: 01 July 2019
View articletitled, Abstract 2506: Exploring the complex etiology of oncogenic fusions in childhood cancer
Journal Articles

Abstract 3887: Whole exome sequencing to identify genetic markers for trastuzumab-induced cardiotoxicity

Free
Chihiro Udagawa, Hiromi Nakamura, Hiroshi Ohnishi, Kenji Tamura, Tatsunori Shimoi, Masayuki Yoshida, Teruhiko Yoshida, Hiroshi Okamura, Yasushi Totoki, Tatsuhiro Shibata, Hitoshi Zembutsu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3887.
https://doi.org/10.1158/1538-7445.AM2018-3887
Published: 01 July 2018
View articletitled, Abstract 3887: Whole exome sequencing to identify genetic markers for trastuzumab-induced cardiotoxicity
Journal Articles

Abstract 2095: E7090, a novel and selective FGFR inhibitor, for the treatment of cholangiocarcinoma cells harboring FGFR2-fusion genes

Free
Saori W. Miyano, Yasuhito Arai, Junji Matsui, Tatsuhiro Shibata
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2095.
https://doi.org/10.1158/1538-7445.AM2017-2095
Published: 01 July 2017
View articletitled, Abstract 2095: E7090, a novel and selective FGFR inhibitor, for the treatment of cholangiocarcinoma cells harboring FGFR2-fusion genes
Journal Articles

Abstract 5378: Genes involved in development and differentiation are commonly methylated in cancers derived from multiple organs: A single-institutional methylome analysis using 1007 tissue specimens

Free
Kentaro Ohara, Eri Arai, Yoriko Takahashi, Nanako Ito, Ayako Shibuya, Koji Tsuta, Ryoji Kushima, Hitoshi Tsuda, Hidenori Ojima, Hiroyuki Fujimoto, Shun-ichi Watanabe, Hitoshi Katai, Takayuki Kinoshita, Tatsuhiro Shibata, Takashi Kohno, Yae Kanai
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5378.
https://doi.org/10.1158/1538-7445.AM2017-5378
Published: 01 July 2017
View articletitled, Abstract 5378: Genes involved in development and differentiation are commonly methylated in cancers derived from multiple organs: A single-institutional methylome analysis using 1007 tissue specimens
Journal Articles

Abstract 4517: Epigenome landscape of human normal purified hepatocytes: analysis by the International Human Epigenome Consortium (IHEC)

Free
Eri Arai, Fumihito Miura, Yasushi Totoki, Satoshi Yamashita, Ying Tian, Masahiro Gotoh, Hidenori Ojima, Hiroyuki Nakagawa, Yoriko Takahashi, Hiromi Nakamura, Natsuko Hama, Mamoru Kato, Hiroshi Kimura, Yutaka Suzuki, Takashi Ito, Tatsuhiro Shibata, Yae Kanai
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4517.
https://doi.org/10.1158/1538-7445.AM2016-4517
Published: 15 July 2016
View articletitled, Abstract 4517: Epigenome landscape of human normal purified hepatocytes: analysis by the International Human Epigenome Consortium (IHEC)
Journal Articles

Abstract 1832: Large variations in clinical and ethical aspects of genomic sequencing initiatives: A Global Alliance for Genomics and Health (GA4GH) survey

Free
Jeremy Lewin, Daniel J. Vis, Mark Lawler, Rachel Liao, Mao Mao, Bin Tean Teh, William Sellers, Robyn Ward, Anamaria Aranha Camargo, Fabrice Andre, Richard Schilsky, Denis Lacombe, Tatsuhiro Shibata, Stephen Fox, Christophe Le Tourneau, William S. Dalton, Bartha Maria Knoppers, Charles Sawyers, Emile E. Voest, Lillian L. Siu
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1832.
https://doi.org/10.1158/1538-7445.AM2016-1832
Published: 15 July 2016
View articletitled, Abstract 1832: Large variations in clinical and ethical aspects of genomic sequencing initiatives: A Global Alliance for Genomics and Health (GA4GH) survey
Journal Articles

NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth

Free
Hironori Satoh, Takashi Moriguchi, Daisuke Saigusa, Liam Baird, Lei Yu, Hirofumi Rokutan, Keiko Igarashi, Masahito Ebina, Tatsuhiro Shibata, Masayuki Yamamoto
Journal: Cancer Research
Cancer Res (2016) 76 (10): 3088–3096.
https://doi.org/10.1158/0008-5472.CAN-15-1584
Published: 12 May 2016
View articletitled, NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth
Open the PDF for NRF2 Intensifies Host Defense Systems to Prevent Lung Carcinogenesis, but After Tumor Initiation Accelerates Malignant Cell Growth in another window
Includes: Supplementary data
Journal Articles

Abstract 958: Early hepatocellular carcinoma as another entity from classical hepatocellular carcinoma by integrated genomic analysis

Free
Yutaka Midorikawa, Shogo Yamamoto, Kenji Tatsuno, Hiroki Ueda, Shingo Tsuji, Genta Nagae, Kotaro Sonoda, Tatsuhiro Shibata, Kyle R. Covington, Chad J. Creighton, Masahiko Sugitani, David A. Wheeler, Tadatoshi Takayama, Hiroyuki Aburatani
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 958.
https://doi.org/10.1158/1538-7445.AM2015-958
Published: 01 August 2015
View articletitled, Abstract 958: Early hepatocellular carcinoma as another entity from classical hepatocellular carcinoma by integrated genomic analysis
Journal Articles

Abstract 1394: Role of non-coding RNA in regulation of stemness and differentiation via notch signaling pathway in glioblastoma

Free
Keisuke Katsushima, Keiko Shinjo, Fumiharu Ohka, Atsushi Natsume, Tatsuhiro Shibata, Yutaka Kondo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1394.
https://doi.org/10.1158/1538-7445.AM2014-1394
Published: 01 October 2014
View articletitled, Abstract 1394: Role of non-coding RNA in regulation of stemness and differentiation via notch signaling pathway in glioblastoma
Journal Articles

Abstract 5167: Identification of inactivating mutations in stepwise hepatocarcinogenesis using next generation sequencer

Free
Yutaka Midorikawa, Shogo Yamamoto, Hiroo Ueda, Kotaro Sonoda, Shingo Tsuji, Kenji Tatsuno, Tatsuhiro Shibata, Kyle Covington, David Wheeler, Tadatoshi Takayama, Hiroyuki Aburatani
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5167.
https://doi.org/10.1158/1538-7445.AM2014-5167
Published: 01 October 2014
View articletitled, Abstract 5167: Identification of inactivating mutations in stepwise hepatocarcinogenesis using next generation sequencer
Journal Articles

Abstract 2211: Viral subtypes in hepatocellular carcinoma are associated with different mechanisms of WNT/CTNNB1 alteration

Free
Kyle R. Covington, Lawrence A. Donehower, Chad Creighton, Betty L. Slagle, John A. Goss, Ronald T. Cotton, Marie-Claude Gingras, Eve Shinbrot, Jacfranz J. Guiteau, Thao N. Nguyen, Theresa R. Harring, Donna M. Muzny, Kimberly Walker, HarshaVardhan Doddapaneni, Richard A. Gibbs, Hiroyuki Aburatani, Tatsuhiro Shibata, David A. Wheeler, Japan ICGC HCC Project
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2211.
https://doi.org/10.1158/1538-7445.AM2014-2211
Published: 01 October 2014
View articletitled, Abstract 2211: Viral subtypes in hepatocellular carcinoma are associated with different mechanisms of WNT/CTNNB1 alteration
Journal Articles

Abstract 4264: Whole exome and targeted sequencing identified the MAPK and PI3K pathways as the main targets in intracranial and testicular germ cell tumors

Free
Koichi Ichimura, Shintaro Fukushima, Yasushi Totoki, Yuko Matsushita, Ayaka Otsuka, Arata Tomiyama, Tohru Niwa, Ryuichi Sakai, Toshikazu Ushijima, Taishi Nakamura, Tomonari Suzuki, Kouhei Fukuoka, Takaaki Yanagisawa, Kazuhiko Mishima, Yoichi Nakazato, Fumie Hosoda, Yoshitaka Narita, Soichiro Shibui, Akihiko Yoshida, Hirokazu Takami, Akitake Mukasa, Koki Aihara, Nobuhito Saito, Toshihiro Kumabe, Masayuki Kanamori, Teiji Tominaga, Keiichi Kobayashi, Saki Shimizu, Motoo Nagane, Toshihiko Iuchi, Masahiro Mizoguchi, Koji Yoshimoto, Kaoru Tamura, Taketoshi Maehara, Kazuhiko Sugiyama, Mitsutoshi Nakada, Keiichi Sakai, Yonehiro Kanemura, Masahiro Nonaka, Kiyotaka Yokogami, Hideo Takeshima, Nobutaka Kawahara, Tatsuya Takayama, Masahiro Yao, Hiromi Nakamura, Natsuko Hama, Masao Matsutani, Tatsuhiro Shibata, Ryo Nishikawa
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4264.
https://doi.org/10.1158/1538-7445.AM2014-4264
Published: 01 October 2014
View articletitled, Abstract 4264: Whole exome and targeted sequencing identified the MAPK and PI3K pathways as the main targets in intracranial and testicular germ cell tumors
Journal Articles

Abstract 1214: RET fusion gene: translation to the therapy of lung adenocarcinoma.

Free
Takashi Kohno, Hitoshi Ichikawa, Koji Tsuta, Tatsuji Mizukami, Yoko Shimada, Mamoru Kato, Hiromi Sakamoto, Katsuya Tsuchihara, Shun-ichi Watanabe, Hiroshi Nokihara, Koichi Goto, Jun Yokota, Teruhiko Yoshida, Tatsuhiro Shibata
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1214.
https://doi.org/10.1158/1538-7445.AM2013-1214
Published: 15 April 2013
View articletitled, Abstract 1214: RET fusion gene: translation to the therapy of lung adenocarcinoma.
Journal Articles

Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas

Free
Hirokazu Okayama, Takashi Kohno, Yuko Ishii, Yoko Shimada, Kouya Shiraishi, Reika Iwakawa, Koh Furuta, Koji Tsuta, Tatsuhiro Shibata, Seiichiro Yamamoto, Shun-ichi Watanabe, Hiromi Sakamoto, Kensuke Kumamoto, Seiichi Takenoshita, Noriko Gotoh, Hideaki Mizuno, Akinori Sarai, Shuichi Kawano, Rui Yamaguchi, Satoru Miyano, Jun Yokota
Journal: Cancer Research
Cancer Res (2012) 72 (1): 100–111.
https://doi.org/10.1158/0008-5472.CAN-11-1403
Published: 02 January 2012
View articletitled, Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas
Open the PDF for Identification of Genes Upregulated in ALK-Positive and EGFR/KRAS/ALK-Negative Lung Adenocarcinomas in another window
Includes: Supplementary data
Journal Articles

Abstract 318: Hierarchical clustering analysis of array CGH data identifies clinicopathologically distinct groups of lymph-node-negative invasive breast cancer

Free
Ryoko Kikuchi, Yasuyuki Ishii, Takayuki Kobayashi, Yae Kanai, Tatsuhiro Shibata, Osamu Matsubara, Issei Imoto, Johji Inazawa, Hitoshi Tsuda
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 318.
https://doi.org/10.1158/1538-7445.AM2011-318
Published: 15 April 2011
View articletitled, Abstract 318: Hierarchical clustering analysis of array CGH data identifies clinicopathologically distinct groups of lymph-node-negative invasive breast cancer