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Journal Articles

Abstract A054 A genome-derived cell state reporter permits dissection and control of intratumoral heterogeneity and chemoresistance

Noha AM Shendy, Yang Zhang, Ha-Won Lee, Stephanie Nance, Yousef Khashana, Mohammad AM Nezhady, Elaine Ritter, Shivendra Singh, Qi Liu, Yiping Fan, Jun Yang, Anand G. Patel, Jun Qi, Taosheng Chen, Brian J. Abraham, Adam D. Durbin
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): A054.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-A054
Published: 05 September 2024
View articletitled, Abstract A054 A genome-derived cell state reporter permits dissection and control of intratumoral heterogeneity and chemoresistance
Journal Articles

Abstract B005: BMP signaling determines neuroblastoma sensitivity to retinoic acid by directing cell fate

Min Pan, Yinwen Zhang, William C. Wright, Hyeong-Min Lee, Richard H. Chapple, Xueying Liu, Jonathan Low, Duane Currier, Allister J. Loughran, Michael A. Dyer, Shondra M. Pruett, Burgess Freeman, III, Taosheng Chen, Brian J. Abraham, Elizabeth Stewart, John Easton, Paul Geeleher
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement): B005.
https://doi.org/10.1158/1538-7445.PEDIATRIC24-B005
Published: 05 September 2024
View articletitled, Abstract B005: BMP signaling determines neuroblastoma sensitivity to retinoic acid by directing cell fate
Journal Articles

Abstract 151: BMP signaling determines neuroblastoma cell fate and sensitivity to retinoic acid

Min Pan, Yinwen Zhang, William C. Wright, Hyeong-Min Lee, Richard H. Chapple, Xueying Liu, Jonathan Low, Duane Currier, Allister J. Loughran, Dyer A. Dyer, Shondra M. Pruett, Burgess Freeman, Taosheng Chen, Brian J. Abraham, Elizabeth Stewart, John Easton, Paul Geeleher
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 151.
https://doi.org/10.1158/1538-7445.AM2024-151
Published: 22 March 2024
View articletitled, Abstract 151: BMP signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Journal Articles

Abstract 1907: Combocat: A high-throughput framework for drug combination studies

William C. Wright, Min Pan, Hyeong-Min Lee, Gregory A. Phelps, Jonathan Low, Duane Currier, Richard E. Lee, Taosheng Chen, Paul Geeleher
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1907.
https://doi.org/10.1158/1538-7445.AM2022-1907
Published: 15 June 2022
View articletitled, Abstract 1907: Combocat: A high-throughput framework for drug combination studies
Journal Articles

Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer

P. Jake Slavish, Liying Chi, Mi-Kyung Yun, Lyudmila Tsurkan, Nancy E. Martinez, Barbara Jonchere, Sergio C. Chai, Michele Connelly, M. Brett Waddell, Sourav Das, Geoffrey Neale, Zhenmei Li, William R. Shadrick, Rachelle R. Olsen, Kevin W. Freeman, Jonathan A. Low, Jeanine E. Price, Brandon M. Young, Nagakumar Bharatham, Vincent A. Boyd, Jun Yang, Richard E. Lee, Marie Morfouace, Martine F. Roussel, Taosheng Chen, Daniel Savic, R. Kiplin Guy, Stephen W. White, Anang A. Shelat, Philip M. Potter
Journal: Cancer Research
Cancer Res (2020) 80 (17): 3507–3518.
https://doi.org/10.1158/0008-5472.CAN-19-3934
Published: 02 September 2020
View articletitled, Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer
Open the PDF for Bromodomain-Selective BET Inhibitors Are Potent Antitumor Agents against MYC-Driven Pediatric Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract IA12: Modeling and targeting CREBBP mutations in relapsed acute lymphoblastic leukemia

Yunchao Chang, David W. Woessner, Wenwei Lin, Taosheng Chen, Beisi Xu, Yiping Fan, Haiyan Tan, Junmin Peng, Lawryn Kasper, Michelle L. Churchman, Daniela S. Gerhard, Mignon L. Loh, Stephen P. Hunger, Aman Seth, Karen Gascoigne, Charles G. Mullighan
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): IA12.
https://doi.org/10.1158/1538-7445.PEDCA17-IA12
Published: 01 October 2018
View articletitled, Abstract IA12: Modeling and targeting CREBBP mutations in relapsed acute lymphoblastic leukemia
Journal Articles

Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox

Jun Yang, Sandra Milasta, Dongli Hu, Alaa M. AlTahan, Rodrigo B. Interiano, Junfang Zhou, Jesse Davidson, Jonathan Low, Wenwei Lin, Ju Bao, Pollyanna Goh, Amit C. Nathwani, Ruoning Wang, Yingdi Wang, Su Sien Ong, Vincent A. Boyd, Brandon Young, Sourav Das, Anang Shelat, Yinan Wu, Zhenmei Li, Jie J. Zheng, Ashutosh Mishra, Yong Cheng, Chunxu Qu, Junmin Peng, Douglas R. Green, Stephen White, R. Kiplin Guy, Taosheng Chen, Andrew M. Davidoff
Journal: Cancer Research
Cancer Res (2017) 77 (17): 4626–4638.
https://doi.org/10.1158/0008-5472.CAN-16-0826
Published: 31 August 2017
View articletitled, Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox
Open the PDF for Targeting Histone Demethylases in MYC-Driven Neuroblastomas with Ciclopirox in another window
Includes: Supplementary data
Journal Articles

Abstract LB-056: Discovery of novel small molecule inhibitors of the DCN1-Ubc12 interaction by high throughput screening technology

Jaeki Min, Daniel C. Scott, Sergio C. Chai, Asli N. Goktug, Jared T. Hammill, Guochang Huang, Michele C. Connelly, Amy Matheny, Anang Shelat, Bhuvanesh Singh, Taosheng Chen, Brenda A. Schulman, R. Kiplin Guy
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-056.
https://doi.org/10.1158/1538-7445.AM2016-LB-056
Published: 15 July 2016
View articletitled, Abstract LB-056: Discovery of novel small molecule inhibitors of the DCN1-Ubc12 interaction by high throughput screening technology
Journal Articles

Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death

Eric I. Zimmerman, Alice A. Gibson, Shuiying Hu, Aksana Vasilyeva, Shelley J. Orwick, Guoqing Du, Gerard P. Mascara, Su Sien Ong, Taosheng Chen, Peter Vogel, Hiroto Inaba, Michael L. Maitland, Alex Sparreboom, Sharyn D. Baker
Journal: Cancer Research
Cancer Res (2016) 76 (1): 117–126.
https://doi.org/10.1158/0008-5472.CAN-15-0694
Published: 03 January 2016
View articletitled, Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death
Open the PDF for Multikinase Inhibitors Induce Cutaneous Toxicity through OAT6-Mediated Uptake and MAP3K7-Driven Cell Death in another window
Includes: Supplementary data
Journal Articles

Abstract 4415: Tyrosine phosphorylation is essential for OCT2 function and a target of inhibition by TKIs

Navjotsingh Pabla, Jason A. Sprowl, Su Sien Ong, Alice A. Gibson, Guoqing Du, Wenwei Lin, Shuiying Hu, Lie Li, Taosheng Chen, Alex Sparreboom
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4415.
https://doi.org/10.1158/1538-7445.AM2015-4415
Published: 01 August 2015
View articletitled, Abstract 4415: Tyrosine phosphorylation is essential for OCT2 function and a target of inhibition by TKIs
Journal Articles

Abstract 3393: Nuclear receptor Nurr1 mediates cell proliferation and is involved in a p53-microRNA-34 regulatory network

Jordan A. Beard, Justin L. Hills, Alexa Tenga, Apana A. Takwi, Taosheng Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3393.
https://doi.org/10.1158/1538-7445.AM2014-3393
Published: 01 October 2014
View articletitled, Abstract 3393: Nuclear receptor Nurr1 mediates cell proliferation and is involved in a p53-microRNA-34 regulatory network
Journal Articles

Abstract 1556: Regulation of cellular apoptosis via a novel protein-protein interaction of tumor suppressor p53 with the xenobiotic pregnane X receptor (PXR) in colon cancer cells

Delira F. Robbins, Jing Wu, Taosheng Chen
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1556.
https://doi.org/10.1158/1538-7445.AM2014-1556
Published: 01 October 2014
View articletitled, Abstract 1556: Regulation of cellular apoptosis via a novel protein-protein interaction of tumor suppressor p53 with the xenobiotic pregnane X receptor (PXR) in colon cancer cells
Journal Articles

Abstract 2482: Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells

Lingling Liu, Taosheng Chen
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2482.
https://doi.org/10.1158/1538-7445.AM2012-2482
Published: 15 April 2012
View articletitled, Abstract 2482: Carnitine palmitoyltransferase 1A (CPT1A): a transcriptional target of PAX3-FKHR and mediates PAX3-FKHR-dependent motility in alveolar rhabdomyosarcoma cells
Journal Articles

Abstract 4522: Identification of small molecule agonists/activators of BMP-2, 4, 7 signaling

Karen Vrijens, Wenwei Lin, Jimmy Cui, Anang Shelat, Michael Taylor, Kip R. Guy, Taosheng Chen, Martine F. Roussel
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 4522.
https://doi.org/10.1158/1538-7445.AM2011-4522
Published: 15 April 2011
View articletitled, Abstract 4522: Identification of small molecule agonists/activators of BMP-2, 4, 7 signaling
Journal Articles

Interleukin 6 Activates Androgen Receptor-mediated Gene Expression through a Signal Transducer and Activator of Transcription 3-dependent Pathway in LNCaP Prostate Cancer Cells

Taosheng Chen, Li Hua Wang, William L. Farrar
Journal: Cancer Research
Cancer Res (2000) 60 (8): 2132–2135.
Published: 01 April 2000
View articletitled, Interleukin 6 Activates Androgen Receptor-mediated Gene Expression through a Signal Transducer and Activator of Transcription 3-dependent Pathway in LNCaP Prostate Cancer Cells
Open the PDF for Interleukin 6 Activates Androgen Receptor-mediated Gene Expression through a Signal Transducer and Activator of Transcription 3-dependent Pathway in LNCaP Prostate Cancer Cells in another window
Journal Articles

Elevation of Cyclic Adenosine 3′,5′-Monophosphate Potentiates Activation of Mitogen-activated Protein Kinase by Growth Factors in LNCaP Prostate Cancer Cells

Taosheng Chen, Richard W. Cho, Philip J. S. Stork, Michael J. Weber
Journal: Cancer Research
Cancer Res (1999) 59 (1): 213–218.
Published: 01 January 1999
View articletitled, Elevation of Cyclic Adenosine 3′,5′-Monophosphate Potentiates Activation of Mitogen-activated Protein Kinase by Growth Factors in LNCaP Prostate Cancer Cells
Open the PDF for Elevation of Cyclic Adenosine 3′,5′-Monophosphate Potentiates Activation of Mitogen-activated Protein Kinase by Growth Factors in LNCaP Prostate Cancer Cells in another window