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Journal Articles

Editor’s Note: Recombinant Immunoproapoptotic Proteins with Furin Site Can Translocate and Kill HER2-Positive Cancer Cells

Free
Tao Wang, Jing Zhao, Jun-Lin Ren, Li Zhang, Wei-Hong Wen, Rui Zhang, Wei-Wei Qin, Lin-Tao Jia, Li-Bo Yao, Ying-Qi Zhang, Si-Yi Chen, An-Gang Yang
Journal: Cancer Research
Cancer Res (2025) 85 (12): 2340.
https://doi.org/10.1158/0008-5472.CAN-25-1561
Published: 16 June 2025
View article titled, Editor’s Note: Recombinant Immunoproapoptotic Proteins with Furin Site Can Translocate and Kill HER2-Positive Cancer Cells
Open the PDF for Editor’s Note: Recombinant Immunoproapoptotic Proteins with Furin Site Can Translocate and Kill HER2-Positive Cancer Cells in another window
Journal Articles

Abstract 2128: Uncovering the multiple therapeutic mechanisms of trastuzumab deruxtecan (T-DXd): effective extracellular payload release and immunomodulatory stimulation

Free
Li-Chung Tsao, John S. Wang, Xingru Ma, Sirajbir Sodhi, Joey V. Ragusa, Bushangqing Liu, Jason McBane, Tao Wang, Junping Wei, Cong-Xiao Liu, Xiao-Yi Yang, Gang-jun Lei, Ivan Spasojevic, Ping Fan, Timothy N. Trotter, Michael A. Morse, Herbert K. Lyerly, Zachary C. Hartman
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2128.
https://doi.org/10.1158/1538-7445.AM2025-2128
Published: 21 April 2025
View article titled, Abstract 2128: Uncovering the multiple therapeutic mechanisms of trastuzumab deruxtecan (T-DXd): effective extracellular payload release and immunomodulatory stimulation
Journal Articles

Abstract 2675: Tumor clones display intrinsic and stable rates of progression and coordination of the tumor microenvironment in association with epithelial mesenchymal plasticity

Free
Timothy N. Trotter, Jason McBane, Xing Gao, Carina Dagotto, Tao Wang, H. Kim Lyerly, Zachary C. Hartman
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2675.
https://doi.org/10.1158/1538-7445.AM2025-2675
Published: 21 April 2025
View article titled, Abstract 2675: Tumor clones display intrinsic and stable rates of progression and coordination of the tumor microenvironment in association with epithelial mesenchymal plasticity
Journal Articles

Abstract 739: Patient-derived xenografts allow deconvolution and prediction of chemotherapy responses

Free
Jonathan T. Lei, Lacey E. Dobrolecki, Chen Huang, Ramakrishnan R. Srinivasan, Suhas V. Vasaikar, Alaina N. Lewis, Christina Sallas, Na Zhao, Jin Cao, John D. Landua, Chang I. Moon, Yuxing Liao, Susan G. Hilsenbeck, C K. Osborne, Mothaffar F. Rimawi, Matthew J. Ellis, Varduhi Petrosyan, Bo Wen, Kai Li, Alexander B. Saltzman, Antrix Jain, Anna Malovannaya, Gerburg M. Wulf, Elisabetta Marangoni, Shunqiang Li, Daniel C. Kraushaar, Tao Wang, Senthil Damodaran, Xiaofeng Zheng, Funda Meric-Bernstam, Gloria V. Echeverria, Meenakshi Anurag, Xi Chen, Bryan E. Welm, Alana L. Welm, Bing Zhang, Michael T. Lewis
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 739.
https://doi.org/10.1158/1538-7445.AM2025-739
Published: 21 April 2025
View article titled, Abstract 739: Patient-derived xenografts allow deconvolution and prediction of chemotherapy responses
Journal Articles

Abstract 3507: Discovery and preclinical characterization of novel TCR-mimetic T-cell engagers targeting TERT peptide-HLA complex for the treatment of solid and hematologic malignancies

Free
Yu Huang, Bhupal Ban, Jessica Jimenez, Preethi Sankaran, Christine A. Devlin, Melissa Bikowitz, Qunyan Yu, Ricard Masia, Delainey O’Connor, Emily McNally, Sarah Jaffe, Tanzila Rahman, Jennifer Helble, Alona Kulesha, Andrew Wolpert, Brendan Whalen, Shawn O’Malley, Yue Li, Michael Jennings, Galina Gabriely, Amanda Mak, Tao Wang, Benjamin Lee, Michi Schebesta, Michael Princiotta, Geraldine L. Paulus, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3507.
https://doi.org/10.1158/1538-7445.AM2025-3507
Published: 21 April 2025
View article titled, Abstract 3507: Discovery and preclinical characterization of novel TCR-mimetic T-cell engagers targeting TERT peptide-HLA complex for the treatment of solid and hematologic malignancies
Journal Articles

Abstract 3449: The role of N-terminal cleavage of Trop2 in tumor progression and therapeutic resistance in triple negative breast cancer

Free
Andrea E. Wilson, Junping Wei, Gangjun Lei, Tao Wang, Xiao-Yi Yang, Melissa Gajda, Cong-Xiao Liu, Zachary C. Hartman
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 3449.
https://doi.org/10.1158/1538-7445.AM2025-3449
Published: 21 April 2025
View article titled, Abstract 3449: The role of N-terminal cleavage of Trop2 in tumor progression and therapeutic resistance in triple negative breast cancer
Journal Articles

Abstract 6171: Flt3 ligand and CD40 agonist-based therapy in breast cancer promotes myeloid cell CXCL9 secretion and CD8 T cell recruitment but is not dependent on CXCL9 for efficacy

Free
Preteesh L. Mylabathula, Anas Alkhani, James Zhu, Skanda Hebbale, Riyasat Ali, Vivek Mathesh, Isaac Chan, Tao Wang, Sangeetha M. Reddy
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6171.
https://doi.org/10.1158/1538-7445.AM2025-6171
Published: 21 April 2025
View article titled, Abstract 6171: Flt3 ligand and CD40 agonist-based therapy in breast cancer promotes myeloid cell CXCL9 secretion and CD8 T cell recruitment but is not dependent on CXCL9 for efficacy
Journal Articles

Abstract 6297: Mapping cellular interactions from spatially resolved transcriptomics data

Free
James Zhu, Yunguan Wang, Woo Yong Chang, Alicia Malewska, Fabiana Napolitano, Jeffrey C. Gahan, Nisha Unni, Min Zhao, Rongqing Yuan, Fangjiang Wu, Lauren Yue, Lei Guo, Zhuo Zhao, Danny Chen, Raquibul Hannan, Siyuan Zhang, Guanghua Xiao, Ping Mu, Ariella B. Hanker, Douglas Strand, Carlos L. Arteaga, Neil Desai, Xinlei Wang, Yang Xie, Tao Wang
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 6297.
https://doi.org/10.1158/1538-7445.AM2025-6297
Published: 21 April 2025
View article titled, Abstract 6297: Mapping cellular interactions from spatially resolved transcriptomics data
Journal Articles

Abstract 4375: LY4066434, an oral small molecule pan-KRAS inhibitor, demonstrates robust anti-tumor activity in KRAS-mutant models, including in the CNS

Free
Hong Gao, Youyan Zhang, Chun Ping Yu, Wei Guo Xu, Binghui Li, Huimin Bian, Manuj Tandon, Tao Wang, Trent R. Stewart, Mark H. Bender, Wenyu Ming, Megan A. Johnson, Lisa M. Kays, Madeleine Leonard, Mark A. Castanares, Andrew Capen, Arthur Xintian You, Wen Ting Bian, Lourdes Prieto, Timothy Kercher, Laurie LeBrun, Anke Klippel, Chandrasekar Iyer, Xueqian Gong
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4375.
https://doi.org/10.1158/1538-7445.AM2025-4375
Published: 21 April 2025
View article titled, Abstract 4375: LY4066434, an oral small molecule pan-KRAS inhibitor, demonstrates robust anti-tumor activity in KRAS-mutant models, including in the CNS
Journal Articles

Abstract 908: Decoding the role of intrinsic pancreatic cellular signaling in shaping the immunosuppressive tumor microenvironment

Free
Bushangqing Liu, Ethan Agritelley, Junping Wei, Gangjun Lei, Tao Wang, Jason McBane, Daniel Nussbaum, Zachary Hartman
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 908.
https://doi.org/10.1158/1538-7445.AM2025-908
Published: 21 April 2025
View article titled, Abstract 908: Decoding the role of intrinsic pancreatic cellular signaling in shaping the immunosuppressive tumor microenvironment
Journal Articles

Abstract B052: Single-cell and spatial analysis of the immune landscape unveils a subset of potentially tumor-reactive T cells in patients with localized PDAC

Free
Elishama N Kanu, Ashley A Fletcher, Sri Krishna, Frank J Lowery, Haotian Zhuang, Ethan S Agritelley, Jiayin Bao, Austin M Eckhoff, Karrie Comatas, Tao Wang, Bin-Jin Hwang, Michael E Lidsky, Sabino Zani, Dan G Blazer, III, Peter J Allen, Nicholas D Klemen, Zhicheng Ji, Daniel P Nussbaum, Erika J Crosby
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): B052.
https://doi.org/10.1158/1538-7445.PANCREATIC24-B052
Published: 15 September 2024
View article titled, Abstract B052: Single-cell and spatial analysis of the immune landscape unveils a subset of potentially tumor-reactive T cells in patients with localized PDAC
Journal Articles

Abstract PO1-19-04: Dalpiciclib and tucidinostat in patients with HR+/HER2- advanced breast cancer and resistance to CDK4/6 inhibitors: A phase Ib trial

Free
Tao Wang, Jinmei Zhou, Xuexue Wu, Zefei Jiang
Journal: Cancer Research
Cancer Res (2024) 84 (9_Supplement): PO1-19-04.
https://doi.org/10.1158/1538-7445.SABCS23-PO1-19-04
Published: 02 May 2024
View article titled, Abstract PO1-19-04: Dalpiciclib and tucidinostat in patients with HR+/HER2- advanced breast cancer and resistance to CDK4/6 inhibitors: A phase Ib trial
Journal Articles

Abstract LB341: Clinical validation and mechanistic insights of ThisCART: A novel allogeneic platform enhancing CAR-T signaling via intracellular TCRαβ/CD3 retention

Free
Jun Li, Lei Xue, Sujun Li, Ling He, Kaichun Liu, Rong Jin, Tao Wang, Yinhang Zhang, Shanshan Chen, Yulian Gao, Dan Liu, Liyun Yang, Xingbing Wang
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB341.
https://doi.org/10.1158/1538-7445.AM2024-LB341
Published: 05 April 2024
View article titled, Abstract LB341: Clinical validation and mechanistic insights of ThisCART: A novel allogeneic platform enhancing CAR-T signaling via intracellular TCRαβ/CD3 retention
Journal Articles

Abstract 3316: LY3962673, an oral, highly potent, mutant-selective, and non-covalent KRAS G12D inhibitor demonstrates robust anti-tumor activity in KRAS G12D models

Free
Xueqian Gong, Hong Gao, Mark H. Bender, Wenyu Ming, Youyan Zhang, Trent R. Stewart, Chun Ping Yu, Wei Guo Xu, Aurthur Xintian You, Wen Ting Bian, Binghui Li, Tao Wang, Huimin Bian, Manuj Tandon, Andrew Capen, Rachel N. Cavitt, Bryan D. Anderson, Wayne Bocchinfuso, Anke Klippel, Chandrasekar Iyer
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3316.
https://doi.org/10.1158/1538-7445.AM2024-3316
Published: 22 March 2024
View article titled, Abstract 3316: LY3962673, an oral, highly potent, mutant-selective, and non-covalent KRAS G12D inhibitor demonstrates robust anti-tumor activity in KRAS G12D models
Journal Articles

Abstract 2377: HER2-ADC efficacy is rooted in its induction of immunogenic cell death with FcGR activation and a systemic bystander effect

Free
Li-Chung Tsao, Xingru Ma, John S. Wang, Timothy N. Trotter, Tao Wang, Jun-Ping Wei, Gang-jun Lei, Jason McBane, Ping Fan, Ivan Spasojevic, Zachary C. Hartman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2377.
https://doi.org/10.1158/1538-7445.AM2024-2377
Published: 22 March 2024
View article titled, Abstract 2377: HER2-ADC efficacy is rooted in its induction of immunogenic cell death with FcGR activation and a systemic bystander effect
Journal Articles

Abstract 1236: Characterization of CBX-250, a first-in-class TCR-mimetic-based T-cell engager targeting a cathepsin G peptide-HLA complex for the treatment of myeloid leukemia

Free
Geraldine Paulus, Benjamin Lee, Preethi Sankaran, Tanzila Rahman, Jessica Jimenez, Delainey O'Connor, Simon Yue, Yu Huang, Melissa Bikowitz, Sarah Jaffe, Shawn O'Malley, Bhupal Ban, Galina Gabriely, Tao Wang, Amanda Mak, Michael Princiotta, Chunhua Shi, Helen He, Ningping Feng, Jun Yan, Timothy Heffernan, Gheath Alatrash, Jeffrey Molldrem, Dmitri Wiederschain
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1236.
https://doi.org/10.1158/1538-7445.AM2024-1236
Published: 22 March 2024
View article titled, Abstract 1236: Characterization of CBX-250, a first-in-class TCR-mimetic-based T-cell engager targeting a cathepsin G peptide-HLA complex for the treatment of myeloid leukemia
Journal Articles

Abstract 5296: Enhancing the strength and durability of vaccine-induced anti-tumor immunity with CD27 agonism of CD4+ T cells

Free
Bin-Jin Hwang, Erika Crosby, Timothy Trotter, Li-Chung Tsao, Tao Wang, Congxiao Liu, Xiao Yang, Gangjun Lei, Junping Wei, Xingru Ma, Bushanqing Liu, Amy Hobeika, Michael Morse, Tibor Keler, Li-Zhen He, Herbert Kim Lyerly, Zachary Hartman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5296.
https://doi.org/10.1158/1538-7445.AM2024-5296
Published: 22 March 2024
View article titled, Abstract 5296: Enhancing the strength and durability of vaccine-induced anti-tumor immunity with CD27 agonism of CD4+ T cells
Journal Articles

Abstract 3716: Enhancing anti-tumor responses in triple-negative breast cancer by combining SIRPα inhibition with immunogenic chemotherapy or antibody-drug conjugates

Free
Xingru Ma, Li-Chung Tsao, Tao Wang, Cong-Xiao Liu, Melissa Gajda, Xiao Yang, Gangjun Lei, Junping Wei, Zachary Hartman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3716.
https://doi.org/10.1158/1538-7445.AM2024-3716
Published: 22 March 2024
View article titled, Abstract 3716: Enhancing anti-tumor responses in triple-negative breast cancer by combining SIRPα inhibition with immunogenic chemotherapy or antibody-drug conjugates
Journal Articles

Abstract 5443: Identifying key regulators of glioblastoma cancer stem cells

Free
Tao Wang, Xuanhua Xie, Luis F. Parada
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5443.
https://doi.org/10.1158/1538-7445.AM2024-5443
Published: 22 March 2024
View article titled, Abstract 5443: Identifying key regulators of glioblastoma cancer stem cells
Journal Articles

Abstract 3981: Immune targeting progesterone receptor in hormone receptor positive breast cancer

Free
Andrea E. Wilson, Junping Wei, Gangjun Lei, Xiao-Yi Yang, Cong-Xiao Liu, Melissa Gajda, Tao Wang, Christy Hagan, Zachary C. Hartman
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3981.
https://doi.org/10.1158/1538-7445.AM2024-3981
Published: 22 March 2024
View article titled, Abstract 3981: Immune targeting progesterone receptor in hormone receptor positive breast cancer