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Journal Articles

Abstract 4394: GFH375 (VS-7375): An oral, selective KRAS G12D (ON/OFF) inhibitor with potent anti-tumor efficacy as single agent and in combination with other anticancer therapies in preclinical models

Free
Jonathan A. Pachter, Feng Yan, Silvia Coma, Cristina Caffarra Malvezzi, Xiuting Liu, Emilia Berardelli, Tao Jiang, Siyuan Le, Nathan Sanburn, Fusheng Zhou, Jiong Lan, David G. DeNardo, Chiara Ambrogio, Qiang Lu
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4394.
https://doi.org/10.1158/1538-7445.AM2025-4394
Published: 21 April 2025
View article titled, Abstract 4394: GFH375 (VS-7375): An oral, selective KRAS G12D (ON/OFF) inhibitor with potent anti-tumor efficacy as single agent and in combination with other anticancer therapies in preclinical models
Journal Articles

Abstract 2299: Risk assessment and development of a machine learning-based prediction model for survival in patients with medulloblastoma

Free
Yu Su, Kaiwen Deng, Tao Jiang, Xiaoguang Qiu, Jiao Zhang, Hailong Liu, Yu Tian
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2299.
https://doi.org/10.1158/1538-7445.AM2025-2299
Published: 21 April 2025
View article titled, Abstract 2299: Risk assessment and development of a machine learning-based prediction model for survival in patients with medulloblastoma
Journal Articles

Abstract CT009: IMvoke010: A phase III, double-blind randomized trial of atezolizumab (atezo) after definitive local therapy vs placebo in patients (pts) with high-risk locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN)

Free
Deborah J. Wong, Jérôme Fayette, Maria Teixeira, Kumar Prabhash, Ricard Mesia, Andrzej Kawecki, Arunee Dechaphunkul, José Dinis, Ye Guo, Muneyuki Masuda, Ching-Yun Hsieh, Maria Grazia Ghi, Claudia Vaz de Melo Sette, Tao Jiang, Yibing Yan, Monika Kaul, Ritika Jagtiani, Christina Matheny, Vaikunth Cuchelkar, Robert Haddad
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT009.
https://doi.org/10.1158/1538-7445.AM2024-CT009
Published: 05 April 2024
View article titled, Abstract CT009: IMvoke010: A phase III, double-blind randomized trial of atezolizumab (atezo) after definitive local therapy vs placebo in patients (pts) with high-risk locally advanced (LA) squamous cell carcinoma of the head and neck (SCCHN)
Journal Articles

Abstract LB165: GFH547: An orally bioavailable, cyclophilin A-hijacking panRAS(on) inhibitor with broad spectrum anti-tumor activities

Free
Feng Yan, Jichen Zhao, Tao Liang, Tao Jiang, Chonglan Lin, Ling Peng, Kai Ma, Huabin Yang, Wan He, Zhen Li, Leitao Zhang, Xiaoming Xu, Yanhui Zhao, Xiaohui Zhang, Yonghong Ni, Qiang Liu, Jinting Gao, Fubo Xie, Xueyan Gao, Xiaoling Lan, Li Wang, Jingyang Zhang, Hongcan Ren, Dong Liu, Siyuan Le, Fusheng Zhou, Jiong Lan, Qiang Lu
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB165.
https://doi.org/10.1158/1538-7445.AM2024-LB165
Published: 05 April 2024
View article titled, Abstract LB165: GFH547: An orally bioavailable, cyclophilin A-hijacking panRAS(on) inhibitor with broad spectrum anti-tumor activities
Journal Articles

Abstract 6939: Residual disease after HER2 inhibition is driven by a primary tumor subpopulation expressing an ERBB2-low associated transcriptional program

Free
Sheheryar K. Kabraji, Weihua Wang, Yali Zhang, Johann Bergholz, Tao Jiang, Vittal Kurisetty, Maia Homsi, Jianmin Wang, Jean Zhao
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6939.
https://doi.org/10.1158/1538-7445.AM2024-6939
Published: 22 March 2024
View article titled, Abstract 6939: Residual disease after HER2 inhibition is driven by a primary tumor subpopulation expressing an ERBB2-low associated transcriptional program
Journal Articles

Abstract 3318: GFH375 (VS-7375): An oral, selective KRAS G12D (ON/OFF) inhibitor with potent anti-tumor efficacy

Free
Feng Yan, Tao Jiang, Tao Liang, Lijian Cai, Leitao Zhang, Xiaoming Xu, Yanhui Zhao, Xiaoling Lan, Xiaohui Zhang, Meng Liu, Qiang Liu, Jinting Gao, Fubo Xie, Xueyan Gao, Li Wang, Jingyang Zhang, Hongcan Ren, Dong Liu, Siyuan Le, Lili Tang, Silvia Coma, Yaofeng Cheng, Nathan Sanburn, Jonathan A. Pachter, Fusheng Zhou, Jiong Lan, Qiang Lu
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3318.
https://doi.org/10.1158/1538-7445.AM2024-3318
Published: 22 March 2024
View article titled, Abstract 3318: GFH375 (VS-7375): An oral, selective KRAS G12D (ON/OFF) inhibitor with potent anti-tumor efficacy
Journal Articles

Abstract 7564: DNA methylation profiling identifies two distinct groups of oligosarcoma, IDH-mutant with distinct genetic alterations and clinical outcomes

Free
Kenan Zhang, Lingyu Liu, Xing Liu, Tao Jiang
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 7564.
https://doi.org/10.1158/1538-7445.AM2024-7564
Published: 22 March 2024
View article titled, Abstract 7564: DNA methylation profiling identifies two distinct groups of oligosarcoma, IDH-mutant with distinct genetic alterations and clinical outcomes
Journal Articles

Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma

Free
Hong Wu, Xuefeng Leng, Qianshi Liu, Tianqin Mao, Tao Jiang, Yiqiang Liu, Feifei Li, Chenhui Cao, Jun Fan, Liang Chen, Yaqi Chen, Quan Yao, Shun Lu, Renchuan Liang, Lanlin Hu, Mingxin Liu, Yejian Wan, Zhaoshen Li, Jun Peng, Qiyu Luo, Hang Zhou, Jun Yin, Ke Xu, Mei Lan, Xinhao Peng, Haitao Lan, Gang Li, Yongtao Han, Xia Zhang, Zhi-Xiong Jim Xiao, Jinyi Lang, Guihua Wang, Chuan Xu
Journal: Cancer Research
Cancer Res (2023) 83 (18): 3131–3144.
https://doi.org/10.1158/0008-5472.CAN-22-2593
Published: 15 September 2023
View article titled, Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma
Open the PDF for Intratumoral Microbiota Composition Regulates Chemoimmunotherapy Response in Esophageal Squamous Cell Carcinoma in another window
Includes: Supplementary data
Journal Articles

Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages

Open Access
Min Wu, Lingxiang Wu, Wei Wu, Mengyan Zhu, Jianyu Li, Ziyu Wang, Jie Li, Rong Ding, Yuan Liang, Liangyu Li, Tingting Zhang, Bin Huang, Yun Cai, Kening Li, Lu Li, Rui Zhang, Baoli Hu, Fan Lin, Xiuxing Wang, Siyuan Zheng, Jian Chen, Yongping You, Tao Jiang, Junxia Zhang, Hongshan Chen, Qianghu Wang
Journal: Cancer Research
Cancer Res (2023) 83 (5): 771–785.
https://doi.org/10.1158/0008-5472.CAN-22-1570
Published: 02 March 2023
View article titled, Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages
Open the PDF for Phagocytosis of Glioma Cells Enhances the Immunosuppressive Phenotype of Bone Marrow–Derived Macrophages in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract LB004: Upregulation of STAT3 signaling in tumor cells fosters a TME-dependent secondary resistance of BRCA1-deficient HGSOC to PARP inhibition

Free
Liya Ding, Qiwei Wang, Michael Kearns, Tao Jiang, Xin Cheng, Changli Qian, Jean Zhao
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): LB004.
https://doi.org/10.1158/1538-7445.AM2022-LB004
Published: 15 June 2022
View article titled, Abstract LB004: Upregulation of STAT3 signaling in tumor cells fosters a TME-dependent secondary resistance of BRCA1-deficient HGSOC to PARP inhibition
Journal Articles

Abstract LB159: Overcoming immunosuppression and therapeutic resistance to PARP inhibition in BRCA1-deficient breast cancer with STING agonists

Free
Qiwei Wang, Johann S. Bergholz, Liya Ding, Ziying Lin, Shaozhen Xie, Tao Jiang, Hye-Jung Kim, Thomas M. Roberts, Jean J. Zhao
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): LB159.
https://doi.org/10.1158/1538-7445.AM2021-LB159
Published: 01 July 2021
View article titled, Abstract LB159: Overcoming immunosuppression and therapeutic resistance to PARP inhibition in BRCA1-deficient breast cancer with STING agonists
Journal Articles

Abstract 97: Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities

Free
Luciano Garofano, Simona Migliozzi, Young Taek Oh, Fulvio D'Angelo, Ryan D. Najac, Aram Ko, Brulinda Frangaj, Francesca Pia Caruso, Kai Yu, Jinzhou Yuan, Wenting Zhao, Anna Luisa Di Stefano, Franck Bielle, Tao Jiang, Peter Sims, Mario L. Suvà, Fuchou Tang, Xiao-Dong Su, Michele Ceccarelli, Marc Sanson, Anna Lasorella, Antonio Iavarone
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 97.
https://doi.org/10.1158/1538-7445.AM2021-97
Published: 01 July 2021
View article titled, Abstract 97: Pathway-based classification of glioblastoma uncovers a mitochondrial subtype with therapeutic vulnerabilities
Journal Articles

Prostaglandin E1 Inhibits GLI2 Amplification–Associated Activation of the Hedgehog Pathway and Drug Refractory Tumor Growth

Available to Purchase
Fujia Wu, Chenze Zhang, Chen Zhao, Hao Wu, Zhaoqian Teng, Tao Jiang, Yu Wang
Journal: Cancer Research
Cancer Res (2020) 80 (13): 2818–2832.
https://doi.org/10.1158/0008-5472.CAN-19-2052
Published: 02 July 2020
View article titled, Prostaglandin E1 Inhibits GLI2 Amplification–Associated Activation of the Hedgehog Pathway and Drug Refractory Tumor Growth
Open the PDF for Prostaglandin E1 Inhibits GLI2 Amplification–Associated Activation of the Hedgehog Pathway and Drug Refractory Tumor Growth in another window
Includes: Supplementary data
Journal Articles

Correction: Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis

Free
Xiaofeng Wang, Guangtao Luo, Kundong Zhang, Jun Cao, Chen Huang, Tao Jiang, Bingya Liu, Liping Su, Zhengjun Qiu
Journal: Cancer Research
Cancer Res (2020) 80 (4): 922.
https://doi.org/10.1158/0008-5472.CAN-19-3872
Published: 14 February 2020
View article titled, Correction: Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis
Open the PDF for Correction: Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis in another window
Journal Articles

Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis

Free
Xiaofeng Wang, Guangtao Luo, Kundong Zhang, Jun Cao, Chen Huang, Tao Jiang, Bingya Liu, Liping Su, Zhengjun Qiu
Journal: Cancer Research
Series: Author Choice
Cancer Res (2018) 78 (16): 4586–4598.
https://doi.org/10.1158/0008-5472.CAN-17-3841
Published: 14 August 2018
View article titled, Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis
Open the PDF for Hypoxic Tumor-Derived Exosomal miR-301a Mediates M2 Macrophage Polarization via PTEN/PI3Kγ to Promote Pancreatic Cancer Metastasis in another window
Includes: Supplementary data
Journal Articles

Abstract 1956: miR-181d degradation mediated genetic heterogeneity and acquired resistance

Free
Valya Ramakrishnan, Johnny Akers, Thien Nguyen, Aaron Wang, Bandita Adhikari, Brian Hirshman, Jie Li, Jann Sarkaria, Wei Hua, Mao Ying, Masayuki Nitta, Tao Jiang, Bob Carter, Clark C. Chen
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1956.
https://doi.org/10.1158/1538-7445.AM2018-1956
Published: 01 July 2018
View article titled, Abstract 1956: miR-181d degradation mediated genetic heterogeneity and acquired resistance
Journal Articles

Abstract 284: The trending of lymph node dissection for esophageal squamous cell carcinoma over 40 years in China

Free
Pei Nan Chen, Fu You Zhou, Hong Mei Chen, Xiao Shan Feng, Lei Sun, Ling Yuan, Ping He, Ying Pan, Tao Jiang, Min Jie Wu, Wen Jun Gao, Jin Chang Wei, Li Dong Wang
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 284.
https://doi.org/10.1158/1538-7445.AM2017-284
Published: 01 July 2017
View article titled, Abstract 284: The trending of lymph node dissection for esophageal squamous cell carcinoma over 40 years in China
Journal Articles

Abstract LB-207: PI3Kγ inhibition suppresses glioblastoma tumorigenicity through disruption of an IL11-STAT3-MYC signaling axis between microglia and glioblastoma

Free
Jie Li, Megan M. Kaneda, Jiangfei Wang, Kunal Patel, Johnny Akers, Valya Ramakrishnan, Tao Jiang, Bob S. Carter, Judith A. Varner, Clark C. Chen
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-207.
https://doi.org/10.1158/1538-7445.AM2017-LB-207
Published: 01 July 2017
View article titled, Abstract LB-207: PI3Kγ inhibition suppresses glioblastoma tumorigenicity through disruption of an IL11-STAT3-MYC signaling axis between microglia and glioblastoma
Journal Articles

Abstract CT130: Intravenous chemotherapy plus intraperitoneal perfusion chemotherapy for gastric cancer: A systematic review and meta-analysis

Free
Sheng Yang, Rui Feng, Zhangchi Pan, Tao Jiang, Qian Xu, Qiang Chen
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): CT130.
https://doi.org/10.1158/1538-7445.AM2015-CT130
Published: 01 August 2015
View article titled, Abstract CT130: Intravenous chemotherapy plus intraperitoneal perfusion chemotherapy for gastric cancer: A systematic review and meta-analysis
Journal Articles

Abstract IA1: Building molecules to guide anticancer therapy

Free
Emilia S. Olson, Roger Y. Tsien, Elamprakash N. Savariar, Jessica L. Crisp, Tao Jiang, Todd A. Aguilera, Mike A. Whitney, Paul Steinbach, Lesley G. Ellies, Quyen T. Nguyen
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): IA1.
https://doi.org/10.1158/1538-7445.FBCR11-IA1
Published: 28 October 2014
View article titled, Abstract IA1: Building molecules to guide anticancer therapy