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Abstract CT236: INTERLINK-1: A phase 3, randomized, double-blind, placebo-controlled, multicenter, global study of monalizumab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma previously treated with an immune checkpoint inhibitor

Jérôme Fayette, Tanguy Seiwert, Robert L. Ferris, Kevin Harrington, Robert Haddad, Makoto Tahara, Lisa Licitra, Lillian L. Siu, Jean-Pascal Machiels, Malgorzata Dominiewska, Julia Xiong, Paramjit Kaur, Dario Ruscica, Roger B. Cohen

Cancer Res (2022) 82 (12_Supplement): CT236.

DOI: https://doi.org/10.1158/1538-7445.AM2022-CT236

Published: 15 June 2022

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Journal Articles

Abstract 27: Early dynamics in peripheral blood immune cell subsets and ctDNA are predictive of outcome to immunotherapy

Cancer Res (2021) 81 (13_Supplement): 27.

DOI: https://doi.org/10.1158/1538-7445.AM2021-27

Published: 01 July 2021

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Journal Articles

Abstract CT189: Improved progression-free and overall survival (PFS/OS) in patients (pts) with emergence of JTX-2011 associated biomarker (ICOS high CD4 T cells) on the ICONIC trial

Cancer Res (2019) 79 (13_Supplement): CT189.

DOI: https://doi.org/10.1158/1538-7445.AM2019-CT189

Published: 01 July 2019

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Journal Articles

Abstract CT158: Phase II study of monalizumab, a first-in-class NKG2A monoclonal antibody, in combination with cetuximab in previously treated recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Preliminary assessment of safety and efficacy

Roger Cohen, Jérôme Fayette, Marshall Posner, Gautier Lefebvre, Jessica Bauman, Sébastien Salas, Caroline Even, Tanguy Seiwert, Dimitrios Colevas, Antonio Jimeno, Esma Saada, Barbara Burtness, Pascale André, Carine Paturel, Cécile Bonnafous, Anne-Marie Soulié, Anne Tirouvanziam-Martin, Robert Zerbib, Agnès Boyer-Chammard

Cancer Res (2018) 78 (13_Supplement): CT158.

DOI: https://doi.org/10.1158/1538-7445.AM2018-CT158

Published: 01 July 2018

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Journal Articles

Abstract 963: Screening of neoantigen-specific T cells in head and neck cancer and establishment of T-cell receptor-engineered T cells with cytotoxic reactivity

Lili Ren, Tatsuo Matsuda, Boya Deng, Kazuma Kiyotani, Taigo Kato, Jae-Hyun Park, Tanguy Seiwert, Everett Vokes, Nishant Agrawal, Yusuke Nakamura

Cancer Res (2018) 78 (13_Supplement): 963.

DOI: https://doi.org/10.1158/1538-7445.AM2018-963

Published: 01 July 2018

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Journal Articles

Abstract 101: WHSC1L1 as a therapeutic target in squamous cell carcinoma of the head and neck

Vassiliki Saloura, Theodore Vougiouklakis, Mark Lingen, Tanguy Seiwert, Everett Vokes, Yusuke Nakamura, Ryuji Hamamoto

Cancer Res (2015) 75 (15_Supplement): 101.

DOI: https://doi.org/10.1158/1538-7445.AM2015-101

Published: 01 August 2015

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Journal Articles

Abstract 1553: Biomarker evaluation in a randomized phase 2 study of MEHD7945A (MEHD) versus cetuximab (Cet) in ≥2 line recurrent/metastatic (R/M) squamous cell carcinomas of the head and neck (SCCHN) [MEHGAN]

Elicia Penuel, Amy V. Kapp, An Do, Rachel Tam, Teiko Sumiyoshi, Chaitra Marathe, Susan Sa, Franklin Peale, Mark Lackner, Scott Holden, Tanguy Seiwert, Andrea Pirzkall

Cancer Res (2015) 75 (15_Supplement): 1553.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1553

Published: 01 August 2015

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Journal Articles

Abstract 1847: Influence of growth factors on resistance to EGFR inhibitor treatment in HNSCC - Temsirolimus as a potential concept

Susanne R. Tepper, Zhixiang Zuo, Arun Khattri, Jana Heitmann, Jochen Heß, Tanguy Seiwert

Cancer Res (2014) 74 (19_Supplement): 1847.

DOI: https://doi.org/10.1158/1538-7445.AM2014-1847

Published: 01 October 2014

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Journal Articles

Abstract 2746: An evaluation of poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer

Jana Heitmann, Paul Geeleher, Michaela Keck, Zhixiang Zuo, Arun Khattri, Susanne Tepper, Michael Beckett, Ralph R. Weichselbaum, Sebastian Fetscher, Everett E. Vokes, Tanguy Seiwert

Cancer Res (2014) 74 (19_Supplement): 2746.

DOI: https://doi.org/10.1158/1538-7445.AM2014-2746

Published: 01 October 2014

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Journal Articles

Abstract 5153: Wolf-Hirschhorn syndrome candidate 1 as a potential novel therapeutic target for head and neck cancer

Vassiliki Saloura, Makoto Nakakido, Houda Alachkar, Tanguy Seiwert, Mark Lingen, Ezra Cohen, Yusuke Nakamura, Ryuji Hamamoto

Cancer Res (2014) 74 (19_Supplement): 5153.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5153

Published: 01 October 2014

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Abstract 5472: Role of Harvey Ras (HRAS) mutations in head and neck squamous cell carcinoma (HNSCC)

Katharina U. Endhardt, Arun Khattri, Michaela Keck, Johannes Braegelmann, Derya Mahmutoglu, Kelley Leung, Mohamed El Dinali, Damian Rieke, Ezra Cohen, Tanguy Seiwert

Cancer Res (2012) 72 (8_Supplement): 5472.

DOI: https://doi.org/10.1158/1538-7445.AM2012-5472

Published: 15 April 2012

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Journal Articles

Abstract LB-7: HPV-associated HNSCC: Widespread mTOR pathway activity and preclinical evaluation of mTOR inhibitors rapamycin and RAD-001

Christina A. Marsh, Vyomesh Patel, Mohamed El Dinali, Tanguy Seiwert, Alfredo A. Molinolo, J. Silvio Gutkind

Cancer Res (2011) 71 (8_Supplement): LB-7.

DOI: https://doi.org/10.1158/1538-7445.AM2011-LB-7

Published: 15 April 2011

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Journal Articles

Abstract 2223: Screening for oncoviruses using next-generation sequencing

Mohamed El-Dinali, Johannes Braegelmann, Ravi Salgia, Tanguy Seiwert

Cancer Res (2010) 70 (8_Supplement): 2223.

DOI: https://doi.org/10.1158/1538-7445.AM10-2223

Published: 15 April 2010

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Journal Articles

IGF-1R as a target in head and neck cancer, lung cancer, and cervical cancer: Expression in patient samples and in vitro inhibition studies.

Tanguy Seiwert, Leo Faoro, Vidya Nallasura, Wasim Naqshbandi, Maria Tretiakova, Mark Lingen, Aliya Husain, Ravi Salgia

Cancer Res (2008) 68 (9_Supplement): 1527.

Published: 01 May 2008

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Journal Articles

Identification and evaluation of DNA repair biomarkers in head & neck squamous cell carcinoma

XiaoZhe Wang, Vivian Villegas, Esther ORegan, Stephen Finn, Tanguy Seiwert, Everett Vokes, David Weaver

Cancer Res (2008) 68 (9_Supplement): 1455.

Published: 01 May 2008

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Journal Articles

The focal adhesion paxillin is a target for somatic mutations in lung cancer: implications for enhanced cell growth and invasion

Cancer Res (2007) 67 (9_Supplement): 358.

Published: 01 May 2007

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Journal Articles

HSP27 - a novel target for non-small cell lung cancer affecting tumor growth and motility.

Tanguy Seiwert, Palma Rocchi, Lynn Bracht, Varalakshmi Janamanchi, Ramasamy Jagadeeswaran, Aliya Husain, Dongfeng Tan, Li Qiang, Martin Gleave, Ravi Salgia

Cancer Res (2007) 67 (9_Supplement): 1343.

Published: 01 May 2007

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Journal Articles

Activated c-Met receptor tyrosine kinase: A novel molecular therapeutic target for the treatment of malignant pleural mesothelioma

Ramasamy Jagadeeswaran, Patrick C. Ma, Hedy L. Kindler, Sujatha Jagadeeswaran, Tanguy Seiwert, Osvaldo Zumba, Gavin J. Gordon, Robert A. Kratzke, David J. Sugarbaker, Raphael Bueno, Ravi Salgia

Cancer Res (2005) 65 (9_Supplement): 604.

Published: 01 May 2005

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NARROW

Abstract CT236: INTERLINK-1: A phase 3, randomized, double-blind, placebo-controlled, multicenter, global study of monalizumab in combination with cetuximab in patients with recurrent or metastatic head and neck squamous cell carcinoma previously treated with an immune checkpoint inhibitor

Abstract 27: Early dynamics in peripheral blood immune cell subsets and ctDNA are predictive of outcome to immunotherapy

Abstract CT189: Improved progression-free and overall survival (PFS/OS) in patients (pts) with emergence of JTX-2011 associated biomarker (ICOS high CD4 T cells) on the ICONIC trial

Abstract CT158: Phase II study of monalizumab, a first-in-class NKG2A monoclonal antibody, in combination with cetuximab in previously treated recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): Preliminary assessment of safety and efficacy

Abstract 963: Screening of neoantigen-specific T cells in head and neck cancer and establishment of T-cell receptor-engineered T cells with cytotoxic reactivity

Abstract 101: WHSC1L1 as a therapeutic target in squamous cell carcinoma of the head and neck

Abstract 1553: Biomarker evaluation in a randomized phase 2 study of MEHD7945A (MEHD) versus cetuximab (Cet) in ≥2 line recurrent/metastatic (R/M) squamous cell carcinomas of the head and neck (SCCHN) [MEHGAN]

Abstract 1847: Influence of growth factors on resistance to EGFR inhibitor treatment in HNSCC - Temsirolimus as a potential concept

Abstract 2746: An evaluation of poly (ADP-ribose) polymerase inhibitor efficacy in head and neck cancer

Abstract 5153: Wolf-Hirschhorn syndrome candidate 1 as a potential novel therapeutic target for head and neck cancer

Abstract 5472: Role of Harvey Ras (HRAS) mutations in head and neck squamous cell carcinoma (HNSCC)

Abstract LB-7: HPV-associated HNSCC: Widespread mTOR pathway activity and preclinical evaluation of mTOR inhibitors rapamycin and RAD-001

Abstract 2223: Screening for oncoviruses using next-generation sequencing

IGF-1R as a target in head and neck cancer, lung cancer, and cervical cancer: Expression in patient samples and in vitro inhibition studies.

Identification and evaluation of DNA repair biomarkers in head & neck squamous cell carcinoma

The focal adhesion paxillin is a target for somatic mutations in lung cancer: implications for enhanced cell growth and invasion

HSP27 - a novel target for non-small cell lung cancer affecting tumor growth and motility.

Activated c-Met receptor tyrosine kinase: A novel molecular therapeutic target for the treatment of malignant pleural mesothelioma

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