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Journal Articles

Abstract 3531: Sensitizing immune unresponsive colorectal cancers to immune checkpoint inhibitors through MAVS overexpression

Bin-Jin Hwang, Li-Chung Tsao, Chaitanya Acharya, Timothy Trotter, Pankaj Agarwal, Tao Wang, Junping Wei, Xiao-Yi Yang, Gang-jun Lei, Takuya Osada, Herbert Kim Lyerly, Michael A. Morse, Zachary Hartman
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3531.
DOI: https://doi.org/10.1158/1538-7445.AM2022-3531
Published: 15 June 2022
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Journal Articles

Abstract 1557: Intratumoral plasmid IL-12 enhanced the systemic anti-tumor effect of anti-PD-1 antibody in triple-negative breast cancer

Hiroshi Nagata, Takuya Osada, Erika J. Crosby, David A. Canton, Chris G. Twitty, H. Kim Lyerly
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1557.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1557
Published: 01 July 2021
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Abstract PS17-22: Intratumoral delivery of tavokinogene telseplasmid (plasmid IL-12) and electroporation induces an immune signature that predicts successful combination in patients

Erika J Crosby, Hiroshi Nagata, Melinda L Telli, Chaitanya R Acharya, Irene Wapnir, Kaitlin Zablotsky, Erica Browning, Reneta Hermiz, Lauren Svenson, Donna Bannavong, Kellie Malloy, David A Canton, Chris G Twitty, Takuya Osada, Herbert Kim Lyerly
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS17-22.
DOI: https://doi.org/10.1158/1538-7445.SABCS20-PS17-22
Published: 15 February 2021
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Journal Articles

Abstract 4071: A novel combination therapy of high intensity focused ultrasound and PDL1 blockades against advanced breast cancer

Shinya Abe, Takuya Osada, Kensuke Kaneko, Pei Zhong, Herbert K. Lyerly
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4071.
DOI: https://doi.org/10.1158/1538-7445.AM2019-4071
Published: 01 July 2019
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Journal Articles

Abstract 3731: A novel heat shock protein 90-targeted photosensitizer (HS-201) enables enhanced tumor-specific photodynamic therapy of inflammatory breast cancers

Kensuke Kaneko, Takuya Osada, Philip F. Hughes, Timothy A. Haystead, Michael A. Morse, Herbert K. Lyerly
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3731.
DOI: https://doi.org/10.1158/1538-7445.AM2019-3731
Published: 01 July 2019
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Journal Articles

Abstract 4709: Induction of enhanced tumor-specific immunity by Hsp90 targeted photodynamic therapy (Hsp90-PDT) combined with immune checkpoint inhibition

Kensuke Kaneko, Takuya Osada, Timothy A. Haystead, Michael A. Morse, Herbert K. Lyerly
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4709.
DOI: https://doi.org/10.1158/1538-7445.AM2017-4709
Published: 01 July 2017
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Journal Articles

Abstract 1859: Hsp90 targeted near infrared molecular imaging to detect mammografically occult invasive lobular breast cancer

Takuya Osada, Kensuke Kaneko, Zachary Hartman, Amy Hobeika, Philip Hughes, Timothy Haystead, Michael Morse, H. Kim Lyerly
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1859.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1859
Published: 01 July 2017
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Journal Articles

HER2 Overexpression Elicits a Proinflammatory IL-6 Autocrine Signaling Loop That Is Critical for Tumorigenesis

Zachary C. Hartman, Xiao-Yi Yang, Oliver Glass, Gangjun Lei, Takuya Osada, Sandeep S. Dave, Michael A. Morse, Timothy M. Clay, Herbert K. Lyerly
Journal: Cancer Research
Cancer Res (2011) 71 (13): 4380–4391.
DOI: https://doi.org/10.1158/0008-5472.CAN-11-0308
Published: 30 June 2011
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Includes: Supplementary data
Journal Articles

Antihelminth Compound Niclosamide Downregulates Wnt Signaling and Elicits Antitumor Responses in Tumors with Activating APC Mutations

Takuya Osada, Minyong Chen, Xiao Yi Yang, Ivan Spasojevic, Jeffrey B. Vandeusen, David Hsu, Bryan M. Clary, Timothy M. Clay, Wei Chen, Michael A. Morse, H. Kim Lyerly
Journal: Cancer Research
Cancer Res (2011) 71 (12): 4172–4182.
DOI: https://doi.org/10.1158/0008-5472.CAN-10-3978
Published: 14 June 2011
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Includes: Supplementary data
Journal Articles

Ligand-Independent Toll-like Receptor Signals Generated by Ectopic Overexpression of MyD88 Generate Local and Systemic Antitumor Immunity

Zachary C. Hartman, Takuya Osada, Oliver Glass, Xiao Y. Yang, Gang-jun Lei, H. Kim Lyerly, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2010) 70 (18): 7209–7220.
DOI: https://doi.org/10.1158/0008-5472.CAN-10-0905
Published: 14 September 2010
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Includes: Supplementary data
Journal Articles

Abstract 5338: Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T cell killing mediated by CEA/CD3-bispecific T cell-engaging BiTE antibody

Takuya Osada, David Hsu, Scott Hammond, Amy Hobeika, Gayathri Devi, Timothy M. Clay, H. Kim Lyerly, Michael A. Morse
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5338.
DOI: https://doi.org/10.1158/1538-7445.AM10-5338
Published: 15 April 2010
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Journal Articles

Antibody-based immunotherapy: targeting HMW-MAA on human breast cancer stem cells

Xinhui Wang, Takuya Osada, Akihiro Katayama, Wei Luo, Timothy Clay, Soldano Ferrone
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 1321.
Published: 01 May 2007
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Journal Articles

Id proteins regulate VEGF secretion of gastric cancer

Takeshi Tsuchiya, Nelson Tsuno, Yurai Okaji, Yasutaka Syuno, Jun Yamada, Satomi Yoneyama, Junichiro Tanaka, Takeshi Nishikawa, Shin Sasaki, Joji Kitayama, Takuya Osada, Koki Takahashi, Hirokazu Nagawa
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 3820.
Published: 01 May 2007
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Journal Articles

Anti-angiogenic activity of Zoledronic acid by inhibition of endothelial progenitor cells differentiation

Jun Yamada, Nelson Tsuno, Joji Kitayama, Yasutaka Shuno, Takeshi Nishikawa, Satomi Yaneyama, Takeshi Tsuchiya, Masahiro Asakage, Yurai Okaji, Takuya Osada, Shin Sasaki, Koki Takahashi, Hirokazu Nagawa
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 4652.
Published: 01 May 2007
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Journal Articles

Endothelial dendritic cell vaccines inhibit tumor growth and metastasis of colon cancer through anti-angiogenesis

Satomi Yoneyama, Nelson Tsuno, Yurai Okaji, Kazushige Kawai, Takeshi Tsuchiya, Jun Yamada, Yasutaka Syuuno, Takeshi Nishikawa, Eiji Sunami, Takuya Osada, Joji Kitayama, Koki Takahashi, Hirokazu Nagawa
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 2737.
Published: 01 May 2007
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Journal Articles

Induction of Wilms’ tumor protein (WT1)-specific immunity using a WT1-expressing adenovirus vaccine

Christopher Y. Woo, Takuya Osada, Xiao Yi Yang, Gangjun Lei, Matthew McKinney, Heather Labreche, Zachary C. Hartman, Andrea Amalfitano, Michael A. Morse, H. Kim Lyerly, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 332.
Published: 15 April 2006
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Journal Articles

Replication-competent packaging-deficient [E1+,100k-] adenoviral vector-transduced dendritic cells can efficiently induce antigen-specific immune responses

Takuya Osada, Heather Labreche, Zachery C. Hartman, Delila Serra, Michael A. Morse, H Kim Lyerly, Andrea Amalfitano, Timothy M. Clay
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 706.
Published: 15 April 2006
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Journal Articles

Depletion of regulatory T cells increases the in vivo CEA specific T cell response

Amy C. Hobeika, Takuya Osada, Teresa Brehm, Xiao Yi Yang, H. Kim Lyerly, Michael Morse, Timothy Clay
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 1121.
Published: 15 April 2006
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Journal Articles

Plaunotol inhibits gastric cancer cells by induction of apoptosis

Jun Yamada, Kazushige Kawai, Nelson H. Tsuno, Joji Kitayama, Kentaro Yazawa, Yurai Okaji, Masahiro Asakage, Takeshi Tsuchiya, Satomi Yoneyama, Takuya Osada, Nobukazu Hori, Koki Takahashi, Hirokazu Nagawa
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1389.
Published: 01 May 2005
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Induction of apoptosis in human dendritic cells by (-)-epigallocatechin gallate

Satomi Yoneyama, Kazushige Kawai, Nelson H. Tsuno, Joji Kitayama, Yurai Okaji, Masahiro Asakage, Jun Yamada, Takeshi Tsuchiya, Takuya Osada, Nobukazu Hori, Toshiaki Watanabe, Koki Takahashi, Hirokazu Nagawa
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1002.
Published: 01 May 2005
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