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Takeshi Shimamura
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Journal Articles

Abstract LB453: Distinct mechanism of CXCR7 activation in EGFR-mutated NSCLC by chemokines

Laura C. Gunder, Ines Pulido, Jeffrey H. Becker, Malek G. Massad, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB453.
https://doi.org/10.1158/1538-7445.AM2024-LB453
Published: 05 April 2024
View article titled, Abstract LB453: Distinct mechanism of CXCR7 activation in EGFR-mutated NSCLC by chemokines
Journal Articles

Abstract 234: Microfluidic chip for drug response studies in non-small cell lung carcinoma patient-derived organoids

Qiyue Luan, Ines Pulido, Angelique Isagirre, Jian Zhou, Takeshi Shimamura, Ian Papautsky
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 234.
https://doi.org/10.1158/1538-7445.AM2024-234
Published: 22 March 2024
View article titled, Abstract 234: Microfluidic chip for drug response studies in non-small cell lung carcinoma patient-derived organoids
Journal Articles

Abstract LB231: Overcoming KRAS G12C inhibitor resistance with a chaperone-mediated protein degrader (CHAMP)

Ines Pulido Endrino, Qiyue Luan, Jennifer Graeber, Brianna Borger, Chenghao Ying, Jinhua Li, Zimo Yang, Zhiyong Wang, Yaya Wang, Yuetong Sun, Yan Dai, Ian Papautsky, Thomas L. Prince, Guoqiang Wang, Kevin P. Foley, Weiwen Ying, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB231.
https://doi.org/10.1158/1538-7445.AM2023-LB231
Published: 14 April 2023
View article titled, Abstract LB231: Overcoming KRAS G12C inhibitor resistance with a chaperone-mediated protein degrader (CHAMP)
Journal Articles

Abstract 5268: Drug screening of non-small cell lung cancer patient-derived organoids in a microwell platform

Qiyue Luan, Ines Pulido, Jian Zhou, Takeshi Shimamura, Ian Papautsky
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5268.
https://doi.org/10.1158/1538-7445.AM2023-5268
Published: 04 April 2023
View article titled, Abstract 5268: Drug screening of non-small cell lung cancer patient-derived organoids in a microwell platform
Journal Articles

Endothelin-1–Mediated Drug Resistance in EGFR-Mutant Non-Small Cell Lung Carcinoma

Inés Pulido, Stephen Ollosi, Salvador Aparisi, Jeffrey H. Becker, Alicia Aliena-Valero, Marta Benet, María L. Rodríguez, Adrián López, Eva Tamayo-Torres, Lourdes Chuliá-Peris, Juan Carlos García-Cañaveras, Margaret Soucheray, Annika V. Dalheim, Juan B. Salom, Wei Qiu, Simon Kaja, Javier Alcácer Fernández-Coronado, Sandra Alandes, Javier Alcácer, Fátima Al-Shahrour, Jeffrey A. Borgia, Oscar Juan, Michael I. Nishimura, Agustín Lahoz, Julián Carretero, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2020) 80 (19): 4224–4232.
https://doi.org/10.1158/0008-5472.CAN-20-0141
Published: 02 October 2020
View article titled, Endothelin-1–Mediated Drug Resistance in <em>EGFR</em>-Mutant Non-Small Cell Lung Carcinoma
Open the PDF for Endothelin-1–Mediated Drug Resistance in <em>EGFR</em>-Mutant Non-Small Cell Lung Carcinoma in another window
Includes: Supplementary data
Journal Articles

CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC

Jeffrey H. Becker, Yandi Gao, Margaret Soucheray, Ines Pulido, Eiki Kikuchi, María L. Rodríguez, Rutu Gandhi, Aranzazu Lafuente-Sanchis, Miguel Aupí, Javier Alcácer Fernández-Coronado, Paloma Martín-Martorell, Antonio Cremades, José M. Galbis-Caravajal, Javier Alcácer, Camilla L. Christensen, Patricia Simms, Ashley Hess, Hajime Asahina, Michael P. Kahle, Fatima Al-Shahrour, Jeffrey A. Borgia, Agustín Lahoz, Amelia Insa, Oscar Juan, Pasi A. Jänne, Kwok-Kin Wong, Julian Carretero, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2019) 79 (17): 4439–4452.
https://doi.org/10.1158/0008-5472.CAN-19-0024
Published: 03 September 2019
View article titled, CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC
Open the PDF for CXCR7 Reactivates ERK Signaling to Promote Resistance to EGFR Kinase Inhibitors in NSCLC in another window
Includes: Supplementary data
Journal Articles

Abstract LB-099: Metabolic vulnerabilities of mesenchymal-like EGFR-mutant NSCLC cells with acquired resistance to tyrosine kinase inhibitors

Ines Pulido, Jeff Becker, Miguel Aupi, Juan Carlos García Cañaveras, Javier Alcacer, María Rodríguez, Paloma Martín, Javier Perales, Salvador Aparisi, Lourdes Chulia, Arantxa Lafuente, Maribel Alcoriza, Salvador Mena, Javier Pereda, José Galbis-Carabajal, Amelia Insa, Oscar Juan, Fatima Al-Shahrour, Manuel Sanchez del Pino, Agustín Lahoz, Takeshi Shimamura, Julian Carretero
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-099.
https://doi.org/10.1158/1538-7445.AM2018-LB-099
Published: 01 July 2018
View article titled, Abstract LB-099: Metabolic vulnerabilities of mesenchymal-like EGFR-mutant NSCLC cells with acquired resistance to tyrosine kinase inhibitors
Journal Articles

Abstract 20: Inhibition of mutant EGFR in NSCLC promotes endothelin-1-mediated NSCLC disease progression and angiogenesis

Stephen L. Ollosi, Margaret Soucheray, Jeffrey Becker, Ines Pulido, Annika Dalheim, Fatima Al-Shahrour, Wei Qui, Michael Nishimura, Julian Carretero, Simon Kaja, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 20.
https://doi.org/10.1158/1538-7445.AM2018-20
Published: 01 July 2018
View article titled, Abstract 20: Inhibition of mutant EGFR in NSCLC promotes endothelin-1-mediated NSCLC disease progression and angiogenesis
Journal Articles

Abstract LB-085: A new role for LKB1 to regulate Heat Shock Protein 90 activity

Jeffrey H. Becker, Michael P. Kahle, Margaret Soucheray, Ines Pulido, Fatima Al-Shahrour, Manuel Sanchez del Pino, Kwok-Kin Wong, Julian Carretero, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-085.
https://doi.org/10.1158/1538-7445.AM2018-LB-085
Published: 01 July 2018
View article titled, Abstract LB-085: A new role for LKB1 to regulate Heat Shock Protein 90 activity
Journal Articles

Abstract 15: Suppression of adaptive responses to targeted therapies by transcriptional inhibition

Maria Rusan, Kapsok Li, Yvonne Li, Camilla L. Christensen, Brian J. Abraham, Nicholas Kwiatkowski, Kevin Buczkowski, Bruno Bockorny, Ting Chen, Shuai Li, Haikuo Zhang, Hideko Terai, Tiffany Tavares, Tinghu Zhang, Tae Jung Kim, Michael Silkes, Tenny Mudianto, Li Tan, Takeshi Shimamura, Matthew Meyerson, Hideo Watanabe, Nathanael S. Gray, Richard A. Young, Kwok-Kin Wong, Peter S. Hammerman
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 15.
https://doi.org/10.1158/1538-7445.AM2017-15
Published: 01 July 2017
View article titled, Abstract 15: Suppression of adaptive responses to targeted therapies by transcriptional inhibition
Journal Articles

Abstract 890: TGFâ upregulation mediates growth retardation in EGFR T790M mutant non-small cell lung cancer

Claire E. Repellin, Pinar O. Eser, Marzia Capelletti, Takeshi Shimamura, Dalia Ercan, Chunxiao Xu, Nathanael S. Gray, Kwok-Kin Wong, Pasi A. Jänne
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 890.
https://doi.org/10.1158/1538-7445.AM2016-890
Published: 15 July 2016
View article titled, Abstract 890: TGFâ upregulation mediates growth retardation in EGFR T790M mutant non-small cell lung cancer
Journal Articles

Heterogeneity in Tumors and Resistance to EGFR TKI Therapy—Response

Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2016) 76 (10): 3111.
https://doi.org/10.1158/0008-5472.CAN-16-0610
Published: 12 May 2016
View article titled, Heterogeneity in Tumors and Resistance to EGFR TKI Therapy—Response
Open the PDF for Heterogeneity in Tumors and Resistance to EGFR TKI Therapy—Response in another window
Journal Articles

STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment

Shohei Koyama, Esra A. Akbay, Yvonne Y. Li, Amir R. Aref, Ferdinandos Skoulidis, Grit S. Herter-Sprie, Kevin A. Buczkowski, Yan Liu, Mark M. Awad, Warren L. Denning, Lixia Diao, Jing Wang, Edwin R. Parra-Cuentas, Ignacio I. Wistuba, Margaret Soucheray, Tran Thai, Hajime Asahina, Shunsuke Kitajima, Abigail Altabef, Jillian D. Cavanaugh, Kevin Rhee, Peng Gao, Haikuo Zhang, Peter E. Fecci, Takeshi Shimamura, Matthew D. Hellmann, John V. Heymach, F. Stephen Hodi, Gordon J. Freeman, David A. Barbie, Glenn Dranoff, Peter S. Hammerman, Kwok-Kin Wong
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (5): 999–1008.
https://doi.org/10.1158/0008-5472.CAN-15-1439
Published: 29 February 2016
View article titled, STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment
Open the PDF for STK11/LKB1 Deficiency Promotes Neutrophil Recruitment and Proinflammatory Cytokine Production to Suppress T-cell Activity in the Lung Tumor Microenvironment in another window
Includes: Supplementary data
Journal Articles

Intratumoral Heterogeneity in EGFR-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition

Margaret Soucheray, Marzia Capelletti, Inés Pulido, Yanan Kuang, Cloud P. Paweletz, Jeffrey H. Becker, Eiki Kikuchi, Chunxiao Xu, Tarun B. Patel, Fatima Al-shahrour, Julián Carretero, Kwok-Kin Wong, Pasi A. Jänne, Geoffrey I. Shapiro, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2015) 75 (20): 4372–4383.
https://doi.org/10.1158/0008-5472.CAN-15-0377
Published: 14 October 2015
View article titled, Intratumoral Heterogeneity in <em>EGFR</em>-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition
Open the PDF for Intratumoral Heterogeneity in <em>EGFR</em>-Mutant NSCLC Results in Divergent Resistance Mechanisms in Response to EGFR Tyrosine Kinase Inhibition in another window
Includes: Supplementary data
Journal Articles

Abstract 753: Genomic alterations of autophagy genes disrupts autophagic flux in human lung adenocarcinomas

Ines Pulido, Juan L. Pascual, Margaret Soucheray, Maria L. Rodriguez, Daniel T. Crespo, Salvador Aparisi, Joan A. Sirerol, Salvador Mena, Javier Pereda, Fatima Al-shahrour, Angel L. Ortega, Takeshi Shimamura, Julian Carretero
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 753.
https://doi.org/10.1158/1538-7445.AM2015-753
Published: 01 August 2015
View article titled, Abstract 753: Genomic alterations of autophagy genes disrupts autophagic flux in human lung adenocarcinomas
Journal Articles

Abstract 766: Suppression of gefitinib-induced EMT in EGFR mutant NSCLC preferentially selects for acquired T790M

Margaret Soucheray, Marzia Capelletti, Ines Pulido, Yunan Kuang, Cloud P. Paweletz, Jeffrey H. Becker, Eiki Kikuchi, Chunxiao Xu, Tarun B. Patel, Fatima Al-shahrour, Julian Carretero, Kwok-Kin Wong, Pasi A. Janne, Geoffrey I. Shapiro, Takeshi Shimamura
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 766.
https://doi.org/10.1158/1538-7445.AM2015-766
Published: 01 August 2015
View article titled, Abstract 766: Suppression of gefitinib-induced EMT in EGFR mutant NSCLC preferentially selects for acquired T790M
Journal Articles

Abstract 1355: Functional inactivation of LKB1 increases the production of pro-inflammatory cytokines and governs response to immune modulation

Esra A. Akbay, Shohei Koyama, Yvonne Li, Grit S. Herter-Sprie, Tran C. Thai, Amir R. Aref, Margaret Soucheray, Takeshi Shimamura, David A. Barbie, Glenn Dranoff, Peter S. Hammerman, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1355.
https://doi.org/10.1158/1538-7445.AM2015-1355
Published: 01 August 2015
View article titled, Abstract 1355: Functional inactivation of LKB1 increases the production of pro-inflammatory cytokines and governs response to immune modulation
Journal Articles

Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.

Takeshi Shimamura, Zhao Chen, Margaret Soucheray, Julian Carretero, Eiki Kikuchi, Jeremy H. Tchaicha, Yandhi Gao, Katherine A. Cheng, Travis J. Cohoon, Jun Qi, Esra A. Akbay, Alec C. Kimmelman, Andrew L. Kung, James E. Bradner, Kwok Kin Wong
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1126.
https://doi.org/10.1158/1538-7445.AM2013-1126
Published: 15 April 2013
View article titled, Abstract 1126: Efficacy of BET bromodomain inhibition in Kras-positive non-small cell lung cancer.
Journal Articles

Abstract 3126: Insulinoma-associated 1 is a key transcriptional regulator of growth and survival-promoting pathways in small cell lung cancer.

Camilla L. Christensen, Takeshi Shimamura, Esra A. Akbay, Signe R. Michaelsen, Hans S. Poulsen, Kwok-kin Wong
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3126.
https://doi.org/10.1158/1538-7445.AM2013-3126
Published: 15 April 2013
View article titled, Abstract 3126: Insulinoma-associated 1 is a key transcriptional regulator of growth and survival-promoting pathways in small cell lung cancer.
Journal Articles

Abstract 1690: Differential autophagy activation in KRAS and EGFR mutant lung adenocarcinomas.

Maria L. Rodriguez, Ines Pulido, Margaret Soucheray, Daniel Crespo, Fatima Al-shahrour, Takeshi Shimamura, Angel Ortega, Julian Carretero
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1690.
https://doi.org/10.1158/1538-7445.AM2013-1690
Published: 15 April 2013
View article titled, Abstract 1690: Differential autophagy activation in KRAS and EGFR mutant lung adenocarcinomas.