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Takayuki Yoshioka
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Journal Articles

Physicochemical and Pharmacokinetic Characterization of Highly Potent Recombinant l-Methionine γ-Lyase Conjugated with Polyethylene Glycol as an Antitumor Agent

Tomoaki Takakura, Akio Takimoto, Yoshihide Notsu, Hiroshi Yoshida, Takaomi Ito, Hirofumi Nagatome, Masahiro Ohno, Yoshinao Kobayashi, Takayuki Yoshioka, Kenji Inagaki, Shigeo Yagi, Robert M. Hoffman, Nobuyoshi Esaki
Journal: Cancer Research
Cancer Res (2006) 66 (5): 2807–2814.
https://doi.org/10.1158/0008-5472.CAN-05-3910
Published: 01 March 2006
View article titled, Physicochemical and Pharmacokinetic Characterization of Highly Potent Recombinant <sc>l</sc>-Methionine γ-Lyase Conjugated with Polyethylene Glycol as an Antitumor Agent
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Journal Articles

PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates

Zhijian Yang, Junhua Wang, Quan Lu, Jinbao Xu, Yoshinao Kobayashi, Tomoaki Takakura, Akio Takimoto, Takayuki Yoshioka, Changgen Lian, Chunmei Chen, Dongdong Zhang, Ying Zhang, Shukuan Li, Xinghua Sun, Yuying Tan, Shigeo Yagi, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 329.
Published: 01 May 2005
View article titled, PEGylation confers greatly extended half-life and attenuated immunogenicity to recombinant methioninase in primates
Journal Articles

Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate

Zhijian Yang, Xinghua Sun, Shukuan Li, Yuying Tan, Xiaoen Wang, Nan Zhang, Shigeo Yagi, Tomoaki Takakura, Yoshinao Kobayashi, Akio Takimoto, Takayuki Yoshioka, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (16): 5775–5778.
https://doi.org/10.1158/0008-5472.CAN-04-1406
Published: 16 August 2004
View article titled, Circulating Half-Life of PEGylated Recombinant Methioninase Holoenzyme Is Highly Dose Dependent on Cofactor Pyridoxal-5′-Phosphate
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Journal Articles

In vivo stabilization of polyethylene glycol (PEG)-modified recombinant methioninase (rMETase) activity by pyridoxal phosphate

Xinghua Sun, Zhijian Yang, Shukuan Li, Yuying Tan, Nan Zhang, Xiaoen Wang, Shigeo Yagi, Takayuki Yoshioka, Akinori Suginaka, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 234.
Published: 01 April 2004
View article titled, <em>In vivo</em> stabilization of polyethylene glycol (PEG)-modified recombinant methioninase (rMETase) activity by pyridoxal phosphate
Journal Articles

In Vivo Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation

Xinghua Sun, Zhijian Yang, Shukuan Li, Yuying Tan, Nan Zhang, Xiaoen Wang, Shigeo Yagi, Takayuki Yoshioka, Akio Takimoto, Kenji Mitsushima, Akinori Suginaka, Eugene P. Frenkel, Robert M. Hoffman
Journal: Cancer Research
Cancer Res (2003) 63 (23): 8377–8383.
Published: 16 December 2003
View article titled, <em>In Vivo</em> Efficacy of Recombinant Methioninase Is Enhanced by the Combination of Polyethylene Glycol Conjugation and Pyridoxal 5′-Phosphate Supplementation
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Journal Articles

Correlation of Antiangiogenic and Antitumor Efficacy of N-biphenyl Sulfonyl-phenylalanine Hydroxiamic Acid (BPHA), an Orally-active, Selective Matrix Metalloproteinase Inhibitor

Ryuji Maekawa, Hideo Maki, Hiroshi Yoshida, Kanji Hojo, Hidekazu Tanaka, Tohru Wada, Naomi Uchida, Yukihiro Takeda, Hisanori Kasai, Hiroyuki Okamoto, Hiroshige Tsuzuki, Yoshikazu Kambayashi, Fumihiko Watanabe, Kenji Kawada, Ken-ichi Toda, Mitsuaki Ohtani, Kenji Sugita, Takayuki Yoshioka
Journal: Cancer Research
Cancer Res (1999) 59 (6): 1231–1235.
Published: 15 March 1999
View article titled, Correlation of Antiangiogenic and Antitumor Efficacy of N-biphenyl Sulfonyl-phenylalanine Hydroxiamic Acid (BPHA), an Orally-active, Selective Matrix Metalloproteinase Inhibitor
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Journal Articles

Anticancer Efficacy in Vivo and in Vitro, Synergy with 5-Fluorouracil, and Safety of Recombinant Methioninase

Takayuki Yoshioka, Tohru Wada, Naomi Uchida, Hideo Maki, Hiroshi Yoshida, Nobuyuki Ide, Hisanori Kasai, Kanji Hojo, Kimiyo Shono, Ryuji Maekawa, Shigeo Yagi, Robert M. Hoffman, Kenji Sugita
Journal: Cancer Research
Cancer Res (1998) 58 (12): 2583–2587.
Published: 01 June 1998
View article titled, Anticancer Efficacy <em>in Vivo</em> and <em>in Vitro</em>, Synergy with 5-Fluorouracil, and Safety of Recombinant Methioninase
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Journal Articles

Reduced Angiogenesis and Tumor Progression in Gelatinase A-deficient Mice

Takeshi Itoh, Masatoshi Tanioka, Hiroshi Yoshida, Takayuki Yoshioka, Hirofumi Nishimoto, Shigeyoshi Itohara
Journal: Cancer Research
Cancer Res (1998) 58 (5): 1048–1051.
Published: 01 March 1998
View article titled, Reduced Angiogenesis and Tumor Progression in Gelatinase A-deficient Mice
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Journal Articles

Suppression of Cell-mediated Antitumor Immunity by Complete Freund's Adjuvant

Shohei Koyama, Takayuki Yoshioka, Takao Sakita
Journal: Cancer Research
Cancer Res (1982) 42 (8): 3215–3219.
Published: 01 August 1982
View article titled, Suppression of Cell-mediated Antitumor Immunity by Complete Freund's Adjuvant
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