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Takayuki Kimura
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Journal Articles

Abstract 2026: Single-cell RNA-sequencing analysis of tumor endothelial cells reveals suppression of specific endothelial subtypes by the combination treatment of Wnt/β-catenin signaling modulator E7386 plus lenvatinib

Masahiko Kume, Ryoga Ishida, Yoichi Ozawa, Jialing Shen, Hiroto Konishi, Megumi Kuronishi, Takayuki Kimura, Yusuke Adachi, Yu Kato
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2026.
https://doi.org/10.1158/1538-7445.AM2024-2026
Published: 22 March 2024
View article titled, Abstract 2026: Single-cell RNA-sequencing analysis of tumor endothelial cells reveals suppression of specific endothelial subtypes by the combination treatment of Wnt/β-catenin signaling modulator E7386 plus lenvatinib
Journal Articles

Abstract 2022: E7386, a Wnt/β-catenin signaling modulator, suppresses the differentiation of regulatory T cells in combination with lenvatinib plus anti-PD-1 antibody

Jialing Shen, Ryoga Ishida, Masahiko Kume, Takayuki Kimura, Yusuke Adachi, Yu Kato
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2022.
https://doi.org/10.1158/1538-7445.AM2024-2022
Published: 22 March 2024
View article titled, Abstract 2022: E7386, a Wnt/β-catenin signaling modulator, suppresses the differentiation of regulatory T cells in combination with lenvatinib plus anti-PD-1 antibody
Journal Articles

Abstract 1837: E7386, a selective inhibitor of the interaction between β-catenin and CREB-binding protein (CBP), enhances antitumor activity in combination with lenvatinib (LEN), and LEN + anti-PD-1 antibody in a preclinical tumor model

Yusuke Adachi, Yoichi Ozawa, Mizuki Kimura, Jialing Shen, Masahiko Kume, Ryoga Ishida, Takayuki Kimura, Junji Matsui, Akira Yokoi, Yu Kato, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1837.
https://doi.org/10.1158/1538-7445.AM2023-1837
Published: 04 April 2023
View article titled, Abstract 1837: E7386, a selective inhibitor of the interaction between β-catenin and CREB-binding protein (CBP), enhances antitumor activity in combination with lenvatinib (LEN), and LEN + anti-PD-1 antibody in a preclinical tumor model
Journal Articles

Abstract 1830: E7386, a selective inhibitor of the interaction between β-catenin and CREB-binding protein (CBP), in combination with lenvatinib (LEN), exerts antitumor activity in preclinical tumor models with prior immune checkpoint inhibitor (ICI)-based combination treatment

Satoshi Kawano, Yusuke Adachi, Megumi Kuronishi, Kohta Toshimitsu, Kotaro Kodama, Takayuki Kimura, Masahiko Kume, Jialing Shen, Saori Watanabe Miyano, Akira Yokoi, Junji Matsui, Yu Kato, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 1830.
https://doi.org/10.1158/1538-7445.AM2023-1830
Published: 04 April 2023
View article titled, Abstract 1830: E7386, a selective inhibitor of the interaction between β-catenin and CREB-binding protein (CBP), in combination with lenvatinib (LEN), exerts antitumor activity in preclinical tumor models with prior immune checkpoint inhibitor (ICI)-based combination treatment
Journal Articles

Abstract 5136: Development of a novel gene expression signature that correlates with intratumor microvessel density and antitumor activity of lenvatinib

Megumi Kuronishi, Yoichi Ozawa, Takayuki Kimura, Yu Kato
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5136.
https://doi.org/10.1158/1538-7445.AM2022-5136
Published: 15 June 2022
View article titled, Abstract 5136: Development of a novel gene expression signature that correlates with intratumor microvessel density and antitumor activity of lenvatinib
Journal Articles

Inhibition of FGFR Reactivates IFNγ Signaling in Tumor Cells to Enhance the Combined Antitumor Activity of Lenvatinib with Anti-PD-1 Antibodies

Yusuke Adachi, Hiroshi Kamiyama, Kenji Ichikawa, Sayo Fukushima, Yoichi Ozawa, Shogo Yamaguchi, Satoshi Goda, Takayuki Kimura, Kotaro Kodama, Masahiro Matsuki, Saori Watanabe Miyano, Akira Yokoi, Yu Kato, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2022) 82 (2): 292–306.
https://doi.org/10.1158/0008-5472.CAN-20-2426
Published: 15 January 2022
View article titled, Inhibition of FGFR Reactivates IFNγ Signaling in Tumor Cells to Enhance the Combined Antitumor Activity of Lenvatinib with Anti-PD-1 Antibodies
Open the PDF for Inhibition of FGFR Reactivates IFNγ Signaling in Tumor Cells to Enhance the Combined Antitumor Activity of Lenvatinib with Anti-PD-1 Antibodies in another window
Includes: Supplementary data
Journal Articles

Abstract 1437: E7386, a CREB binding protein (CBP)/β-catenin interaction inhibitor, suppresses the hypoxic response induced by angiogenesis inhibition in hepatocellular carcinoma models

Mizuki Kimura, Yusaku Hori, Megumi Kuronishi, Takayuki Kimura, Ryoga Ishida, Kenji Ichikawa, Yoichi Ozawa, Yu Kato
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1437.
https://doi.org/10.1158/1538-7445.AM2021-1437
Published: 01 July 2021
View article titled, Abstract 1437: E7386, a CREB binding protein (CBP)/β-catenin interaction inhibitor, suppresses the hypoxic response induced by angiogenesis inhibition in hepatocellular carcinoma models
Journal Articles

E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling

Kazuhiko Yamada, Yusaku Hori, Satoshi Inoue, Yuji Yamamoto, Kentaro Iso, Hiroshi Kamiyama, Atsumi Yamaguchi, Takayuki Kimura, Mai Uesugi, Junichi Ito, Masahiro Matsuki, Kazutaka Nakamoto, Hitoshi Harada, Naoki Yoneda, Atsushi Takemura, Ikuo Kushida, Naomi Wakayama, Kenji Kubara, Yu Kato, Taro Semba, Akira Yokoi, Masayuki Matsukura, Takenao Odagami, Masao Iwata, Akihiko Tsuruoka, Toshimitsu Uenaka, Junji Matsui, Tomohiro Matsushima, Kenichi Nomoto, Hiroyuki Kouji, Takashi Owa, Yasuhiro Funahashi, Yoichi Ozawa
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (4): 1052–1062.
https://doi.org/10.1158/0008-5472.CAN-20-0782
Published: 15 February 2021
View article titled, E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling
Open the PDF for E7386, a Selective Inhibitor of the Interaction between β-Catenin and CBP, Exerts Antitumor Activity in Tumor Models with Activated Canonical Wnt Signaling in another window
Includes: Supplementary data
Journal Articles

Abstract 2927: Antitumor and antiangiogenesis activities of E7386, an orally active CBP/β-catenin modulator, as a single agent and in combination with lenvatinib in human HCC xenograft models

Kazuhiko Yamada, Yusaku Hori, Hiroshi Kamiyama, Takayuki Kimura, Yasuhiro Funahashi, Junji Matsui, Yoichi Ozawa
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 2927.
https://doi.org/10.1158/1538-7445.AM2018-2927
Published: 01 July 2018
View article titled, Abstract 2927: Antitumor and antiangiogenesis activities of E7386, an orally active CBP/β-catenin modulator, as a single agent and in combination with lenvatinib in human HCC xenograft models
Journal Articles

Abstract 12: Antitumor activity of lenvatinib in combination with everolimus or an anti-PD1 antibody in preclinical RCC models

Yusuke Adachi, Takayuki Kimura, Masahiro Matsuki, Junji Matsui, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 12.
https://doi.org/10.1158/1538-7445.AM2018-12
Published: 01 July 2018
View article titled, Abstract 12: Antitumor activity of lenvatinib in combination with everolimus or an anti-PD1 antibody in preclinical RCC models
Journal Articles

Abstract 1805: Antitumor activity of lenvatinib mesilate in human hepatocellular carcinoma preclinical models

Masahiro Matsuki, Yuji Yamamoto, Taisuke Hoshi, Takayuki Kimura, Yasuhiro Funahashi, Junji Matsui
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1805.
https://doi.org/10.1158/1538-7445.AM2017-1805
Published: 01 July 2017
View article titled, Abstract 1805: Antitumor activity of lenvatinib mesilate in human hepatocellular carcinoma preclinical models
Journal Articles

Abstract 3264: Lenvatinib in combination with everolimus demonstrated enhanced antiangiogenesis and antitumor activity in human RCC xenograft models

Yusuke Adachi, Masahiro Matsuki, Atsumi Yamaguchi, Yoichi Ozawa, Kiyochi Okamoto, Kaoru Mitsuhashi, Takayuki Kimura, Taisuke Hoshi, Osamu Tohyama, Kenji Tai, Makoto Ogo, Yasuhiro Funahashi, Junji Matsui
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3264.
https://doi.org/10.1158/1538-7445.AM2016-3264
Published: 15 July 2016
View article titled, Abstract 3264: Lenvatinib in combination with everolimus demonstrated enhanced antiangiogenesis and antitumor activity in human RCC xenograft models
Journal Articles

Abstract 3262: Effects of lenvatinib mesilate in combination with everolimus on VEGF and FGF-driven angiogenesis and tumor growth

Kaoru Mitsuhashi, Takayuki Kimura, Taisuke Hoshi, Osamu Tohyama, Kenji Tai, Makoto Ogo, Masahiro Matsuki, Atsumi Yamaguchi, Yoichi Ozawa, Yusuke Adachi, Kiyoshi Okamoto, Junji Matsui, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3262.
https://doi.org/10.1158/1538-7445.AM2016-3262
Published: 15 July 2016
View article titled, Abstract 3262: Effects of lenvatinib mesilate in combination with everolimus on VEGF and FGF-driven angiogenesis and tumor growth
Journal Articles

Abstract 1377: Chemical probe-based approach clarifies binding of receptor tyrosine kinases (RTKs) to lenvatinib in preclinical models

Takayuki Kimura, Noboru Yamamoto, Hiroshi Kamiyama, Megumi Ikemori Kawada, Akihiko Yamamoto, Yoshihiko Kotake, Yasutaka Takase, Yasuhiro Funahashi, Yoshiya Oda
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1377.
https://doi.org/10.1158/1538-7445.AM2015-1377
Published: 01 August 2015
View article titled, Abstract 1377: Chemical probe-based approach clarifies binding of receptor tyrosine kinases (RTKs) to lenvatinib in preclinical models
Journal Articles

Abstract 1376: Receptor tyrosine kinase (RTK) signaling pathway in preclinical thyroid cancer models: Antitumor and antiangiogenic activity of lenvatinib to target VEGFR/FGFR/RET

Osamu Tohyama, Junji Matsui, Kotaro Kodama, Naoko Hata Sugi, Takayuki Kimura, Kiyoshi Okamoto, Yukinori Minoshima, Masao Iwata, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1376.
https://doi.org/10.1158/1538-7445.AM2015-1376
Published: 01 August 2015
View article titled, Abstract 1376: Receptor tyrosine kinase (RTK) signaling pathway in preclinical thyroid cancer models: Antitumor and antiangiogenic activity of lenvatinib to target VEGFR/FGFR/RET
Journal Articles

Abstract 1413: Eribulin caused re-modeling of tumor vasculature altering gene expression profiling in angiogenesis and Epithelial Mesenchymal Transition (EMT) signaling pathway of host cells within human breast cancer cell (BCC) xenografts in nude mice.

Junji Matsui, Osamu Toyama, Mitsuhiro Ino, Taro Semba, Mai Uesugi, Hiroki Muto, Judith L. Oestreicher, Kentaro Takahashi, Kentaro Matsuura, Yoshiaki Sato, Taisuke Uehara, Takayuki Kimura, Hideki Watanabe, Yoichi Ozawa, Makoto Asano, Yusuke Adachi, Ken Aoshima, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1413.
https://doi.org/10.1158/1538-7445.AM2013-1413
Published: 15 April 2013
View article titled, Abstract 1413: Eribulin caused re-modeling of tumor vasculature altering gene expression profiling in angiogenesis and Epithelial Mesenchymal Transition (EMT) signaling pathway of host cells within human breast cancer cell (BCC) xenografts in nude mice.
Journal Articles

Abstract 1089: Effect of lenvatinib (E7080) on site specific phosphorylation in cancer cells with activated FGFR2 signaling

Takayuki Kimura, Taisuke Uehara, Mamoru Yanagimachi, Lei Wang, Yasuhiro Funahashi
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1089.
https://doi.org/10.1158/1538-7445.AM2012-1089
Published: 15 April 2012
View article titled, Abstract 1089: Effect of lenvatinib (E7080) on site specific phosphorylation in cancer cells with activated FGFR2 signaling
Journal Articles

Frequent Aberration of FHIT Gene Expression in Acute Leukemias

Toshiki Iwai, Shouhei Yokota, Makoto Nakao, Naozo Nakazawa, Masafumi Taniwaki, Takayuki Kimura, Yoshiaki Sonoda, Hiroto Kaneko, Tsukasa Okuda, Hiroshi Azuma, Toshiaki Oka, Takeo Takeda, Arata Watanabe, Atsushi Kikuta, Keiko Asami, Isao Sekine, Takeji Matsushita, Takayoshi Tsuchiya, Junichi Mimaya, Shoichi Koizumi, Shigeru Ohta, Munenori Miyake, Yoichi Takaue, Asayuki Iwai, Kenichi Nishikawa, Kazuhiro Matsumoto, Kiyoshi Kawakami, Nobuyuki Hyakuna, Takeo Fujimoto
Journal: Cancer Research
Cancer Res (1998) 58 (22): 5182–5187.
Published: 01 November 1998
View article titled, Frequent Aberration of <em>FHIT</em> Gene Expression in Acute Leukemias
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