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Takatsugu Ishimoto
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Journal Articles

Abstract 5861: Tumor cell-intrinsic factors promoting fibrotic tumor microenvironment in gastric cancer

Takashi Semba, Yiling Tong, Feng Wei, Atsuko Yonemura, Tadahito Yasuda, Tomoyuki Uchihara, Huaito Wang, Hideo Baba, Takatsugu Ishimoto
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5861.
https://doi.org/10.1158/1538-7445.AM2023-5861
Published: 04 April 2023
View article titled, Abstract 5861: Tumor cell-intrinsic factors promoting fibrotic tumor microenvironment in gastric cancer
Journal Articles

Abstract 956: FBXW7 regulates imatinib chemoresistance through targeting MCL1 for apoptotic regulation in gastrointestinal stromal tumors

Xiyu Wu, Masaaki Iwatsuki, Meiyue Lou, Takatsugu Ishimoto, Yoshifumi Baba, Yuji Miyamoto, Hideo Baba
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 956.
https://doi.org/10.1158/1538-7445.AM2023-956
Published: 04 April 2023
View article titled, Abstract 956: <em>FBXW7</em> regulates imatinib chemoresistance through targeting <em>MCL1</em> for apoptotic regulation in gastrointestinal stromal tumors
Journal Articles

Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors

Takahiko Akiyama, Tadahito Yasuda, Tomoyuki Uchihara, Noriko Yasuda-Yoshihara, Benjy J.Y. Tan, Atsuko Yonemura, Takashi Semba, Juntaro Yamasaki, Yoshihiro Komohara, Koji Ohnishi, Feng Wei, Lingfeng Fu, Jun Zhang, Fumimasa Kitamura, Kohei Yamashita, Kojiro Eto, Shiro Iwagami, Hirotake Tsukamoto, Terumasa Umemoto, Mari Masuda, Osamu Nagano, Yorifumi Satou, Hideyuki Saya, Patrick Tan, Hideo Baba, Takatsugu Ishimoto
Journal: Cancer Research
Cancer Res (2023) 83 (5): 753–770.
https://doi.org/10.1158/0008-5472.CAN-22-1890
Published: 02 March 2023
View article titled, Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors
Open the PDF for Stromal Reprogramming through Dual PDGFRα/β Blockade Boosts the Efficacy of Anti–PD-1 Immunotherapy in Fibrotic Tumors in another window
Includes: Supplementary data
Journal Articles

Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance

Tomoyuki Uchihara, Keisuke Miyake, Atsuko Yonemura, Yoshihiro Komohara, Rumi Itoyama, Mayu Koiwa, Tadahito Yasuda, Kota Arima, Kazuto Harada, Kojiro Eto, Hiromitsu Hayashi, Masaaki Iwatsuki, Shiro Iwagami, Yoshifumi Baba, Naoya Yoshida, Masakazu Yashiro, Mari Masuda, Jaffer A. Ajani, Patrick Tan, Hideo Baba, Takatsugu Ishimoto
Journal: Cancer Research
Cancer Res (2020) 80 (16): 3222–3235.
https://doi.org/10.1158/0008-5472.CAN-19-3803
Published: 14 August 2020
View article titled, Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance
Open the PDF for Extracellular Vesicles from Cancer-Associated Fibroblasts Containing Annexin A6 Induces FAK-YAP Activation by Stabilizing β1 Integrin, Enhancing Drug Resistance in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 107: Extracellular vesicles from cancer associated fibroblasts induce drug resistance via integrinβ1/FAK signaling in gastric cancer cells

Tomoyuki Uchihara, Atsuko Yonemura, Keisuke Miyake, Tadahito Yasuda, Rumi Itoyama, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hideo Baba, Takatsugu Ishimoto
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 107.
https://doi.org/10.1158/1538-7445.AM2019-107
Published: 01 July 2019
View article titled, Abstract 107: Extracellular vesicles from cancer associated fibroblasts induce drug resistance via integrinβ1/FAK signaling in gastric cancer cells
Journal Articles

Abstract 2837: Fusobacterium nucleatum and T cells in colorectal cancer liver metastasis

Yuki Sakamoto, Kosuke Mima, Nobuya Daitoku, Yukiharu Hiyoshi, Katsunori Imai, Masaaki Iwatsuki, Takatsugu Ishimoto, Yoshifumi Baba, Shiro Iwagami, Yuji Miyamoto, Yoichi Yamashita, Naoya Yoshida, Hideo Baba
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2837.
https://doi.org/10.1158/1538-7445.AM2019-2837
Published: 01 July 2019
View article titled, Abstract 2837: Fusobacterium nucleatum and T cells in colorectal cancer liver metastasis
Journal Articles

Abstract 3154: Tumor expression of Activin A is associated with clinical outcomes in patients with colorectal cancer

Nobuya Daitoku, Yuji Miyamoto, Yuki Sakamoto, Kojiro Etoh, Yukiharu Hiyoshi, Yohei Nagai, Masaaki Iwatsuki, Takatsugu Ishimoto, Yoshifumi Baba, Shiro Iwagami, Naoya Yoshida, Hideo Baba
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3154.
https://doi.org/10.1158/1538-7445.AM2019-3154
Published: 01 July 2019
View article titled, Abstract 3154: Tumor expression of Activin A is associated with clinical outcomes in patients with colorectal cancer
Journal Articles

Abstract 4677: Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas

Takatsugu Ishimoto, Kota Arima, Tomoyuki Uchihara, Keisuke Miyake, Atsuko Yonemura, Tadahito Yasuda, Rumi Itoyama, Masaaki Iwatsuki, Yoshifumi Baba, Naoya Yoshida, Hideo Baba
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4677.
https://doi.org/10.1158/1538-7445.AM2019-4677
Published: 01 July 2019
View article titled, Abstract 4677: Inhibition of 15-PGDH causes Kras-driven tumor expansion through prostaglandin E2-ALDH1 signaling in the pancreas
Journal Articles

Abstract 4123: Clinical significance and the difference between programmed death-1 ligand-1 and ligand-2 in patients with esophageal cancer

Kazuo Okadome, Yoshifumi Baba, Taisuke Yagi, Yuki Kiyozumi, Kojiro Eto, Yukiharu Hiyoshi, Yohei Nagai, Takatsugu Ishimoto, Masaaki Iwatsuki, Shiro Iwagami, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4123.
https://doi.org/10.1158/1538-7445.AM2019-4123
Published: 01 July 2019
View article titled, Abstract 4123: Clinical significance and the difference between programmed death-1 ligand-1 and ligand-2 in patients with esophageal cancer
Journal Articles

Abstract 4362: Glucose transporter 1 regulates cell glycolysis and proliferation in gastrointestinal stromal tumor and its clinicopathological significance

Masaaki Iwatsuki, Hiroshi Sawayama, Daisuke Kuroda, Yuki Koga, Kohei Yamashita, Kazuto Harada, Shiro Iwagami, Kojiro Eto, Takatsugu Ishimoto, Yoshifumi Baba, Naoya Yoshida, Jaffer A. Ajani, Hideo Baba
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4362.
https://doi.org/10.1158/1538-7445.AM2019-4362
Published: 01 July 2019
View article titled, Abstract 4362: Glucose transporter 1 regulates cell glycolysis and proliferation in gastrointestinal stromal tumor and its clinicopathological significance
Journal Articles

Abstract 3140: Infiltrating macrophage-derived TNF-α promotes PD-L1 expression, leading to poor prognosis of patients with pancreatic cancer

Masayo Tsukamoto, Katsunori Imai, Takatsugu Ishimoto, Yoshihiro Komohara, Naoki Umezaki, Takanobu Yamao, Yuki Kitano, Kota Arima, Tatsunori Miyata, Hirohisa Okabe, Shigeki Nakagawa, Hidetoshi Nitta, Yo-ichi Yamashita, Akira Chikamoto, Takatoshi Ishiko, Hideo Baba
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 3140.
https://doi.org/10.1158/1538-7445.AM2018-3140
Published: 01 July 2018
View article titled, Abstract 3140: Infiltrating macrophage-derived TNF-α promotes PD-L1 expression, leading to poor prognosis of patients with pancreatic cancer
Journal Articles

Abstract 1987: Expansion of pancreatic cancer stem-like cells through PGE2 accumulation in inflammatory environment

Takatsugu Ishimoto, Kota Arima, Luke Bu, Tomoyuki Uchihara, Keisuke Miyake, Tsugio Eto, Rumi Itoyama, Hideo Baba
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1987.
https://doi.org/10.1158/1538-7445.AM2018-1987
Published: 01 July 2018
View article titled, Abstract 1987: Expansion of pancreatic cancer stem-like cells through PGE2 accumulation in inflammatory environment
Journal Articles

Abstract 5125: The relationship between microbiome Fusobacterium nucleatum and autophagy in esophageal cancer

Yang Liu, Yoshifumi Baba, Shigeki Nakagawa, Hiroshi Sawayama, Takatsugu Ishimoto, Masaaki Iwatsuki, Yoichi Yamashita, Yuji Miyamoto, Naoya Yoshida, Hideo Baba
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5125.
https://doi.org/10.1158/1538-7445.AM2018-5125
Published: 01 July 2018
View article titled, Abstract 5125: The relationship between microbiome <em>Fusobacterium nucleatum</em> and autophagy in esophageal cancer
Journal Articles

Abstract 5086: To identify the critical factors in extracellular vesicles derived from cancer-associated fibroblasts for drug resistance of gastric cancer cells

Tomoyuki Uchihara, Keisuke Miyake, Eri Oda, Yuki Koga, Taisuke Yagi, Daisuke Kuroda, Tsugio Eto, Yuki Kiyozumi, Kota Arima, Hiroshi Sawayama, Yukiharu Hiyoshi, Masaaki Iwatsuki, Yoshifumi Baba, Yuji Miyamoto, Naoya Yoshida, Hideo Baba, Takatsugu Ishimoto
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5086.
https://doi.org/10.1158/1538-7445.AM2018-5086
Published: 01 July 2018
View article titled, Abstract 5086: To identify the critical factors in extracellular vesicles derived from cancer-associated fibroblasts for drug resistance of gastric cancer cells
Journal Articles

Abstract 1920: Prostaglandin E2 accumulation enhances the expansion of ALDH1-positive cells and Kras-driven tumorigenesis in the pancreas

Kota Arima, Takatsugu Ishimoto, Masaki Ohmuraya, Keisuke Miyake, Tsugio Eto, Hirohisa Okabe, Yuki Kitano, Kensuke Yamamura, Takayoshi Kaida, Katsunori Imai, Daisuke Hashimoto, Akira Chikamoto, Hideo Baba
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1920.
https://doi.org/10.1158/1538-7445.AM2017-1920
Published: 01 July 2017
View article titled, Abstract 1920: Prostaglandin E2 accumulation enhances the expansion of ALDH1-positive cells and Kras-driven tumorigenesis in the pancreas
Journal Articles

Abstract 5903: Interaction with extracellular matrix enhance the chemoresistance via CXCL12/CXCR4 and integrin signal activation by cancer-associated fibroblasts in gastric cancers

Keisuke Miyake, Takatsugu Ishimoto, Daisuke Izumi, Kota Arima, Tsugio Eto, Daisuke Kuroda, Masaaki Iwatsuki, Yoshifumi Baba, Yasuo Sakamoto, Naoya Yoshida, Hideo Baba
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5903.
https://doi.org/10.1158/1538-7445.AM2017-5903
Published: 01 July 2017
View article titled, Abstract 5903: Interaction with extracellular matrix enhance the chemoresistance via CXCL12/CXCR4 and integrin signal activation by cancer-associated fibroblasts in gastric cancers
Journal Articles

Abstract 4825: Functional role of Ring Finger Protein 43 in intestinal stem cell during colorectal tumorigenesis

Tsugio Eto, Takatsugu Ishimoto, Eri Oda, Daisuke Kuroda, Kota Arima, Mayuko Ohuchi, Kenichi Nakamura, Hiroshi Sawayama, Koichi Kinoshita, Masaaki Iwatsuki, Yoshifumi Baba, Yasuo Sakamoto, Naoya Yoshida, Hideo Baba
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4825.
https://doi.org/10.1158/1538-7445.AM2017-4825
Published: 01 July 2017
View article titled, Abstract 4825: Functional role of Ring Finger Protein 43 in intestinal stem cell during colorectal tumorigenesis
Journal Articles

Abstract 4930: Genetic and epigenetic characteristics of esophageal cancer tissues with microbiome fusobacterium nucleatum

Yoshifumi Baba, Kensuke Yamamura, Shigeki Nakagawa, Kosuke Mima, Takatsugu Ishimoto, Masaaki Iwatsuki, Yasuo Sakamoto, Naoya Yoshida, Hideo Baba
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4930.
https://doi.org/10.1158/1538-7445.AM2017-4930
Published: 01 July 2017
View article titled, Abstract 4930: Genetic and epigenetic characteristics of esophageal cancer tissues with microbiome fusobacterium nucleatum
Journal Articles

Abstract 4340: RHBDF2 in stromal fibroblasts mediates TGF-β signaling and enhances gastric cancer cell invasion via intercellular crosstalk

Takatsugu Ishimoto, Keisuke Miyake, Masakazu Yashiro, Tsugio Eto, Daisuke Izumi, Kota Arima, Yoshifumi Baba, Masayuki Watanabe, Kosei Hirakawa, Hideo Baba, Patrick Tan
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4340.
https://doi.org/10.1158/1538-7445.AM2017-4340
Published: 01 July 2017
View article titled, Abstract 4340: RHBDF2 in stromal fibroblasts mediates TGF-β signaling and enhances gastric cancer cell invasion via intercellular crosstalk
Journal Articles

Abstract 1336: Significance of SERPINE2 expression in peritoneal metastasis in gastric carcinoma

Daisuke Kuroda, Junji Kurashige, Hiroshi Sawayama, Masaaki Iwatsuki, Tomoyuki Uchihara, Tasuku Toihata, Eri Oda, Taisuke Yagi, Tsugio Eto, Keisuke Miyake, Mayuko Ouchi, Kenichi Nakamura, Koichi Kinoshita, Kousuke Mima, Takatsugu Ishimoto, Yasuo Sakamoto, Yoshifumi Baba, Naoya Yoshida, Koshi Mimori, Hideo Baba
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1336.
https://doi.org/10.1158/1538-7445.AM2017-1336
Published: 01 July 2017
View article titled, Abstract 1336: Significance of SERPINE2 expression in peritoneal metastasis in gastric carcinoma