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Journal Articles

Abstract 694: Structure-function analysis of RPL18A, a putative binding target of rigosertib

Irina A. Oussenko, Yogesh K. Gupta, Rodrigo Vasquez-Del Carpio, M.V. Ramana-Reddy, Aneel K. Aggarwal, E. Premkumar Reddy, James F. Holland, Takao Ohnuma

Cancer Res (2015) 75 (15_Supplement): 694.

https://doi.org/10.1158/1538-7445.AM2015-694

Published: 01 August 2015

View articletitled, Abstract 694: Structure-function analysis of RPL18A, a putative binding target of rigosertib

Journal Articles

Abstract 4595: RPL18A as putative target of rigosertib

Irina Oussenko, Saikrishna Divakar, M. V. Ramana Reddy, James F. Holland, E. Premkumar Reddy, Takao Ohnuma

Cancer Res (2014) 74 (19_Supplement): 4595.

https://doi.org/10.1158/1538-7445.AM2014-4595

Published: 01 October 2014

View articletitled, Abstract 4595: RPL18A as putative target of rigosertib

Journal Articles

Abstract 1171: Urinary excretion of rigosertib (ON 01910.Na), a novel synthetic benzylstyrylsulfone, in a phase I trial.

Sool Y. Cho, John Roboz, Takao Ohnuma

Cancer Res (2013) 73 (8_Supplement): 1171.

https://doi.org/10.1158/1538-7445.AM2013-1171

Published: 15 April 2013

View articletitled, Abstract 1171: Urinary excretion of rigosertib (ON 01910.Na), a novel synthetic benzylstyrylsulfone, in a phase I trial.

Journal Articles

Abstract 3797: Hyperphosphorylation and desumoylation of RanGAP1·SUMO1

Irina Oussenko, James F. Holland, E. Premkumar Reddy, Takao Ohnuma

Cancer Res (2012) 72 (8_Supplement): 3797.

https://doi.org/10.1158/1538-7445.AM2012-3797

Published: 15 April 2012

View articletitled, Abstract 3797: Hyperphosphorylation and desumoylation of RanGAP1·SUMO1

Journal Articles

Effect of ON 01910.Na, an Anticancer Mitotic Inhibitor, on Cell-Cycle Progression Correlates with RanGAP1 Hyperphosphorylation

Irina A. Oussenko, James F. Holland, E. Premkumar Reddy, Takao Ohnuma

Cancer Res (2011) 71 (14): 4968–4976.

https://doi.org/10.1158/0008-5472.CAN-10-1603

Published: 14 July 2011

View articletitled, Effect of ON 01910.Na, an Anticancer Mitotic Inhibitor, on Cell-Cycle Progression Correlates with RanGAP1 Hyperphosphorylation

Journal Articles

Abstract 2639: RanGAP1·SUMO1 hyperphosphorylation (RGSH) and mitotic arrest by ON 01910.Na, okadaic acid or tubulin agents

Irina Oussenko, James F. Holland, E. Premkumar Reddy, Takao Ohnuma

Cancer Res (2011) 71 (8_Supplement): 2639.

https://doi.org/10.1158/1538-7445.AM2011-2639

Published: 15 April 2011

View articletitled, Abstract 2639: RanGAP1·SUMO1 hyperphosphorylation (RGSH) and mitotic arrest by ON 01910.Na, okadaic acid or tubulin agents

Journal Articles

Abstract 2766: Multicenter pharmacokinetic evaluation of ON 01910. Na, a novel broad-spectrum anticancer agent, in Phase I single agent clinical trials in patients with solid tumors

Manoj Maniar, Sridhar Mani, Mohammed H. Ghalib, John Roboz, Takao Ohnuma, Suresh Advani, Raghunadh Rao, D Doval, Manmohan Acharya, Edward O'Rourke, Francois Wilhelm, James F. Holland, David Taft

Cancer Res (2010) 70 (8_Supplement): 2766.

https://doi.org/10.1158/1538-7445.AM10-2766

Published: 15 April 2010

View articletitled, Abstract 2766: Multicenter pharmacokinetic evaluation of ON 01910. Na, a novel broad-spectrum anticancer agent, in Phase I single agent clinical trials in patients with solid tumors

Journal Articles

Abstract 2500: ON 01910. Na, a clinical stage anticancer mitotic inhibitor, produces prolonged hyperphosphorylation of RanGAP1•SUMO1 as a potential mechanism of G2/M arrest and apoptosis

Irina Oussenko, James F. Holland, E. Premkumar Reddy, Takao Ohnuma

Cancer Res (2010) 70 (8_Supplement): 2500.

https://doi.org/10.1158/1538-7445.AM10-2500

Published: 15 April 2010

View articletitled, Abstract 2500: ON 01910. Na, a clinical stage anticancer mitotic inhibitor, produces prolonged hyperphosphorylation of RanGAP1•SUMO1 as a potential mechanism of G2/M arrest and apoptosis

Journal Articles

Abstract #3866: Modulation of Chk1, Chk2, p-Chk2 dimer and p-ATM in cancer cells treated with ON 01910.Na, a clinical stage mitotic inhibitor

Irina Oussenko, James F. Holland, E. Premkumar Reddy, Takao Ohnuma

Cancer Res (2009) 69 (9_Supplement): 3866.

Published: 01 May 2009

View articletitled, Abstract #3866: Modulation of Chk1, Chk2, p-Chk2 dimer and p-ATM in cancer cells treated with ON 01910.Na, a clinical stage mitotic inhibitor

Journal Articles

Combination of ON 01910.Na and Oxaliplatin against DU-145 human prostate carcinoma and Bel7404 hepatoma cells in vitro

Irina Oussenko, Takao Ohnuma, Jian-Dong Jiang, E. Premkumar Reddy, James F. Holland

Cancer Res (2008) 68 (9_Supplement): 654.

Published: 01 May 2008

View articletitled, Combination of ON 01910.Na and Oxaliplatin against DU-145 human prostate carcinoma and Bel7404 hepatoma cells in vitro

Journal Articles

Mass spectrometric study of drug binding to proteins

Sool Cho, John Roboz, Takao Ohnuma, James Holland

Cancer Res (2007) 67 (9_Supplement): 3182.

Published: 01 May 2007

View articletitled, Mass spectrometric study of drug binding to proteins

Journal Articles

siRNAs against deletion mutant EGFR in the treatment of glioblastoma multiforme (GBM)

Irina Oussenko, Takao Ohnuma, James Holland

Cancer Res (2007) 67 (9_Supplement): 4820.

Published: 01 May 2007

View articletitled, siRNAs against deletion mutant EGFR in the treatment of glioblastoma multiforme (GBM)

Journal Articles

Mass spectrometry of intact complexes of benzyl styryl sulfone ON1910Na with albumin using direct serum injection

John Roboz, Sool Yeon Cho, Takao Ohnuma, Jian-Dong Jiang, Yanling Wang, Stanley Bell, Premkumar E. Reddy, James F. Holland

Cancer Res (2006) 66 (8_Supplement): 729–730.

Published: 15 April 2006

View articletitled, Mass spectrometry of intact complexes of benzyl styryl sulfone ON1910Na with albumin using direct serum injection

Journal Articles

Cross-resistance to ON01910.Na among drug-resistant human tumor cell lines

Adrian Preda, Takao Ohnuma, Jian-Dong Jiang, James F. Holland, E. Premkumar Reddy

Cancer Res (2006) 66 (8_Supplement): 1106.

Published: 15 April 2006

View articletitled, Cross-resistance to ON01910.Na among drug-resistant human tumor cell lines

Journal Articles

Influence of human serum albumin on cytotoxic activity of ON01910.Na

Takao Ohnuma, Adrian Preda, E. Premkumar Reddy, John Roboz, James F. Holland

Cancer Res (2005) 65 (9_Supplement): 968.

Published: 01 May 2005

View articletitled, Influence of human serum albumin on cytotoxic activity of ON01910.Na

Journal Articles

Cytotoxic effect of ON 01910.Na in combination with ciplatin, flavopiridol, doxorubicin and other antitumor agents in vitro

Adrian Preda, Takao Ohnuma, E. Premkumar Reddy, James F. Holland

Cancer Res (2005) 65 (9_Supplement): 1182–1183.

Published: 01 May 2005

View articletitled, Cytotoxic effect of ON 01910.Na in combination with ciplatin, flavopiridol, doxorubicin and other antitumor agents in vitro

Journal Articles

Anticancer effects of ON-1910Na

Jian-Dong Jiang, Yan Li, Yanling Wang, Epremkumar Reddy, John Roboz, Takao Ohnuma, Lewis Silverman, James F. Holland

Cancer Res (2004) 64 (7_Supplement): 1241.

Published: 01 April 2004

View articletitled, Anticancer effects of ON-1910Na

Journal Articles

Reversal of Drug Sensitivity in Multidrug-Resistant Tumor Cells by an MDR1 (PGY1) Ribozyme

Hiroyuki Kobayashi, Thambi Dorai, James F. Holland, Takao Ohnuma

Cancer Res (1994) 54 (5): 1271–1275.

Published: 01 March 1994

View articletitled, Reversal of Drug Sensitivity in Multidrug-Resistant Tumor Cells by an MDR1 (PGY1) Ribozyme

Journal Articles

Protein Kinase C Activity and Multidrug Resistance in MOLT-3 Human Lymphoblastic Leukemia Cells Resistant to Trimetrexate

Gary K. Schwartz, Hadara Arkin, James F. Holland, Takao Ohnuma

Cancer Res (1991) 51 (1): 55–61.

Published: 01 January 1991

View articletitled, Protein Kinase C Activity and Multidrug Resistance in MOLT-3 Human Lymphoblastic Leukemia Cells Resistant to Trimetrexate

Journal Articles

Multidrug Resistance in a Human Leukemic Cell Line Selected for Resistance to Trimetrexate

Hadara Arkin, Takao Ohnuma, Barton A. Kamen, James F. Holland, Shanker Vallabhajosula

Cancer Res (1989) 49 (23): 6556–6561.

Published: 01 December 1989

View articletitled, Multidrug Resistance in a Human Leukemic Cell Line Selected for Resistance to Trimetrexate

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Abstract 694: Structure-function analysis of RPL18A, a putative binding target of rigosertib

Abstract 4595: RPL18A as putative target of rigosertib

Abstract 1171: Urinary excretion of rigosertib (ON 01910.Na), a novel synthetic benzylstyrylsulfone, in a phase I trial.

Abstract 3797: Hyperphosphorylation and desumoylation of RanGAP1·SUMO1

Effect of ON 01910.Na, an Anticancer Mitotic Inhibitor, on Cell-Cycle Progression Correlates with RanGAP1 Hyperphosphorylation

Abstract 2639: RanGAP1·SUMO1 hyperphosphorylation (RGSH) and mitotic arrest by ON 01910.Na, okadaic acid or tubulin agents

Abstract 2766: Multicenter pharmacokinetic evaluation of ON 01910. Na, a novel broad-spectrum anticancer agent, in Phase I single agent clinical trials in patients with solid tumors

Abstract 2500: ON 01910. Na, a clinical stage anticancer mitotic inhibitor, produces prolonged hyperphosphorylation of RanGAP1•SUMO1 as a potential mechanism of G2/M arrest and apoptosis

Abstract #3866: Modulation of Chk1, Chk2, p-Chk2 dimer and p-ATM in cancer cells treated with ON 01910.Na, a clinical stage mitotic inhibitor

Combination of ON 01910.Na and Oxaliplatin against DU-145 human prostate carcinoma and Bel7404 hepatoma cells in vitro

Mass spectrometric study of drug binding to proteins

siRNAs against deletion mutant EGFR in the treatment of glioblastoma multiforme (GBM)

Mass spectrometry of intact complexes of benzyl styryl sulfone ON1910Na with albumin using direct serum injection

Cross-resistance to ON01910.Na among drug-resistant human tumor cell lines

Influence of human serum albumin on cytotoxic activity of ON01910.Na

Cytotoxic effect of ON 01910.Na in combination with ciplatin, flavopiridol, doxorubicin and other antitumor agents in vitro

Anticancer effects of ON-1910Na

Reversal of Drug Sensitivity in Multidrug-Resistant Tumor Cells by an MDR1 (PGY1) Ribozyme

Protein Kinase C Activity and Multidrug Resistance in MOLT-3 Human Lymphoblastic Leukemia Cells Resistant to Trimetrexate

Multidrug Resistance in a Human Leukemic Cell Line Selected for Resistance to Trimetrexate

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