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Journal Articles

Abstract P1-18-17: Phase I study of cfi-402257, an oral ttk inhibitor, in patients with advanced solid tumors with breast cancer expansion cohorts

John Hilton, Daniel J Renouf, David W Cescon, Aaron R Hansen, Albiruni RA Razak, Lee-Anne Stayner, Trisha Denny, Graham Fletcher, Tak W Mak, Mark Bray, Philippe L Bedard

Cancer Res (2022) 82 (4_Supplement): P1-18-17.

DOI: https://doi.org/10.1158/1538-7445.SABCS21-P1-18-17

Published: 15 February 2022

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Journal Articles

Abstract PD2-03: CDK4/6 inhibitor-resistant ER+ breast cancer cell lines are hypersensitive to TTK inhibition

Isabel Soria Bretones, Kelsie L Thu, Jennifer Silvester, Reza Kiarash, Graham C Fletcher, Jennifer Cruickshank, Mark R Bray, Tak W Mak, David W Cescon

Cancer Res (2020) 80 (4_Supplement): PD2-03.

DOI: https://doi.org/10.1158/1538-7445.SABCS19-PD2-03

Published: 15 February 2020

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Journal Articles

Abstract 3935: PLK4 inhibition as a strategy for non-small cell lung cancer radiosensitization

Thomas J. Hayman, Mark R. Bray, Jacqueline M. Mason, Tak W. Mak, Joseph N. Contessa

Cancer Res (2019) 79 (13_Supplement): 3935.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3935

Published: 01 July 2019

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Journal Articles

Abstract 1948: Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

Masanori Kawakami, Lisa Maria Mustachio, Lin Zheng, Yulong Chen, Jaime Rodriguez-Canales, Barbara Mino, Jonathan M. Kurie, Jason Roszik, Pamela Andrea Villalobos, Kelsie L. Thu, David W. Cescon, Jennifer Silvester, Ignacio Wistuba, Tak W. Mak, Xi Liu, Ethan Dmitrovsky

Cancer Res (2018) 78 (13_Supplement): 1948.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1948

Published: 01 July 2018

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Journal Articles

Abstract CT066: First-in-human phase I trial of the oral PLK4 inhibitor CFI-400945 in patients with advanced solid tumors

Philippe L. Bedard, David W. Cescon, Graham Fletcher, Trish Denny, Richard Brokx, Peter Sampson, Mark R. Bray, Dennis J. Slamon, Tak W. Mak, Zev A. Wainberg

Cancer Res (2016) 76 (14_Supplement): CT066.

DOI: https://doi.org/10.1158/1538-7445.AM2016-CT066

Published: 15 July 2016

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Journal Articles

Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

Cancer Res (2015) 75 (15_Supplement): 2075.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2075

Published: 01 August 2015

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Journal Articles

Abstract 5452: Cancer-associated metabolite 2-hydroxyglutarate accumulates in AML with IDH1/2 mutations

Valeria R. Fantin, Stefan Gross, Rob A. Cairns, Mark D. Minden, Edward M. Driggers, Hyun Gyung Jang, Masato Sasaki, Shengfang Jin, David P. Schenkein, Shinsan M. Su, Lenny Dang, Tak W. Mak

Cancer Res (2010) 70 (8_Supplement): 5452.

DOI: https://doi.org/10.1158/1538-7445.AM10-5452

Published: 15 April 2010

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Abstract SY31-04: Metabolic regulation of tumor cells survival

Tak W. Mak

Cancer Res (2010) 70 (8_Supplement): SY31-04.

DOI: https://doi.org/10.1158/1538-7445.AM10-SY31-04

Published: 15 April 2010

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Journal Articles

Smac/DIABLO and inhibitors of apoptosis (IAPs) constitute an alternative axis of caspase 9 activation independent of Apaf1-associated apoptosome

Andrew T. Ho, Hui-Qin Li, Hitoshi Okada, Tak W. Mak, Eldad Zacksenhaus

Cancer Res (2006) 66 (8_Supplement): 562.

Published: 15 April 2006

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Journal Articles

Oncogenic pathways in breast cancer downstream of Pten

Rajwinder Lehal, Ming-Sound Tsao, Tak W. Mak, Eldad Zacksenhaus

Cancer Res (2006) 66 (8_Supplement): 939.

Published: 15 April 2006

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Journal Articles

Transforming Acidic Coiled Coil 1 Promotes Transformation and Mammary Tumorigenesis

Megan Cully, Jessica Shiu, Roland P. Piekorz, William J. Muller, Susan J. Done, Tak W. Mak

Cancer Res (2005) 65 (22): 10363–10370.

DOI: https://doi.org/10.1158/0008-5472.CAN-05-1633

Published: 15 November 2005

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Journal Articles

Soluble Interleukin-13Rα2 Decoy Receptor Inhibits Hodgkin’s Lymphoma Growth in Vitro and in Vivo

Young Trieu, Xiao-Yan Wen, Brian F. Skinnider, Mark R. Bray, Zhihua Li, Jaime O. Claudio, Esther Masih-Khan, Yuan-Xiao Zhu, Suzanne Trudel, J. Andrea McCart, Tak W. Mak, A. Keith Stewart

Cancer Res (2004) 64 (9): 3271–3275.

DOI: https://doi.org/10.1158/0008-5472.CAN-03-3764

Published: 03 May 2004

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Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in p53 ^+/− Mutant Mice

Alison M. Y. Cheung, Andrew Elia, Ming-Sound Tsao, Susan Done, Kay-Uwe Wagner, Lothar Hennighausen, Razqallah Hakem, Tak W. Mak

Cancer Res (2004) 64 (6): 1959–1965.

DOI: https://doi.org/10.1158/0008-5472.CAN-03-2270

Published: 16 March 2004

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Journal Articles

Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis

Alison M. Y. Cheung, M. Prakash Hande, Farid Jalali, Ming-Sound Tsao, Brian Skinnider, Atsushi Hirao, J. Peter McPherson, Jana Karaskova, Akira Suzuki, Andrew Wakeham, Annick You-Ten, Andrew Elia, Jeremy Squire, Rob Bristow, Razqallah Hakem, Tak W. Mak

Cancer Res (2002) 62 (21): 6194–6204.

Published: 01 November 2002

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Journal Articles

Absence of the CD44 Gene Prevents Sarcoma Metastasis

Georg F. Weber, Roderick T. Bronson, John Ilagan, Harvey Cantor, Rudolf Schmits, Tak W. Mak

Cancer Res (2002) 62 (8): 2281–2286.

Published: 01 April 2002

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Journal Articles

Inactivation of the Retinoblastoma Tumor Suppressor Induces Apoptosis Protease-activating Factor-1 Dependent and Independent Apoptotic Pathways during Embryogenesis

Zhong Guo, Shi Yikang, Hiroki Yoshida, Tak W. Mak, Eldad Zacksenhaus

Cancer Res (2001) 61 (23): 8395–8400.

Published: 01 December 2001

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Journal Articles

High Incidence of Breast and Endometrial Neoplasia Resembling Human Cowden Syndrome in pten^+/− Mice

Vuk Stambolic, Ming-Sound Tsao, David Macpherson, Akira Suzuki, William B. Chapman, Tak W. Mak

Cancer Res (2000) 60 (13): 3605–3611.

Published: 01 July 2000

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Journal Articles

Mutator Phenotype in Msh2-deficient Murine Embryonic Fibroblasts

Armin H. Reitmair, Robert Risley, Robert G. Bristow, Teresa Wilson, Anil Ganesh, Anne Jang, James Peacock, Samuel Benchimol, Richard P. Hill, Tak W. Mak, Richard Fishel, Mark Meuth

Cancer Res (1997) 57 (17): 3765–3771.

Published: 01 September 1997

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Journal Articles

Spontaneous Intestinal Carcinomas and Skin Neoplasms in Msh2-deficient Mice

Armin H. Reitmair, Mark Redston, Jian Chun Cai, Tony C.Y. Chuang, Matthew Bjerknes, Hazel Cheng, Kazy Hay, Steven Gallinger, Bharati Bapat, Tak W. Mak

Cancer Res (1996) 56 (16): 3842–3849.

Published: 01 August 1996

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Journal Articles

MSH2 Deficiency Contributes to Accelerated APC-mediated Intestinal Tumorigenesis

Armin H. Reitmair, Jian-Chun Cai, Matthew Bjerknes, Mark Redston, Hazel Cheng, Molly T. L. Pind, Kazy Hay, Angela Mitri, Bharati V. Bapat, Tak W. Mak, Steven Gallinger

Cancer Res (1996) 56 (13): 2922–2926.

Published: 01 July 1996

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NARROW

Abstract P1-18-17: Phase I study of cfi-402257, an oral ttk inhibitor, in patients with advanced solid tumors with breast cancer expansion cohorts

Abstract PD2-03: CDK4/6 inhibitor-resistant ER+ breast cancer cell lines are hypersensitive to TTK inhibition

Abstract 3935: PLK4 inhibition as a strategy for non-small cell lung cancer radiosensitization

Abstract 1948: Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

Abstract CT066: First-in-human phase I trial of the oral PLK4 inhibitor CFI-400945 in patients with advanced solid tumors

Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

Abstract 5452: Cancer-associated metabolite 2-hydroxyglutarate accumulates in AML with IDH1/2 mutations

Abstract SY31-04: Metabolic regulation of tumor cells survival

Smac/DIABLO and inhibitors of apoptosis (IAPs) constitute an alternative axis of caspase 9 activation independent of Apaf1-associated apoptosome

Oncogenic pathways in breast cancer downstream of Pten

Transforming Acidic Coiled Coil 1 Promotes Transformation and Mammary Tumorigenesis

Soluble Interleukin-13Rα2 Decoy Receptor Inhibits Hodgkin’s Lymphoma Growth in Vitro and in Vivo

Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in p53 ^+/− Mutant Mice

Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis

Absence of the CD44 Gene Prevents Sarcoma Metastasis

Inactivation of the Retinoblastoma Tumor Suppressor Induces Apoptosis Protease-activating Factor-1 Dependent and Independent Apoptotic Pathways during Embryogenesis

High Incidence of Breast and Endometrial Neoplasia Resembling Human Cowden Syndrome in pten^+/− Mice

Mutator Phenotype in Msh2-deficient Murine Embryonic Fibroblasts

Spontaneous Intestinal Carcinomas and Skin Neoplasms in Msh2-deficient Mice

MSH2 Deficiency Contributes to Accelerated APC-mediated Intestinal Tumorigenesis

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