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Journal Articles

Abstract 6908: Autophagy disruption via PIKfyve inhibition as a novel strategy to enhance immunotherapy responses in multiple myeloma

Cecilia Bonolo de Campos, Dor D. Abelman, Ruijuan He, Tessa Pelino, Ding Yan Wang, David S. Scott, Zhihua Li, Michael St Paul, Trevor J. Pugh, Olga Issakova, Nikolai Sepetov, Tak W. Mak, Suzanne Trudel, A Keith Stewart

Cancer Res (2025) 85 (8_Supplement_1): 6908.

https://doi.org/10.1158/1538-7445.AM2025-6908

Published: 21 April 2025

View articletitled, Abstract 6908: Autophagy disruption via PIKfyve inhibition as a novel strategy to enhance immunotherapy responses in multiple myeloma

Journal Articles

Abstract 5919: The significant role of HMGB1 in mesothelial cells in contributing to the mesothelioma development induced by asbestos

Joelle S. Suarez, Giovanni Gaudino, Tak W. Mak, Michele Carbone, Haining Yang

Cancer Res (2023) 83 (7_Supplement): 5919.

https://doi.org/10.1158/1538-7445.AM2023-5919

Published: 04 April 2023

View articletitled, Abstract 5919: The significant role of HMGB1 in mesothelial cells in contributing to the mesothelioma development induced by asbestos

Journal Articles

Abstract 3965: KIFC1 is a therapeutic target in lung cancers with extra centrosomes

Christopher Z. Zhang, Benson Z. Wu, Yin Fang Wu, Caterina di Ciano-Oliveira, Ju-Yoon Yoon, Tak W. Mak, David W. Cescon, Kelsie L. Thu

Cancer Res (2023) 83 (7_Supplement): 3965.

https://doi.org/10.1158/1538-7445.AM2023-3965

Published: 04 April 2023

View articletitled, Abstract 3965: KIFC1 is a therapeutic target in lung cancers with extra centrosomes

Journal Articles

Abstract 5182: CD47 is a promising therapeutic target in non-small cell lung cancer

Asa P. Lau, Shawn P. Kubli, Andrew Wakeham, Tak W. Mak, Kelsie L. Thu

Cancer Res (2023) 83 (7_Supplement): 5182.

https://doi.org/10.1158/1538-7445.AM2023-5182

Published: 04 April 2023

View articletitled, Abstract 5182: CD47 is a promising therapeutic target in non-small cell lung cancer

Journal Articles

Abstract P1-18-17: Phase I study of cfi-402257, an oral ttk inhibitor, in patients with advanced solid tumors with breast cancer expansion cohorts

John Hilton, Daniel J Renouf, David W Cescon, Aaron R Hansen, Albiruni RA Razak, Lee-Anne Stayner, Trisha Denny, Graham Fletcher, Tak W Mak, Mark Bray, Philippe L Bedard

Cancer Res (2022) 82 (4_Supplement): P1-18-17.

https://doi.org/10.1158/1538-7445.SABCS21-P1-18-17

Published: 15 February 2022

View articletitled, Abstract P1-18-17: Phase I study of cfi-402257, an oral ttk inhibitor, in patients with advanced solid tumors with breast cancer expansion cohorts

Journal Articles

Abstract PD2-03: CDK4/6 inhibitor-resistant ER+ breast cancer cell lines are hypersensitive to TTK inhibition

Isabel Soria Bretones, Kelsie L Thu, Jennifer Silvester, Reza Kiarash, Graham C Fletcher, Jennifer Cruickshank, Mark R Bray, Tak W Mak, David W Cescon

Cancer Res (2020) 80 (4_Supplement): PD2-03.

https://doi.org/10.1158/1538-7445.SABCS19-PD2-03

Published: 15 February 2020

View articletitled, Abstract PD2-03: CDK4/6 inhibitor-resistant ER+ breast cancer cell lines are hypersensitive to TTK inhibition

Journal Articles

Abstract 3935: PLK4 inhibition as a strategy for non-small cell lung cancer radiosensitization

Thomas J. Hayman, Mark R. Bray, Jacqueline M. Mason, Tak W. Mak, Joseph N. Contessa

Cancer Res (2019) 79 (13_Supplement): 3935.

https://doi.org/10.1158/1538-7445.AM2019-3935

Published: 01 July 2019

View articletitled, Abstract 3935: PLK4 inhibition as a strategy for non-small cell lung cancer radiosensitization

Journal Articles

Abstract 1948: Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

Masanori Kawakami, Lisa Maria Mustachio, Lin Zheng, Yulong Chen, Jaime Rodriguez-Canales, Barbara Mino, Jonathan M. Kurie, Jason Roszik, Pamela Andrea Villalobos, Kelsie L. Thu, David W. Cescon, Jennifer Silvester, Ignacio Wistuba, Tak W. Mak, Xi Liu, Ethan Dmitrovsky

Cancer Res (2018) 78 (13_Supplement): 1948.

https://doi.org/10.1158/1538-7445.AM2018-1948

Published: 01 July 2018

View articletitled, Abstract 1948: Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

Journal Articles

Abstract CT066: First-in-human phase I trial of the oral PLK4 inhibitor CFI-400945 in patients with advanced solid tumors

Philippe L. Bedard, David W. Cescon, Graham Fletcher, Trish Denny, Richard Brokx, Peter Sampson, Mark R. Bray, Dennis J. Slamon, Tak W. Mak, Zev A. Wainberg

Cancer Res (2016) 76 (14_Supplement): CT066.

https://doi.org/10.1158/1538-7445.AM2016-CT066

Published: 15 July 2016

View articletitled, Abstract CT066: First-in-human phase I trial of the oral PLK4 inhibitor CFI-400945 in patients with advanced solid tumors

Journal Articles

Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

Cancer Res (2015) 75 (15_Supplement): 2075.

https://doi.org/10.1158/1538-7445.AM2015-2075

Published: 01 August 2015

View articletitled, Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

Journal Articles

Abstract 5452: Cancer-associated metabolite 2-hydroxyglutarate accumulates in AML with IDH1/2 mutations

Valeria R. Fantin, Stefan Gross, Rob A. Cairns, Mark D. Minden, Edward M. Driggers, Hyun Gyung Jang, Masato Sasaki, Shengfang Jin, David P. Schenkein, Shinsan M. Su, Lenny Dang, Tak W. Mak

Cancer Res (2010) 70 (8_Supplement): 5452.

https://doi.org/10.1158/1538-7445.AM10-5452

Published: 15 April 2010

View articletitled, Abstract 5452: Cancer-associated metabolite 2-hydroxyglutarate accumulates in AML with IDH1/2 mutations

Journal Articles

Abstract SY31-04: Metabolic regulation of tumor cells survival

Tak W. Mak

Cancer Res (2010) 70 (8_Supplement): SY31-04.

https://doi.org/10.1158/1538-7445.AM10-SY31-04

Published: 15 April 2010

View articletitled, Abstract SY31-04: Metabolic regulation of tumor cells survival

Journal Articles

Oncogenic pathways in breast cancer downstream of Pten

Rajwinder Lehal, Ming-Sound Tsao, Tak W. Mak, Eldad Zacksenhaus

Cancer Res (2006) 66 (8_Supplement): 939.

Published: 15 April 2006

View articletitled, Oncogenic pathways in breast cancer downstream of Pten

Journal Articles

Smac/DIABLO and inhibitors of apoptosis (IAPs) constitute an alternative axis of caspase 9 activation independent of Apaf1-associated apoptosome

Andrew T. Ho, Hui-Qin Li, Hitoshi Okada, Tak W. Mak, Eldad Zacksenhaus

Cancer Res (2006) 66 (8_Supplement): 562.

Published: 15 April 2006

View articletitled, Smac/DIABLO and inhibitors of apoptosis (IAPs) constitute an alternative axis of caspase 9 activation independent of Apaf1-associated apoptosome

Journal Articles

Transforming Acidic Coiled Coil 1 Promotes Transformation and Mammary Tumorigenesis

Megan Cully, Jessica Shiu, Roland P. Piekorz, William J. Muller, Susan J. Done, Tak W. Mak

Cancer Res (2005) 65 (22): 10363–10370.

https://doi.org/10.1158/0008-5472.CAN-05-1633

Published: 15 November 2005

View articletitled, Transforming Acidic Coiled Coil 1 Promotes Transformation and Mammary Tumorigenesis

Journal Articles

Soluble Interleukin-13Rα2 Decoy Receptor Inhibits Hodgkin’s Lymphoma Growth in Vitro and in Vivo

Young Trieu, Xiao-Yan Wen, Brian F. Skinnider, Mark R. Bray, Zhihua Li, Jaime O. Claudio, Esther Masih-Khan, Yuan-Xiao Zhu, Suzanne Trudel, J. Andrea McCart, Tak W. Mak, A. Keith Stewart

Cancer Res (2004) 64 (9): 3271–3275.

https://doi.org/10.1158/0008-5472.CAN-03-3764

Published: 03 May 2004

View articletitled, Soluble Interleukin-13Rα2 Decoy Receptor Inhibits Hodgkin’s Lymphoma Growth in Vitro and in Vivo

Journal Articles

Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in p53 ^+/− Mutant Mice

Alison M. Y. Cheung, Andrew Elia, Ming-Sound Tsao, Susan Done, Kay-Uwe Wagner, Lothar Hennighausen, Razqallah Hakem, Tak W. Mak

Cancer Res (2004) 64 (6): 1959–1965.

https://doi.org/10.1158/0008-5472.CAN-03-2270

Published: 16 March 2004

View articletitled, Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in p53 +/− Mutant Mice

Journal Articles

Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis

Alison M. Y. Cheung, M. Prakash Hande, Farid Jalali, Ming-Sound Tsao, Brian Skinnider, Atsushi Hirao, J. Peter McPherson, Jana Karaskova, Akira Suzuki, Andrew Wakeham, Annick You-Ten, Andrew Elia, Jeremy Squire, Rob Bristow, Razqallah Hakem, Tak W. Mak

Cancer Res (2002) 62 (21): 6194–6204.

Published: 01 November 2002

View articletitled, Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis

Journal Articles

Absence of the CD44 Gene Prevents Sarcoma Metastasis

Georg F. Weber, Roderick T. Bronson, John Ilagan, Harvey Cantor, Rudolf Schmits, Tak W. Mak

Cancer Res (2002) 62 (8): 2281–2286.

Published: 01 April 2002

View articletitled, Absence of the CD44 Gene Prevents Sarcoma Metastasis

Journal Articles

Inactivation of the Retinoblastoma Tumor Suppressor Induces Apoptosis Protease-activating Factor-1 Dependent and Independent Apoptotic Pathways during Embryogenesis

Zhong Guo, Shi Yikang, Hiroki Yoshida, Tak W. Mak, Eldad Zacksenhaus

Cancer Res (2001) 61 (23): 8395–8400.

Published: 01 December 2001

View articletitled, Inactivation of the Retinoblastoma Tumor Suppressor Induces Apoptosis Protease-activating Factor-1 Dependent and Independent Apoptotic Pathways during Embryogenesis

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Abstract 6908: Autophagy disruption via PIKfyve inhibition as a novel strategy to enhance immunotherapy responses in multiple myeloma

Abstract 5919: The significant role of HMGB1 in mesothelial cells in contributing to the mesothelioma development induced by asbestos

Abstract 3965: KIFC1 is a therapeutic target in lung cancers with extra centrosomes

Abstract 5182: CD47 is a promising therapeutic target in non-small cell lung cancer

Abstract P1-18-17: Phase I study of cfi-402257, an oral ttk inhibitor, in patients with advanced solid tumors with breast cancer expansion cohorts

Abstract PD2-03: CDK4/6 inhibitor-resistant ER+ breast cancer cell lines are hypersensitive to TTK inhibition

Abstract 3935: PLK4 inhibition as a strategy for non-small cell lung cancer radiosensitization

Abstract 1948: Polo-like kinase 4 inhibition produces polyploidy and apoptotic death of lung cancers

Abstract CT066: First-in-human phase I trial of the oral PLK4 inhibitor CFI-400945 in patients with advanced solid tumors

Abstract 2075: Signaling thresholds and negative B cell selection in acute lymphoblastic leukemia

Abstract 5452: Cancer-associated metabolite 2-hydroxyglutarate accumulates in AML with IDH1/2 mutations

Abstract SY31-04: Metabolic regulation of tumor cells survival

Oncogenic pathways in breast cancer downstream of Pten

Smac/DIABLO and inhibitors of apoptosis (IAPs) constitute an alternative axis of caspase 9 activation independent of Apaf1-associated apoptosome

Transforming Acidic Coiled Coil 1 Promotes Transformation and Mammary Tumorigenesis

Soluble Interleukin-13Rα2 Decoy Receptor Inhibits Hodgkin’s Lymphoma Growth in Vitro and in Vivo

Brca2 Deficiency Does Not Impair Mammary Epithelium Development but Promotes Mammary Adenocarcinoma Formation in p53 ^+/− Mutant Mice

Loss of Brca2 and p53 Synergistically Promotes Genomic Instability and Deregulation of T-cell Apoptosis

Absence of the CD44 Gene Prevents Sarcoma Metastasis

Inactivation of the Retinoblastoma Tumor Suppressor Induces Apoptosis Protease-activating Factor-1 Dependent and Independent Apoptotic Pathways during Embryogenesis

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