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Journal Articles

Abstract LB-345: Acetylenic tricyclic bis-(cyano enone) interacts with cysteine residues of actin and inhibits non-small cell lung cancer cell migration

Eddie Chan, Akira Saito, Tadashi Honda, John Di Guglielmo
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-345.
https://doi.org/10.1158/1538-7445.AM2016-LB-345
Published: 15 July 2016
View article titled, Abstract LB-345: Acetylenic tricyclic bis-(cyano enone) interacts with cysteine residues of actin and inhibits non-small cell lung cancer cell migration
Journal Articles

Abstract 524: Assessing the interaction between acetylenic tricyclic bis-(cyano enone) and cysteine residues of actin to inhibit non-small cell lung cancer cell migration

Eddie Chan, Akira Saito, Tadashi Honda, John Di Guglielmo
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 524.
https://doi.org/10.1158/1538-7445.AM2015-524
Published: 01 August 2015
View article titled, Abstract 524: Assessing the interaction between acetylenic tricyclic bis-(cyano enone) and cysteine residues of actin to inhibit non-small cell lung cancer cell migration
Journal Articles

Abstract 5008: The acetylenic tricyclic bis(cyanoeneone), TBE-31 inhibits non-small cell lung cancer cell migration through direct binding with actin

Eddie Chan, Akira Saito, Tadashi Honda, John D. Guglielmo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5008.
https://doi.org/10.1158/1538-7445.AM2014-5008
Published: 01 October 2014
View article titled, Abstract 5008: The acetylenic tricyclic bis(cyanoeneone), TBE-31 inhibits non-small cell lung cancer cell migration through direct binding with actin
Journal Articles

A Novel Acetylenic Tricyclic bis-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin

Karen Liby, Mark M. Yore, Bill D. Roebuck, Karen J. Baumgartner, Tadashi Honda, Chitra Sundararajan, Hidenori Yoshizawa, Gordon W. Gribble, Charlotte R. Williams, Renee Risingsong, Darlene B. Royce, Albena T. Dinkova-Kostova, Katherine K. Stephenson, Patricia A. Egner, Melinda S. Yates, John D. Groopman, Thomas W. Kensler, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2008) 68 (16): 6727–6733.
https://doi.org/10.1158/0008-5472.CAN-08-1123
Published: 12 August 2008
View article titled, A Novel Acetylenic Tricyclic <em>bis</em>-(Cyano Enone) Potently Induces Phase 2 Cytoprotective Pathways and Blocks Liver Carcinogenesis Induced by Aflatoxin
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Journal Articles

The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice

Karen Liby, Darlene B. Royce, Charlotte R. Williams, Renee Risingsong, Mark M. Yore, Tadashi Honda, Gordon W. Gribble, Ethan Dmitrovsky, Thomas A. Sporn, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2414–2419.
https://doi.org/10.1158/0008-5472.CAN-06-4534
Published: 15 March 2007
View article titled, The Synthetic Triterpenoids CDDO-Methyl Ester and CDDO-Ethyl Amide Prevent Lung Cancer Induced by Vinyl Carbamate in A/J Mice
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Journal Articles

Potent Protection against Aflatoxin-Induced Tumorigenesis through Induction of Nrf2-Regulated Pathways by the Triterpenoid 1-[2-Cyano-3-,12-Dioxooleana-1,9(11)-Dien-28-Oyl]Imidazole

Melinda S. Yates, Mi-Kyoung Kwak, Patricia A. Egner, John D. Groopman, Sridevi Bodreddigari, Thomas R. Sutter, Karen J. Baumgartner, B.D. Roebuck, Karen T. Liby, Mark M. Yore, Tadashi Honda, Gordon W. Gribble, Michael B. Sporn, Thomas W. Kensler
Journal: Cancer Research
Cancer Res (2006) 66 (4): 2488–2494.
https://doi.org/10.1158/0008-5472.CAN-05-3823
Published: 17 February 2006
View article titled, Potent Protection against Aflatoxin-Induced Tumorigenesis through Induction of Nrf2-Regulated Pathways by the Triterpenoid 1-[2-Cyano-3-,12-Dioxooleana-1,9(11)-Dien-28-Oyl]Imidazole
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Journal Articles

The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling

Karen Liby, Thomas Hock, Mark M. Yore, Nanjoo Suh, Andrew E. Place, Renee Risingsong, Charlotte R. Williams, Darlene B. Royce, Tadashi Honda, Yukiko Honda, Gordon W. Gribble, Nathalie Hill-Kapturczak, Anupam Agarwal, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2005) 65 (11): 4789–4798.
https://doi.org/10.1158/0008-5472.CAN-04-4539
Published: 01 June 2005
View article titled, The Synthetic Triterpenoids, CDDO and CDDO-Imidazolide, Are Potent Inducers of Heme Oxygenase-1 and Nrf2/ARE Signaling
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Journal Articles

The synthetic triterpenoid, CDDO-Imidazolide, activates heme oxygenase-1 and other Nrf2-responsive genes in human leukemia cells

Karen Liby, Andrew E. Place, Nanjoo Suh, Renee Risingsong, Charlotte Williams, Nathalie Hill-Kapturczak, Anupam Agarwal, Tadashi Honda, Gordon Gribble, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 318.
Published: 01 April 2004
View article titled, The synthetic triterpenoid, CDDO-Imidazolide, activates heme oxygenase-1 and other Nrf2-responsive genes in human leukemia cells
Journal Articles

The Novel Triterpenoid CDDO and its Derivatives Induce Apoptosis by Disruption of Intracellular Redox Balance

Takashi Ikeda, Michael Sporn, Tadashi Honda, Gordon W. Gribble, Donald Kufe
Journal: Cancer Research
Cancer Res (2003) 63 (17): 5551–5558.
Published: 18 September 2003
View article titled, The Novel Triterpenoid CDDO and its Derivatives Induce Apoptosis by Disruption of Intracellular Redox Balance
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Journal Articles

Synthetic Triterpenoids Enhance Transforming Growth Factor β/Smad Signaling

Nanjoo Suh, Anita B. Roberts, Stephanie Birkey Reffey, Kohei Miyazono, Susumu Itoh, Peter ten Dijke, Elke H. Heiss, Andrew E. Place, Renee Risingsong, Charlotte R. Williams, Tadashi Honda, Gordon W. Gribble, Michael B. Sporn
Journal: Cancer Research
Cancer Res (2003) 63 (6): 1371–1376.
Published: 15 March 2003
View article titled, Synthetic Triterpenoids Enhance Transforming Growth Factor β/Smad Signaling
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Journal Articles

A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity

Nanjoo Suh, Yongping Wang, Tadashi Honda, Gordon W. Gribble, Ethan Dmitrovsky, William F. Hickey, Robert A. Maue, Andrew E. Place, Donna M. Porter, Michael J. Spinella, Charlotte R. Williams, Gengfei Wu, Andrew J. Dannenberg, Kathleen C. Flanders, John J. Letterio, David J. Mangelsdorf, Carl F. Nathan, Lananh Nguyen, Weston W. Porter, Renee F. Ren, Anita B. Roberts, Nanette S. Roche, Kotha Subbaramaiah, Michael B. Sporn
Journal: Cancer Research
Cancer Res (1999) 59 (2): 336–341.
Published: 15 January 1999
View article titled, A Novel Synthetic Oleanane Triterpenoid, 2-Cyano-3,12-dioxoolean-1,9-dien-28-oic Acid, with Potent Differentiating, Antiproliferative, and Anti-Inflammatory Activity
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Journal Articles

Novel Triterpenoids Suppress Inducible Nitric Oxide Synthase (iNOS) and Inducible Cyclooxygenase (COX-2) in Mouse Macrophages

Najoo Suh, Tadashi Honda, Heather J. Finlay, Aaron Barchowsky, Charlotte Williams, Nicole E. Benoit, Qiao-wen Xie, Carl Nathan, Gordon W. Gribble, Michael B. Sporn
Journal: Cancer Research
Cancer Res (1998) 58 (4): 717–723.
Published: 01 February 1998
View article titled, Novel Triterpenoids Suppress Inducible Nitric Oxide Synthase (iNOS) and Inducible Cyclooxygenase (COX-2) in Mouse Macrophages
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