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Sylvie Vincent
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Journal Articles

Abstract 2781: De novo molecular mechanisms of resistance to mobocertinib

Sylvie Vincent, Zhenqiang Su, Adarsh Joshi, Kalyani Penta, Pingkuan Zhang
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2781.
https://doi.org/10.1158/1538-7445.AM2022-2781
Published: 15 June 2022
View article titled, Abstract 2781: De novo molecular mechanisms of resistance to mobocertinib
Journal Articles

Targeting HER2 Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib

Han Han, Shuai Li, Ting Chen, Michael Fitzgerald, Shengwu Liu, Chengwei Peng, Kwan Ho Tang, Shougen Cao, Johara Chouitar, Jiansheng Wu, David Peng, Jiehui Deng, Zhendong Gao, Theresa E. Baker, Fei Li, Hua Zhang, Yuanwang Pan, Hailin Ding, Hai Hu, Val Pyon, Cassandra Thakurdin, Eleni Papadopoulos, Sittinon Tang, Francois Gonzalvez, Haiquan Chen, Victor M. Rivera, Rachael Brake, Sylvie Vincent, Kwok-Kin Wong
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5311–5324.
https://doi.org/10.1158/0008-5472.CAN-21-1526
Published: 15 October 2021
View article titled, Targeting <em>HER2</em> Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib
Open the PDF for Targeting <em>HER2</em> Exon 20 Insertion–Mutant Lung Adenocarcinoma with a Novel Tyrosine Kinase Inhibitor Mobocertinib in another window
Includes: Supplementary data
Journal Articles

Abstract 5775: Identification of SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that has strong anti-tumor activity in wild-type and mutant ER+ breast cancer models

Maysoun Shomali, Youssef El-Ahmad, Frank Halley, Jane Cheng, Michael Weinstein, Muchun Wang, Fangxian Sun, Natalia Malkova, Mikhail Levit, Malvika Koundinya, Zhuyan Gou, Andrew Hebert, Jessica McManus, Dietmar Hoffman, Hui Cao, Joonil Jung, Jack Pollard, Sylvie Vincent, Timothy Ackerson, Francisco Adrian, Chris Winter, Victoria Richon, Hong Chen, Karl Hsu, Joanne Lager, Albane Courjaud, Rosalia Arrebola, Laurent Besret, Pierre-Yves Abecassis, Laurent Schio, Gary McCort, Michel Tabart, Victor Certal, Fabienne Thompson, Bruno Filoche-Rommé, Laurent Debussche, Patrick Cohen, Carlos Garcia-Echeverria, Monsif Bouaboula
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 5775.
https://doi.org/10.1158/1538-7445.AM2018-5775
Published: 01 July 2018
View article titled, Abstract 5775: Identification of SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that has strong anti-tumor activity in wild-type and mutant ER+ breast cancer models
Journal Articles

Abstract 943: SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer

Monsif Bouaboula, Maysoun Shomali, Jane Cheng, Natalia Malkova, Fangxian Sun, Malvika Koundinya, Zhuyan Guo, Stephane Poirier, Mikhail Levit, Dietmar Hoffman, Hui Cao, Laurent Bestret, Francisco Adrian, Christoph Winter, Youssef El-Ahmad, Sylvie Vincent, Frank Halley, Gary McCort, Laurent Schio, Vicky Richon, Hong Cheng, Karl Hsu, Chris Soria, Patrick Cohen, Joanne Lager, Carlos Garcia-Echeverria, Laurent Debussche
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 943.
https://doi.org/10.1158/1538-7445.AM2018-943
Published: 01 July 2018
View article titled, Abstract 943: SAR439859, an orally bioavailable selective estrogen receptor degrader (SERD) that demonstrates robust antitumor efficacy and limited cross-resistance in ER+ breast cancer
Journal Articles

Abstract LB-226: Exosomal liquid biopsy reveals mRNA and lincRNA biomarkers in early stage breast cancer patient plasma

Sudipto K. Chakrabortty, Robert R. Kitchen, Christine M. Coticchia, Vasisht R. Tadigotla, Erez Eitan, Elena Castellanos-Rizaldos, Lisa Bedford, Sunita Badola, Michael D. Valentino, Nicholas Colafemina, Hidefumi Uchiyama, Mario Morken, Miguel Williams, Sylvie Vincent, Hadi Danaee, Seth Yu, Johan Skog
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-226.
https://doi.org/10.1158/1538-7445.AM2018-LB-226
Published: 01 July 2018
View article titled, Abstract LB-226: Exosomal liquid biopsy reveals mRNA and lincRNA biomarkers in early stage breast cancer patient plasma
Journal Articles

Abstract 1228: AV-203, a fully humanized ERBB3 inhibitory antibody, reverses ERBB3-induced resistance to targeted therapies.

Steven M. Tyler, Sylvie Vincent, Christina Fleet, Steve Bottega, Donna McIntosh, Kristan Meetze, Jeno Gyuris
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 1228.
https://doi.org/10.1158/1538-7445.AM2013-1228
Published: 15 April 2013
View article titled, Abstract 1228: AV-203, a fully humanized ERBB3 inhibitory antibody, reverses ERBB3-induced resistance to targeted therapies.
Journal Articles

Abstract 3787: Pharmacokinetics and pharmacodynamics of AV-203, a humanized anti-ERBB3 antibody

Kristan Meetze, Steven M. Tyler, Christina Fleet, Sylvie Vincent, James Gifford, Jeno Gyuris
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3787.
https://doi.org/10.1158/1538-7445.AM2012-3787
Published: 15 April 2012
View article titled, Abstract 3787: Pharmacokinetics and pharmacodynamics of AV-203, a humanized anti-ERBB3 antibody
Journal Articles

Abstract 2509: AV-203, a humanized ERBB3 inhibitory antibody inhibits ligand-dependent and ligand-independent ERBB3 signaling in vitro and in vivo

Sylvie Vincent, Christina Fleet, Steven Bottega, Donna McIntosh, William Winston, Ting Chen, Steven Tyler, Kristan Meetze, Solly Weiler, Jeno Gyuris
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2509.
https://doi.org/10.1158/1538-7445.AM2012-2509
Published: 15 April 2012
View article titled, Abstract 2509: AV-203, a humanized ERBB3 inhibitory antibody inhibits ligand-dependent and ligand-independent ERBB3 signaling in vitro and in vivo
Journal Articles

Abstract 642: Novel EGFR inhibitory antibodies directed against EGFR mutants with potentially reduced toxicity

Fang Wang, Donna McIntosh, Steve Bottega, Yinghui Zhou, Christina Fleet, Jinwei Jiang, Tin Chen, Solly Weiler, William Winston, Joerg Heyer, Steven Clark, Jeno Gyuris, Sylvie Vincent
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 642.
https://doi.org/10.1158/1538-7445.AM2011-642
Published: 15 April 2011
View article titled, Abstract 642: Novel EGFR inhibitory antibodies directed against EGFR mutants with potentially reduced toxicity
Journal Articles

Abstract 628: Functional characterization of a diverse set of ERBB3 inhibitory antibodies

Sylvie Vincent, Solly Weiler, Christina Fleet, Steve Bottega, Michael Di Prima, Fang Wang, Donna McIntosh, Lyne Breault, Steven Tyler, Kristan Meetze, William Winston, Jeno Gyuris
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 628.
https://doi.org/10.1158/1538-7445.AM2011-628
Published: 15 April 2011
View article titled, Abstract 628: Functional characterization of a diverse set of ERBB3 inhibitory antibodies
Journal Articles

Genetically engineered human breast cancer in mouse (HIM): a novel cancer model system that progresses in vivo and exhibits phenotypic variations

Min Wu, Lina Jung, Adrian Cooper, Lihao Chen, Christina Fleet, Lyne Breault, Sylvie Vincent, Steve Bottega, Qiong Shen, Andrea Richardson, Stephen Naber, Ronald DePinho, Charlotte Kuperwasser, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5720.
Published: 01 May 2007
View article titled, Genetically engineered human breast cancer in mouse (HIM): a novel cancer model system that progresses in vivo and exhibits phenotypic variations
Journal Articles

Comprehensive in vivo genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis

Isabel Chiu, Lorena Lerner, Ti Cai, Jodi Zarycki, Omar Kabbarah, John Yang, Wei Hu, Sireesha Yalavarthi, Karuppiah Kannan, David Bailey, Kathryn Sun, Dmitri Bichko, Fanglei You, Jianhua Zhao, Sylvie Vincent, Steve Bottega, Ronan O'Hagan, Alisa Bell, Heidi Okamura, Yinghui Zhou, William Rideout, Min Wu, Joerg Heyer, Steve Clark, Murray Robinson
Journal: Cancer Research
Cancer Res (2007) 67 (9_Supplement): 5686.
Published: 01 May 2007
View article titled, Comprehensive <em>in vivo</em> genetic screens for tumor maintenance pathways in solid tumor models by retroviral mutagenesis