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Abstract 3079: FT-6876, a potent and selective inhibitor of CBP/p300 with antitumor activity in AR-positive breast cancer

Maureen Caligiuri, Grace L. Williams, Jennifer Castro, Linda Battalagine, Kristina Muskiewicz, Erik Wilker, Lili Yao, Shawn Schiller, Angela Toms, Ping Li, Eneida Pardo, Bradford Graves, Kenneth W. Wood, Sylvie M. Guichard

Cancer Res (2020) 80 (16_Supplement): 3079.

https://doi.org/10.1158/1538-7445.AM2020-3079

Published: 15 August 2020

View articletitled, Abstract 3079: FT-6876, a potent and selective inhibitor of CBP/p300 with antitumor activity in AR-positive breast cancer

Journal Articles

Abstract 2348: Discovery of AZD6738, a potent and selective inhibitor with the potential to test the clinical efficacy of ATR kinase inhibition in cancer patients.

Clifford D. Jones, Kevin Blades, Kevin M. Foote, Sylvie M. Guichard, Philip J. Jewsbury, Thomas McGuire, Johannes W. Nissink, Rajesh Odedra, Kin Tam, Pia Thommes, Paul Turner, Gary Wilkinson, Christine Wood, James W. Yates

Cancer Res (2013) 73 (8_Supplement): 2348.

https://doi.org/10.1158/1538-7445.AM2013-2348

Published: 15 April 2013

View articletitled, Abstract 2348: Discovery of AZD6738, a potent and selective inhibitor with the potential to test the clinical efficacy of ATR kinase inhibition in cancer patients.

Journal Articles

Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase.

Sylvie M. Guichard, Elaine Brown, Rajesh Odedra, Adina Hughes, Dan Heathcote, Jen Barnes, Alan Lau, Steve Powell, Clifford D. Jones, Willem Nissink, Kevin M. Foote, Philip J. Jewsbury, Martin Pass

Cancer Res (2013) 73 (8_Supplement): 3343.

https://doi.org/10.1158/1538-7445.AM2013-3343

Published: 15 April 2013

View articletitled, Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase.

Journal Articles

Abstract 1823: AZ20, a novel potent and selective inhibitor of ATR kinase with in vivo antitumour activity

Xavier Jacq, Lisa Smith, Elaine Brown, Adina Hughes, Rajesh Odedra, Dan Heathcote, Jen Barnes, Steve Powell, Sharon Maguire, Victoria Pearson, Joana Boros, Peter Caie, Pia A. Thommes, Willem Nissink, Kevin Foote, Philip J. Jewsbury, Sylvie M. Guichard

Cancer Res (2012) 72 (8_Supplement): 1823.

https://doi.org/10.1158/1538-7445.AM2012-1823

Published: 15 April 2012

View articletitled, Abstract 1823: AZ20, a novel potent and selective inhibitor of ATR kinase with in vivo antitumour activity

Journal Articles

Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer

Sylvie M. Guichard, Zoe Howard, Dan Heathcote, Mark Roth, Gareth Hughes, Jon Curwen, James Yates, Armelle Logie, Sarah Holt, Christine M. Chresta, Barry R. Davies, Karine Malagu, Marc Hummersone, Sarah L. Pass, Stephen Green, Martin Pass

Cancer Res (2012) 72 (8_Supplement): 917.

https://doi.org/10.1158/1538-7445.AM2012-917

Published: 15 April 2012

View articletitled, Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer

Journal Articles

Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)

Sarah V. Holt, Armelle Logie, Barry R. Davies, Denis Alferez, Sarah Runswick, Sarah Fenton, Christine M. Chresta, Yi Gu, Jingchuan Zhang, Yi-Long Wu, Robert W. Wilkinson, Sylvie M. Guichard, Paul D. Smith

Cancer Res (2012) 72 (7): 1804–1813.

https://doi.org/10.1158/0008-5472.CAN-11-1780

Published: 01 April 2012

View articletitled, Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)

Includes: Supplementary data

Journal Articles

Differential metabolism of capecitabine in liver and tumor: Use of preclinical studies and fresh human hepatocytes in vitro to identify predictive markers of response

Sylvie M. Guichard, Janet S. Macpherson, Eilidh Reid, Iain Mayer, Duncan I. Jodrell

Cancer Res (2006) 66 (8_Supplement): 734–735.

Published: 15 April 2006

View articletitled, Differential metabolism of capecitabine in liver and tumor: Use of preclinical studies and fresh human hepatocytes in vitro to identify predictive markers of response

Journal Articles

Evaluation of fresh human hepatocytes and hepatoma cell lines for in vitro prediction of hepatotoxicity caused by anticancer agents

Eilidh M. Reid, Duncan I. Jodrell, Sylvie M. Guichard

Cancer Res (2006) 66 (8_Supplement): 311.

Published: 15 April 2006

View articletitled, Evaluation of fresh human hepatocytes and hepatoma cell lines for in vitro prediction of hepatotoxicity caused by anticancer agents

Journal Articles

Bcl-xl downregulation using short hairpin RNA (shRNA) sensitises HCT-116 colon cancer cells to topoisomerase I inhibition

Sylvie M. Guichard, Mei-Ling Hua, Duncan I. Jodrell

Cancer Res (2005) 65 (9_Supplement): 1263.

Published: 01 May 2005

View articletitled, Bcl-xl downregulation using short hairpin RNA (shRNA) sensitises HCT-116 colon cancer cells to topoisomerase I inhibition

Journal Articles

Impact on the cell cycle and involvement of ATM, ATR, chk1 and chk2 kinases in the cytotoxicity of SJG-136, a new pyrrolobenzodiazepine dimer

Stephanie Arnould, Janet S. Macpherson, David E. Thurston, Duncan I. Jodrell, Sylvie M. Guichard

Cancer Res (2004) 64 (7_Supplement): 1298.

Published: 01 April 2004

View articletitled, Impact on the cell cycle and involvement of ATM, ATR, chk1 and chk2 kinases in the cytotoxicity of SJG-136, a new pyrrolobenzodiazepine dimer

Journal Articles

Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients

Lars M. Wagner, Sylvie M. Guichard, Rebecca A. Burger, Christopher L. Morton, Charles M. Straign, Richard A. Ashmun, Linda C. Harris, Peter J. Houghton, Philip M. Potter, Mary K. Danks

Cancer Res (2002) 62 (17): 5001–5007.

Published: 01 September 2002

View articletitled, Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients

Journal Articles

A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11

Mandy M. Meck, Monika Wierdl, Lars M. Wagner, Rebecca A. Burger, Sylvie M. Guichard, Erik. J. Krull, Linda C. Harris, Philip M. Potter, Mary K. Danks

Cancer Res (2001) 61 (13): 5083–5089.

Published: 01 July 2001

View articletitled, A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11

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Abstract 3079: FT-6876, a potent and selective inhibitor of CBP/p300 with antitumor activity in AR-positive breast cancer

Abstract 2348: Discovery of AZD6738, a potent and selective inhibitor with the potential to test the clinical efficacy of ATR kinase inhibition in cancer patients.

Abstract 3343: The pre-clinical in vitro and in vivo activity of AZD6738: A potent and selective inhibitor of ATR kinase.

Abstract 1823: AZ20, a novel potent and selective inhibitor of ATR kinase with in vivo antitumour activity

Abstract 917: AZD2014, a dual mTORC1 and mTORC2 inhibitor is differentiated from allosteric inhibitors of mTORC1 in ER+ breast cancer

Enhanced Apoptosis and Tumor Growth Suppression Elicited by Combination of MEK (Selumetinib) and mTOR Kinase Inhibitors (AZD8055)

Differential metabolism of capecitabine in liver and tumor: Use of preclinical studies and fresh human hepatocytes in vitro to identify predictive markers of response

Evaluation of fresh human hepatocytes and hepatoma cell lines for in vitro prediction of hepatotoxicity caused by anticancer agents

Bcl-xl downregulation using short hairpin RNA (shRNA) sensitises HCT-116 colon cancer cells to topoisomerase I inhibition

Impact on the cell cycle and involvement of ATM, ATR, chk1 and chk2 kinases in the cytotoxicity of SJG-136, a new pyrrolobenzodiazepine dimer

Efficacy and Toxicity of a Virus-directed Enzyme Prodrug Therapy Purging Method: Preclinical Assessment and Application to Bone Marrow Samples from Neuroblastoma Patients

A Virus-directed Enzyme Prodrug Therapy Approach to Purging Neuroblastoma Cells from Hematopoietic Cells Using Adenovirus Encoding Rabbit Carboxylesterase and CPT-11

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