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Journal Articles

Targeting transcriptional regulation with a CDK9 inhibitor suppresses growth of endocrine- and palbociclib-resistant ER+ breast cancers

Arany Soosainathan, Marjan Iravani, Rania El-Botty, John Alexander, Laura Sourd, Ludivine Morisset, Pierre Painsec, Rebecca Orha, Joanna Nikitorowicz-Buniak, Sunil Pancholi, Syed Haider, Mitch Dowsett, Elisabetta Marangoni, Lesley-Ann Martin, Clare M. Isacke
Journal: Cancer Research
Cancer Res (2023)
https://doi.org/10.1158/0008-5472.CAN-23-0650
Published: 06 October 2023
View article titled, Targeting transcriptional regulation with a CDK9 inhibitor suppresses growth of endocrine- and palbociclib-resistant ER+ breast cancers
Open the PDF for Targeting transcriptional regulation with a CDK9 inhibitor suppresses growth of endocrine- and palbociclib-resistant ER+ breast cancers in another window
Includes: Supplementary data
Journal Articles

Abstract 6094: Longitudinal analysis of PARP inhibitor and platinum resistance in BRCA1/2m breast cancer using liquid biopsy

Elizabeth Harvey-Jones, Maya Raghunandan, Luisa Robbez-Masson, Alaguthurai Thanussuyah, Roberta Liccardo, Arielle Yablonovitch, Mingyang Cai, Leylah Drusbosky, Michael Dorschner, Lorena Magraner Pardo, Rebecca Marlow, Asha Konde, Jennifer Trendell, John Alexander, Syed Haider, Chris Starling, Ioannis Roxanis, Jennifer Yen, Stephen J. Pettitt, Christopher J. Lord, Andrew N. Tutt
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6094.
https://doi.org/10.1158/1538-7445.AM2023-6094
Published: 04 April 2023
View article titled, Abstract 6094: Longitudinal analysis of PARP inhibitor and platinum resistance in <em>BRCA1/2m</em> breast cancer using liquid biopsy
Journal Articles

Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition

Phil Bland, Harry Saville, Abigail Read, Patty Wai, Gareth Muirhead, Lucinda Curnow, Jadwiga Nieminuszczy, Nivedita Ravindran, Marie John, Somaieh Hedayat, Holly Barker, James Wright, Lu Yu, Ioanna Mavrommati, Barrie Peck, Mark Allen, Patrycja Gazinska, Helen Pemberton, Aditi Gulati, Sarah Nash, Farzana Noor, Naomi Guppy, Ioannis Roxanis, Samantha Barlow, Helen Kalirai, Sarah Coupland, Ronan Broderick, Samar Alsafadi, Alexandre Houy, Marc-Henri Stern, Stephen Pettit, Jyoti Choudhary, Syed Haider, Wojciech Niedzwiedz, Christopher Lord, Rachael Natrajan
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P6-10-05.
https://doi.org/10.1158/1538-7445.SABCS22-P6-10-05
Published: 01 March 2023
View article titled, Abstract P6-10-05: Mutations in the RNA Splicing Factor SF3B1 drive endocrine therapy resistance and confer a targetable replication stress response defect through PARP inhibition
Journal Articles

Abstract PD9-06: Histopathological and molecular immune landscape and DNA damage response signatures to predict response to carboplatin and docetaxel in TNT trial TNBC cohort

Holly Tovey, Orsolya Sipos, Katherine A Hoadley, Joel S Parker, Jelmar Quist, Sarah Kernaghan, Lucy Kilburn, Roberto Salgado, Sherene Loi, Richard D Kennedy, Ioannis Roxanis, Patrycja Gazinska, Sarah E. Pinder, Judith Bliss, Charles M. Perou, Syed Haider, Andrew Tutt, Anita Grigoriadis, Maggie Chon U Cheang
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): PD9-06.
https://doi.org/10.1158/1538-7445.SABCS22-PD9-06
Published: 01 March 2023
View article titled, Abstract PD9-06: Histopathological and molecular immune landscape and DNA damage response signatures to predict response to carboplatin and docetaxel in TNT trial TNBC cohort
Journal Articles

SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance

Marta J. Llorca-Cardenosa, Lauren I. Aronson, Dragomir B. Krastev, Jadwiga Nieminuszczy, John Alexander, Feifei Song, Malgorzata Dylewska, Ronan Broderick, Rachel Brough, Astrid Zimmermann, Frank T. Zenke, Bora Gurel, Ruth Riisnaes, Ana Ferreira, Theodoros Roumeliotis, Jyoti Choudhary, Stephen J. Pettitt, Johann de Bono, Andres Cervantes, Syed Haider, Wojciech Niedzwiedz, Christopher J. Lord, Irene Y. Chong
Journal: Cancer Research
Cancer Res (2022) 82 (21): 3962–3973.
https://doi.org/10.1158/0008-5472.CAN-21-4339
Published: 02 November 2022
View article titled, SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance
Open the PDF for SMG8/SMG9 Heterodimer Loss Modulates SMG1 Kinase to Drive ATR Inhibitor Resistance in another window
Includes: Supplementary data
Journal Articles

Cancer-Associated Fibroblasts Suppress CD8+ T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade

Liam Jenkins, Ute Jungwirth, Alexandra Avgustinova, Marjan Iravani, Adam Mills, Syed Haider, James Harper, Clare M. Isacke
Journal: Cancer Research
Cancer Res (2022) 82 (16): 2904–2917.
https://doi.org/10.1158/0008-5472.CAN-21-4141
Published: 16 August 2022
View article titled, Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade
Open the PDF for Cancer-Associated Fibroblasts Suppress CD8<sup>+</sup> T-cell Infiltration and Confer Resistance to Immune-Checkpoint Blockade in another window
Includes: Supplementary data
Journal Articles

Abstract 5697: Targeting PARP inhibitor resistance with Polθ inhibitors

Diana Zatreanu, Helen Robinson, Omar Alkhatib, Marie Boursier, Harry Finch, Lerin Geo, Diego Grande, Vera Grinkevich, Robert Heald, Sophie Langdon, Jayesh Majithiya, Claire McWhirter, Niall Martin, Shaun Moore, Joana Neves, Eeson Rajendra, Marco Ranzani, Theresia Schaedler, Martin Stockley, Kimberley Wiggins, Rachel Brough, Sandhya Sridhar, Aditi Gulati, Nan Shao, Luted Badder, Daniela Novo, Eleanor Knight, Rebecca Marlow, Syed Haider, Elsa Callen, Graeme Hewitt, Joost Schimmel, Remko Prevo, Christina Alli, Amanda Ferdinand, Cameron Bell, Peter Blencowe, Chris Bot, Mathew Calder, Mark Charles, Jayne Curry, Tennyson Ekwuru, Andre Nussenzweig, Marcel Tijsterman, Andrew N. Tutt, Simon Boulton, Geoff Higgins, Stephen J. Pettitt, Graeme C. Smith, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5697.
https://doi.org/10.1158/1538-7445.AM2022-5697
Published: 15 June 2022
View article titled, Abstract 5697: Targeting PARP inhibitor resistance with Polθ inhibitors
Journal Articles

Abstract P4-02-05: Exploiting novel models of endocrine-resistant breast cancer to identify new therapeutic targets

Arany Soosainathan, Joanna Nikitorowicz-Buniak, Sunil Pancholi, Marjan Iravani, John Alexander, Syed Haider, Stephen R Johnston, Mitchell Dowsett, Lesley A Martin, Clare M Isacke
Journal: Cancer Research
Cancer Res (2022) 82 (4_Supplement): P4-02-05.
https://doi.org/10.1158/1538-7445.SABCS21-P4-02-05
Published: 15 February 2022
View article titled, Abstract P4-02-05: Exploiting novel models of endocrine-resistant breast cancer to identify new therapeutic targets
Journal Articles

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

Barrie Peck, Philip Bland, Ioanna Mavrommati, Gareth Muirhead, Hannah Cottom, Patty T. Wai, Sarah L. Maguire, Holly E. Barker, Eamonn Morrison, Divya Kriplani, Lu Yu, Amy Gibson, Giulia Falgari, Keith Brennan, Gillian Farnie, Richard Buus, Rebecca Marlow, Daniela Novo, Eleanor Knight, Naomi Guppy, Daniela Kolarevic, Snezana Susnjar, Natasa Medic Milijic, Kalnisha Naidoo, Patrycja Gazinska, Ioannis Roxanis, Sunil Pancholi, Lesley-Ann Martin, Erle M. Holgersen, Maggie C.U. Cheang, Farzana Noor, Sophie Postel-Vinay, Gerard Quinn, Simon McDade, Lukas Krasny, Paul Huang, Frances Daley, Fredrik Wallberg, Jyoti S. Choudhary, Syed Haider, Andrew N. Tutt, Rachael Natrajan
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (4): 847–859.
https://doi.org/10.1158/0008-5472.CAN-20-1822
Published: 15 February 2021
View article titled, 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
Open the PDF for 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract PD13-03: Genomic profiling of breast cancer leptomeningeal metastasis (BCLM) reveals a divergent evolution and therapeutic targets

Amanda Fitzpatrick, Marjan Iravani, Adam Mills, Eleanor Knight, Thanussuyah Alaguthurai, Vandna Shah, Alicia Okines, Nick Turner, Mark Harries, Syed Haider, Andrew Tutt, Clare Isacke
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD13-03.
https://doi.org/10.1158/1538-7445.SABCS20-PD13-03
Published: 15 February 2021
View article titled, Abstract PD13-03: Genomic profiling of breast cancer leptomeningeal metastasis (BCLM) reveals a divergent evolution and therapeutic targets
Journal Articles

Abstract 4072: Analysis of clinical BRCA1/2 reversions identifies hotspot mutations and predicted neoantigens associated with therapy resistance

Stephen Pettitt, Jessica Frankum, Marco Punta, Stefano Lise, John Alexander, Yi Chen, Syed Haider, Andrew N. Tutt, Christopher J. Lord
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4072.
https://doi.org/10.1158/1538-7445.AM2020-4072
Published: 15 August 2020
View article titled, Abstract 4072: Analysis of clinical <em>BRCA1/2</em> reversions identifies hotspot mutations and predicted neoantigens associated with therapy resistance
Journal Articles

Sex Differences in Cancer Driver Genes and Biomarkers

Constance H. Li, Syed Haider, Yu-Jia Shiah, Kevin Thai, Paul C. Boutros
Journal: Cancer Research
Cancer Res (2018) 78 (19): 5527–5537.
https://doi.org/10.1158/0008-5472.CAN-18-0362
Published: 01 October 2018
View article titled, Sex Differences in Cancer Driver Genes and Biomarkers
Open the PDF for Sex Differences in Cancer Driver Genes and Biomarkers in another window
Includes: Supplementary data
Journal Articles

Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer

Barrie Peck, Philip J. Bland, Patty T. Wai, Hannah Cottom, Sarah L. Maguire, Eamonn Morrison, Holly E. Barker, Divya Kriplani, Rebecca Marlow, Kalnisha Naidoo, Gareth Muirhead, Syed Haider, Frances Daley, Frederik Wallberg, Andrew N. Tutt, Rachael C. Natrajan
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 788.
https://doi.org/10.1158/1538-7445.AM2018-788
Published: 01 July 2018
View article titled, Abstract 788: Modeling tumor microenvironmental heterogeneity identifies CREBBP as a novel tumor suppressor in breast cancer
Journal Articles

Abstract SY10-02: Pan-cancer study of recurrent and heterogeneous RNA aberrations and association with whole-genome variants

Samirkumar Amin, Philip Awadalla, Andrew Biankin, Paul Boutros, Alvis Brazma, Angela Norie Brooks, Claudia Calabrese, David Chang, Aurélien Chateigner, Ken Chen, Zechen Chong, Brian Craft, Chad Creighton, Deniz Demircioğlu, Nuno Fonseca, Milana Frenkel-Morgenstern, Gad Getz, Jonathan Göke, Mary Goldman, Liliana Greger, Syed Haider, Yao He, Katherine Hoadley, Yuan Ji, Andre Kahles, Ekta Khurana, Jan Korbel, Kjong Lehmann, Han Liang, Fenglin Liu, Maximillian Marin, Matthew Meyerson, Akinyemi Ojesina, Francis Ouellette, Chandra Pedamallu, Marc Perry, Gunnar Rätsch, Roland Schwarz, Yuichi Shiraishi, Cameron Soulette, Oliver Stegle, Patrick Tan, Alfonso Valencia, Linda Xiang, Christina Yung, Junjun Zhang, Fan Zhang, Zemin Zhang, Jingchun Zhu
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): SY10-02.
https://doi.org/10.1158/1538-7445.AM2017-SY10-02
Published: 01 July 2017
View article titled, Abstract SY10-02: Pan-cancer study of recurrent and heterogeneous RNA aberrations and association with whole-genome variants
Journal Articles

Abstract 102: Pan-cancer analysis of sex differences in somatic mutation profiles

Constance H. Li, Syed Haider, Paul C. Boutros
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 102.
https://doi.org/10.1158/1538-7445.AM2016-102
Published: 15 July 2016
View article titled, Abstract 102: Pan-cancer analysis of sex differences in somatic mutation profiles
Journal Articles

Abstract LB-200: Integrating dynamic 18F-FDG PET-CT, tumor metabolomics and functional genomics to understand metformin's pharmacodynamic effects in breast cancer: results of a phase 0 clinical trial

Simon Lord, Daniel Liu, Syed Haider, Edoardo Gaude, Eugene Teoh, Patel Neel, Qifeng Zhang, Fergus Gleeson, Michael Wakelam, Christian Frezza, Francesca Buffa, Fenwick John, Adrian Harris
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): LB-200.
https://doi.org/10.1158/1538-7445.AM2016-LB-200
Published: 15 July 2016
View article titled, Abstract LB-200: Integrating dynamic 18F-FDG PET-CT, tumor metabolomics and functional genomics to understand metformin's pharmacodynamic effects in breast cancer: results of a phase 0 clinical trial
Journal Articles

Abstract A29: Hypoxia regulated long noncoding RNAs and antisense transcripts in breast cancer: Novel insights of noncoding transcriptional regulation in hypoxic microenvironment

Hani Choudhry, Ashwag Albukhari, Matteo Morotti, Syed Haider, Daniela Moralli, Johannes Schödel, Catherine Green, Carme Camps, Francesca Buffa, Peter Ratcliffe, Ioannis Ragoussis, David Mole, Adrian Harris
Journal: Cancer Research
Cancer Res (2016) 76 (6_Supplement): A29.
https://doi.org/10.1158/1538-7445.NONRNA15-A29
Published: 13 May 2016
View article titled, Abstract A29: Hypoxia regulated long noncoding RNAs and antisense transcripts in breast cancer: Novel insights of noncoding transcriptional regulation in hypoxic microenvironment
Journal Articles

Abstract 2903: Differential regulation of LC3 A and B, GABARAPL 1 and 2 autophagy genes by micro-environmental stress and role in breast cancer survival

Christos E. Zois, Syed Haider, Simon Wigfield, Alexandra Giatromanolaki, Efthimios Sivridis, Karl Morten, Ioannis Roxanis, Russell Leek, Francesca Buffa, Michael Koukourakis, Adrian L. Harris
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2903.
https://doi.org/10.1158/1538-7445.AM2015-2903
Published: 01 August 2015
View article titled, Abstract 2903: Differential regulation of LC3 A and B, GABARAPL 1 and 2 autophagy genes by micro-environmental stress and role in breast cancer survival
Journal Articles

Abstract 3750: Genomic alterations underlie a pan-cancer metabolic transcriptome shift

Syed Haider, Alan McIntyre, Ruud GPM van Stiphout, Laura M. Winchester, Simon Wigfield, Adrian L. Harris, Francesca M. Buffa
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 3750.
https://doi.org/10.1158/1538-7445.AM2015-3750
Published: 01 August 2015
View article titled, Abstract 3750: Genomic alterations underlie a pan-cancer metabolic transcriptome shift
Journal Articles

Abstract S2-01: Theranostic multiparametric tests improve residual risk assessment in early luminal breast cancer

John MS Bartlett, Vicky S Sabine, Syed Haider, Camilla Drake, Cheryl Crozier, Cindy Q Yao, Cassandra L Brookes, Cornelis JH van de Velde, Annette Hasenburg, Dirk G Kieback, Christos Markopoulos, Luc Y Dirix, Caroline Seynaeve, Daniel W Rea, Paul C Boutros
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): S2-01.
https://doi.org/10.1158/1538-7445.SABCS14-S2-01
Published: 01 May 2015
View article titled, Abstract S2-01: Theranostic multiparametric tests improve residual risk assessment in early luminal breast cancer