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Susan Jaken
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Journal Articles

Abstract 3231: Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996

Gaiying Zhao, William T. McMillen, Shufen Cai, Baohui Zhao, Matthew Whitesell, Wenjuan Wu, Karen Huss, Bryan Anderson, Xiu-Juan Yuan, Susan Jaken, Lisa Kindler, Robert S. Flack, Denis McCann, Brian Mathes, Andrew J. Dropsey, Jennie Walgren, Eunice Yuen, Jason Manro, Xueqian Gong, Guillermo Cortez, Johnathan McLean, Michael J. Rodriguez, Ramon V. Tiu, Shripad V. Bhagwat, Sajan Joseph
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3231.
https://doi.org/10.1158/1538-7445.AM2017-3231
Published: 01 July 2017
View article titled, Abstract 3231: Identifying high quality, potent and selective pyrimidinylthienopyrrolone inhibitors of ERK1/2 kinase: LY3214996
Journal Articles

Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations

Shripad V. Bhagwat, William T. McMillen, Shufen Cai, Baohui Zhao, Matthew Whitesell, Lisa Kindler, Robert S. Flack, Wenjuan Wu, Karen Huss, Bryan Anderson, Xiu-Juan Yuan, Susan Jaken, Denis McCann, Brian Mathes, Andrew J. Dropsey, Jason Manro, Jennie Walgren, Eunice Yuen, Xueqian Gong, Michael J. Rodriguez, Jianping Huang, Ramon V. Tiu, Sajan Joseph, Sheng-Bin Peng
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4973.
https://doi.org/10.1158/1538-7445.AM2017-4973
Published: 01 July 2017
View article titled, Abstract 4973: Discovery of LY3214996, a selective and novel ERK1/2 inhibitor with potent antitumor activities in cancer models with MAPK pathway alterations
Journal Articles

Protein Kinase C δ Involvement in Mammary Tumor Cell Metastasis

Susan C. Kiley, Kimberly J. Clark, Michelle Goodnough, Danny R. Welch, Susan Jaken
Journal: Cancer Research
Cancer Res (1999) 59 (13): 3230–3238.
Published: 01 July 1999
View article titled, Protein Kinase C δ Involvement in Mammary Tumor Cell Metastasis
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Journal Articles

Inhibition of Protein Kinase C Prevents Asbestos-induced c-fos and c-jun Proto-Oncogene Expression in Mesothelial Cells

Hua Fung, Timothy R. Quinlan, Yvonne M. W. Janssen, Cynthia R. Timblin, Joanne P. Marsh, Nicholas H. Heintz, Douglas J. Taatjes, Pamela Vacek, Susan Jaken, Brooke T. Mossman
Journal: Cancer Research
Cancer Res (1997) 57 (15): 3101–3105.
Published: 01 August 1997
View article titled, Inhibition of Protein Kinase C Prevents Asbestos-induced c-<em>fos</em> and c-<em>jun</em> Proto-Oncogene Expression in Mesothelial Cells
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Journal Articles

Regulation of Protein Kinase C Isozymes in Kidney Regeneration

Liqun Dong, James L. Stevens, Doriano Fabbro, Susan Jaken
Journal: Cancer Research
Cancer Res (1993) 53 (19): 4542–4549.
Published: 01 October 1993
View article titled, Regulation of Protein Kinase C Isozymes in Kidney Regeneration
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Journal Articles

Association of Phorbol Ester Receptor Down Modulation with a Cryptic Receptor State

Susan Jaken, Henry Feldman, Peter M. Blumberg, Armen H. Tashjian, Jr.
Journal: Cancer Research
Cancer Res (1983) 43 (12_Part_1): 5795–5800.
Published: 01 December 1983
View article titled, Association of Phorbol Ester Receptor Down Modulation with a Cryptic Receptor State
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Journal Articles

Relationship between Mezerein-mediated Biological Responses and Phorbol Ester Receptor Occupancy

Susan Jaken, Margaret A. Shupnik, Peter M. Blumberg, Armen H. Tashjian, Jr.
Journal: Cancer Research
Cancer Res (1983) 43 (1): 11–14.
Published: 01 January 1983
View article titled, Relationship between Mezerein-mediated Biological Responses and Phorbol Ester Receptor Occupancy
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Journal Articles

Relationship between Biological Responsiveness to Phorbol Esters and Receptor Levels in GH4C1 Rat Pituitary Cells

Susan Jaken, Armen H. Tashjian, Jr., Peter M. Blumberg
Journal: Cancer Research
Cancer Res (1981) 41 (12_Part_1): 4956–4960.
Published: 01 December 1981
View article titled, Relationship between Biological Responsiveness to Phorbol Esters and Receptor Levels in GH<sub>4</sub>C<sub>1</sub> Rat Pituitary Cells
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Journal Articles

Characterization of Phorbol Ester Receptors and Their Down-Modulation in GH4C1 Rat Pituitary Cells

Susan Jaken, Armen H. Tashjian, Jr., Peter M. Blumberg
Journal: Cancer Research
Cancer Res (1981) 41 (6): 2175–2181.
Published: 01 June 1981
View article titled, Characterization of Phorbol Ester Receptors and Their Down-Modulation in GH<sub>4</sub>C<sub>1</sub> Rat Pituitary Cells
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Journal Articles

Variation with Embryonic Development and Regional Localization of Specific [3H]Phorbol 12,13-Dibutyrate Binding to Brain

Denise S. Nagle, Susan Jaken, Monique Castagna, Peter M. Blumberg
Journal: Cancer Research
Cancer Res (1981) 41 (1): 89–93.
Published: 01 January 1981
View article titled, Variation with Embryonic Development and Regional Localization of Specific [<sup>3</sup>H]Phorbol 12,13-Dibutyrate Binding to Brain
Open the PDF for Variation with Embryonic Development and Regional Localization of Specific [<sup>3</sup>H]Phorbol 12,13-Dibutyrate Binding to Brain in another window