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Journal Articles

Abstract 407: OTS964, a TOPK inhibitor, is susceptible to ABCG2-mediated drug resistance

Yuqi Yang, Zhuo-Xun Wu, Jing-Quan Wang, Qiu-Xu Teng, Zi-Ning Lei, Sabrina Lusvarghi, Suresh V. Ambudkar, Ning Ji, Zhe-Sheng Chen

Cancer Res (2022) 82 (12_Supplement): 407.

DOI: https://doi.org/10.1158/1538-7445.AM2022-407

Published: 15 June 2022

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Journal Articles

Abstract 1270: Human P-glycoprotein-mediated drug transport: Two aromatic residues in the drug-binding pocket are critical for function

Megumi Murakami, Eduardo E. Chufan, Sabrina Lusvarghi, Suresh V. Ambudkar

Cancer Res (2019) 79 (13_Supplement): 1270.

DOI: https://doi.org/10.1158/1538-7445.AM2019-1270

Published: 01 July 2019

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Journal Articles

Abstract 3796: Selonsertib, an ASK1 inhibitor, antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance

Ning Ji, Yuqi Yang, Chao-Yun Cai, Zi-Ning Lei, Jing-Quan Wang, Pranav Gupta, Suneet Shukla, Suresh V. Ambudkar, Dexin Kong, Zhe-Sheng Chen

Cancer Res (2019) 79 (13_Supplement): 3796.

DOI: https://doi.org/10.1158/1538-7445.AM2019-3796

Published: 01 July 2019

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Journal Articles

Abstract 4895: Human ATP-binding cassette proteins ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY-1215) in cancer cell lines

Sung-Han Hsiao, Shahrooz Vahedi, Suresh V. Ambudkar, Chung-Pu Wu

Cancer Res (2018) 78 (13_Supplement): 4895.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4895

Published: 01 July 2018

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Journal Articles

Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein

Tobie D. Lee, Olivia W. Lee, Kyle R. Brimacombe, Min Shen, Lu Chen, Rajarshi Guha, Bethelihem Tebase, Robert W. Robey, Suresh V. Ambudkar, Michael M. Gottesman, Matthew D. Hall

Cancer Res (2018) 78 (13_Supplement): LB-066.

DOI: https://doi.org/10.1158/1538-7445.AM2018-LB-066

Published: 01 July 2018

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Journal Articles

Abstract 5217: Mechanism of polyspecificity of P-glycoprotein: Substitution of fifteen residues in the drug-binding pocket with tyrosine reveals a negative correlation between substrate size and transport

Shahrooz Vahedi, Eduardo Chufan, Suresh V. Ambudkar

Cancer Res (2017) 77 (13_Supplement): 5217.

DOI: https://doi.org/10.1158/1538-7445.AM2017-5217

Published: 01 July 2017

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Journal Articles

Abstract 3242: Synthetic analogs of curcumin as modulators of multidrug resistance-linked ABC transporters

Megumi Obara, Shinobu Ohnuma, Eduardo E. Chufan, Masaharu Ishida, Katsuyoshi Kudoh, Norihiko Sugisawa, Hideo Ohtsuka, Takeshi Naitoh, Hiroyuki Shibata, Yoshiharu Iwabuchi, Suresh V. Ambudkar, Michiaki Unno

Cancer Res (2017) 77 (13_Supplement): 3242.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3242

Published: 01 July 2017

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Journal Articles

Abstract 4432: A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo

Nagaraju Anreddy, Atish Patel, Yun-Kai Zhang, Yi-Jun Wang, Suneet Shukla, Rishil J. Kathawala, Priyank Kumar, Pranav Gupta, Suresh V. Ambudkar, John ND Wurpel, Zhe-Sheng Chen

Cancer Res (2015) 75 (15_Supplement): 4432.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4432

Published: 01 August 2015

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Journal Articles

Abstract 4419: Design, synthesis and biological evaluation of N-aryl-3,3,3-triﬂuoro-2-hydroxy-2-methylpropionamide analog as a promising inhibitor of the multidrug resistance-linked ABCG2 transporter

Atish S. Patel, Tianwen Li, Nagaraju Anreddy, Yufen Zhao, Rishil J. Kathawala, Yijun Wang, Suresh V. Ambudkar, Zhe-Sheng Chen, Changmei Cheng

Cancer Res (2015) 75 (15_Supplement): 4419.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4419

Published: 01 August 2015

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Journal Articles

Abstract 4422: TTT-28, a newly synthesized thiazole-valine peptide, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1 transporter

Yi-Jun Wang, Nagaraju Anreddy, Bhargav A. Patel, Eduardo E. Chufan, Satyakam Singh, Guan-Nan Zhang, Yun-Kai Zhang, Anna Maria Barbuti, Suresh V. Ambudkar, Tanaji T. Talele, Zhe-Sheng Chen

Cancer Res (2015) 75 (15_Supplement): 4422.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4422

Published: 01 August 2015

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Journal Articles

Abstract LB-224: Identification of a binding site for the tyrosine kinase inhibitor Nilotinib on the human ABC drug transporter, P-glycoprotein as determined by 3D-QSAR, molecular docking and mutational mapping

Suneet Shukla, Eduardo E. Chufan, Satyakam Singh, Amanda P. Skoumbourdis, Khyati Kapoor, Matthew B. Boxer, Damien Y. Duveau, Craig J. Thomas, Tanaji T. Talele, Suresh V. Ambudkar

Cancer Res (2014) 74 (19_Supplement): LB-224.

DOI: https://doi.org/10.1158/1538-7445.AM2014-LB-224

Published: 01 October 2014

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Journal Articles

Abstract 766: Human ABCB1 and ABCG2 confer acquired resistance to Polo-like kinase 1 inhibitors, BI 2536, volasertib and GSK641364

Chung-Pu Wu, Hong-May Sim, Suresh V. Ambudkar

Cancer Res (2014) 74 (19_Supplement): 766.

DOI: https://doi.org/10.1158/1538-7445.AM2014-766

Published: 01 October 2014

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Journal Articles

MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer

King Leung Fung, James Pan, Shinobu Ohnuma, Paul E. Lund, Jessica N. Pixley, Chava Kimchi-Sarfaty, Suresh V. Ambudkar, Michael M. Gottesman

Cancer Res (2014) 74 (2): 598–608.

DOI: https://doi.org/10.1158/0008-5472.CAN-13-2064

Published: 16 January 2014

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Includes: Supplementary data

Journal Articles

Abstract 5635: Development of a high-throughput cell and fluorescent image-based ABCB1-mediated efflux assay for screening inhibitors of ABCB1.

Megan R. Ansbro, Suneet Shukla, Suresh V. Ambudkar, Stuart H. Yuspa, Luowei Li

Cancer Res (2013) 73 (8_Supplement): 5635.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5635

Published: 15 April 2013

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Journal Articles

Abstract 898: Probing accessibility and conformational changes in ATP-binding sites during the catalytic cycle of human P-glycoprotein (ABCB1).

Hong-May Sim, Jaya Bhatnagar, Samantha A. Green, Adam Gonzalez, Eduardo E. Chufan, Suresh V. Ambudkar

Cancer Res (2013) 73 (8_Supplement): 898.

DOI: https://doi.org/10.1158/1538-7445.AM2013-898

Published: 15 April 2013

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Journal Articles

Abstract 897: Role of intracellular loops 1 and 3 in folding and cell surface expression of human P-glycoprotein (ABCB1).

Khyati Kapoor, Jaya Bhatnagar, Eduardo E. Chufan, Suresh V. Ambudkar

Cancer Res (2013) 73 (8_Supplement): 897.

DOI: https://doi.org/10.1158/1538-7445.AM2013-897

Published: 15 April 2013

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Journal Articles

Abstract 884: A metabolomics approach to identify differences between P-glycoprotein (ABCB1) expressing drug resistant and sensitive cancer cells.

Suneet Shukla, Candice Schwartz, Suresh V. Ambudkar

Cancer Res (2013) 73 (8_Supplement): 884.

DOI: https://doi.org/10.1158/1538-7445.AM2013-884

Published: 15 April 2013

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Journal Articles

Abstract 954: Multidrug resistance transcriptome analysis highlights compounds that sensitize resistant hepatocellular carcinoma through increased histone acetylation.

Jean-Pierre Gillet, Jesper B. Andersen, James P. Madigan, Sudhir Varma, Chung-Pu Wu, Anna M. Calcagno, Suresh V. Ambudkar, Snorri S. Thorgeirsson, Michael M. Gottesman

Cancer Res (2013) 73 (8_Supplement): 954.

DOI: https://doi.org/10.1158/1538-7445.AM2013-954

Published: 15 April 2013

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Journal Articles

Abstract 947: The FLT3 inhibitor AC220 (quizartinib) inhibits drug transport by ABCG2 at pharmacologically relevant concentrations and sensitizes cells to ABCG2 substrate chemotherapy drugs.

Jasjeet Bhullar, Karthika Natarajan, Suneet Shukla, Suresh V. Ambudkar, Maria R. Baer

Cancer Res (2013) 73 (8_Supplement): 947.

DOI: https://doi.org/10.1158/1538-7445.AM2013-947

Published: 15 April 2013

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Journal Articles

Abstract LB-222: Chemical and structural flexibility contribute to the broad substrate and modulator specificity of multidrug resistance-linked P-glycoprotein (ABCB1).

Suresh V. Ambudkar, Eduardo E. Chufan, Khyati Kapoor, Stewart R. Durell, Hong-May Sim

Cancer Res (2013) 73 (8_Supplement): LB-222.

DOI: https://doi.org/10.1158/1538-7445.AM2013-LB-222

Published: 15 April 2013

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NARROW

Abstract 407: OTS964, a TOPK inhibitor, is susceptible to ABCG2-mediated drug resistance

Abstract 1270: Human P-glycoprotein-mediated drug transport: Two aromatic residues in the drug-binding pocket are critical for function

Abstract 3796: Selonsertib, an ASK1 inhibitor, antagonizes ABCB1- and ABCG2-mediated chemotherapeutic drug resistance

Abstract 4895: Human ATP-binding cassette proteins ABCB1 and ABCG2 confer resistance to histone deacetylase 6 inhibitor ricolinostat (ACY-1215) in cancer cell lines

Abstract LB-066: A high-throughput screen of an annotated small molecule library identifies substrates of P-glycoprotein

Abstract 5217: Mechanism of polyspecificity of P-glycoprotein: Substitution of fifteen residues in the drug-binding pocket with tyrosine reveals a negative correlation between substrate size and transport

Abstract 3242: Synthetic analogs of curcumin as modulators of multidrug resistance-linked ABC transporters

Abstract 4432: A-803467, a tetrodotoxin-resistant sodium channel blocker, modulates ABCG2-mediated MDR in vitro and in vivo

Abstract 4419: Design, synthesis and biological evaluation of N-aryl-3,3,3-triﬂuoro-2-hydroxy-2-methylpropionamide analog as a promising inhibitor of the multidrug resistance-linked ABCG2 transporter

Abstract 4422: TTT-28, a newly synthesized thiazole-valine peptide, antagonizes multidrug resistance by inhibiting the efflux activity of the ABCB1 transporter

Abstract LB-224: Identification of a binding site for the tyrosine kinase inhibitor Nilotinib on the human ABC drug transporter, P-glycoprotein as determined by 3D-QSAR, molecular docking and mutational mapping

Abstract 766: Human ABCB1 and ABCG2 confer acquired resistance to Polo-like kinase 1 inhibitors, BI 2536, volasertib and GSK641364

MDR1 Synonymous Polymorphisms Alter Transporter Specificity and Protein Stability in a Stable Epithelial Monolayer

Abstract 5635: Development of a high-throughput cell and fluorescent image-based ABCB1-mediated efflux assay for screening inhibitors of ABCB1.

Abstract 898: Probing accessibility and conformational changes in ATP-binding sites during the catalytic cycle of human P-glycoprotein (ABCB1).

Abstract 897: Role of intracellular loops 1 and 3 in folding and cell surface expression of human P-glycoprotein (ABCB1).

Abstract 884: A metabolomics approach to identify differences between P-glycoprotein (ABCB1) expressing drug resistant and sensitive cancer cells.

Abstract 954: Multidrug resistance transcriptome analysis highlights compounds that sensitize resistant hepatocellular carcinoma through increased histone acetylation.

Abstract 947: The FLT3 inhibitor AC220 (quizartinib) inhibits drug transport by ABCG2 at pharmacologically relevant concentrations and sensitizes cells to ABCG2 substrate chemotherapy drugs.

Abstract LB-222: Chemical and structural flexibility contribute to the broad substrate and modulator specificity of multidrug resistance-linked P-glycoprotein (ABCB1).

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