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Sunyana Gadal
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Journal Articles

Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration

Open Access
Sunyana Gadal, Jacob A. Boyer, Simon F. Roy, Noah A. Outmezguine, Malvika Sharma, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Afsar Barlas, Qing Chang, Priya Pancholi, Neilawattie Merna Timaul, Michael Overholtzer, Rona Yaeger, Katia Manova-Todorova, Elisa de Stanchina, Marcus W. Bosenberg, Neal Rosen
Journal: Cancer Research
Cancer Res (2025) 85 (9): 1611–1627.
https://doi.org/10.1158/0008-5472.CAN-24-2220
Published: 02 May 2025
View articletitled, Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration
Open the PDF for Tumorigenesis Driven by BRAFV600E Requires Secondary Mutations That Overcome Its Feedback Inhibition of RAC1 and Migration in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract CT178: Phase 1 trial of PF-07799933 (ARRY-440), a next-generation BRAF inhibitor, for BRAF-mutant cancers

Free
Rona Yaeger, Meredith McKean, Rizwan Haq, Joseph T. Beck, Matthew H. Taylor, Jonathan Cohen, Daniel Bowles, Shirish M. Gadgeel, Catalin Mihalcioiu, Kyriakos P. Papadopoulos, Eli L. Diamond, Keren B. Sturtz, Gang Feng, Stefanie K. Drescher, Micaela B. Reddy, Bhaswati Sengupta, Arnab K. Maity, Suzy A. Brown, Anurag Singh, Eric N. Brown, Brian R. Baer, Jim Wong, Tung-Chung Mou, Wen I. Wu, Dean Kahn, Sunyana Gadal, Neal Rosen, John J. Gaudino, Patrice A. Lee, Dylan P. Hartley, Stephen Michael Rothenberg
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT178.
https://doi.org/10.1158/1538-7445.AM2024-CT178
Published: 05 April 2024
View articletitled, Abstract CT178: Phase 1 trial of PF-07799933 (ARRY-440), a next-generation BRAF inhibitor, for BRAF-mutant cancers
Journal Articles

Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations

Free
Sunyana Gadal, Jacob A. Boyer, Hongyan Li, Ning Fan, Eric Chan, Yevgeniy Romin, Elisa De Stanchina, Rona Yeager, Marcus Bosenberg, Katia M. Todorova, Neal Rosen
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2422.
https://doi.org/10.1158/1538-7445.AM2022-2422
Published: 15 June 2022
View articletitled, Abstract 2422: Migration of V600E-expressing cells is suppressed by ERK-dependent feedback inhibition of RAC1 and rescued in melanoma by secondary mutations
Journal Articles

Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2

Free
Ninghui Mao, Dong Gao, Wenhuo Hu, Sunyana Gadal, Haley Hieronymus, Shangqian Wang, Young Sun Lee, Patrick Sullivan, Zeda Zhang, Danielle Choi, Neal Rosen, Charles L. Sawyers, Anuradha Gopalan, Yu Chen, Brett S. Carver
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (7): 1428–1437.
https://doi.org/10.1158/0008-5472.CAN-19-1394
Published: 02 April 2020
View articletitled, Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2
Open the PDF for Oncogenic ERG Represses PI3K Signaling through Downregulation of IRS2 in another window
Includes: Supplementary data