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Stuart A. Aaronson
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Journal Articles

Abstract LB424: Mechanistic rationale for combination of RAF/MEK glue avutometinib with a pan-RAF inhibitor for RAS-mutant tumor-selective therapy

Ana Orive-Ramos, Bijaya Gaire, Christos Adamopoulos, Silvia Coma, Beau Baars, Stuart A. Aaronson, Jian Jin, Evripidis Gavathiotis, Jonathan A. Pachter, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB424.
https://doi.org/10.1158/1538-7445.AM2025-LB424
Published: 25 April 2025
View articletitled, Abstract LB424: Mechanistic rationale for combination of RAF/MEK glue avutometinib with a pan-RAF inhibitor for RAS-mutant tumor-selective therapy
Journal Articles

Abstract LB294: Mechanism of tumor-selective inhibition of dimeric RAF by a Type 1 RAF inhibitor

Mathieu Desaunay, Tara L. Peters, Beau Baars, Bijaya Gaire, Ana Orive-Ramos, Li Ren, Joseph P. Lyssikatos, Stuart A. Aaronson, Evripidis Gavathiotis, Stefan D. Gross, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB294.
https://doi.org/10.1158/1538-7445.AM2025-LB294
Published: 25 April 2025
View articletitled, Abstract LB294: Mechanism of tumor-selective inhibition of dimeric RAF by a Type 1 RAF inhibitor
Journal Articles

Abstract 5734: Designing RAF and MEK inhibitor combinations based on their biochemical properties to effectively target MAPK-driven cancers

Ana Orive-Ramos, Christos Adamopoulos, Beau Baars, Jason Lam, Ankita Punetha, Jason Huang, Vasileios I. Petrou, Stuart A. Aaronson, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 5734.
https://doi.org/10.1158/1538-7445.AM2023-5734
Published: 04 April 2023
View articletitled, Abstract 5734: Designing RAF and MEK inhibitor combinations based on their biochemical properties to effectively target MAPK-driven cancers
Journal Articles

Abstract 3413: RTK/SHP2 dependency and feedback adaptation to MEK inhibition defines sensitivity of RAS-mutant proteins to SHP2 inhibitor-based therapies

Beau Baars, Christos Adamopoulos, Ana Orive-Ramos, Stuart A. Aaronson, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3413.
https://doi.org/10.1158/1538-7445.AM2023-3413
Published: 04 April 2023
View articletitled, Abstract 3413: RTK/SHP2 dependency and feedback adaptation to MEK inhibition defines sensitivity of RAS-mutant proteins to SHP2 inhibitor-based therapies
Journal Articles

Abstract 78: A strategy for effective targeting of oncogenic BRAF signaling with increased therapeutic index using conformation-selective RAF and MEK inhibitors

Christos Adamopoulos, Tamer A. Ahmed, Maxwell R. Tucker, Peter M. Ung, Min Xiao, Zoi Karoulia, Xuewei Wu, Stuart A. Aaronson, Celina Ang, Vito Rebecca, Avner Schlessinger, Meenhard Herlyn, Qi Wang, David E. Shaw, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 78.
https://doi.org/10.1158/1538-7445.AM2021-78
Published: 01 July 2021
View articletitled, Abstract 78: A strategy for effective targeting of oncogenic BRAF signaling with increased therapeutic index using conformation-selective RAF and MEK inhibitors
Journal Articles

Abstract LB-119: SHP2 drives adaptive resistance to ERK signaling inhibition in molecularly defined subsets of ERK-dependent tumors

Christos Adamopoulos, Tamer A. Ahmed, Zoi Karoulia, Xuewei Wu, Ravi Sachidanandam, Stuart A. Aaronson, Poulikos I. Poulikakos
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): LB-119.
https://doi.org/10.1158/1538-7445.AM2019-LB-119
Published: 01 July 2019
View articletitled, Abstract LB-119: SHP2 drives adaptive resistance to ERK signaling inhibition in molecularly defined subsets of ERK-dependent tumors
Journal Articles

Abstract PR10: Functional analysis of oncogenic driver mutations in human cancer cells through CRISPR-barcoding

Alexis Guernet, Dorthe Cartier, Sathish Kumar Mungamuri, Sahil Adriouch, Myriam Vezain, Françoise Charbonnier, Sophie Coutant, Shen Yao, Hassan Ainani, David Alexandre, Olivier Boyer, Stuart A. Aaronson, Youssef Anouar, Luca Grumolato
Journal: Cancer Research
Cancer Res (2016) 76 (3_Supplement): PR10.
https://doi.org/10.1158/1538-7445.FBCR15-PR10
Published: 07 April 2016
View articletitled, Abstract PR10: Functional analysis of oncogenic driver mutations in human cancer cells through CRISPR-barcoding
Journal Articles

Abstract A53: Dose‐dependent levels of p53 mediate different cell fate decisions in human mammary epithelial cells

Martina Kracikova, Gal Akiri, Ajish Geroge, Ravi Sachidanandam, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): A53.
https://doi.org/10.1158/0008-5472.FBCR09-A53
Published: 28 October 2014
View articletitled, Abstract A53: Dose‐dependent levels of p53 mediate different cell fate decisions in human mammary epithelial cells
Journal Articles

Abstract A60: Role of telomere dysfunction in the premature cellular senescence of Hutchinson‐Gilford progeria syndrome

Erica K. Benson, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2009) 69 (23_Supplement): A60.
https://doi.org/10.1158/0008-5472.FBCR09-A60
Published: 28 October 2014
View articletitled, Abstract A60: Role of telomere dysfunction in the premature cellular senescence of Hutchinson‐Gilford progeria syndrome
Journal Articles

Abstract B28: Pro-survival role of p53 in regulating epidermal differentiation

Martina Kracikova, Gal Akiri, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): B28.
https://doi.org/10.1158/1538-7445.FBCR13-B28
Published: 15 May 2014
View articletitled, Abstract B28: Pro-survival role of p53 in regulating epidermal differentiation
Journal Articles

Abstract A02: Beta-catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors

Luca Grumolato, Guizhong Liu, Tomomi Haremaki, Sathish Kumar Mungamuri, Phyllus Mong, Gal Akiri, Pablo Lopez-Bergami, Adriana Arita, Anouar Youssef, Marek Mlodzik, Ze'ev A. Ronai, Joshua Brody, Daniel C. Weinstein, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): A02.
https://doi.org/10.1158/1538-7445.FBCR13-A02
Published: 15 May 2014
View articletitled, Abstract A02: Beta-catenin-independent activation of TCF1/LEF1 in human hematopoietic tumor cells through interaction with ATF2 transcription factors
Journal Articles

Expression of the p53 Target CDIP Correlates with Sensitivity to TNFα-Induced Apoptosis in Cancer Cells

Lauren Brown-Endres, David Schoenfeld, Fang Tian, Hyung-Gu Kim, Takushi Namba, César Muñoz-Fontela, Anna Mandinova, Stuart A. Aaronson, Sam W. Lee
Journal: Cancer Research
Cancer Res (2012) 72 (9): 2373–2382.
https://doi.org/10.1158/0008-5472.CAN-11-3369
Published: 30 April 2012
View articletitled, Expression of the p53 Target CDIP Correlates with Sensitivity to TNFα-Induced Apoptosis in Cancer Cells
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Includes: Supplementary data
Journal Articles

Clonal Selection in Malignant Transformation of Human Fibroblasts Transduced with Defined Cellular Oncogenes

Alka M. Mahale, Zahid A.T. Khan, Makoto Igarashi, Gouri J. Nanjangud, Rui Fang Qiao, Shen Yao, Sam W. Lee, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2008) 68 (5): 1417–1426.
https://doi.org/10.1158/0008-5472.CAN-07-3021
Published: 03 March 2008
View articletitled, Clonal Selection in Malignant Transformation of Human Fibroblasts Transduced with Defined Cellular Oncogenes
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Includes: Supplementary data
Journal Articles

Androgen-Induced Wnt Signaling in Preosteoblasts Promotes the Growth of MDA-PCa-2b Human Prostate Cancer Cells

Xin-Hua Liu, Alexander Kirschenbaum, Shen Yao, Guizhong Liu, Stuart A. Aaronson, Alice C. Levine
Journal: Cancer Research
Cancer Res (2007) 67 (12): 5747–5753.
https://doi.org/10.1158/0008-5472.CAN-07-0478
Published: 15 June 2007
View articletitled, Androgen-Induced Wnt Signaling in Preosteoblasts Promotes the Growth of MDA-PCa-2b Human Prostate Cancer Cells
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Journal Articles

Discoidin Domain Receptor 1 Receptor Tyrosine Kinase Induces Cyclooxygenase-2 and Promotes Chemoresistance through Nuclear Factor-κB Pathway Activation

Sanjeev Das, Pat P. Ongusaha, Yoon Sun Yang, Jin-Mo Park, Stuart A. Aaronson, Sam W. Lee
Journal: Cancer Research
Cancer Res (2006) 66 (16): 8123–8130.
https://doi.org/10.1158/0008-5472.CAN-06-1215
Published: 15 August 2006
View articletitled, Discoidin Domain Receptor 1 Receptor Tyrosine Kinase Induces Cyclooxygenase-2 and Promotes Chemoresistance through Nuclear Factor-κB Pathway Activation
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Journal Articles

Dickkopf-1 promotes prostate cancer cell growth within the bone

Christopher L. Hall, Anna Bafico, Stuart A. Aaronson, Evan T. Keller
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 936–937.
Published: 15 April 2006
View articletitled, Dickkopf-1 promotes prostate cancer cell growth within the bone
Journal Articles

Prostate Cancer Cells Promote Osteoblastic Bone Metastases through Wnts

Christopher L. Hall, Anna Bafico, Jinlu Dai, Stuart A. Aaronson, Evan T. Keller
Journal: Cancer Research
Cancer Res (2005) 65 (17): 7554–7560.
https://doi.org/10.1158/0008-5472.CAN-05-1317
Published: 01 September 2005
View articletitled, Prostate Cancer Cells Promote Osteoblastic Bone Metastases through Wnts
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Journal Articles

Evidence against a Role for SV40 in Human Mesothelioma

James J. Manfredi, Jianli Dong, Wen-jun Liu, Lois Resnick-Silverman, Rui Qiao, Philippe Chahinian, Marko Saric, Allen R. Gibbs, James I. Phillips, J. Murray, Charles W. Axten, Robert P. Nolan, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2005) 65 (7): 2602–2609.
https://doi.org/10.1158/0008-5472.CAN-04-2461
Published: 01 April 2005
View articletitled, Evidence against a Role for SV40 in Human Mesothelioma
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Journal Articles

BRAF Oncogenic Mutations Correlate with Progression rather than Initiation of Human Melanoma

Jianli Dong, Robert G. Phelps, Rui Qiao, Shen Yao, Outhiriaradjou Benard, Zeev Ronai, Stuart A. Aaronson
Journal: Cancer Research
Cancer Res (2003) 63 (14): 3883–3885.
Published: 21 July 2003
View articletitled, BRAF Oncogenic Mutations Correlate with Progression rather than Initiation of Human Melanoma
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Journal Articles

Inhibition of Tumor Cell Growth by RTP/rit42 and Its Responsiveness to p53 and DNA Damage

Siavash K. Kurdistani, Paz Arizti, Corinne L. Reimer, Mary M. Sugrue, Stuart A. Aaronson, Sam W. Lee
Journal: Cancer Research
Cancer Res (1998) 58 (19): 4439–4444.
Published: 01 October 1998
View articletitled, Inhibition of Tumor Cell Growth by RTP/rit42 and Its Responsiveness to p53 and DNA Damage
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