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Steven P. Balk
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Journal Articles

Abstract A009: Distinct activity of androgen receptor splice variants in promoting prostate cancer metastasis

Maryam Labaf, Dong Han, Yawei Zhao, Jude Owiredu, Songqi Zhang, Kavita Venkataramani, Jocelyn S. Steinfeld, Wanting Han, Muqing Li, Mingyu Liu, Zifeng Wang, Anna Besschetnova, Susan C. Patalano-Salsman, Jill A. Macoska, Xin Yuan, Steven P. Balk, Stephen R. Plymate, Shuai Gao, Kellee R. Siegfried-Harris, Ruihua Liu, Gabrielle Foxa, Mary M. Stangis, Piotr J. Czernik, Bart Williams, Kourosh Zarringhalam, Xiaohong Li, Changmeng Cai
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A009.
https://doi.org/10.1158/1538-7445.PRCA2023-A009
Published: 02 June 2023
View article titled, Abstract A009: Distinct activity of androgen receptor splice variants in promoting prostate cancer metastasis
Journal Articles

Abstract A014: NFI-family transcriptional factors direct AR cistrome redistribution during prostate cancer tumorigenesis

Larysa Poluben, Joshua Russo, Olga Voznesensky, Mannan Nouri, Anastasia Stavridi, Xintao Qiu, Matthew Freedman, Henry W. Long, Steven P. Balk
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A014.
https://doi.org/10.1158/1538-7445.PRCA2023-A014
Published: 02 June 2023
View article titled, Abstract A014: NFI-family transcriptional factors direct AR cistrome redistribution during prostate cancer tumorigenesis
Journal Articles

Abstract A019: Enzalutamide resistance is driven by adaptations that enhance AR splice variant and FOXA1 activities

Betul Ersoy-Fazlioglu, Larysa Poluben, Mannan Nouri, Henry W. Long, Joshua W. Russo, Steven P. Balk
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): A019.
https://doi.org/10.1158/1538-7445.PRCA2023-A019
Published: 02 June 2023
View article titled, Abstract A019: Enzalutamide resistance is driven by adaptations that enhance AR splice variant and FOXA1 activities
Journal Articles

Abstract B020: BCL2 expression is enriched in AR-independent advanced prostate cancer

Daniel Westaby, Juan M. Jimenez-Vacas, Ines Figueiredo, Claire Pettinger, Bora Gurel, Denisa Bogdan, Jan Rekowski, Lorenzo Buroni, Antje Neeb, Ruth Riisnaes, Mateus Crespo, Susana Miranda, Ana Ferreira, Daniel Nava Rodrigues, George Seed, Claudia Bertan, Maria de los Dolores Fenor de la Maza, Christina Guo, Juliet Carmichael, Rafael Grochot, Khobe Chandran, Andreas Varkaris, Steven P. Balk, Wei Yuan, Suzanne Carreira, Peter S. Nelson, Michael Haffner, Eva Corey, Johann de Bono, Adam Sharp
Journal: Cancer Research
Cancer Res (2023) 83 (11_Supplement): B020.
https://doi.org/10.1158/1538-7445.PRCA2023-B020
Published: 02 June 2023
View article titled, Abstract B020: BCL2 expression is enriched in AR-independent advanced prostate cancer
Journal Articles

LSD1 Inhibition Disrupts Super-Enhancer–Driven Oncogenic Transcriptional Programs in Castration-Resistant Prostate Cancer

Muqing Li, Mingyu Liu, Wanting Han, Zifeng Wang, Dong Han, Susan Patalano, Jill A. Macoska, Steven P. Balk, Housheng Hansen He, Eva Corey, Shuai Gao, Changmeng Cai
Journal: Cancer Research
Cancer Res (2023) 83 (10): 1684–1698.
https://doi.org/10.1158/0008-5472.CAN-22-2433
Published: 15 May 2023
View article titled, LSD1 Inhibition Disrupts Super-Enhancer–Driven Oncogenic Transcriptional Programs in Castration-Resistant Prostate Cancer
Open the PDF for LSD1 Inhibition Disrupts Super-Enhancer–Driven Oncogenic Transcriptional Programs in Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth

Keshan Wang, Fen Ma, Seiji Arai, Yun Wang, Andreas Varkaris, Larysa Poluben, Olga Voznesensky, Fang Xie, Xiaoping Zhang, Xin Yuan, Steven P. Balk
Journal: Cancer Research
Cancer Res (2023) 83 (7): 1016–1030.
https://doi.org/10.1158/0008-5472.CAN-22-3003
Published: 04 April 2023
View article titled, WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth
Open the PDF for WNT5a Signaling through ROR2 Activates the Hippo Pathway to Suppress YAP1 Activity and Tumor Growth in another window
Includes: Supplementary data
Journal Articles

Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling

Jesse C. Patterson, Andreas Varkaris, Peter J.P. Croucher, Maya Ridinger, Susan Dalrymple, Mannan Nouri, Fang Xie, Shohreh Varmeh, Oliver Jonas, Matthew A. Whitman, Sen Chen, Saleh Rashed, Lovemore Makusha, Jun Luo, John T. Isaacs, Mark G. Erlander, David J. Einstein, Steven P. Balk, Michael B. Yaffe
Journal: Cancer Research
Cancer Res (2023) 83 (2): 219–238.
https://doi.org/10.1158/0008-5472.CAN-22-1533
Published: 18 January 2023
View article titled, Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling
Open the PDF for Plk1 Inhibitors and Abiraterone Synergistically Disrupt Mitosis and Kill Cancer Cells of Disparate Origin Independently of Androgen Receptor Signaling in another window
Includes: Multimedia, Supplementary data
Journal Articles

Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer

Fen Ma, Seiji Arai, Keshan Wang, Carla Calagua, Amanda R. Yuan, Larysa Poluben, Zhongkai Gu, Joshua W. Russo, David J. Einstein, Huihui Ye, Meng Xiao He, Yu Liu, Eliezer Van Allen, Adam G. Sowalsky, Manoj K. Bhasin, Xin Yuan, Steven P. Balk
Journal: Cancer Research
Cancer Res (2022) 82 (8): 1518–1533.
https://doi.org/10.1158/0008-5472.CAN-21-1807
Published: 15 April 2022
View article titled, Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer
Open the PDF for Autocrine Canonical Wnt Signaling Primes Noncanonical Signaling through ROR1 in Metastatic Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 973: The selective polo-like kinase (Plk1) inhibitor onvansertib and the antiandrogen abiraterone synergistically kill cancer cells through disruption of mitosis independently of androgen receptor signaling

Jesse C. Patterson, Peter J. Croucher, Maya Ridinger, David J. Einstein, Andreas Varkaris, Steven P. Balk, Glenn J. Bubley, Mark G. Erlander, Michael B. Yaffe
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 973.
https://doi.org/10.1158/1538-7445.AM2021-973
Published: 01 July 2021
View article titled, Abstract 973: The selective polo-like kinase (Plk1) inhibitor onvansertib and the antiandrogen abiraterone synergistically kill cancer cells through disruption of mitosis independently of androgen receptor signaling
Journal Articles

ATM Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer

Shahrzad Rafiei, Kenyon Fitzpatrick, David Liu, Mu-Yan Cai, Haitham A. Elmarakeby, Jihye Park, Cora Ricker, Bose S. Kochupurakkal, Atish D. Choudhury, William C. Hahn, Steven P. Balk, Justin H. Hwang, Eliezer M. Van Allen, Kent W. Mouw
Journal: Cancer Research
Series: Author Choice
Cancer Res (2020) 80 (11): 2094–2100.
https://doi.org/10.1158/0008-5472.CAN-19-3126
Published: 02 June 2020
View article titled, <em>ATM</em> Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer
Open the PDF for <em>ATM</em> Loss Confers Greater Sensitivity to ATR Inhibition Than PARP Inhibition in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

ZBTB7A Mediates the Transcriptional Repression Activity of the Androgen Receptor in Prostate Cancer

Dong Han, Sujun Chen, Wanting Han, Shuai Gao, Jude N. Owiredu, Muqing Li, Steven P. Balk, Housheng Hansen He, Changmeng Cai
Journal: Cancer Research
Cancer Res (2019) 79 (20): 5260–5271.
https://doi.org/10.1158/0008-5472.CAN-19-0815
Published: 15 October 2019
View article titled, ZBTB7A Mediates the Transcriptional Repression Activity of the Androgen Receptor in Prostate Cancer
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Includes: Supplementary data
Journal Articles

Abstract 923: FOXA1 chromatin binding is regulated by LSD1-mediated methylation in prostate cancer cells

Shuai Gao, Sujun Chen, Dong Han, Wanting Han, Jude N. Owiredu, Steven P. Balk, Housheng H. He, Changmeng Cai
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 923.
https://doi.org/10.1158/1538-7445.AM2019-923
Published: 01 July 2019
View article titled, Abstract 923: FOXA1 chromatin binding is regulated by LSD1-mediated methylation in prostate cancer cells
Journal Articles

Abstract 395: Aberrant HER2 signaling is a therapeutic target in a subset of castration-resistant prostate cancer

Joshua W. Russo, Xin Gao, David J. Einstein, Glenn J. Bubley, Steven P. Balk
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 395.
https://doi.org/10.1158/1538-7445.AM2019-395
Published: 01 July 2019
View article titled, Abstract 395: Aberrant HER2 signaling is a therapeutic target in a subset of castration-resistant prostate cancer
Journal Articles

Downregulation of Dipeptidyl Peptidase 4 Accelerates Progression to Castration-Resistant Prostate Cancer

Joshua W. Russo, Ce Gao, Swati S. Bhasin, Olga S. Voznesensky, Carla Calagua, Seiji Arai, Peter S. Nelson, Bruce Montgomery, Elahe A. Mostaghel, Eva Corey, Mary-Ellen Taplin, Huihui Ye, Manoj Bhasin, Steven P. Balk
Journal: Cancer Research
Cancer Res (2018) 78 (22): 6354–6362.
https://doi.org/10.1158/0008-5472.CAN-18-0687
Published: 15 November 2018
View article titled, Downregulation of <em>Dipeptidyl Peptidase 4</em> Accelerates Progression to Castration-Resistant Prostate Cancer
Open the PDF for Downregulation of <em>Dipeptidyl Peptidase 4</em> Accelerates Progression to Castration-Resistant Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer

Sen Chen, Changmeng Cai, Adam G. Sowalsky, Huihui Ye, Fen Ma, Xin Yuan, Nicholas I. Simon, Nathanael S. Gray, Steven P. Balk
Journal: Cancer Research
Cancer Res (2018) 78 (18): 5203–5215.
https://doi.org/10.1158/0008-5472.CAN-17-3615
Published: 14 September 2018
View article titled, BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer
Open the PDF for BMX-Mediated Regulation of Multiple Tyrosine Kinases Contributes to Castration Resistance in Prostate Cancer in another window
Includes: Supplementary data
Journal Articles

Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations

Adam G. Sowalsky, Huihui Ye, Manoj Bhasin, Eliezer M. Van Allen, Massimo Loda, Rosina T. Lis, Laleh Montaser-Kouhsari, Carla Calagua, Fen Ma, Joshua W. Russo, Rachel J. Schaefer, Olga S. Voznesensky, Zhenwei Zhang, Glenn J. Bubley, Bruce Montgomery, Elahe A. Mostaghel, Peter S. Nelson, Mary-Ellen Taplin, Steven P. Balk
Journal: Cancer Research
Cancer Res (2018) 78 (16): 4716–4730.
https://doi.org/10.1158/0008-5472.CAN-18-0610
Published: 14 August 2018
View article titled, Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations
Open the PDF for Neoadjuvant-Intensive Androgen Deprivation Therapy Selects for Prostate Tumor Foci with Diverse Subclonal Oncogenic Alterations in another window
Includes: Supplementary data
Journal Articles

Abstract A041: LSD1 inhibition disrupts FOXA1-dependent AR cistrome

Shuai Gao, Dong Han, Sujun Chen, Wanting Han, Housheng Hansen He, Steven P. Balk, Changmeng Cai
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A041.
https://doi.org/10.1158/1538-7445.PRCA2017-A041
Published: 14 August 2018
View article titled, Abstract A041: LSD1 inhibition disrupts FOXA1-dependent AR cistrome
Journal Articles

Abstract A024: Prostate cancer neoadjuvant intensive androgen deprivation therapy selects for tumor foci with diverse oncogenic alterations

Adam G. Sowalsky, Huihui Ye, Manoj Bhasin, Eliezer M. Van Allen, Massimo Loda, Rosina T. Lis, Laleh Montaser, Carla Calagua, Fen Ma, Joshua W. Russo, Rachel J. Schaefer, Olga S. Voznesensky, Zhenwei Zhang, Glenn J. Bubley, Robert B. Montgomery, Elahe A. Mostaghel, Peter S. Nelson, Mary-Ellen Taplin, Steven P. Balk
Journal: Cancer Research
Cancer Res (2018) 78 (16_Supplement): A024.
https://doi.org/10.1158/1538-7445.PRCA2017-A024
Published: 14 August 2018
View article titled, Abstract A024: Prostate cancer neoadjuvant intensive androgen deprivation therapy selects for tumor foci with diverse oncogenic alterations
Journal Articles

Abstract 5497: LSD1 modulates androgen receptor cistrome in prostate cancer via regulation of FOXA1 chromatin binding

Shuai Gao, Sujun Chen, Dong Han, Wanting Han, Steven P. Balk, Housheng Hansen He, Changmeng Cai
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5497.
https://doi.org/10.1158/1538-7445.AM2017-5497
Published: 01 July 2017
View article titled, Abstract 5497: LSD1 modulates androgen receptor cistrome in prostate cancer via regulation of FOXA1 chromatin binding
Journal Articles

Abstract 4979: Cabozantinib eradicates advanced murine prostate cancer by activating neutrophil-mediated anti-tumor innate immunity

Akash Patnaik, Kenneth D. Swanson, Eva Csizmadia, Marina P. Gehring, Katja Helenius, Athalia R. Pyzer, Lily C. Wang, Jesse Novak, Olivier Elemento, Thomas B. Thornley, John M. Asara, John G. Clohessy, Kathy Kelly, Pier Paolo Pandolfi, Jacalyn M. Rosenblatt, David E. Avigan, Huihui Ye, Sabina Signoretti, Steven P. Balk, Lewis C. Cantley
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4979.
https://doi.org/10.1158/1538-7445.AM2016-4979
Published: 15 July 2016
View article titled, Abstract 4979: Cabozantinib eradicates advanced murine prostate cancer by activating neutrophil-mediated anti-tumor innate immunity