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Steven N. Hart
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Journal Articles

Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C

Chunling Hu, Anil Belur Nagaraj, Hermela Shimelis, Gemma Montalban, Kun Y. Lee, Huaizhi Huang, Carolyn A. Lumby, Jie Na, Lisa R. Susswein, Maegan E. Roberts, Megan L. Marshall, Susan Hiraki, Holly LaDuca, Elizabeth Chao, Amal Yussuf, Tina Pesaran, Susan L. Neuhausen, Christopher A. Haiman, Peter Kraft, Sara Lindstrom, Julie R. Palmer, Lauren R. Teras, Celine M. Vachon, Song Yao, Irene Ong, Katherine L. Nathanson, Jeffrey N. Weitzel, Nicholas Boddicker, Rohan Gnanaolivu, Eric C. Polley, Georges Mer, Gaofeng Cui, Rachid Karam, Marcy E. Richardson, Susan M. Domchek, Siddhartha Yadav, Kathleen S. Hruska, Jill Dolinsky, S. John Weroha, Steven N. Hart, Jacques Simard, Jean Yves Masson, Yuan-Ping Pang, Fergus J. Couch
Journal: Cancer Research
Cancer Res (2023) 83 (15): 2557–2571.
https://doi.org/10.1158/0008-5472.CAN-22-2319
Published: 01 August 2023
View article titled, Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C
Open the PDF for Functional and Clinical Characterization of Variants of Uncertain Significance Identifies a Hotspot for Inactivating Missense Variants in RAD51C in another window
Includes: Supplementary data
Journal Articles

Abstract GS4-04: Population-based Estimates of contralateral Breast Cancer Risk among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2

Siddhartha Yadav, Nicholas J. Boddicker, Jie Na, Eric C. Polley, Chunling Hu, Steven N. Hart, Rohan D. Gnanaolivu, Nicole Larson, Carolyn Dunn, Susan Holtegaard, Huaizhi Huang, Lauren R. Teras, Alpa V. Patel, James V. Lacey, Jr., Susan Neuhausen, Leslie Bernstein, Elena Martinez, Christopher Haiman, Fei Chen, Kathryn Ruddy, Janet Olson, Esther John, Allison W. Kurian, Dale P. Sandler, Katie M. O’Brien, Jack A. Taylor, Clarice R. Weinberg, Hoda Anton-Culver, Argyrios Ziogas, Gary R. Zirpoli, David E. Goldgar, Katherine L. Nathanson, Susan Domchek, Julie R. Palmer, Jeffrey Weitzel, Peter Kraft, Fergus J. Couch
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): GS4-04.
https://doi.org/10.1158/1538-7445.SABCS22-GS4-04
Published: 01 March 2023
View article titled, Abstract GS4-04: Population-based Estimates of contralateral Breast Cancer Risk among Carriers of Germline Pathogenic Variants in ATM, BRCA1, BRCA2, CHEK2, and PALB2
Journal Articles

Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study

Fei Chen, Sungshim L. Park, Lynne R. Wilkens, Peggy Wan, Steven N. Hart, Chunling Hu, Siddhartha Yadav, Fergus J. Couch, David V. Conti, Adam J. de Smith, Christopher A. Haiman
Journal: Cancer Research
Cancer Res (2022) 82 (18): 3201–3208.
https://doi.org/10.1158/0008-5472.CAN-21-4461
Published: 16 September 2022
View article titled, Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study
Open the PDF for Genetic Risk of Second Primary Cancer in Breast Cancer Survivors: The Multiethnic Cohort Study in another window
Includes: Supplementary data
Journal Articles

Abstract PD13-01: Homologous recombination deficiency represents a new therapeutic strategy for breast cancer brain metastases

Nicola S Cosgrove, Damir Varešlija, Stephen Keelan, Simon Furney, Jodi M Carter, Steven N Hart, Siddhartha Yadav, Arnold DK Hill, Steffi Oesterreich, Adrian V Lee, Fergus J Couch, Leonie Young
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PD13-01.
https://doi.org/10.1158/1538-7445.SABCS20-PD13-01
Published: 15 February 2021
View article titled, Abstract PD13-01: Homologous recombination deficiency represents a new therapeutic strategy for breast cancer brain metastases
Journal Articles

Abstract PD3-01: Population-based breast cancer risk estimates for predisposition gene mutations: Results from the CARRIERS study

Fergus J Couch, Chunling Hu, Steven N Hart, Rohan Gnanaolivu, Kun Y Lee, Jie Na, Chi Gao, Nicholas J Boddicker, Bruce Eckloff, Raed Samara, Josh Klebba, Christine B Ambrosone, Hoda Anton-Culver, Paul Auer, Leslie Bernstein, Mia M Gaudet, Christopher Haiman, Esther M John, Susan Neuhausen, Janet E Olson, Tuya Pal, Julie R Palmer, Dale P Sandler, Jack A Taylor, Amy Trentham-Dietz, Celine M Vachon, Clarice Weinberg, Song Yao, Jeffrey N Weitzel, David E Goldgar, Susan M Domchek, Katherine L Nathanson, Peter Kraft, Eric C Polley
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD3-01.
https://doi.org/10.1158/1538-7445.SABCS19-PD3-01
Published: 15 February 2020
View article titled, Abstract PD3-01: Population-based breast cancer risk estimates for predisposition gene mutations: Results from the CARRIERS study
Journal Articles

Abstract PD3-02: Polygenic risk scores provide clinically meaningful risk stratification among women carrying moderate penetrance pathogenic variants in breast cancer predisposition genes: Results from the CARRIERS study

Chi Gao, Eric C. Polley, Chunling Hu, Steven N. Hart, Rohan Gnanaolivu, Kun Y. Lee, Jie Na, Nicholas J. Boddicker, Raed Samara, Paul Auer, Leslie Bernstein, Mia Gaudet, Amy Trentham-Dietz, Song Yao, Christopher Haiman, Janet E. Olson, Susan Neuhausen, Jeffrey N. Weitzel, David E. Goldgar, Susan Domchek, Katherine L. Nathanson, Fergus J. Couch, Peter Kraft, on behalf of the CARRIERS consortium
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): PD3-02.
https://doi.org/10.1158/1538-7445.SABCS19-PD3-02
Published: 15 February 2020
View article titled, Abstract PD3-02: Polygenic risk scores provide clinically meaningful risk stratification among women carrying moderate penetrance pathogenic variants in breast cancer predisposition genes: Results from the CARRIERS study
Journal Articles

Abstract P6-08-04: Germline mutations in cancer predisposition genes in patients with invasive lobular carcinoma of the breast

Siddhartha Yadav, Holly LaDuca, Eric C. Polley, Chunling Hu, Steven N. Hart, Jie Na, Rohan Gnanaolivu, Brandon Smith, David E Goldgar, Tina Pesaran, Jill S. Dolinsky, Fergus J. Couch
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-08-04.
https://doi.org/10.1158/1538-7445.SABCS19-P6-08-04
Published: 15 February 2020
View article titled, Abstract P6-08-04: Germline mutations in cancer predisposition genes in patients with invasive lobular carcinoma of the breast
Journal Articles

Abstract P6-08-01: Comparison of recommendations for germline genetic testing in an unselected cohort of patients with breast cancer

Siddhartha Yadav, Chunling Hu, Steven N. Hart, Nicholas Boddicker, Eric C. Polley, Jie Na, Rohan Gnanaolivu, Kun Y. Lee, Janet E. Olson, Kathryn J. Ruddy, Fergus J. Couch
Journal: Cancer Research
Cancer Res (2020) 80 (4_Supplement): P6-08-01.
https://doi.org/10.1158/1538-7445.SABCS19-P6-08-01
Published: 15 February 2020
View article titled, Abstract P6-08-01: Comparison of recommendations for germline genetic testing in an unselected cohort of patients with breast cancer
Journal Articles

Abstract 4177: The joint effects of polygenic risk scores and pathogenic variants in cancer predisposition genes on breast cancer risk in the general population: results from the CARRIERS study

Chi Gao, Chunling Hu, Steven N. Hart, Rohan Gnanaolivu, Kun Y. Lee, Jenna Lilyquist, Nicholas J. Boddicker, Bruce Eckloff, Raed Samara, Josh Klebba, Paul Auer, Leslie Bernstein, Mia Gaudet, Hoda Anton-Culver, Amy Trentham-Dietz, Julie R. Palmer, Song Yao, Christopher Haiman, Janet E. Olson, Susan Domchek, Jeffrey Weitzel, David Goldgar, Katherine L. Nathanson, Eric C. Polley, Fergus J. Couch, Peter Kraft
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4177.
https://doi.org/10.1158/1538-7445.AM2019-4177
Published: 01 July 2019
View article titled, Abstract 4177: The joint effects of polygenic risk scores and pathogenic variants in cancer predisposition genes on breast cancer risk in the general population: results from the CARRIERS study
Journal Articles

Abstract 4169: Population-based breast cancer risk estimates associated with cancer predisposition gene mutations from 32,298 breast cancer patients and 31,869 matched unaffected controls from the CARRIERS study

Fergus J. Couch, Chunling Hu, Steven N. Hart, Rohan Gnanaolivu, Jenna Lilyquist, Kun Y. Lee, Chi Gao, Bruce Eckloff, Hoda Anton-Culver, Paul Auer, Leslie Bernstein, Mia Gaudet, Christopher Haiman, Julie Palmer, Amy Tentham-Dietz, Song Yao, Susan Domchek, Jeffrey N. Weitzel, David E. Goldgar, Katherine L. Nathanson, Peter Kraft, Eric C. Polley
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4169.
https://doi.org/10.1158/1538-7445.AM2019-4169
Published: 01 July 2019
View article titled, Abstract 4169: Population-based breast cancer risk estimates associated with cancer predisposition gene mutations from 32,298 breast cancer patients and 31,869 matched unaffected controls from the CARRIERS study
Journal Articles

Abstract 4265: Risks of familial breast cancer associated with known and proposed breast cancer susceptibility genes

Kara N. Maxwell, Thomas Paul Slavin, Jenna M. Lilyquist, Joseph Vijai, Susan L. Neuhausen, Steven N. Hart, Vignesh Ravichandran, Tinu Thomas, Ann Maria, Kasmintan A. Schrader, Raymond Moore, Chunling Hu, Brad Wubbenhorst, Brandon M. Wenz, Kurt D'Andrea, Susan M. Domchek, Mark E. Robson, Paulo Peterlongo, Paolo Radice, James M. Ford, Judy E. Garber, Csilla Szabo, Kenneth Offit, Katherine L. Nathanson, Fergus J. Couch, Jeffrey N. Weitzel
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 4265.
https://doi.org/10.1158/1538-7445.AM2017-4265
Published: 01 July 2017
View article titled, Abstract 4265: Risks of familial breast cancer associated with known and proposed breast cancer susceptibility genes
Journal Articles

Abstract 1287: Multigene panel testing and risk estimates in 10,233 ovarian cancer cases

Jenna Lilyquist, Holly LaDuca, Eric Polley, Hermela Shimelis, Chunling Hu, Raymond Moore, Steven N. Hart, Fergus J. Couch, Jill Dolinsky, David E. Goldgar
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1287.
https://doi.org/10.1158/1538-7445.AM2017-1287
Published: 01 July 2017
View article titled, Abstract 1287: Multigene panel testing and risk estimates in 10,233 ovarian cancer cases
Journal Articles

Abstract 2597: Breast and ovarian cancer risks associated with cancer predisposition gene mutations identified by multigene panel testing

Fergus J. Couch, David E. Goldgar, Steven N. Hart, Emily Hallberg, Raymond Moore, Huong Meeks, Robert Huether, Holly LaDuca, Elizabeth Chao, Jill Dolinsky
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 2597.
https://doi.org/10.1158/1538-7445.AM2016-2597
Published: 15 July 2016
View article titled, Abstract 2597: Breast and ovarian cancer risks associated with cancer predisposition gene mutations identified by multigene panel testing
Journal Articles

Abstract 5220: Evaluation of ACMG guideline classified variants in 180 cancer and incidental non-cancer genes in families with breast/ovarian cancer

Kara N. Maxwell, Steven N. Hart, Joseph Vijai, Kasmintan A. Schrader, Tinu Thomas, Bradley Wubbenhorst, Vignesh Ravichandran, Raymond M. Moore, Chunling Hu, Lucia Guidugli, Brandon Wenz, Thomas P. Slavin, Susan M. Domchek, Mark E. Robson, Csilla Szabo, Susan L. Neuhausen, Jeffrey N. Weitzel, Kenneth Offit, Fergus J. Couch, Katherine L. Nathanson
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 5220.
https://doi.org/10.1158/1538-7445.AM2016-5220
Published: 15 July 2016
View article titled, Abstract 5220: Evaluation of ACMG guideline classified variants in 180 cancer and incidental non-cancer genes in families with breast/ovarian cancer
Journal Articles

Abstract 810: The CARRIERS consortium: Establishing refined breast cancer risk estimates in known predisposition genes

Jenna Lilyquist, Peter Kraft, Steven N. Hart, Emily J. Hallberg, Chunling Hu, Raymond Moore, Rohan Gnanaolivu, Susan M. Domchek, Jeffrey N. Weitzel, Katherine L. Nathanson, David E. Goldgar, Fergus J. Couch
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 810.
https://doi.org/10.1158/1538-7445.AM2016-810
Published: 15 July 2016
View article titled, Abstract 810: The CARRIERS consortium: Establishing refined breast cancer risk estimates in known predisposition genes
Journal Articles

Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease

Stephen J. Murphy, Steven N. Hart, Geoffrey C. Halling, Sarah H. Johnson, James B. Smadbeck, Travis Drucker, Joema Felipe Lima, Fariborz Rakhshan Rohakhtar, Faye R. Harris, Farhad Kosari, Subbaya Subramanian, Gloria M. Petersen, Timothy D. Wiltshire, Benjamin R. Kipp, Mark J. Truty, Robert R. McWilliams, Fergus J. Couch, George Vasmatzis
Journal: Cancer Research
Cancer Res (2016) 76 (3): 749–761.
https://doi.org/10.1158/0008-5472.CAN-15-2198
Published: 31 January 2016
View article titled, Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease
Open the PDF for Integrated Genomic Analysis of Pancreatic Ductal Adenocarcinomas Reveals Genomic Rearrangement Events as Significant Drivers of Disease in another window
Includes: Supplementary data
Journal Articles

Abstract P4-12-03: Triple-negative breast cancer: Frequency of inherited mutations in breast cancer susceptibility genes

Fergus J Couch, Steven N Hart, Priyanka Sharma, Amanda Ewart Toland, Penelope Miron, Janet E Olson, Andrew Godwin, Vernon S Pankratz, Curtis Olswold, Seth Slettedahl, Lucia Guidugli, Matthias W Beckmann, Brigitte Rack, Arif B Ekici, Irene Konstantopoulou, Florentia Fostira, George Fountzilas, Liisa M Pelttari, Song Yao, Judy Garber, Angela Cox, Hiltrud Brauch, Christine Ambrosone, Heli Nevanlinna, Drakoulis Yannoukakos, Susan L Slager, Celine M Vachon, Diana M Eccles, Peter A Fasching
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P4-12-03.
https://doi.org/10.1158/1538-7445.SABCS14-P4-12-03
Published: 01 May 2015
View article titled, Abstract P4-12-03: Triple-negative breast cancer: Frequency of inherited mutations in breast cancer susceptibility genes
Journal Articles

Abstract PD3-3: Impact of neoadjuvant chemotherapy on the clonal composition of breast cancer

Matthew P Goetz, Michael T Barrett, Krishna R Kalari, Vera J Suman, Sarah A McLaughlin, Alvaro Moreno-Aspitia, Ann M Moyer, Donald W Northfelt, Richard J Gray, Jason Sinnwell, Douglas Mahoney, Poulami Barman, Peter Vedell, Xiaojia Tang, Kevin Thompson, Travis Dockter, Katie Jones, Sara J Felten, Amy Conners, Jeanette Eckel-Passow, Hughes Sicotte, Steven N Hart, Jia Yu, Daniel W Visscher, Eric D Wieben, Cloann Schultz, Minetta C Liu, James N Ingle, Liewei Wang, Richard W Weinshilboum, Judy C Boughey
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): PD3-3.
https://doi.org/10.1158/1538-7445.SABCS14-PD3-3
Published: 01 May 2015
View article titled, Abstract PD3-3: Impact of neoadjuvant chemotherapy on the clonal composition of breast cancer
Journal Articles

Abstract 1195: Feasibility of using percutaneous tumor biopsies from a prospective neoadjuvant breast cancer study to develop patient derived xenografts and assess in vivo chemotherapy sensitivity

Jia Yu, Ping Yin, Bowen Gao, Jason P. Sinnwell, Ann M. Moyer, Daniel W. Visscher, Amy L. Conners, Travis J. Dockter, Krishna R. Kalari, Xiaojia Tang, Kevin J. Thompson, Hugues Sicotte, Douglas W. Mahoney, Steven N. Hart, Peter T. Vedell, Poulami Barman, Katie N. Jones, Sarah A. McLaughlin, John A. Copland, Alvaro Moreno Aspitia, Donald W. Northfelt, Richard J. Gray, Vera J. Suman, Jeanette E. Eckel Passow, Eric D. Wieben, James N. Ingle, Zhenkun Lou, Gianrico Farrugia, Richard Weinshilboum, Matthew P. Goetz, Judy C. Boughey, Liewei Wang
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1195.
https://doi.org/10.1158/1538-7445.AM2014-1195
Published: 01 October 2014
View article titled, Abstract 1195: Feasibility of using percutaneous tumor biopsies from a prospective neoadjuvant breast cancer study to develop patient derived xenografts and assess <em>in vivo</em> chemotherapy sensitivity
Journal Articles

Abstract 4185: Analysis of sequencing data to identify potential drug targets for an individual newly diagnosed with basal breast cancer who failed to respond to current standard neoadjuvant chemotherapy

Krishna R. Kalari, Xiaojia Tang, Kevin J. Thompson, Douglas W. Mahoney, Poulami Barman, Jason P. Sinnwell, Hugues Sicotte, Peter Vedell, Steven N. Hart, Travis J. Dockter, Katie N. Jones, Amy L. Conners, Ann M. Moyer, Daniel W. Visscher, Jia Yu, Bowen Gao, Sarah A. McLaughlin, John A. Copland, Alvaro Moreno-Aspitia, Donald W. Northfelt, Richard J. Gray, Vera J. Suman, Jeanette E. Eckel Passow, Jean-Pierre A. Kocher, Eric D. Wieben, Gianrico Farrugia, Cloann G. Schultz, James N. Ingle, Richard Weinshilboum, Matthew P. Goetz, Liewei Wang, Judy C. Boughey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4185.
https://doi.org/10.1158/1538-7445.AM2014-4185
Published: 01 October 2014
View article titled, Abstract 4185: Analysis of sequencing data to identify potential drug targets for an individual newly diagnosed with basal breast cancer who failed to respond to current standard neoadjuvant chemotherapy