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Abstract 3602: Mechanisms of CAR T cell dysfunction and identification of transcription factors that drive the exhaustion phenotype

Cancer Res (2022) 82 (12_Supplement): 3602.

DOI: https://doi.org/10.1158/1538-7445.AM2022-3602

Published: 15 June 2022

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Journal Articles

Abstract 1585: T-regulatory cells impair CAR T cell-mediated antitumor activity in a murine solid tumor model

Michael S. Leibowitz, Nicholas S. Olimpo, Liqing Wang, Aparna Jorapur, Deepa Pookot, Maria Liousia, Evguenia Arguiri, Jing Sun, Astero Klampatsa, Dirk G. Brockstedt, Wayne W. Hancock, Steven M. Albelda

Cancer Res (2021) 81 (13_Supplement): 1585.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1585

Published: 01 July 2021

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Abstract 60: Induction of T cell dysfunction and NK-like T cell differentiation in vitro and in patients after CAR T cell treatment

Cancer Res (2021) 81 (13_Supplement): 60.

DOI: https://doi.org/10.1158/1538-7445.AM2021-60

Published: 01 July 2021

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Journal Articles

Abstract 3790: Human tumor-infiltrating monocytes/macrophages do not predominantly inhibit tumor-specific effector T cell responses in early-stage lung cancer: The role of macrophage versus tumor PD-L1

Jason Stadanlick, Abhishek Rao, Sunil Singhal, Michael Annunziata, Pratick Bhojnagarwala, Shaun Obrien, Edmund Moon, Edward Cantu, Gwenn Danet-Desnoyers, Hyun-Jeong Ra, Leslie Litzky, Wayne W. Hancock, Steven M. Albelda, Evgeniy Eruslanov

Cancer Res (2018) 78 (13_Supplement): 3790.

DOI: https://doi.org/10.1158/1538-7445.AM2018-3790

Published: 01 July 2018

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Journal Articles

Abstract 1013: Location matters: unique functional and transcriptional, but not flow cytometric, characteristics of intratumoral FOXP3+ Tregs vs. Tregs from other sites of patients with lung tumors

Wayne W. Hancock, Tatiana Akimova, Tianyi Zhang, Evgeniy Eruslanov, Sunil Singhal, Steven M. Albelda

Cancer Res (2017) 77 (13_Supplement): 1013.

DOI: https://doi.org/10.1158/1538-7445.AM2017-1013

Published: 01 July 2017

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Journal Articles

Abstract B27: Blockade of protein kinase A (PKA) localization augments the trafficking and anti-tumor efficacy of adoptively transferred chimeric antigen receptor-expressing T cells

Kheng Newick, Shaun O'Brien, Jing Sun, Veena Kapoor, Steve Maceyko, Albert Lo, Ellen Pure, Ed K. Moon, Steven M. Albelda

Cancer Res (2016) 76 (15_Supplement): B27.

DOI: https://doi.org/10.1158/1538-7445.TME16-B27

Published: 28 July 2016

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Journal Articles

Abstract 2294: Reversible regulation of chimeric antigen receptor surface expression

Sarah A. Richman, Liang-Chuan Wang, Edmund K. Moon, Steven M. Albelda, Michael C. Milone

Cancer Res (2016) 76 (14_Supplement): 2294.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2294

Published: 15 July 2016

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Journal Articles

Abstract 5164: Protein kinase C epsilon is a mediator of KRAS-driven lung tumorigenesis

Rachana Garg, Veena Kapoor, Martin Abba, David M. Feldser, Steven M. Albelda, Marcelo G. Kazanietz

Cancer Res (2016) 76 (14_Supplement): 5164.

DOI: https://doi.org/10.1158/1538-7445.AM2016-5164

Published: 15 July 2016

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Journal Articles

Abstract A03: Inhibition of the histone/protein acetyltransferase, Tip60, impairs Foxp3 acetylation and Treg function and thereby promotes antitumor immunity

Wayne W. Hancock, Liqing Wang, Kheng Newick, Aaron Beeler, Steven M. Albelda

Cancer Res (2016) 76 (3_Supplement): A03.

DOI: https://doi.org/10.1158/1538-7445.FBCR15-A03

Published: 07 April 2016

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Journal Articles

Abstract 1291: Tumor-infiltrating FOXP3+ T-regulatory (Treg) cells in early-stage human lung cancer exhibit enhanced suppressive function when compared to blood or lymph node (LN) Treg cells

Tatiana Akimova, Evgeniy B. Eruslanov, Pratik S. Bhojnagarwala, Jon G. Quatromoni, Jacqueline Morgen, Sunil Singhal, Steven M. Albelda, Wayne W. Hancock

Cancer Res (2015) 75 (15_Supplement): 1291.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1291

Published: 01 August 2015

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Journal Articles

Abstract 5542: Flaxseed and its lignan component protect from asbestos-induced inflammation in mice

Steven M. Albelda, Ralph A. Pietrofesa, Craig W. Menges, Joseph R. Testa, Melpo Christofidou-Solomidou

Cancer Res (2015) 75 (15_Supplement): 5542.

DOI: https://doi.org/10.1158/1538-7445.AM2015-5542

Published: 01 August 2015

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Journal Articles

Abstract 4706: TCR engineered adoptive T-cell therapy for lung cancer is augmented by combined PD1 and TIM3 antibody blockade

Edmund K. Moon, Raghuveer Ranganathan, Xiaojun Liu, Raluca Verona, Linda Snyder, Carl H. June, Yangbing Zhao, Steven M. Albelda

Cancer Res (2015) 75 (15_Supplement): 4706.

DOI: https://doi.org/10.1158/1538-7445.AM2015-4706

Published: 01 August 2015

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Journal Articles

Abstract 3187: Depleting cells expressing fibroblast activation protein disrupts tumor-promoting desmoplasia

Albert Lo, Liang-Chuan S Wang, John Scholler, James Monslow, Diana Avery, Rebecca A. Evans, David J. Bajor, Amy C. Durham, Elizabeth L. Buza, Robert H. Vonderheide, Carl H. June, Steven M. Albelda, Ellen Puré

Cancer Res (2015) 75 (15_Supplement): 3187.

DOI: https://doi.org/10.1158/1538-7445.AM2015-3187

Published: 01 August 2015

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Journal Articles

Abstract 3142: Inhibition of the transcription factor Ikaros augments the tumoricidal capacity of CD8+ T cells expressing chimeric antigen receptors

Shaun O'Brien, Liang-Chuan Wang, Kheng Newick, Rajan M. Thomas, Andrew Wells, Steven M. Albelda

Cancer Res (2015) 75 (15_Supplement): 3142.

DOI: https://doi.org/10.1158/1538-7445.AM2015-3142

Published: 01 August 2015

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Journal Articles

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

Albert Lo, Liang-Chuan S. Wang, John Scholler, James Monslow, Diana Avery, Kheng Newick, Shaun O'Brien, Rebecca A. Evans, David J. Bajor, Cynthia Clendenin, Amy C. Durham, Elizabeth L. Buza, Robert H. Vonderheide, Carl H. June, Steven M. Albelda, Ellen Puré

Cancer Res (2015) 75 (14): 2800–2810.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-3041

Published: 14 July 2015

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Includes: Supplementary data

Journal Articles

Abstract A68: Tumor-associated neutrophils (TAN) develop protumorigenic properties during tumor progression.

Inbal Mishalian, Rachel Bayuh, Lida Zolotarov, Liran Levy, Sunil Singhal, Steven M. Albelda, Zvi Gregorio Fridlender

Cancer Res (2013) 73 (1_Supplement): A68.

DOI: https://doi.org/10.1158/1538-7445.TUMIMM2012-A68

Published: 02 April 2014

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Journal Articles

Abstract PR14: Fibroblast activation protein as a universal target for chimeric antigen receptor T cell therapy in solid tumors.

Liang-Chuan S. Wang, Albert Lo, John Scholler, Carl H. June, Ellen Pure, Steven M. Albelda

Cancer Res (2013) 73 (1_Supplement): PR14.

DOI: https://doi.org/10.1158/1538-7445.TUMIMM2012-PR14

Published: 02 April 2014

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Journal Articles

Enhanced Effector Responses in Activated CD8⁺ T Cells Deficient in Diacylglycerol Kinases

Matthew J. Riese, Liang-Chuan S. Wang, Edmund K. Moon, Rohan P. Joshi, Anjana Ranganathan, Carl H. June, Gary A. Koretzky, Steven M. Albelda

Cancer Res (2013) 73 (12): 3566–3577.

DOI: https://doi.org/10.1158/0008-5472.CAN-12-3874

Published: 13 June 2013

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Includes: Supplementary data

Journal Articles

Progression of Human Bronchioloalveolar Carcinoma to Invasive Adenocarcinoma Is Modeled in a Transgenic Mouse Model of K-ras–Induced Lung Cancer by Loss of the TGF-β Type II Receptor

Alain C. Borczuk, Marieta Sole, Ping Lu, Jinli Chen, May-Lin Wilgus, Richard A. Friedman, Steven M. Albelda, Charles A. Powell

Cancer Res (2011) 71 (21): 6665–6675.

DOI: https://doi.org/10.1158/0008-5472.CAN-11-1590

Published: 30 October 2011

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Includes: Supplementary data

Journal Articles

Abstract 1236: Upregulation of stem cell markers in senescent lung cancer cells following chemotherapy

Liang-Chuan S. Wang, Guanjun Cheng, Maria C. Crisanti, Jing Sun, Steven M. Albelda

Cancer Res (2011) 71 (8_Supplement): 1236.

DOI: https://doi.org/10.1158/1538-7445.AM2011-1236

Published: 15 April 2011

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NARROW

Abstract 3602: Mechanisms of CAR T cell dysfunction and identification of transcription factors that drive the exhaustion phenotype

Abstract 1585: T-regulatory cells impair CAR T cell-mediated antitumor activity in a murine solid tumor model

Abstract 60: Induction of T cell dysfunction and NK-like T cell differentiation in vitro and in patients after CAR T cell treatment

Abstract 3790: Human tumor-infiltrating monocytes/macrophages do not predominantly inhibit tumor-specific effector T cell responses in early-stage lung cancer: The role of macrophage versus tumor PD-L1

Abstract 1013: Location matters: unique functional and transcriptional, but not flow cytometric, characteristics of intratumoral FOXP3+ Tregs vs. Tregs from other sites of patients with lung tumors

Abstract B27: Blockade of protein kinase A (PKA) localization augments the trafficking and anti-tumor efficacy of adoptively transferred chimeric antigen receptor-expressing T cells

Abstract 2294: Reversible regulation of chimeric antigen receptor surface expression

Abstract 5164: Protein kinase C epsilon is a mediator of KRAS-driven lung tumorigenesis

Abstract A03: Inhibition of the histone/protein acetyltransferase, Tip60, impairs Foxp3 acetylation and Treg function and thereby promotes antitumor immunity

Abstract 1291: Tumor-infiltrating FOXP3+ T-regulatory (Treg) cells in early-stage human lung cancer exhibit enhanced suppressive function when compared to blood or lymph node (LN) Treg cells

Abstract 5542: Flaxseed and its lignan component protect from asbestos-induced inflammation in mice

Abstract 4706: TCR engineered adoptive T-cell therapy for lung cancer is augmented by combined PD1 and TIM3 antibody blockade

Abstract 3187: Depleting cells expressing fibroblast activation protein disrupts tumor-promoting desmoplasia

Abstract 3142: Inhibition of the transcription factor Ikaros augments the tumoricidal capacity of CD8+ T cells expressing chimeric antigen receptors

Tumor-Promoting Desmoplasia Is Disrupted by Depleting FAP-Expressing Stromal Cells

Abstract A68: Tumor-associated neutrophils (TAN) develop protumorigenic properties during tumor progression.

Abstract PR14: Fibroblast activation protein as a universal target for chimeric antigen receptor T cell therapy in solid tumors.

Enhanced Effector Responses in Activated CD8⁺ T Cells Deficient in Diacylglycerol Kinases

Progression of Human Bronchioloalveolar Carcinoma to Invasive Adenocarcinoma Is Modeled in a Transgenic Mouse Model of K-ras–Induced Lung Cancer by Loss of the TGF-β Type II Receptor

Abstract 1236: Upregulation of stem cell markers in senescent lung cancer cells following chemotherapy

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