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Steven Grant
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Journal Articles

Abstract B41: Modeling marginal zone lymphomagenesis

Victor Yazbeck, Ian McConnell, Emily Harris, Joseph Lownick, Ariel Sindel, Roy Sabo, Alden Chesney, Guanhua Lai, Adolfo Mauro, Chad Cain, Fadi Salloum, Steven Grant, Jamal Zweit, Jolene Windle, Steven Grossman
Journal: Cancer Research
Cancer Res (2020) 80 (11_Supplement): B41.
https://doi.org/10.1158/1538-7445.CAMODELS2020-B41
Published: 02 June 2020
View articletitled, Abstract B41: Modeling marginal zone lymphomagenesis
Journal Articles

Abstract 4634: Mouse model for nodal marginal zone lymphoma

Victor Yazbeck, Ian McConnell, Joseph Lownik, Ariel Sindel, Roy Sabo, Alden Chesney, Guanhua Lai, Adolfo Mauro, Jamal Zweit, Rebecca Martin, Daniel Conrad, Steven Grant, Jolene Windle, Steven Grossman
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4634.
https://doi.org/10.1158/1538-7445.AM2019-4634
Published: 01 July 2019
View articletitled, Abstract 4634: Mouse model for nodal marginal zone lymphoma
Journal Articles

Abstract LB-081: Co-targeting BCL-2 and PI3K potently induces BAXdependent mitochondrial apoptosis in AML

Steven Grant, Mohamed Rahmani, Jewel Nkwocha, Maciej Kmieciak, Joel Leverson, Deepak Sampath
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): LB-081.
https://doi.org/10.1158/1538-7445.AM2018-LB-081
Published: 01 July 2018
View articletitled, Abstract LB-081: Co-targeting BCL-2 and PI3K potently induces BAXdependent mitochondrial apoptosis in AML
Journal Articles

Abstract 4836: Targeting transcriptional regulation in multiple myeloma with a covalent CDK7 inhibitor THZ1

Liang Zhou, Yu Zhang, Kanika Sharma, Jacquelyn McCarter, William Craun, Steven Grant
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4836.
https://doi.org/10.1158/1538-7445.AM2018-4836
Published: 01 July 2018
View articletitled, Abstract 4836: Targeting transcriptional regulation in multiple myeloma with a covalent CDK7 inhibitor THZ1
Journal Articles

Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells

Mohamed Rahmani, Jewel Nkwocha, Elisa Hawkins, Xinyan Pei, Rebecca E. Parker, Maciej Kmieciak, Joel D. Leverson, Deepak Sampath, Andrea Ferreira-Gonzalez, Steven Grant
Journal: Cancer Research
Cancer Res (2018) 78 (11): 3075–3086.
https://doi.org/10.1158/0008-5472.CAN-17-3024
Published: 31 May 2018
View articletitled, Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells
Open the PDF for Cotargeting BCL-2 and PI3K Induces BAX-Dependent Mitochondrial Apoptosis in AML Cells in another window
Includes: Supplementary data
Journal Articles

Abstract 2018: Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin’s lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms

Tri Nguyen, Rebecca Parker, Elisa Hawkins, Victor Yazbeck, Akhil Kolluri, Maciej Kmieciak, Mohamed Rahmani, Steven Grant
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2018.
https://doi.org/10.1158/1538-7445.AM2017-2018
Published: 01 July 2017
View articletitled, Abstract 2018: Synergistic interactions between PLK1 and HDAC inhibitors in non-Hodgkin’s lymphoma cells occur in vitro and in vivo and proceed through multiple mechanisms
Journal Articles

Abstract 3020: Targeting both canonical and non-canonical NF-kB pathways by the IAP antagonist birinapant potentiates bortezomib anti-myeloma activity

Liang Zhou, Shuang Chen, Yu Zhang, Maciej Kmieciak, Yun Leng, Lihong Li, Hui Lin, Joel Turner, Daniel Sullivan, Yun Dai, Steven Grant
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3020.
https://doi.org/10.1158/1538-7445.AM2016-3020
Published: 15 July 2016
View articletitled, Abstract 3020: Targeting both canonical and non-canonical NF-kB pathways by the IAP antagonist birinapant potentiates bortezomib anti-myeloma activity
Journal Articles

Abstract LB-258: The NAE inhibitor pevonedistat (MLN4924) interacts with the HDAC inhibitor belinostat via disruption of the intra-S checkpoint and both HR and NHEJ DNA repair in AML cells

Liang Zhou, Shuang Chen, Yu Zhang, Yun Leng, Lihong Li, Hui Lin, Maciej Kmieciak, Kathryn A. Rizzo, Catherine I. Dumur, Andrea Ferreira-Gonzalez, Yun Dai, Steven Grant
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): LB-258.
https://doi.org/10.1158/1538-7445.AM2015-LB-258
Published: 01 August 2015
View articletitled, Abstract LB-258: The NAE inhibitor pevonedistat (MLN4924) interacts with the HDAC inhibitor belinostat via disruption of the intra-S checkpoint and both HR and NHEJ DNA repair in AML cells
Journal Articles

Abstract 4600: P-TEFb is a therapeutic target in human bortezomib-resistant multiple myeloma cells

Yun Dai, Shuang Chen, Liang Zhou, Yu Zhang, Yun Leng, Xin-Yan Pei, Hui Lin, Robert Z. Orlowski, Steven Grant
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4600.
https://doi.org/10.1158/1538-7445.AM2014-4600
Published: 01 October 2014
View articletitled, Abstract 4600: P-TEFb is a therapeutic target in human bortezomib-resistant multiple myeloma cells
Journal Articles

Abstract 2686: The CDK inhibitor dinaciclib (SCH727965) inhibits the unfolded protein response (UPR) through a CDK1- and CDK5-dependent mechanism

Tri K. Nguyen, Steven Grant
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2686.
https://doi.org/10.1158/1538-7445.AM2014-2686
Published: 01 October 2014
View articletitled, Abstract 2686: The CDK inhibitor dinaciclib (SCH727965) inhibits the unfolded protein response (UPR) through a CDK1- and CDK5-dependent mechanism
Journal Articles

Abstract 2690: Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells

Larry A. Booth, Nichola A. Cruickshanks, G B. Sajithlal, Hossein A. Hamed, Seyedmehrad Tavallai, J Syed, Steven Grant, Andrew Poklepovic, Paul Dent
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2690.
https://doi.org/10.1158/1538-7445.AM2014-2690
Published: 01 October 2014
View articletitled, Abstract 2690: Sorafenib/regorafenib and phosphatidyl inositol 3 kinase/thymoma viral proto-oncogene inhibition interact to kill tumor cells
Journal Articles

Abstract 4556: A therapeutic strategy combining the Wee1 inhibitor MK1775 with HDAC inhibitors targets both p53 wild-type or mutant AML cells

Yu Zhang, Liang Zhou, Shuang Chen, Maciej Kmieciak, Hui Lin, Yun Dai, Steven Grant
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4556.
https://doi.org/10.1158/1538-7445.AM2014-4556
Published: 01 October 2014
View articletitled, Abstract 4556: A therapeutic strategy combining the Wee1 inhibitor MK1775 with HDAC inhibitors targets both p53 wild-type or mutant AML cells
Journal Articles

Abstract 1772: Overcoming drug-resistance in multiple myeloma by CRM1 inhibitor combination therapy

Joel G. Turner, Kenneth H. Shain, Yun Dai, Jana L. Dawson, Christopher L. Cubitt, Sharon Shacham, Michael Kauffman, Steven Grant, Daniel M. Sullivan
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1772.
https://doi.org/10.1158/1538-7445.AM2014-1772
Published: 01 October 2014
View articletitled, Abstract 1772: Overcoming drug-resistance in multiple myeloma by CRM1 inhibitor combination therapy
Journal Articles

Abstract 796: Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy

Nichola A. Cruickshanks, Hossein A. Hamed, Larry A. Booth, Seyedmehrad Tavallai, G B. Sajithlal, Steven Grant, Andrew Poklepovic, Paul Dent
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 796.
https://doi.org/10.1158/1538-7445.AM2014-796
Published: 01 October 2014
View articletitled, Abstract 796: Histone deacetylase inhibitors restore toxic BH3 domain protein expression in anoikis-resistant mammary and brain cancer stem cells, thereby enhancing the response to anti-ERBB1/ERBB2 therapy
Journal Articles

Abstract LB-225: E2F1 potentiates proteasome inhibition-mediated cell death in leukemia cells through induction of Noxa

Mohamed Rahmani, Mandy Mayo Aust, Steven Grant
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): LB-225.
https://doi.org/10.1158/1538-7445.AM2014-LB-225
Published: 01 October 2014
View articletitled, Abstract LB-225: E2F1 potentiates proteasome inhibition-mediated cell death in leukemia cells through induction of Noxa
Journal Articles

Abstract 3420: The novel Chk1 inhibitor MK8776 sensitizes AML cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.

Shuang Chen, Maciej Kmieciak, Liang Zhou, Hui Lin, Xin-Yan Pei, Yun Dai, Steven Grant
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3420.
https://doi.org/10.1158/1538-7445.AM2013-3420
Published: 15 April 2013
View articletitled, Abstract 3420: The novel Chk1 inhibitor MK8776 sensitizes AML cells to HDAC inhibitors by targeting the intra-S checkpoint and DNA replication and repair.
Journal Articles

Abstract 3390: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1-mediated anti-apoptotic functions and bortezomib resistance in human multiple myeloma cells.

Xin-Yan Pei, Yun Dai, Jessica Felthousen, Shuang Chen, Yukie Takabatake, Leena E. Youssefian, Wesley W. Bodie, Lora B. Kramer, Robert Z. Orlowski, Steven Grant
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3390.
https://doi.org/10.1158/1538-7445.AM2013-3390
Published: 15 April 2013
View articletitled, Abstract 3390: Simultaneous Chk1 and MEK1/2 inhibition circumvents Mcl-1-mediated anti-apoptotic functions and bortezomib resistance in human multiple myeloma cells.
Journal Articles

Abstract 3902: MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.

Swadesh K. Das, Timothy P. Kegelman, Prasanna K. Santhekadur, Santanu Dasgupta, Paul Dent, Steven Grant, Luni Emdad, Devanand Sarkar, Paul B. Fisher, Maurizio Pellecchia
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3902.
https://doi.org/10.1158/1538-7445.AM2013-3902
Published: 15 April 2013
View articletitled, Abstract 3902: MDA-9/syntenin and IGFBP-2 promote angiogenesis in human melanoma.
Journal Articles

Abstract 2960: Flavopiridol-mediated multiple modulatory effects synergistically increase sensitivity to TRAIL-induced cell death in human leukemia cells.

Swaminathan P. Iyer, Jaime Mejia, Adriana E. Rosato, Steven Grant, Roberto R. Rosato
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2960.
https://doi.org/10.1158/1538-7445.AM2013-2960
Published: 15 April 2013
View articletitled, Abstract 2960: Flavopiridol-mediated multiple modulatory effects synergistically increase sensitivity to TRAIL-induced cell death in human leukemia cells.
Journal Articles

Abstract 588: PLK1 inhibitors interact synergistically with HDAC inhibitors in IM-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.

Girija Prasad Dasmahapatra, Hiral Patel, Tri Nguyen, Elisa Benson, Steven Grant
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 588.
https://doi.org/10.1158/1538-7445.AM2013-588
Published: 15 April 2013
View articletitled, Abstract 588: PLK1 inhibitors interact synergistically with HDAC inhibitors in IM-sensitive or -resistant BCR/ABL+ leukemia cells in vitro and in vivo.