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Steven D. Leach
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Journal Articles

Abstract PR-11: Altered mRNA splicing mimics chromosome loss and drives pancreatic cancer

Free
Natasha Pinto Medici, Diana Martinez-Saucedo, Danny Lee, Tianyi Chu, Robert Tseng, Vincent Cannataro, Jeffrey Townsend, Christine Iacobuzio-Donahue, Marie Robert, Omar Abdel-Wahab, Steven D. Leach, Luisa Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): PR-11.
https://doi.org/10.1158/1538-7445.PANCREATIC24-PR-11
Published: 15 September 2024
View articletitled, Abstract PR-11: Altered mRNA splicing mimics chromosome loss and drives pancreatic cancer
Journal Articles

Abstract B112: Single-cell profiling of neoplastic cell populations in a KRAS-initiated zebrafish pancreatic cancer model

Free
Somer M. Matar, Britton C. Goodale, Xiaoying Liu, Annie Katanga, Nicole F. Gallien, Sandra Blazquez, Direna Alonso-Curbelo, Steven D. Leach
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): B112.
https://doi.org/10.1158/1538-7445.PANCA2023-B112
Published: 16 January 2024
View articletitled, Abstract B112: Single-cell profiling of neoplastic cell populations in a KRAS-initiated zebrafish pancreatic cancer model
Journal Articles

Abstract C075: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability

Free
Natasha Pinto Medici, Diana Martinez Saucedo, Danny Lee, Li-Ting Ku, Robert Tseng, Xinning Shan, Tianyi Chu, Pablo Perez-Piñera, Vincent Cannataro, Jeffrey Townsend, Christine Iacobuzio-Donahue, Marie Robert, Omar Abdel-Wahab, Steven D. Leach, Luisa Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2024) 84 (2_Supplement): C075.
https://doi.org/10.1158/1538-7445.PANCA2023-C075
Published: 16 January 2024
View articletitled, Abstract C075: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability
Journal Articles

Abstract A055: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability

Free
Natasha Pinto Medici, Diana Martinez Saucedo, Danny Lee, Li-Ting Ku, Robert Tseng, Vincent Cannataro, Deanne Yugawa, Sumedha Chowdhury, Jeffrey Townsend, Christine A. Iacobuzio-Donahue, Omar Abdel-Wahab, Steven D. Leach, Luisa Escobar-Hoyos
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): A055.
https://doi.org/10.1158/1538-7445.PANCA22-A055
Published: 15 November 2022
View articletitled, Abstract A055: Altered RNA splicing causes pancreatic cancer and exposes a therapeutic vulnerability
Journal Articles

Abstract B055: Rac1 is essential for the maintenance of established KrasG12D-driven pancreatic ductal adenocarcinoma through senescence escape

Free
Adrien Grimont, David J. Falvo, Paul Zumbo, Grace Pan, John Nguyen, Rhonda K. Yantiss, Doron Betel, Laura Martin, Steven D. Leach, Rohit Chandwani
Journal: Cancer Research
Cancer Res (2022) 82 (22_Supplement): B055.
https://doi.org/10.1158/1538-7445.PANCA22-B055
Published: 15 November 2022
View articletitled, Abstract B055: Rac1 is essential for the maintenance of established KrasG12D-driven pancreatic ductal adenocarcinoma through senescence escape
Journal Articles

Abstract PR-005: Chromatin dynamics in vivo define coordinate functions of inflammation and mutant Kras in pancreatic tumorigenesis

Free
David Falvo, Jason Pitarresi, Alexa Osterhoudt, Adrien Grimont, Ben Stanger, Steven D. Leach, Anil K. Rustgi, Rohit Chandwani
Journal: Cancer Research
Cancer Res (2021) 81 (22_Supplement): PR-005.
https://doi.org/10.1158/1538-7445.PANCA21-PR-005
Published: 15 November 2021
View articletitled, Abstract PR-005: Chromatin dynamics in vivo define coordinate functions of inflammation and mutant Kras in pancreatic tumorigenesis
Journal Articles

Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules

Free
Kamini Singh, Jianan Lin, Nicolas Lecomte, Prathibha Mohan, Askan Gokce, Viraj R. Sanghvi, Man Jiang, Olivera Grbovic-Huezo, Antonija Burčul, Stefan G. Stark, Paul B. Romesser, Qing Chang, Jerry P. Melchor, Rachel K. Beyer, Mark Duggan, Yoshiyuki Fukase, Guangli Yang, Ouathek Ouerfelli, Agnes Viale, Elisa de Stanchina, Andrew W. Stamford, Peter T. Meinke, Gunnar Rätsch, Steven D. Leach, Zhengqing Ouyang, Hans-Guido Wendel
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (8): 2002–2014.
https://doi.org/10.1158/0008-5472.CAN-20-2929
Published: 15 April 2021
View articletitled, Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules
Open the PDF for Targeting eIF4A-Dependent Translation of KRAS Signaling Molecules in another window
Includes: Supplementary data
Journal Articles

Abstract IA-20: Team science: Lessons from a few decades on the pancreatic cancer research team

Free
Steven D. Leach
Journal: Cancer Research
Cancer Res (2020) 80 (22_Supplement): IA-20.
https://doi.org/10.1158/1538-7445.PANCA20-IA-20
Published: 13 November 2020
View articletitled, Abstract IA-20: Team science: Lessons from a few decades on the pancreatic cancer research team
Journal Articles

Abstract LB-263: Pancreatic cancer prognosis is predicted by chromatin accessibility microarray

Free
Surajit Dhara, Sagar Chhangawala, Himanshu Chintalapudi, Alexandra L. Massa, Victoria Aveson, Gokce Askan, Liguo Zhang, Remy Nicolle, Alvin P. Makohon-Moore, Smrita Sinha, Jiang Gui, Richard Moffitt, Kenneth H. Yu, Vinod Balachandran, Rohit Chandwani, Christina Leslie, Steven D. Leach
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): LB-263.
https://doi.org/10.1158/1538-7445.AM2020-LB-263
Published: 15 August 2020
View articletitled, Abstract LB-263: Pancreatic cancer prognosis is predicted by chromatin accessibility microarray
Journal Articles

Abstract B20: KrasG12D effector dependencies in the maintenance of pancreatic ductal adenocarcinoma

Free
Adrien Grimont, Zhen Zhao, Steven D. Leach, Rohit Chandwani
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B20.
https://doi.org/10.1158/1538-7445.PANCA19-B20
Published: 13 December 2019
View articletitled, Abstract B20: KrasG12D effector dependencies in the maintenance of pancreatic ductal adenocarcinoma
Journal Articles

Abstract C40: Dissecting key biologic processes in pancreatic cancer metastasis using a genetically defined 3D organoid model

Free
Fong Cheng Pan, Angie Ai-Nok Chong, Steven D. Leach, Shuibing Chen, Todd Evans
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): C40.
https://doi.org/10.1158/1538-7445.PANCA19-C40
Published: 13 December 2019
View articletitled, Abstract C40: Dissecting key biologic processes in pancreatic cancer metastasis using a genetically defined 3D organoid model
Journal Articles

Abstract B02: Tissue-specific innate lymphoid cells are novel targets for pancreatic cancer immunotherapy

Free
Joanne Leung, Luis A Rojas, Jennifer Ruan, Julia Zhao, Billel Gasmi, Zachary Sethna, Anita Ramnarain, Umesh Bhanot, Gokce Askan, Murali Gururajan, Ela Elyada, Youngkyu Park, David A. Tuveson, Mithat Gonen, Steven D. Leach, Jedd D. Wolchok, Ronald P. DeMatteo, Taha Merghoub, Vinod P. Balachandran, John Alec Moral
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): B02.
https://doi.org/10.1158/1538-7445.PANCA19-B02
Published: 13 December 2019
View articletitled, Abstract B02: Tissue-specific innate lymphoid cells are novel targets for pancreatic cancer immunotherapy
Journal Articles

Abstract A05: Chromatin dynamics in vivo reveal a complex cell fate transition and master regulators of the development of pancreatic intraepithelial neoplasia

Free
Rohit Chandwani, Alexa Osterhoudt, Richard Koche, Steven D. Leach
Journal: Cancer Research
Cancer Res (2019) 79 (24_Supplement): A05.
https://doi.org/10.1158/1538-7445.PANCA19-A05
Published: 13 December 2019
View articletitled, Abstract A05: Chromatin dynamics in vivo reveal a complex cell fate transition and master regulators of the development of pancreatic intraepithelial neoplasia
Journal Articles

PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk

Free
Smrita Sinha, Ya-Yuan Fu, Adrien Grimont, Maren Ketcham, Kelly Lafaro, Joseph A. Saglimbeni, Gokce Askan, Jennifer M. Bailey, Jerry P. Melchor, Yi Zhong, Min Geol Joo, Olivera Grbovic-Huezo, In-Hong Yang, Olca Basturk, Lindsey Baker, Young Park, Robert C. Kurtz, David Tuveson, Steven D. Leach, Pankaj J. Pasricha
Journal: Cancer Research
Cancer Res (2017) 77 (8): 1868–1879.
https://doi.org/10.1158/0008-5472.CAN-16-0899
Published: 13 April 2017
View articletitled, PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk
Open the PDF for PanIN Neuroendocrine Cells Promote Tumorigenesis via Neuronal Cross-talk in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract A76: Influence of IL-17-secreting immune cells on pancreatic cancer stemness

Free
Yu Zhang, Ismet Sahin, Sonal Gupta, Anirban Maitra, Jay K. Kolls, Jennifer Bailey, Steven D Leach, Florencia McAllister
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): A76.
https://doi.org/10.1158/1538-7445.PANCA16-A76
Published: 14 December 2016
View articletitled, Abstract A76: Influence of IL-17-secreting immune cells on pancreatic cancer stemness
Journal Articles

Abstract PR03: Mutant p53 promotes adenocarcinoma in pancreatic ductal cells

Free
Kishore Polireddy, Audrey Hendley, Melissa A. Pruski, Kelly Lafaro, Mamoun Younes, Anirban Maitra, Florencia McAllister, Christine A. Iacobuzio-Donahue, Wasim A. Dar, John S. Bynon, Steven D. Leach, Jennifer M. Bailey
Journal: Cancer Research
Cancer Res (2016) 76 (24_Supplement): PR03.
https://doi.org/10.1158/1538-7445.PANCA16-PR03
Published: 14 December 2016
View articletitled, Abstract PR03: Mutant p53 promotes adenocarcinoma in pancreatic ductal cells
Journal Articles

p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia

Free
Audrey M. Hendley, Yue J. Wang, Kishore Polireddy, Janivette Alsina, Ishrat Ahmed, Kelly J. Lafaro, Hao Zhang, Nilotpal Roy, Samuel G. Savidge, Yanna Cao, Matthias Hebrok, Anirban Maitra, Albert B. Reynolds, Michael Goggins, Mamoun Younes, Christine A. Iacobuzio-Donahue, Steven D. Leach, Jennifer M. Bailey
Journal: Cancer Research
Cancer Res (2016) 76 (11): 3351–3363.
https://doi.org/10.1158/0008-5472.CAN-15-2268
Published: 31 May 2016
View articletitled, p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia
Open the PDF for p120 Catenin Suppresses Basal Epithelial Cell Extrusion in Invasive Pancreatic Neoplasia in another window
Includes: Supplementary data
Journal Articles

Abstract 4186: p120 catenin: A novel regulator of epithelial cell delamination in early Kras-driven pancreatic cancer

Free
Audrey M. Hendley, Yue J. Wang, Janivette Alsina, Ishrat Ahmed, Hao Zhang, Samuel Savidge, Hao Ho, Albert Reynolds, Anirban Maitra, Michael Goggins, Christine Iacobuzio-Donahue, Steven D. Leach, Jennifer M. Bailey
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4186.
https://doi.org/10.1158/1538-7445.AM2015-4186
Published: 01 August 2015
View articletitled, Abstract 4186: p120 catenin: A novel regulator of epithelial cell delamination in early Kras-driven pancreatic cancer
Journal Articles

Abstract 66: p120 catenin: A novel regulator of PanIN epithelial cell delamination in preinvasive pancreatic cancer

Free
Audrey M. Hendley, Jennifer M. Bailey, Janivette Alsina, Christine Iacobuzio-Donahue, Anirban Maitra, Albert Reynolds, Steven D. Leach
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 66.
https://doi.org/10.1158/1538-7445.AM2014-66
Published: 01 October 2014
View articletitled, Abstract 66: p120 catenin: A novel regulator of PanIN epithelial cell delamination in preinvasive pancreatic cancer
Journal Articles

Abstract B83: Loss of the Hippo pathway effector Yap disrupts pancreatic morphogenesis and exacerbates exocrine pancreatitis.

Free
Sonal Gupta, Anirban Maitra, Ji-Kon Ryu, Nailing Zhang, Seungmin Bang, Meritxell Rovira, Hanno Matthaei, Seung-Mo Hong, Steven D. Leach, Duojia Pan
Journal: Cancer Research
Cancer Res (2012) 72 (14_Supplement): B83.
https://doi.org/10.1158/1538-7445.PANCA2012-B83
Published: 03 April 2014
View articletitled, Abstract B83: Loss of the Hippo pathway effector Yap disrupts pancreatic morphogenesis and exacerbates exocrine pancreatitis.