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Journal Articles

Abstract 236: Nuclear receptor 4A1 ligands target T-cell exhaustion in colorectal cancer

Kumaravel Mohankumar, Gus Wright, Subhashree Kumaravel, Rupesh Shrestha, Lei Zhang, Maen Abdelrahim, Robert S. Chapkin, Stephen Safe

Cancer Res (2022) 82 (12_Supplement): 236.

DOI: https://doi.org/10.1158/1538-7445.AM2022-236

Published: 15 June 2022

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Journal Articles

Abstract 2428: NR4A1 ligands inhibits PSPC1 regulated EMT and stemness markers in breast, lung and liver cancer cells

Kumaravel Mohankumar, Rupesh Shrestha, Stephen Safe

Cancer Res (2021) 81 (13_Supplement): 2428.

DOI: https://doi.org/10.1158/1538-7445.AM2021-2428

Published: 01 July 2021

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Journal Articles

Abstract 629: Flavonoids are NR4A1 antagonists and target PAX3-FOXO1 and G9a in alveolar rhabdomyosarcoma cells

Rupesh Shrestha, Kumaravel Mohankumar, Gregory Martin, Stephen Safe

Cancer Res (2021) 81 (13_Supplement): 629.

DOI: https://doi.org/10.1158/1538-7445.AM2021-629

Published: 01 July 2021

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Journal Articles

Abstract 1149: Nuclear receptor 4A1 (NR4A1) antagonists target PD-L1 in colon cancer

Kumaravel Mohankumar, Keshav Karki, Stephen Safe, Maen Abdelrahim

Cancer Res (2021) 81 (13_Supplement): 1149.

DOI: https://doi.org/10.1158/1538-7445.AM2021-1149

Published: 01 July 2021

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Journal Articles

A Bis-Indole–Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity

Keshav Karki, Gus A. Wright, Kumaravel Mohankumar, Un-Ho Jin, Xing-Han Zhang, Stephen Safe

Cancer Res (2020) 80 (5): 1011–1023.

DOI: https://doi.org/10.1158/0008-5472.CAN-19-2314

Published: 02 March 2020

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Includes: Supplementary data

Journal Articles

Abstract 154: Inhibition of pancreatic cancer Panc-1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK

Unho Jin, Keshav Karki, Stephen Safe

Cancer Res (2019) 79 (13_Supplement): 154.

DOI: https://doi.org/10.1158/1538-7445.AM2019-154

Published: 01 July 2019

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Journal Articles

Abstract 1714: Nuclear receptor Nurr1 facilitates pancreatic ductal adenocarcinoma cell survival under metabolic stress

Sneha Harishchandra, Xi Li, Stephen Safe, Mahsa Zarei

Cancer Res (2019) 79 (13_Supplement): 1714.

DOI: https://doi.org/10.1158/1538-7445.AM2019-1714

Published: 01 July 2019

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Journal Articles

Abstract 3298: Diindolylmethane and its halogenated analogues induce autophagy in human prostate cancer cells via induction of the astrocyte-elevated gene-1 (AEG-1)

Hossam Draz, Alexander Goldberg, Thomas Sanderson, Stephen Safe

Cancer Res (2017) 77 (13_Supplement): 3298.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3298

Published: 01 July 2017

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Journal Articles

PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1

Alexandra Lacey, Aline Rodrigues-Hoffman, Stephen Safe

Cancer Res (2017) 77 (3): 732–741.

DOI: https://doi.org/10.1158/0008-5472.CAN-16-1546

Published: 31 January 2017

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Includes: Supplementary data

Journal Articles

Abstract 3139: Nurr1, a novel target of 1,1-bis(3’-indolyl)-1-(p-chlorophenyl) methane for inhibition of the initiation and progression of skin cancer tumorigenesis

Ravi Doddapaneni, Cedar Boakye, Punit Shah, Apurva R. Patel, Chandraiah Godugu, Stephen Safe, Santosh Katiyar, Mandip Sachdeva

Cancer Res (2014) 74 (19_Supplement): 3139.

DOI: https://doi.org/10.1158/1538-7445.AM2014-3139

Published: 01 October 2014

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Journal Articles

Abstract 4532: New tolfenamic acid's derivatives inhibit cancer cells growth and tumor progression: Pre-clinical studies update

Maen Abdelrahim, Mehmet Asim Bilen, Stephen Safe, Ala Abudayyeh

Cancer Res (2014) 74 (19_Supplement): 4532.

DOI: https://doi.org/10.1158/1538-7445.AM2014-4532

Published: 01 October 2014

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Journal Articles

Abstract 3361: Pharmacokinetic and pharmacodynamic evaluation of novel dual channel spray dried enteric coated self-emulsifying capsules for anti-cancer agents in dogs.

Apurva R. Patel, Chandraiah Godugu, Wilson R. Heather, Stephen Safe, Mandip S. Sachdeva

Cancer Res (2013) 73 (8_Supplement): 3361.

DOI: https://doi.org/10.1158/1538-7445.AM2013-3361

Published: 15 April 2013

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Journal Articles

Abstract 203: Hotair, a long non-coding RNA, exhibits pro-oncogenic activity in pancreatic cancer

Kyounghyun Kim, Stephen Safe

Cancer Res (2012) 72 (8_Supplement): 203.

DOI: https://doi.org/10.1158/1538-7445.AM2012-203

Published: 15 April 2012

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Journal Articles

Abstract 3361: Sensitization of chemoresistant H1650 lung cancer stem cells to chemotherapy by combination treatment with novel diindolylmethane compounds

Mandip Singh, Terrick Andey, Sandeep Singh, Apurva R. Patel, Chandraiah Godugu, Stephen Safe, Srikumar Chellappan

Cancer Res (2012) 72 (8_Supplement): 3361.

DOI: https://doi.org/10.1158/1538-7445.AM2012-3361

Published: 15 April 2012

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Journal Articles

Abstract 382: In-vivo imaging of lung cancer using tumor homing peptide coated nanoparticles

Apurva R. Patel, Ed Lim, Ning Zhang, Kevin Francis, Stephen Safe, Mandip Sachdeva

Cancer Res (2012) 72 (8_Supplement): 382.

DOI: https://doi.org/10.1158/1538-7445.AM2012-382

Published: 15 April 2012

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Journal Articles

Abstract 4009: Regulation of mTOR pathway by the orphan nuclear receptor NR4A1 (TR3/Nur77) in non-small cell lung cancer: Role of TR3 in AMPK activation

Syng-Ook Lee, Terrick Andey, Un-Ho Jin, Kyounghyun Kim, Mandip Singh, Stephen Safe

Cancer Res (2011) 71 (8_Supplement): 4009.

DOI: https://doi.org/10.1158/1538-7445.AM2011-4009

Published: 15 April 2011

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Journal Articles

Abstract 356: Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer

Yun-Yong Park, Kyoungjyun Kim, Sang-Bae Kim, Bryan Hennessy, Soo Mi Kim, Eun Sung Park, Jae Yun Lim, Jane Li, Yiling Lu, Ana Gonzalez-Angulo, Gordon Mills, Stephen Safe, Ju-Seog Lee

Cancer Res (2011) 71 (8_Supplement): 356.

DOI: https://doi.org/10.1158/1538-7445.AM2011-356

Published: 15 April 2011

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Journal Articles

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

Syng-Ook Lee, Maen Abdelrahim, Kyungsil Yoon, Sudhakar Chintharlapalli, Sabitha Papineni, Kyounghyun Kim, Huamin Wang, Stephen Safe

Cancer Res (2010) 70 (17): 6824–6836.

DOI: https://doi.org/10.1158/0008-5472.CAN-10-1992

Published: 31 August 2010

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Includes: Supplementary data

Journal Articles

Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia

Twee Tsao, Steven Kornblau, Stephen Safe, Julie C. Watt, Vivian Ruvolo, Wenjing Chen, Yihua Qiu, Kevin R. Coombes, Zhenlin Ju, Maen Abdelrahim, Wendy Schober, Xiaoyang Ling, Dimitris Kardassis, Colin Meyer, Aaron Schimmer, Hagop Kantarjian, Michael Andreeff, Marina Konopleva

Cancer Res (2010) 70 (12): 4949–4960.

DOI: https://doi.org/10.1158/0008-5472.CAN-09-1962

Published: 14 June 2010

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Includes: Supplementary data

Journal Articles

Abstract 4075: Tolfenamic Acid Inhibits Prostate Cancer Cells Growth and Tumor Development in Orthotopic Mice

Riyaz B. Mahammad, Rafael Madero-Visbal, Cheryl H. Baker, Jimmie Colon, Stephen Safe, Ala Abudayyeh, Maen Abdelrahim

Cancer Res (2010) 70 (8_Supplement): 4075.

DOI: https://doi.org/10.1158/1538-7445.AM10-4075

Published: 15 April 2010

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NARROW

Abstract 236: Nuclear receptor 4A1 ligands target T-cell exhaustion in colorectal cancer

Abstract 2428: NR4A1 ligands inhibits PSPC1 regulated EMT and stemness markers in breast, lung and liver cancer cells

Abstract 629: Flavonoids are NR4A1 antagonists and target PAX3-FOXO1 and G9a in alveolar rhabdomyosarcoma cells

Abstract 1149: Nuclear receptor 4A1 (NR4A1) antagonists target PD-L1 in colon cancer

A Bis-Indole–Derived NR4A1 Antagonist Induces PD-L1 Degradation and Enhances Antitumor Immunity

Abstract 154: Inhibition of pancreatic cancer Panc-1 cell migration by omeprazole is dependent on aryl hydrocarbon receptor activation of JNK

Abstract 1714: Nuclear receptor Nurr1 facilitates pancreatic ductal adenocarcinoma cell survival under metabolic stress

Abstract 3298: Diindolylmethane and its halogenated analogues induce autophagy in human prostate cancer cells via induction of the astrocyte-elevated gene-1 (AEG-1)

PAX3-FOXO1A Expression in Rhabdomyosarcoma Is Driven by the Targetable Nuclear Receptor NR4A1

Abstract 3139: Nurr1, a novel target of 1,1-bis(3’-indolyl)-1-(p-chlorophenyl) methane for inhibition of the initiation and progression of skin cancer tumorigenesis

Abstract 4532: New tolfenamic acid's derivatives inhibit cancer cells growth and tumor progression: Pre-clinical studies update

Abstract 3361: Pharmacokinetic and pharmacodynamic evaluation of novel dual channel spray dried enteric coated self-emulsifying capsules for anti-cancer agents in dogs.

Abstract 203: Hotair, a long non-coding RNA, exhibits pro-oncogenic activity in pancreatic cancer

Abstract 3361: Sensitization of chemoresistant H1650 lung cancer stem cells to chemotherapy by combination treatment with novel diindolylmethane compounds

Abstract 382: In-vivo imaging of lung cancer using tumor homing peptide coated nanoparticles

Abstract 4009: Regulation of mTOR pathway by the orphan nuclear receptor NR4A1 (TR3/Nur77) in non-small cell lung cancer: Role of TR3 in AMPK activation

Abstract 356: Reconstruction of nuclear receptor network reveals that NR2E3 is a novel upstream regulator of ESR1 in breast cancer

Inactivation of the Orphan Nuclear Receptor TR3/Nur77 Inhibits Pancreatic Cancer Cell and Tumor Growth

Role of Peroxisome Proliferator-Activated Receptor-γ and Its Coactivator DRIP205 in Cellular Responses to CDDO (RTA-401) in Acute Myelogenous Leukemia

Abstract 4075: Tolfenamic Acid Inhibits Prostate Cancer Cells Growth and Tumor Development in Orthotopic Mice

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