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Stephen R. Plymate
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Journal Articles

JMJD6 Is a Druggable Oxygenase That Regulates AR-V7 Expression in Prostate Cancer

Alec Paschalis, Jonathan Welti, Antje J. Neeb, Wei Yuan, Ines Figueiredo, Rita Pereira, Ana Ferreira, Ruth Riisnaes, Daniel Nava Rodrigues, Juan M. Jiménez-Vacas, Soojin Kim, Takuma Uo, Patrizio Di Micco, Anthony Tumber, Md. Saiful Islam, Marc A. Moesser, Martine Abboud, Akane Kawamura, Bora Gurel, Rossitza Christova, Veronica S. Gil, Lorenzo Buroni, Mateus Crespo, Susana Miranda, Maryou B. Lambros, Suzanne Carreira, Nina Tunariu, Andrea Alimonti, Bissan Al-Lazikani, Christopher J. Schofield, Stephen R. Plymate, Adam Sharp, Johann S. de Bono
Journal: Cancer Research
Cancer Res (2021) 81 (4): 1087–1100.
DOI: https://doi.org/10.1158/0008-5472.CAN-20-1807
Published: 15 February 2022
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Includes: Supplementary data
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Abstract 1209: Comprehensive in vitro characterization of the mechanism of action of EPI-7386, an androgen receptor N-terminal domain inhibitor

Nan Hyung Hong, Shihua Sun, Peter Virsik, Alessandra Cesano, Elahe A. Mostaghel, Stephen R. Plymate, Han-Jie Zhou, Ronan Le Moigne
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1209.
DOI: https://doi.org/10.1158/1538-7445.AM2021-1209
Published: 01 July 2021
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Journal Articles

Small-Molecule Activators of Protein Phosphatase 2A for the Treatment of Castration-Resistant Prostate Cancer

Kimberly McClinch, Rita A. Avelar, David Callejas, Sudeh Izadmehr, Danica Wiredja, Abbey Perl, Jaya Sangodkar, David B. Kastrinsky, Daniela Schlatzer, Maxwell Cooper, Janna Kiselar, Agnes Stachnik, Shen Yao, Divya Hoon, Daniel McQuaid, Nilesh Zaware, Yixuan Gong, David L. Brautigan, Stephen R. Plymate, Cynthia C.T. Sprenger, William K. Oh, Alice C. Levine, Alexander Kirschenbaum, John P. Sfakianos, Rosalie Sears, Analisa DiFeo, Yiannis Ioannou, Michael Ohlmeyer, Goutham Narla, Matthew D. Galsky
Journal: Cancer Research
Cancer Res (2018) 78 (8): 2065–2080.
DOI: https://doi.org/10.1158/0008-5472.CAN-17-0123
Published: 12 April 2018
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Includes: Supplementary data
Journal Articles

Novel Androgen Receptor Coregulator GRHL2 Exerts Both Oncogenic and Antimetastatic Functions in Prostate Cancer

Steve Paltoglou, Rajdeep Das, Scott L. Townley, Theresa E. Hickey, Gerard A. Tarulli, Isabel Coutinho, Rayzel Fernandes, Adrienne R. Hanson, Iza Denis, Jason S. Carroll, Scott M. Dehm, Ganesh V. Raj, Stephen R. Plymate, Wayne D. Tilley, Luke A. Selth
Journal: Cancer Research
Cancer Res (2017) 77 (13): 3417–3430.
DOI: https://doi.org/10.1158/0008-5472.CAN-16-1616
Published: 02 July 2017
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Includes: Supplementary data
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Abstract 1194: Neutralization of IGF-I and -II ligands with the fully humanized bispecific monoclonal antibody xentuzumab inhibits AR-V7-induced enzalutamide resistance in castration-resistant prostate cancer

Gang Liu, Holly M. Nguyen, Kristine van Maltzan, Shihua Sun, Cynthia Sprenger, Ulrike Weyer-Czernilofsky, Eva Corey, Stephen R. Plymate
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 1194.
DOI: https://doi.org/10.1158/1538-7445.AM2017-1194
Published: 01 July 2017
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Journal Articles

Abstract 5643: Physical and functional interactions of exon-skipping variants of androgen receptor with the full-length counterpart

Takuma Uo, Cynthia C. Sprenger, Shihua Sun, Robert K. Bradley, Peter S. Nelson, Stephen R. Plymate
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5643.
DOI: https://doi.org/10.1158/1538-7445.AM2017-5643
Published: 01 July 2017
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Journal Articles

Abstract C11: The role of immune cells and androgen receptor splice variant 567 exon-skipping in prostate cancer

Jared HL Hara, Stephen R. Plymate, Cynthia T. Sprenger
Journal: Cancer Research
Cancer Res (2016) 76 (15_Supplement): C11.
DOI: https://doi.org/10.1158/1538-7445.TME16-C11
Published: 28 July 2016
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Journal Articles

Abstract 1819: Intrinsic determinants of constitutive activity of exon-skipping variants of androgen receptor in castration resistant prostate cancer

Takuma Uo, Heidi Dvinge, Cynthia C. Sprenger, Robert K. Bradley, Peter S. Nelson, Stephen R. Plymate
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 1819.
DOI: https://doi.org/10.1158/1538-7445.AM2016-1819
Published: 15 July 2016
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Abstract 4965: Analytic validation and clinical qualification of a novel immunohistochemical assay for AR-V7 protein expression in metastatic prostate cancer

Daniel Nava Rodrigues, Jon Welti, Adam Sharp, Shihua Sun, Ruth Riisnaes, Ines Figueiredo, Zafeiris Zafeiriou, Pasquale Rescigno, Johann S. de Bono, Stephen R. Plymate
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4965.
DOI: https://doi.org/10.1158/1538-7445.AM2016-4965
Published: 15 July 2016
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Journal Articles

Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells

Roberta Ferraldeschi, Jonathan Welti, Marissa V. Powers, Wei Yuan, Tomoko Smyth, George Seed, Ruth Riisnaes, Somaieh Hedayat, Hannah Wang, Mateus Crespo, Daniel Nava Rodrigues, Ines Figueiredo, Susana Miranda, Suzanne Carreira, John F. Lyons, Swee Sharp, Stephen R. Plymate, Gerhardt Attard, Nicola Wallis, Paul Workman, Johann S. de Bono
Journal: Cancer Research
Series: Author Choice
Cancer Res (2016) 76 (9): 2731–2742.
DOI: https://doi.org/10.1158/0008-5472.CAN-15-2186
Published: 01 May 2016
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Journal Articles

Abstract 4676: In silico and in vitro analyses of androgen receptor splicing variants with a special focus on human patient samples

Takuma Uo, Heidi Dvinge, Cynthia C. Sprenger, Shihua Sun, Robert K. Bradley, Peter S. Nelson, Stephen R. Plymate
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4676.
DOI: https://doi.org/10.1158/1538-7445.AM2015-4676
Published: 01 August 2015
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Journal Articles

Abstract 2114: UGT2B17 is a unique co-regulator of the androgen receptor and androgen receptor splice variants in prostate cancer

Gang Liu, Shihua Sun, Kathleen Haugk, Cynthia Sprenger, Xeusen Dong, Elahe Mostaghel, Stephen R. Plymate
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2114.
DOI: https://doi.org/10.1158/1538-7445.AM2014-2114
Published: 01 October 2014
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Journal Articles

Androgen Receptor Splice Variants Determine Taxane Sensitivity in Prostate Cancer

Maria Thadani-Mulero, Luigi Portella, Shihua Sun, Matthew Sung, Alexandre Matov, Robert L. Vessella, Eva Corey, David M. Nanus, Stephen R. Plymate, Paraskevi Giannakakou
Journal: Cancer Research
Cancer Res (2014) 74 (8): 2270–2282.
DOI: https://doi.org/10.1158/0008-5472.CAN-13-2876
Published: 15 April 2014
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Includes: Multimedia, Supplementary data
Journal Articles

Abstract IA21: Transcriptional programs directed by the androgen receptor splice variants

Rong Hu, Changxue Lu, Elahe A. Mostaghel, Srinivasan Yegnasubramanian, Meltem Gurel, Clare Tannahill, Joanne Edwards, William Isaacs, Peter S. Nelson, Eric Bluemn, Stephen R. Plymate, Jun Luo
Journal: Cancer Research
Cancer Res (2012) 72 (4_Supplement): IA21.
DOI: https://doi.org/10.1158/1538-7445.PRCA2012-IA21
Published: 09 May 2013
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Journal Articles

Abstract 4082: Mechanisms of androgen receptor splicing in prostate cancer cells.

Xeusen Dong, Liangliang Liu, Ning Xie, Shihua Sun, Stephen R. Plymate
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4082.
DOI: https://doi.org/10.1158/1538-7445.AM2013-4082
Published: 15 April 2013
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Journal Articles

Abstract 4081: Taxane sensitivity in prostate cancer is determined by androgen receptor splice variants.

Luigi Portella, Maria Thadani-Mulero, Alexandre Matov, David M. Nanus, Stephen R. Plymate, Paraskevi Giannakakou
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4081.
DOI: https://doi.org/10.1158/1538-7445.AM2013-4081
Published: 15 April 2013
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Journal Articles

Distinct Transcriptional Programs Mediated by the Ligand-Dependent Full-Length Androgen Receptor and Its Splice Variants in Castration-Resistant Prostate Cancer

Rong Hu, Changxue Lu, Elahe A. Mostaghel, Srinivasan Yegnasubramanian, Meltem Gurel, Clare Tannahill, Joanne Edwards, William B. Isaacs, Peter S. Nelson, Eric Bluemn, Stephen R. Plymate, Jun Luo
Journal: Cancer Research
Cancer Res (2012) 72 (14): 3457–3462.
DOI: https://doi.org/10.1158/0008-5472.CAN-11-3892
Published: 15 July 2012
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Includes: Supplementary data
Journal Articles

Abstract 5249: LuCaP prostate cancer xenografts: Models that allow clinically relevant investigation of prostate cancer in a preclinical setting

Holly M. Nguyen, Colm M. Morrissey, Peter S. Nelson, Xiaotun Zhang, Stephen R. Plymate, Celestia S. Higano, Paul H. Lange, Lawrence D. True, Martine PM Roudier, Robert L. Vessella, Eva Corey
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 5249.
DOI: https://doi.org/10.1158/1538-7445.AM2012-5249
Published: 15 April 2012
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Journal Articles

Abstract 285: Androgen receptor splice variants determine taxane sensitivity in prostate cancer

Maria Thadani-Mulero, Stephen R. Plymate, Paraskevi Giannakakou
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 285.
DOI: https://doi.org/10.1158/1538-7445.AM2012-285
Published: 15 April 2012
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Journal Articles

Abstract 2163: Microtubule-dependent regulation of a constitutively active androgen receptor splice variant

Maria Thadani-Mulero, Stephen R. Plymate, Paraskevi Giannakakou
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2163.
DOI: https://doi.org/10.1158/1538-7445.AM2011-2163
Published: 15 April 2011
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