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Abstract 2926: Structure-based design of quadruplex-binding small molecule compounds: The essential role of water molecules

Stephen Neidle

Cancer Res (2022) 82 (12_Supplement): 2926.

DOI: https://doi.org/10.1158/1538-7445.AM2022-2926

Published: 15 June 2022

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Journal Articles

Abstract 4068: The potent quadruplex-binding compound SOP1812 shows potent anti-proliferative activity in a prostate cancer cell panel and anti-tumor activity in an in vivo model of metastatic prostate cancer

Nicole Williams, Jenny Worthington, Stephen Neidle, Ahmed Ahmed

Cancer Res (2022) 82 (12_Supplement): 4068.

DOI: https://doi.org/10.1158/1538-7445.AM2022-4068

Published: 15 June 2022

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Journal Articles

Abstract 4069: The potent quadruplex-binding compound SOP1812 shows anti-tumor activity in patient-derived in vivo models of pancreatic cancer

Stephen Neidle, Ahmed Ahmed, Richard Angell, Sally Oxenford

Cancer Res (2022) 82 (12_Supplement): 4069.

DOI: https://doi.org/10.1158/1538-7445.AM2022-4069

Published: 15 June 2022

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Journal Articles

Abstract LB-2: Structure-based design of G-quadruplex ligands leads to enhanced potency against pancreatic cancer cells

Marialuisa Micco, Gavin Collie, Mekala Gunaratnam, Stephen A. Ohnmacht, Anthony P. Reszka, Stephen Neidle

Cancer Res (2012) 72 (8_Supplement): LB-2.

DOI: https://doi.org/10.1158/1538-7445.AM2012-LB-2

Published: 15 April 2012

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Journal Articles

Abstract 2323: Molecular modeling studies of the STAT3 homodimer:DNA complex

Jarmila Husby, Shozeb M. Haider, Giovanna Zinzella, David E. Thurston, Stephen Neidle

Cancer Res (2011) 71 (8_Supplement): 2323.

DOI: https://doi.org/10.1158/1538-7445.AM2011-2323

Published: 15 April 2011

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Journal Articles

Abstract 2310: Down-regulating BCL-2 gene expression in a resistant GIST cell line by a RNA G-quadruplex interacting small molecule ligand

Gary N. Parkinson, Mekala Gunaratnam, Xiong Wei Li, Gavin Collie, Anthony P. Reszka, Alan R. Todd, Jonathan A. Fletcher, Stephen Neidle

Cancer Res (2011) 71 (8_Supplement): 2310.

DOI: https://doi.org/10.1158/1538-7445.AM2011-2310

Published: 15 April 2011

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Journal Articles

Abstract 2326: The first crystal structure of a telomeric quadruplex DNA with a metal-containing ligand

Nancy H. Campbell, Nurul H. Abd Karim, Gary N. Parkinson, Ramon Vilar, Stephen Neidle

Cancer Res (2011) 71 (8_Supplement): 2326.

DOI: https://doi.org/10.1158/1538-7445.AM2011-2326

Published: 15 April 2011

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Journal Articles

Abstract 2517: Hybrid benzofused-biaryl polyamides with selective telomeric G-quadruplex stabilization potential

Khondaker M. Rahman, Kamrun Nahar, Laureen Sander, Tam T.T Bui, Alex Drake, Sunil Lagah, Sarah Walsh, Maria de la Fuente, Andreas G. Schätzlein, Stephen Neidle, David E. Thurston

Cancer Res (2011) 71 (8_Supplement): 2517.

DOI: https://doi.org/10.1158/1538-7445.AM2011-2517

Published: 15 April 2011

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Journal Articles

Abstract 4506: CL67: A novel G-quadruplex stabilising agent inhibits the HIF-1 pathway

Sarah J. Welsh, Caterina M. Lombardo, Helen Valentine, Stephen Neidle

Cancer Res (2011) 71 (8_Supplement): 4506.

DOI: https://doi.org/10.1158/1538-7445.AM2011-4506

Published: 15 April 2011

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Journal Articles

Abstract 5454: Novel STAT3:STAT3 small-molecule inhibitors as potential anticancer agents

Mohammad R. Haque, Giovanna Zinzalla, Samantha L. Kaye, Shozeb Haider, B. Piku Basu, John Anderson, Khondaker M. Rahman, Dyeison Antonow, Samantha Essex, Jonathan Palmer, Edwin Nkansah, Fyeza Hasan, Daniel Morgenstern, Andrew F. Wilderspin, Stephen Neidle, David E. Thurston

Cancer Res (2010) 70 (8_Supplement): 5454.

DOI: https://doi.org/10.1158/1538-7445.AM10-5454

Published: 15 April 2010

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Journal Articles

Abstract 739: Targeting pancreatic cancers with a quadruplex-binding small molecule

Sonja Hampel, Mekala Gunaratnam, Maria de la Fuente, Andreas Schatzlein, Stephen Neidle

Cancer Res (2010) 70 (8_Supplement): 739.

DOI: https://doi.org/10.1158/1538-7445.AM10-739

Published: 15 April 2010

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Journal Articles

Abstract 3679: Targeting drug-resistant GIST cells with a quadruplex-binding small molecule

Mekala Gunaratnam, Gavin Collie, Anthony Reszka, Alan Todd, Gary Parkinson, Jonathan Fletcher, Stephen Neidle

Cancer Res (2010) 70 (8_Supplement): 3679.

DOI: https://doi.org/10.1158/1538-7445.AM10-3679

Published: 15 April 2010

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Journal Articles

Abstract #5356: An RNA sequence-based approach to finding guanine quadruplex targets in cancer genes

Alan Todd, Stephen Neidle

Cancer Res (2009) 69 (9_Supplement): 5356.

Published: 01 May 2009

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Journal Articles

Abstract #681: Molecular modelling studies on P450 enzyme CYP17, a target for prostate cancer therapy: Complexes with Abiraterone and other inhibitors

Shozeb Haider, Jagdish Patel, Stephen Neidle

Cancer Res (2009) 69 (9_Supplement): 681.

Published: 01 May 2009

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Journal Articles

Abstract #5354: Biaryl polyamides as a new class of G-quadruplex ligands

Khondaker Rahman, Mekala Gunaratnam, Anthony Reszka, Shozeb Haider, Philip Howard, Keith Fox, Stephen Neidle, David Thurston

Cancer Res (2009) 69 (9_Supplement): 5354.

Published: 01 May 2009

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Journal Articles

Abstract #5355: Design, synthesis and evaluation of naphthalene-diimides as potent and selective telomeric G-quadruplex ligands

Sonja Hampel, Gary Parkinson, Stephen Neidle

Cancer Res (2009) 69 (9_Supplement): 5355.

Published: 01 May 2009

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Journal Articles

Abstract #668: The development of new telomere-targeted G-quadruplex stabilizing ligands using click chemistry

Caterina Lombardo, John Moses, Stephen Neidle

Cancer Res (2009) 69 (9_Supplement): 668.

Published: 01 May 2009

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Journal Articles

Abstract #667: A G-quadruplex stabilising small molecule that arrests the growth of gastrointestinal tumor (GIST) cells

Mekala Gunaratnam, Monica Beltran, Katja Galesa, Francisco Cuenca, Stephen Swank, Jonathan Fletcher, Stephen Neidle

Cancer Res (2009) 69 (9_Supplement): 667.

Published: 01 May 2009

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Journal Articles

Synthesis and evaluation of ligands based on the actinomycin chromophore as novel G-quadruplex stabilising ligands

Katherine Jarvis, Mark Searcey, Stephen Neidle

Cancer Res (2008) 68 (9_Supplement): 1312.

Published: 01 May 2008

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Journal Articles

Structure-activity relationships of acridine derivatives via click chemistry: A novel class of G-quadruplex binding ligands

Silvia Sparapani, Filippo Doria, Mekala Gunaratnam, Stephen Neidle

Cancer Res (2008) 68 (9_Supplement): 1313.

Published: 01 May 2008

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NARROW

Abstract 2926: Structure-based design of quadruplex-binding small molecule compounds: The essential role of water molecules

Abstract 4068: The potent quadruplex-binding compound SOP1812 shows potent anti-proliferative activity in a prostate cancer cell panel and anti-tumor activity in an in vivo model of metastatic prostate cancer

Abstract 4069: The potent quadruplex-binding compound SOP1812 shows anti-tumor activity in patient-derived in vivo models of pancreatic cancer

Abstract LB-2: Structure-based design of G-quadruplex ligands leads to enhanced potency against pancreatic cancer cells

Abstract 2323: Molecular modeling studies of the STAT3 homodimer:DNA complex

Abstract 2310: Down-regulating BCL-2 gene expression in a resistant GIST cell line by a RNA G-quadruplex interacting small molecule ligand

Abstract 2326: The first crystal structure of a telomeric quadruplex DNA with a metal-containing ligand

Abstract 2517: Hybrid benzofused-biaryl polyamides with selective telomeric G-quadruplex stabilization potential

Abstract 4506: CL67: A novel G-quadruplex stabilising agent inhibits the HIF-1 pathway

Abstract 5454: Novel STAT3:STAT3 small-molecule inhibitors as potential anticancer agents

Abstract 739: Targeting pancreatic cancers with a quadruplex-binding small molecule

Abstract 3679: Targeting drug-resistant GIST cells with a quadruplex-binding small molecule

Abstract #5356: An RNA sequence-based approach to finding guanine quadruplex targets in cancer genes

Abstract #681: Molecular modelling studies on P450 enzyme CYP17, a target for prostate cancer therapy: Complexes with Abiraterone and other inhibitors

Abstract #5354: Biaryl polyamides as a new class of G-quadruplex ligands

Abstract #5355: Design, synthesis and evaluation of naphthalene-diimides as potent and selective telomeric G-quadruplex ligands

Abstract #668: The development of new telomere-targeted G-quadruplex stabilizing ligands using click chemistry

Abstract #667: A G-quadruplex stabilising small molecule that arrests the growth of gastrointestinal tumor (GIST) cells

Synthesis and evaluation of ligands based on the actinomycin chromophore as novel G-quadruplex stabilising ligands

Structure-activity relationships of acridine derivatives via click chemistry: A novel class of G-quadruplex binding ligands

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