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Stephen L. Lessnick
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Journal Articles

Abstract 3558: Role of FLI portion of EWS::FLI in transcription regulation via modulation of chromatin 3D landscape in Ewing sarcoma

Ariunaa Bayanjargal, Cenny Taslim, Jesse Crow, Julia Selich-Anderson, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 3558.
https://doi.org/10.1158/1538-7445.AM2023-3558
Published: 04 April 2023
View articletitled, Abstract 3558: Role of FLI portion of EWS::FLI in transcription regulation via modulation of chromatin 3D landscape in Ewing sarcoma
Journal Articles

Abstract 1305: Structure-function mapping reveal FLI1 contributes more than the DNA-binding properties to drive Ewing sarcoma biology

Megann A. Boone, Jesse C. Crow, Julia Selich-Anderson, Cenny Taslim, Emily R. Theisen, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1305.
https://doi.org/10.1158/1538-7445.AM2020-1305
Published: 15 August 2020
View articletitled, Abstract 1305: Structure-function mapping reveal FLI1 contributes more than the DNA-binding properties to drive Ewing sarcoma biology
Journal Articles

Abstract 6563: Network potential identifies therapeutic miRNA cocktails in Ewings Sarcoma

Davis T. Weaver, Kathleen I. Pishas, Drew Williamson, Jessica Scarborough, Stephen L. Lessnick, Andrew Dhawan, Jacob G. Scott
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 6563.
https://doi.org/10.1158/1538-7445.AM2020-6563
Published: 15 August 2020
View articletitled, Abstract 6563: Network potential identifies therapeutic miRNA cocktails in Ewings Sarcoma
Journal Articles

Abstract CT109: A Phase I dose escalation and expansion study of seclidemstat (SP-2577) a first-in class reversible LSD1 inhibitor for patients with relapsed or refractory Ewing sarcoma

Damon Reed, Steven G. DuBois, Richard Gorlick, Leo Mascarenhas, Douglas Harrison, Jonathan Metts, Stephen L. Lessnick, Brian D. Crompton, David M. Loeb, Rose Hernandez, Jeff Larson, David D. Stenehjem
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT109.
https://doi.org/10.1158/1538-7445.AM2019-CT109
Published: 01 July 2019
View articletitled, Abstract CT109: A Phase I dose escalation and expansion study of seclidemstat (SP-2577) a first-in class reversible LSD1 inhibitor for patients with relapsed or refractory Ewing sarcoma
Journal Articles

Abstract A14: Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma

Kathleen I. Pishas, Sunil Sharma, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): A14.
https://doi.org/10.1158/1538-7445.PEDCA17-A14
Published: 01 October 2018
View articletitled, Abstract A14: Therapeutic targeting of KDM1A/LSD1 in Ewing sarcoma
Journal Articles

Abstract B15: Different structural features of EWS are required for distinct modes of EWS/FLI-mediated oncogenic gene regulation

Emily R. Theisen, Kyle R. Miller, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2018) 78 (19_Supplement): B15.
https://doi.org/10.1158/1538-7445.PEDCA17-B15
Published: 01 October 2018
View articletitled, Abstract B15: Different structural features of EWS are required for distinct modes of EWS/FLI-mediated oncogenic gene regulation
Journal Articles

Abstract 910: Mechanisms of Ewing sarcoma resistance to LSD1 inhibition

Kathleen I. Pishas, Sunil Sharma, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 910.
https://doi.org/10.1158/1538-7445.AM2018-910
Published: 01 July 2018
View articletitled, Abstract 910: Mechanisms of Ewing sarcoma resistance to LSD1 inhibition
Journal Articles

Abstract 3509: EWS/FLI regulates transcriptional activation via length-dependent GGAA microsatellites

Kirsten M. Johnson, Cenny Taslim, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 3509.
https://doi.org/10.1158/1538-7445.AM2017-3509
Published: 01 July 2017
View articletitled, Abstract 3509: EWS/FLI regulates transcriptional activation via length-dependent GGAA microsatellites
Journal Articles

Abstract 5817: Protein phosphatase 1 regulatory subunit 1A promotes tumorigenesis and metastasis in Ewing sarcoma

Wen Luo, Changxin Xu, Janet Ayello, Filemon De La Cruz, Jeremy Rosenblum, Stephen L. Lessnick, Mitchell S. Cairo
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 5817.
https://doi.org/10.1158/1538-7445.AM2017-5817
Published: 01 July 2017
View articletitled, Abstract 5817: Protein phosphatase 1 regulatory subunit 1A promotes tumorigenesis and metastasis in Ewing sarcoma
Journal Articles

Abstract A34: EWS/FLI regulates transcriptional activation in Ewing sarcoma via length dependent GGAA microsatellites

Kirsten M. Johnson, Kunal Gangwal, James Robertson, Thomas E. Cheatham, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2016) 76 (5_Supplement): A34.
https://doi.org/10.1158/1538-7445.PEDCA15-A34
Published: 04 April 2016
View articletitled, Abstract A34: EWS/FLI regulates transcriptional activation in Ewing sarcoma via length dependent GGAA microsatellites
Journal Articles

Abstract 483: Functional validation of CEBPB as an oncogenic target of EWS-FLI1 in Ewing sarcoma

Lisa M. Abegglen, Jamie D. Gardiner, Clinton C. Mason, Bryce E. Carter, Elizabeth A. Schackmann, Marcus Stucki, Angelica R. Putnam, R Lor Randall, Heinrich Kovar, Stephen L. Lessnick, Joshua D. Schiffman
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 483.
https://doi.org/10.1158/1538-7445.AM2015-483
Published: 01 August 2015
View articletitled, Abstract 483: Functional validation of CEBPB as an oncogenic target of EWS-FLI1 in Ewing sarcoma
Journal Articles

Abstract 3965: Modulating glutathione s-transferase M4 activity for the treatment of Ewing sarcoma

Rupeng Zhuo, Kenneth M. Kosak, Savita Sankar, Elizabeth T. Wiles, Yin Sun, Jianxing Zhang, Glenn D. Prestwich, Paul J. Shami, Stephen L. Lessnick, Mitchell S. Cairo, Wen Luo
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3965.
https://doi.org/10.1158/1538-7445.AM2014-3965
Published: 01 October 2014
View articletitled, Abstract 3965: Modulating glutathione s-transferase M4 activity for the treatment of Ewing sarcoma
Journal Articles

Abstract 3679: Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma

Emily Rose Theisen, Savita Sankar, Jared Bearss, Timothy Mulvihill, Venkataswamy Sorna, Sunil Sharma, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 3679.
https://doi.org/10.1158/1538-7445.AM2014-3679
Published: 01 October 2014
View articletitled, Abstract 3679: Inhibition of LSD1 disrupts global EWS/ETS transcriptional function in Ewing sarcoma
Journal Articles

Abstract 2219: Mechanism of trancriptional repression by EWS/FLI in Ewing's sarcoma

Savita Sankar, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 2219.
https://doi.org/10.1158/1538-7445.AM2012-2219
Published: 15 April 2012
View articletitled, Abstract 2219: Mechanism of trancriptional repression by EWS/FLI in Ewing's sarcoma
Journal Articles

Abstract 3979: Ethnic polymorphisms in the GGAA microsatellite response element of key Ewing's sarcoma EWS/FLI-target genes

Michael J. Monument, Robert Beck, W. Scott Watkins, Lynn B. Jorde, R. Lor Randall, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3979.
https://doi.org/10.1158/1538-7445.AM2012-3979
Published: 15 April 2012
View articletitled, Abstract 3979: Ethnic polymorphisms in the GGAA microsatellite response element of key Ewing's sarcoma EWS/FLI-target genes
Journal Articles

Abstract 5134: Mechanistic dissection of EWS-FLI impact on Ewing's sarcoma cell behavior

Aashi Chaturvedi, Stephen L. Lessnick, Mary C. Beckerle
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 5134.
https://doi.org/10.1158/1538-7445.AM10-5134
Published: 15 April 2010
View articletitled, Abstract 5134: Mechanistic dissection of EWS-FLI impact on Ewing's sarcoma cell behavior
Journal Articles

Abstract 3907: Emergent properties of EWS/FLI regulation via GGAA-microsatellites in Ewing's sarcoma

Kunal Gangwal, Camille A. Enriquez, Devin Close, Christopher P. Hill, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3907.
https://doi.org/10.1158/1538-7445.AM10-3907
Published: 15 April 2010
View articletitled, Abstract 3907: Emergent properties of EWS/FLI regulation via GGAA-microsatellites in Ewing's sarcoma
Journal Articles

EWS/FLI and Its Downstream Target NR0B1 Interact Directly to Modulate Transcription and Oncogenesis in Ewing's Sarcoma

Michelle Kinsey, Richard Smith, Anita K. Iyer, Edward R.B. McCabe, Stephen L. Lessnick
Journal: Cancer Research
Cancer Res (2009) 69 (23): 9047–9055.
https://doi.org/10.1158/0008-5472.CAN-09-1540
Published: 30 November 2009
View articletitled, EWS/FLI and Its Downstream Target NR0B1 Interact Directly to Modulate Transcription and Oncogenesis in Ewing's Sarcoma
Open the PDF for EWS/FLI and Its Downstream Target NR0B1 Interact Directly to Modulate Transcription and Oncogenesis in Ewing's Sarcoma in another window
Includes: Supplementary data
Journal Articles

EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins

Gary Potikyan, Rupert O.V. Savene, Julie M. Gaulden, Kelly A. France, Zhichao Zhou, Eugenie S. Kleinerman, Stephen L. Lessnick, Christopher T. Denny
Journal: Cancer Research
Cancer Res (2007) 67 (14): 6675–6684.
https://doi.org/10.1158/0008-5472.CAN-06-4140
Published: 17 July 2007
View articletitled, EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins
Open the PDF for EWS/FLI1 Regulates Tumor Angiogenesis in Ewing's Sarcoma via Suppression of Thrombospondins in another window
Includes: Supplementary data
Journal Articles

A new class of human solid tumors defined by dysregulation of the MiT transcription factor family: MITF as an oncogenic target of EWS-ATF1 in clear cell sarcoma

Ian J. Davis, John M. Goldberg, Scott R. Granter, Hans Widlund, Jinyan Du, Stephen L. Lessnick, Jonathan A. Fletcher, Christopher T. Denny, David E. Fisher
Journal: Cancer Research
Cancer Res (2005) 65 (9_Supplement): 1025–1026.
Published: 01 May 2005
View articletitled, A new class of human solid tumors defined by dysregulation of the MiT transcription factor family: MITF as an oncogenic target of EWS-ATF1 in clear cell sarcoma