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Stephen J. Elledge
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Journal Articles

Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer

Alissandra L. Hillis, Timothy D. Martin, Haley E. Manchester, Jenny Högström, Na Zhang, Emmalyn Lecky, Nina Kozlova, Jonah Lee, Nicole S. Persky, David E. Root, Myles Brown, Karen Cichowski, Stephen J. Elledge, Taru Muranen, David A. Fruman, Simon T. Barry, John G. Clohessy, Ralitsa R. Madsen, Alex Toker
Journal: Cancer Research
Cancer Res (2024) 84 (19): 3250–3266.
https://doi.org/10.1158/0008-5472.CAN-24-0970
Published: 01 October 2024
View article titled, Targeting Cholesterol Biosynthesis with Statins Synergizes with AKT Inhibitors in Triple-Negative Breast Cancer
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Includes: Supplementary data
Journal Articles

Abstract SY10-01: How aneuploidy drives cancer

Teresa Davoli, Hajima Uno, Andrew Xu, Kristen Mengwasser, Laura Sack, Peter J. Park, Stephen J. Elledge
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): SY10-01.
https://doi.org/10.1158/1538-7445.AM2016-SY10-01
Published: 15 July 2016
View article titled, Abstract SY10-01: How aneuploidy drives cancer
Journal Articles

Abstract P6-11-01: A broad spectrum therapeutic strategy for TNBC revealed by a new pathway that coordinates oncogenic RTKs

Thomas F Westbrook, Amritha Nair, Tingting Sun, Kristen L Karlin, Jessica Kessler, Ilenia Migliaccio, Don X Nguyen, Ronald J Bernardi, Alex Renwick, Chad J Creighton, Noah Dephoure, Steven P Gygi, Chad A Shaw, Richard Gibbs, David Wheeler, Rachel Schiff, James G Christensen, David J Shields, C Kent Osborne, Stephen J Elledge, Susan G Hilsenbeck, Michael T Lewis
Journal: Cancer Research
Cancer Res (2015) 75 (9_Supplement): P6-11-01.
https://doi.org/10.1158/1538-7445.SABCS14-P6-11-01
Published: 01 May 2015
View article titled, Abstract P6-11-01: A broad spectrum therapeutic strategy for TNBC revealed by a new pathway that coordinates oncogenic RTKs
Journal Articles

Abstract IA8: Genetic approaches to cancer

Nicole L. Solimini, Andrea L. Bredemeyer, Mamie Z. Li, Rameen Beroukhim, Matthew Meyerson, Stephen J. Elledge, Natalya N. Pavlova, Qikai Xu, Craig H. Mermel, Anthony C. Liang, Michael R. Schlabach, Ji Luo, Anna E. Burrows, Anthony N. Anselmo
Journal: Cancer Research
Cancer Res (2012) 72 (13_Supplement): IA8.
https://doi.org/10.1158/1538-7445.CSB12-IA8
Published: 06 November 2014
View article titled, Abstract IA8: Genetic approaches to cancer
Journal Articles

Abstract A33: A whole genome RNAi screen identifies BRD7 and BAF180 as p53 regulators required for senescence

Anna E. Burrows, Agata Smogorzewska, Stephen J. Elledge
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): A33.
https://doi.org/10.1158/1538-7445.FBCR11-A33
Published: 28 October 2014
View article titled, Abstract A33: A whole genome RNAi screen identifies BRD7 and BAF180 as p53 regulators required for senescence
Journal Articles

Abstract PR2: A genetic screen for novel determinants of anoikis resistance identifies PVRL4

Natalva N. Pavlova, Stephen J. Elledge
Journal: Cancer Research
Cancer Res (2011) 71 (18_Supplement): PR2.
https://doi.org/10.1158/1538-7445.FBCR11-PR2
Published: 28 October 2014
View article titled, Abstract PR2: A genetic screen for novel determinants of anoikis resistance identifies PVRL4
Journal Articles

Abstract SY36-03: How aneuploidy drives tumorigenesis

Teresa Davoli, Wei Xu, Peter Park, Stephen J. Elledge
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): SY36-03.
https://doi.org/10.1158/1538-7445.AM2014-SY36-03
Published: 01 October 2014
View article titled, Abstract SY36-03: How aneuploidy drives tumorigenesis
Journal Articles

Abstract 2404: Cumulative dosage effect of TSGs and OGs drives aneuploidy patterns in cancer

Teresa Davoli, Andrew Wei Xu, Kristen E. Mengwasser, Laura M. Sack, John C. Yoon, Peter J. Park, Stephen J. Elledge
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2404.
https://doi.org/10.1158/1538-7445.AM2014-2404
Published: 01 October 2014
View article titled, Abstract 2404: Cumulative dosage effect of TSGs and OGs drives aneuploidy patterns in cancer
Journal Articles

Abstract IA28: Haploinsufficiency in cancer

Teresa Davoli, Nicole L. Solimini, Natalya N. Pavlova, Qikai Xu, Kristen Mengwasser, Laura M. Sack, Anthony C. Liang, Michael R. Schlabach, Ji Luo, Anna E. Burrows, Anthony N. Anselmo, Mamie Z. Li, Stephen J. Elledge
Journal: Cancer Research
Cancer Res (2013) 73 (19_Supplement): IA28.
https://doi.org/10.1158/1538-7445.FBCR13-IA28
Published: 15 May 2014
View article titled, Abstract IA28: Haploinsufficiency in cancer
Journal Articles

Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR

Qingsong Liu, Chunxiao Xu, Sivapriya Kirubakaran, Xin Zhang, Wooyoung Hur, Yan Liu, Nicholas P. Kwiatkowski, Jinhua Wang, Kenneth D. Westover, Peng Gao, Dalia Ercan, Mario Niepel, Carson C. Thoreen, Seong A. Kang, Matthew P. Patricelli, Yuchuan Wang, Tanya Tupper, Abigail Altabef, Hidemasa Kawamura, Kathryn D. Held, Danny M. Chou, Stephen J. Elledge, Pasi A. Janne, Kwok-Kin Wong, David M. Sabatini, Nathanael S. Gray
Journal: Cancer Research
Cancer Res (2013) 73 (8): 2574–2586.
https://doi.org/10.1158/0008-5472.CAN-12-1702
Published: 15 April 2013
View article titled, Characterization of Torin2, an ATP-Competitive Inhibitor of mTOR, ATM, and ATR
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Includes: Supplementary data
Journal Articles

Abstract SY25-03: Haploinsufficiency in cancer: When half simply isn't good enough.

Nicole Solimini, Natalya N. Pavlova, Craig Mermel, Qikai Xu, Anna E. Burrows, Ji Luo, Mamie li, Rameen Beroukhim, Matthew Meyerson, Stephen J. Elledge
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): SY25-03.
https://doi.org/10.1158/1538-7445.AM2013-SY25-03
Published: 15 April 2013
View article titled, Abstract SY25-03: Haploinsufficiency in cancer: When half simply isn't good enough.
Journal Articles

Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis

Jessica D. Kessler, Kristopher T. Kahle, Tingting Sun, Kristen L. Meerbrey, Michael R. Schlabach, Earlene M. Schmitt, Samuel O. Skinner, Qikai Xu, Mamie Z. Li, Zachary C. Hartman, Mitchell Rao, Peng Yu, Rocio Dominguez-Vidana, Anthony C. Liang, Nicole L. Solimini, Ronald J. Bernardi, Bing Yu, Tiffany Hsu, Ido Golding, Ji Luo, C. Kent Osborne, Chad Creighton, Susan G. Hilsenbeck, Rachel Schiff, Chad A. Shaw, Stephen J. Elledge, Thomas F. Westbrook
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3091.
https://doi.org/10.1158/1538-7445.AM2012-3091
Published: 15 April 2012
View article titled, Abstract 3091: A sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Journal Articles

Abstract 1358: Discovery and optimization of potent and selective benzonaphthyridinone analogs as dual mTOR/ATR small molecular inhibitors for treatment of cancer

Qingsong Liu, Danny Zhou, Bunsho Shiotani, Nathanael S. Gray, Stephen J. Elledge, Lee Zou
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 1358.
https://doi.org/10.1158/1538-7445.AM2011-1358
Published: 15 April 2011
View article titled, Abstract 1358: Discovery and optimization of potent and selective benzonaphthyridinone analogs as dual mTOR/ATR small molecular inhibitors for treatment of cancer
Journal Articles

Reduced Expression and Impaired Kinase Activity of a Chk2 Mutant Identified in Human Lung Cancer

Shuhei Matsuoka, Taku Nakagawa, Akira Masuda, Nobuhiro Haruki, Stephen J. Elledge, Takashi Takahashi
Journal: Cancer Research
Cancer Res (2001) 61 (14): 5362–5365.
Published: 01 July 2001
View article titled, Reduced Expression and Impaired Kinase Activity of a Chk2 Mutant Identified in Human Lung Cancer
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Journal Articles

In Vivo Gene Therapy with p53 or p21 Adenovirus for Prostate Cancer

James A. Eastham, Simon J. Hall, Inder Sehgal, Jianxiang Wang, Terry L. Timme, Guang Yang, Lisa Connell-Crowley, Stephen J. Elledge, Wei-Wei Zhang, J. Wade Harper, Timothy C. Thompson
Journal: Cancer Research
Cancer Res (1995) 55 (22): 5151–5155.
Published: 01 November 1995
View article titled, <em>In Vivo</em> Gene Therapy with <em>p53</em> or <em>p21</em> Adenovirus for Prostate Cancer
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Journal Articles

WAF1/CIP1 Is Induced in p53-mediated G1 Arrest and Apoptosis

Wafik S. El-Deiry, J. Wade Harper, Patrick M. O'Connor, Victor E. Velculescu, Christine E. Canman, Joany Jackman, Jennifer A. Pietenpol, Marilee Burrell, David E. Hill, Yisong Wang, Klas G. Wiman, W. Edward Mercer, Michael B. Kastan, Kurt W. Kohn, Stephen J. Elledge, Kenneth W. Kinzler, Bert Vogelstein
Journal: Cancer Research
Cancer Res (1994) 54 (5): 1169–1174.
Published: 01 March 1994
View article titled, <em>WAF1/CIP1</em> Is Induced in <em>p53</em>-mediated G<sub>1</sub> Arrest and Apoptosis
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Journal Articles

Amplification of Cyclin Genes in Colorectal Carcinomas

Fredrick S. Leach, Stephen J. Elledge, Charles J. Sherr, James K. V. Willson, Sanford Markowitz, Kenneth W. Kinzler, Bert Vogelstein
Journal: Cancer Research
Cancer Res (1993) 53 (9): 1986–1989.
Published: 01 May 1993
View article titled, Amplification of Cyclin Genes in Colorectal Carcinomas
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