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Stephen J. Chanock
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Journal Articles

Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification

Aubrey K. Hubbard, Derek W. Brown, Jie Liu, Irenaeus C. Chan, Weiyin Zhou, Giulio Genovese, Alexander DePaulis, Sruthi Srinivasan, Shu-Hong Lin, Batel Blechter, Ian D. Buller, Qinglin Zeng, Yin Cao, Wen-Yi Huang, Neal D. Freedman, Haoyu Zhang, Diptavo Dutta, Stephen J. Chanock, Kelly L. Bolton, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2025)
https://doi.org/10.1158/0008-5472.CAN-24-4251
Published: 30 April 2025
View articletitled, Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification
Open the PDF for Integration of Germline and Somatic Variation Improves Chronic Lymphocytic Leukemia Risk Stratification in another window
Includes: Supplementary data
Journal Articles

Abstract LB263: A transcriptomic signature predicts mortality risk and immune checkpoint inhibitor response beyond molecular and morphological features in lung adenocarcinoma from never smokers

Wei Zhao, Tongwu Zhang, Xing Hua, Phuc H. Hoang, Mona Miraftab, Monjoy Saha, John P. McElderry, Jian Sang, Olivia Lee, Caleb Hartman, Azhar Khandekar, Sunandini Sharma, Frank J. Colón-Matos, Samuel Anyaso-Samuel, Defei Wang, Kristine Jones, Amy Hutchinson, Belynda Hicks, Jennifer Rosenbaum, Xiaoming Zhong, Yang Yang, Angela Pesatori, Dario Consonni, Karun Mutreja, Scott Lawrence, Nathaniel Rothman, Ludmil B. Alexandrov, Charles Leduc, Marina K. Baine, Philippe Joubert, Lynette M. Sholl, William D. Travis, Robert Homer, Qing Lan, Stephen J. Chanock, Lixing Yang, Soo-Ryum Yang, Jianxin Shi, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB263.
https://doi.org/10.1158/1538-7445.AM2025-LB263
Published: 25 April 2025
View articletitled, Abstract LB263: A transcriptomic signature predicts mortality risk and immune checkpoint inhibitor response beyond molecular and morphological features in lung adenocarcinoma from never smokers
Journal Articles

Abstract LB333: Homologous recombination germline variants and radiotherapy-related subsequent neoplasm risk after childhood cancer: A pooled analysis in two large cohorts

Shahriar A. Zamani, Danielle M. Karyadi, Stephen W. Hartley, Joshua N. Sampson, Todd M. Gibson, Peter Kraft, Stephen J. Chanock, Lindsay M. Morton
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): LB333.
https://doi.org/10.1158/1538-7445.AM2025-LB333
Published: 25 April 2025
View articletitled, Abstract LB333: Homologous recombination germline variants and radiotherapy-related subsequent neoplasm risk after childhood cancer: A pooled analysis in two large cohorts
Journal Articles

Abstract 4096: Altered epigenetic aging in leukocytes with detectable mosaic chromosomal alterations

Corey D. Young, Derek W. Brown, Charles Breeze, Rebecca L. Kelly, Kara M. Barnao, Aubrey K. Hubbard, Weiyin Zhou, Amy A. Hutchinson, Belynda D. Hicks, Aurélie L. Vogt, Wen-Yi Huang, Steven C. Moore, Stephen J. Chanock, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4096.
https://doi.org/10.1158/1538-7445.AM2025-4096
Published: 21 April 2025
View articletitled, Abstract 4096: Altered epigenetic aging in leukocytes with detectable mosaic chromosomal alterations
Journal Articles

Abstract 7415: Association between sleep traits and risk of non-Hodgkin's lymphoma subtypes: a mendelian randomization study in the International Lymphoma Epidemiology (InterLymph) Consortium

Pankhil Shah, Brittany Crawford, Anwar Merchant, Brenda Birmann, Angelica Macauda, Michelle A. Hildebrandt, Aaron Norman, Neil E. Caporaso, Meredith Yeager, Michael Dean, Immaculata De Vivo, Lynn Goldin, Nicola J. Camp, Rosalie Griffin, Delphine Casabonne, Federico Canzian, Pelin Unal, Elad Ziv, Catherine R. Marinac, Alexandra Nieters, Stephen J. Chanock, Mitchell J. Machiela, Michael Conry, Charlie Zhong, Hanla A. Park, Simon Cheah, Jonathan N. Hofmann, Elizabeth E. Brown, Celine Vachon, Susan Slager, Sonja Berndt, Sophia S. Wang, Vijai Joseph, James McKay, Henrik Hjalgrim, Lara Sucheston-Campbell, Karl Smith-Byrne, Alyssa Clay-Gilmour
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7415.
https://doi.org/10.1158/1538-7445.AM2025-7415
Published: 21 April 2025
View articletitled, Abstract 7415: Association between sleep traits and risk of non-Hodgkin's lymphoma subtypes: a mendelian randomization study in the International Lymphoma Epidemiology (InterLymph) Consortium
Journal Articles

Abstract 4916: Co-occurring clonal hematopoiesis in UK Biobank participants with prior cancer

Kara Marie Barnao, Aubrey K. Hubbard, Irenaeus Chan, Weiyin Zhou, Corey D. Young, Rebecca L. Kelly, Derek W. Brown, Giulio Genovese, Duc Tran, Yin Cao, Stephen J. Chanock, Kelly L. Bolton, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4916.
https://doi.org/10.1158/1538-7445.AM2025-4916
Published: 21 April 2025
View articletitled, Abstract 4916: Co-occurring clonal hematopoiesis in UK Biobank participants with prior cancer
Journal Articles

Abstract 7362: Connect for Cancer Prevention Study: a modern prospective cohort

Mia M. Gaudet, Amy Berrington de Gonzalez, Christian C. Abnet, Paul Albert, Jonas S. Almeida, Stephanie Weinstein, Amanda Black, Hannah P. Yang, Michelle Brotzman, Laura Beane-Freeman, Laura Beane-Freeman, Jonine Figueroa, Neal D. Freedman, Nicole M. Gerlanc, Gretchen L. Gierach, Rena R. Jones, Peter Kraft, Charles Matthews, Habibul Ashan, Briseis Aschebrook-Kilfoy, Chun-Hung Chan, Robert T. Greenlee, Stacey A. Honda, Benjamin Rybicki, Katherine Sanchez, Kevin Skyes, Mark A. Schmidt, Larissa L. White, Jeanette Y. Ziegenfuss, Stephen J. Chanock, Montse Garcia-Closas, Nicolas A. Wentzensen
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 7362.
https://doi.org/10.1158/1538-7445.AM2025-7362
Published: 21 April 2025
View articletitled, Abstract 7362: Connect for Cancer Prevention Study: a modern prospective cohort
Journal Articles

Abstract C055: Unraveling pancreatic cancer susceptibility at 5p15.33: Functional characterization of a novel VNTR element

Aidan O'Brien, Hyunkyung Kong, Minal Patel, Katelyn E Connelly, Mai Xu, Irene Collins, Jun Zhong, Jason Hoskins, Michelle Ho, Brenen Papenburg, Mark M Iles, Matthew H Law, Maria-Teresa Landi, Rachael Stolzenber- Solomon, Brian M Wolpin, Alison P Klein, Nick Orr, Stephen J Chanock, Sara Lindström, Marc-Henri Stern, Ludmila Prokunina-Olsson, Jieyon Choi, Kevin M Brown, Laufey T Amundadottir
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): C055.
https://doi.org/10.1158/1538-7445.PANCREATIC24-C055
Published: 15 September 2024
View articletitled, Abstract C055: Unraveling pancreatic cancer susceptibility at 5p15.33: Functional characterization of a novel VNTR element
Journal Articles

Abstract A016: Functional characterization of the 1p36.33 pancreatic cancer GWAS locus

Katelyn E Connelly, Katherine Hullin, Ehssan Abdolalizadeh, Jun Zhong, Daina Eiser, Jason W. Hoskins, Aidan O'Brien, Irene Collins, Stephen J Chanock, Rachael Z Stolzenberg-Solomon, Alison P Klein, Brian M Wolpin, Jill P Smith, Laufey Amundadottir
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A016.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A016
Published: 15 September 2024
View articletitled, Abstract A016: Functional characterization of the 1p36.33 pancreatic cancer GWAS locus
Journal Articles

Abstract A018: The functional characterization of pancreatic ductal adenocarcinoma GWAS risk variants in primary pancreatic cells – A pilot study

Minal B Patel, Aidan O'Brien, Jun Zhong, Irene Collins, Jason W Hoskins, Stephen J Chanock, Samuel O Antwi, Rachel Z Stolzenberg-Solomon, Alison P Klein, Brian M Wolpin, Sara Lindström, H. Efsun Arda, Kevin M Brown, Katelyn E Connelly, Laufey T Amundadottir, Meagan Jezek
Journal: Cancer Research
Cancer Res (2024) 84 (17_Supplement_2): A018.
https://doi.org/10.1158/1538-7445.PANCREATIC24-A018
Published: 15 September 2024
View articletitled, Abstract A018: The functional characterization of pancreatic ductal adenocarcinoma GWAS risk variants in primary pancreatic cells – A pilot study
Journal Articles

Abstract LB226: Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition

Tongwu Zhang, Wei Zhao, Christopher Wirth, Marcos Díaz-Gay, Jinhu Yin, Phuc H. Hoang, Jian Sang, John McElderry, Alyssa Klein, Azhar Khandekar, Caleb Hartman, Jennifer Rosenbaum, Frank Colon-Matos, Kristine M. Jones, Neil E. Caporaso, Robert Homer, Angela C. Pesatori, Dario Consonni, Lixing Yang, Bin Zhu, Jianxin Shi, Kevin Brown, Nathaniel Rothman, Stephen J. Chanock, Ludmil B. Alexandrov, Jiyeon Choi, Maurizio Cardelli, Qing Lan, Martin A. Nowak, David C. Wedge, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB226.
https://doi.org/10.1158/1538-7445.AM2024-LB226
Published: 05 April 2024
View articletitled, Abstract LB226: Deciphering lung adenocarcinoma evolution and the role of LINE-1 retrotransposition
Journal Articles

Abstract LB231: The mutagenic forces shaping the genomic landscape of lung cancer in never smokers

Marcos Diaz-Gay, Tongwu Zhang, Azhar Khandekar, Burçak Otlu, Shuvro Nandi, Christopher D. Steele, Nathaniel Rothman, Stephen J. Chanock, Qing Lan, Ludmil B. Alexandrov, Maria Teresa Landi
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): LB231.
https://doi.org/10.1158/1538-7445.AM2024-LB231
Published: 05 April 2024
View articletitled, Abstract LB231: The mutagenic forces shaping the genomic landscape of lung cancer in never smokers
Journal Articles

Abstract 6149: Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status

Batel Blechter, Chao Agnes Hsiung, Keitaro Matsuo, Kouya Shiraishi, Kevin Wang, Haoyu Zhang, Wei Jie Seow, Jianxin Shi, Nilanjan Chatterjee, Jason Y.Y. Wong, Juncheng Dai, H. Dean Hosgood, I-Shou Chang, Jiyeon Choi, Wei Hu, Wei Zheng, Young Tae Kim, Xiao-Ou Shu, Qiuyin Cai, Pan-Chyr Yang, Dongxin Lin, Kexin Chen, Yi-Long Wu, Hongbin Shen, Takashi Kohno, Stephen J. Chanock, Nathaniel Rothman, Qing Lan
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6149.
https://doi.org/10.1158/1538-7445.AM2024-6149
Published: 22 March 2024
View articletitled, Abstract 6149: Polygenic risk score and lung adenocarcinoma risk among never-smokers by EGFR mutation status
Journal Articles

Abstract 775: Underlying germline genetic architecture of pediatric sarcomas: Evaluating the role of common and rare variants in 4,160 patients

Lisa Mirabello, Laura E. Egolf, Bin Zhu, D. Matthew Gianferante, Kevin Wang, Shengchao Alfred Li, Mitchell J. Machiela, Logan G. Spector, Joshua D. Schiffman, Aniko Sabo, Alexander Renwick, Bailey Martin-Giacalone, Michael E. Scheurer, Sharon Plon, Douglas Hawkins, Rajkumar Venkatramani, Douglas Stewart, Lindsay M. Morton, Melissa M. Hudson, Gregory T. Armstrong, Smita Bhatia, Michael Dean, Katherine A. Janeway, Ana Patiño-Garcia, Fernando Lecanda, Massimo Serra, Claudia Hattinger, Katia Scotlandi, Adrienne M. Flanagan, Fernanda Amary, Irene L. Andrulis, Jay S. Wunder, Mandy L. Ballinger, David M. Thomas, Olivier Delattre, Aubrey K. Hubbard, Jia Liu, Wen Luo, Belynda D. Hicks, Meredith Yeager, Maryam Rafati, Wen-Yi Huang, Maria T. Landi, Adriana Lori, Ryan Diver, Sharon A. Savage, Stephen J. Chanock, Philip J. Lupo
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 775.
https://doi.org/10.1158/1538-7445.AM2024-775
Published: 22 March 2024
View articletitled, Abstract 775: Underlying germline genetic architecture of pediatric sarcomas: Evaluating the role of common and rare variants in 4,160 patients
Journal Articles

Abstract 3433: Characterization of co-occurring clonal hematopoiesis to identify high risk clones associated with hematologic cancer risk

Kara M. Barnao, Aubrey K. Hubbard, Weiyin Zhou, Irenaeus Chan, Duc Tran, Yin Cao, Stephen J. Chanock, Kelly L. Bolton, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3433.
https://doi.org/10.1158/1538-7445.AM2024-3433
Published: 22 March 2024
View articletitled, Abstract 3433: Characterization of co-occurring clonal hematopoiesis to identify high risk clones associated with hematologic cancer risk
Journal Articles

Abstract 3430: Mosaic loss of the Y chromosome is associated with prostate cancer risk

Rebecca L. Kelly, Weiyin Zhou, Kara M. Barnao, Corey D. Young, Aubrey K. Hubbard, Sairah M. Khan, Wen-Yi Huang, Stephen J. Chanock, Mitchell J. Machiela
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3430.
https://doi.org/10.1158/1538-7445.AM2024-3430
Published: 22 March 2024
View articletitled, Abstract 3430: Mosaic loss of the Y chromosome is associated with prostate cancer risk
Journal Articles

Abstract 2205: Modifiable risk factors are associated with clonal hematopoiesis

Corey D. Young, Aubrey K. Hubbard, Pedro Saint-Maurice, Irenaeus Chan, Kelly L. Bolton, Stephen J. Chanock, Charles Matthews, Steven C. Moore, Erikka Loftfield, Yin Cao, Mitchell J. Machiela, Duc Tran
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 2205.
https://doi.org/10.1158/1538-7445.AM2024-2205
Published: 22 March 2024
View articletitled, Abstract 2205: Modifiable risk factors are associated with clonal hematopoiesis
Journal Articles

Abstract 6144: A polymorphic TERT tandem repeat creating an expandable intronic G4 quadruplex is associated with TERT expression, relative leukocyte telomere length and cancer risk

Oscar Florez-Vargas, Michelle Ho, Max Hogshead, Chia-Han Lee, Kaitlin Forsythe, Brenen Papenberg, Kristine Jones, Wen Luo, Kedest Teshome, Cornelis Blauwendraat, Mikhail Kolmogorov, Stephen J. Chanock, Mitchell J. Machiela, John Schneekloth, Shahinaz Gadalla, Sharon A. Savage, Sam M. Mbulaiteye, Ludmila Prokunina-Olsson
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6144.
https://doi.org/10.1158/1538-7445.AM2024-6144
Published: 22 March 2024
View articletitled, Abstract 6144: A polymorphic TERT tandem repeat creating an expandable intronic G4 quadruplex is associated with TERT expression, relative leukocyte telomere length and cancer risk
Journal Articles

Abstract 6155: Germline variants in cancer susceptibility genes and subsequent neoplasm risks after childhood cancer: A pooled analysis of two large-scale cohorts

Shahriar A. Zamani, Danielle M. Karyadi, Stephen W. Hartley, Joshua N. Sampson, Todd Gibson, Peter Kraft, Stephen J. Chanock, Lindsay M. Morton
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6155.
https://doi.org/10.1158/1538-7445.AM2024-6155
Published: 22 March 2024
View articletitled, Abstract 6155: Germline variants in cancer susceptibility genes and subsequent neoplasm risks after childhood cancer: A pooled analysis of two large-scale cohorts
Journal Articles

Abstract 6148: Multiple new Ewing sarcoma susceptibility loci expand knowledge of germline genetic etiology and nominate mechanisms of risk

Aubrey K. Hubbard, Weiyin Zhou, Carrie Boyce, Javed Khan, Melissa M. Hudson, Kirsten K. Ness, Zhaoming Wang, Katherine A. Janeway, Philip J. Lupo, Lindsay M. Morton, Stephen J. Chanock, Thomas G. Grünewald, Olivier Delattre, Mitchell J. Machiela, Ewing Sarcoma Germline Genetics Group
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6148.
https://doi.org/10.1158/1538-7445.AM2024-6148
Published: 22 March 2024
View articletitled, Abstract 6148: Multiple new Ewing sarcoma susceptibility loci expand knowledge of germline genetic etiology and nominate mechanisms of risk