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Stephen D. Gillies
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Journal Articles

Abstract 4011: Effective in situ immunization via local radiation therapy (RT) and tumor-specific immunocytokine (IC): Suppression from distant tumor is blocked by RT or Treg-depleting CTLA-4 antibody

Zachary S. Morris, Emily Guy, David Francis, Monica M. Gressett, Eric A. Armstrong, Shyhmin Huang, Lauryn R. Werner, Stephen D. Gillies, Alan Korman, Jacquelyn A. Hank, Alexander L. Rakhmilevich, Paul M. Harari, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4011.
https://doi.org/10.1158/1538-7445.AM2016-4011
Published: 15 July 2016
View article titled, Abstract 4011: Effective <em>in situ</em> immunization via local radiation therapy (RT) and tumor-specific immunocytokine (IC): Suppression from distant tumor is blocked by RT or Treg-depleting CTLA-4 antibody
Journal Articles

In Situ Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments

Zachary S. Morris, Emily I. Guy, David M. Francis, Monica M. Gressett, Lauryn R. Werner, Lakeesha L. Carmichael, Richard K. Yang, Eric A. Armstrong, Shyhmin Huang, Fariba Navid, Stephen D. Gillies, Alan Korman, Jacquelyn A. Hank, Alexander L. Rakhmilevich, Paul M. Harari, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2016) 76 (13): 3929–3941.
https://doi.org/10.1158/0008-5472.CAN-15-2644
Published: 30 June 2016
View article titled, <em>In Situ</em> Tumor Vaccination by Combining Local Radiation and Tumor-Specific Antibody or Immunocytokine Treatments
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Includes: Supplementary data
Journal Articles

Abstract 2580: Construction of immunoglobulin light chain IL2 immunocytokines and mouse-specific surrogates for studying the effects of IL2 receptor selectivity in mouse tumor models

Stephen D. Gillies
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2580.
https://doi.org/10.1158/1538-7445.AM2014-2580
Published: 01 October 2014
View article titled, Abstract 2580: Construction of immunoglobulin light chain IL2 immunocytokines and mouse-specific surrogates for studying the effects of IL2 receptor selectivity in mouse tumor models
Journal Articles

Abstract 2842: A new platform for constructing antibody-cytokine fusion proteins (immunocytokines) with improved biological properties and adjustable cytokine activity.

Stephen D. Gillies
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2842.
https://doi.org/10.1158/1538-7445.AM2013-2842
Published: 15 April 2013
View article titled, Abstract 2842: A new platform for constructing antibody-cytokine fusion proteins (immunocytokines) with improved biological properties and adjustable cytokine activity.
Journal Articles

Abstract 1538: Enhanced antitumor effects of intratumoral (IT) hu14.18-IL2 immunocytokine (IC) compared to intravenous (IV) hu14.18-IL2 are distinguished by increased activated tumor infiltrating lymphocytes (TILs) and IC retention

Richard K. Yang, Nicholas A. Kalogriopoulos, Alexander L. Rakhmilevich, Erik A. Ranheim, Songwon Seo, KyungMann Kim, Kory L. Alderson, Jacek Gan, Ralph A. Reisfeld, Stephen D. Gillies, Jacquelyn A. Hank, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 1538.
https://doi.org/10.1158/1538-7445.AM2012-1538
Published: 15 April 2012
View article titled, Abstract 1538: Enhanced antitumor effects of intratumoral (IT) hu14.18-IL2 immunocytokine (IC) compared to intravenous (IV) hu14.18-IL2 are distinguished by increased activated tumor infiltrating lymphocytes (TILs) and IC retention
Journal Articles

Genotypes of NK Cell KIR Receptors, Their Ligands, and Fcγ Receptors in the Response of Neuroblastoma Patients to Hu14.18-IL2 Immunotherapy

David C. Delgado, Jacquelyn A. Hank, Jill Kolesar, David Lorentzen, Jacek Gan, Songwon Seo, KyungMann Kim, Suzanne Shusterman, Stephen D. Gillies, Ralph A. Reisfeld, Richard Yang, Brian Gadbaw, Kenneth B. DeSantes, Wendy B. London, Robert C. Seeger, John M. Maris, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2010) 70 (23): 9554–9561.
https://doi.org/10.1158/0008-5472.CAN-10-2211
Published: 06 December 2010
View article titled, Genotypes of NK Cell KIR Receptors, Their Ligands, and Fcγ Receptors in the Response of Neuroblastoma Patients to Hu14.18-IL2 Immunotherapy
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Journal Articles

Abstract LB-325: Antitumor effect of resveratrol combined with immunocytokine immunotherapy

Brenda L. Soto, Jacquelyn A. Hank, Arthur S. Polans, Tyler van de Voort, Alexander L. Rakhmilevich, Songwon Seo, Kim Kuyungmann, Stephen D. Gillies, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-325.
https://doi.org/10.1158/1538-7445.AM10-LB-325
Published: 15 April 2010
View article titled, Abstract LB-325: Antitumor effect of resveratrol combined with immunocytokine immunotherapy
Journal Articles

Abstract LB-195: Anti-CD40 and CpG-ODN enhance the antimelanoma response of hu14.18K322A in vivo.

Kory L. Alderson, Mitchell Luangrath, Stephen D. Gillies, Fariba Navid, Alexander L. Rakhmilevich, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): LB-195.
https://doi.org/10.1158/1538-7445.AM10-LB-195
Published: 15 April 2010
View article titled, Abstract LB-195: Anti-CD40 and CpG-ODN enhance the antimelanoma response of hu14.18K322A <em>in vivo.</em>
Journal Articles

Combining Adoptive Cellular and Immunocytokine Therapies to Improve Treatment of B-Lineage Malignancy

Harjeet Singh, Lisa Marie Serrano, Timothy Pfeiffer, Simon Olivares, George McNamara, David D. Smith, Zaid Al-Kadhimi, Stephen J. Forman, Stephen D. Gillies, Michael C. Jensen, David Colcher, Andrew Raubitschek, Laurence J.N. Cooper
Journal: Cancer Research
Cancer Res (2007) 67 (6): 2872–2880.
https://doi.org/10.1158/0008-5472.CAN-06-2283
Published: 15 March 2007
View article titled, Combining Adoptive Cellular and Immunocytokine Therapies to Improve Treatment of B-Lineage Malignancy
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Includes: Multimedia, Supplementary data
Journal Articles

Human High Molecular Weight Melanoma-Associated Antigen Mimicry by Mouse Anti-Idiotypic Monoclonal Antibody MK2-23: Enhancement of Immunogenicity of Anti-Idiotypic Monoclonal Antibody MK2-23 by Fusion with Interleukin 2

Xinhui Wang, Eric C. Ko, Liaomin Peng, Stephen D. Gillies, Soldano Ferrone
Journal: Cancer Research
Cancer Res (2005) 65 (15): 6976–6983.
https://doi.org/10.1158/0008-5472.CAN-04-2328
Published: 01 August 2005
View article titled, Human High Molecular Weight Melanoma-Associated Antigen Mimicry by Mouse Anti-Idiotypic Monoclonal Antibody MK2-23: Enhancement of Immunogenicity of Anti-Idiotypic Monoclonal Antibody MK2-23 by Fusion with Interleukin 2
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Journal Articles

Engineering of an IL-2 immunocytokine with very low toxicity that retains potent anti-tumor activity in immune competent and immune deficient mouse tumor models

Stephen D. Gillies, Yan Lan, Scott Lauder, Beatrice Brunkhorst, Yaping Sun, Kin-Ming Lo
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 151–152.
Published: 01 April 2004
View article titled, Engineering of an IL-2 immunocytokine with very low toxicity that retains potent anti-tumor activity in immune competent and immune deficient mouse tumor models
Journal Articles

HuBC1-IL12: A very potent immunocytokine which targets the oncofetal fibronectin in the extracellular matrix of tumor vasculature

Kin-Ming Lo, Yan Lan, Scott Lauder, Jinyang Zhang, Beatrice Brunkhorst, Rakesh Verma, Nigel Courtenay-Luck, Stephen D. Gillies
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1082.
Published: 01 April 2004
View article titled, HuBC1-IL12: A very potent immunocytokine which targets the oncofetal fibronectin in the extracellular matrix of tumor vasculature
Journal Articles

MIG (CXCL9) Chemokine Gene Therapy Combines with Antibody-Cytokine Fusion Protein to Suppress Growth and Dissemination of Murine Colon Carcinoma

J. Michael Ruehlmann, Rong Xiang, Andreas G. Niethammer, Yi Ba, Ursula Pertl, Carrie S. Dolman, Stephen D. Gillies, Ralph A. Reisfeld
Journal: Cancer Research
Cancer Res (2001) 61 (23): 8498–8503.
Published: 01 December 2001
View article titled, <em>MIG</em> (CXCL9) Chemokine Gene Therapy Combines with Antibody-Cytokine Fusion Protein to Suppress Growth and Dissemination of Murine Colon Carcinoma
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Journal Articles

Targeted Interleukin 2 Therapy Enhances Protective Immunity Induced by an Autologous Oral DNA Vaccine against Murine Melanoma

Andreas G. Niethammer, Rong Xiang, J. Michael Ruehlmann, Holger N. Lode, Carrie S. Dolman, Stephen D. Gillies, Ralph A. Reisfeld
Journal: Cancer Research
Cancer Res (2001) 61 (16): 6178–6184.
Published: 01 August 2001
View article titled, Targeted Interleukin 2 Therapy Enhances Protective Immunity Induced by an Autologous Oral DNA Vaccine against Murine Melanoma
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Journal Articles

The Level of MHC Class I Expression on Murine Adenocarcinoma Can Change the Antitumor Effector Mechanism of Immunocytokine Therapy

Michael Imboden, Kristopher R. Murphy, Alexander L. Rakhmilevich, Zane C. Neal, Rong Xiang, Ralph A. Reisfeld, Stephen D. Gillies, Paul M. Sondel
Journal: Cancer Research
Cancer Res (2001) 61 (4): 1500–1507.
Published: 02 February 2001
View article titled, The Level of MHC Class I Expression on Murine Adenocarcinoma Can Change the Antitumor Effector Mechanism of Immunocytokine Therapy
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Journal Articles

Improving the Efficacy of Antibody-Interleukin 2 Fusion Proteins by Reducing Their Interaction with Fc Receptors

Stephen D. Gillies, Yan Lan, Kin-Ming Lo, Michael Super, John Wesolowski
Journal: Cancer Research
Cancer Res (1999) 59 (9): 2159–2166.
Published: 01 May 1999
View article titled, Improving the Efficacy of Antibody-Interleukin 2 Fusion Proteins by Reducing Their Interaction with Fc Receptors
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Journal Articles

Induction of Persistent Tumor-protective Immunity in Mice Cured of Established Colon Carcinoma Metastases

Rong Xiang, Holger N. Lode, Torsten Dreier, Stephen D. Gillies, Ralph A. Reisfeld
Journal: Cancer Research
Cancer Res (1998) 58 (17): 3918–3925.
Published: 01 September 1998
View article titled, Induction of Persistent Tumor-protective Immunity in Mice Cured of Established Colon Carcinoma Metastases
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Journal Articles

Elimination of Established Murine Colon Carcinoma Metastases by Antibody- Interleukin 2 Fusion Protein Therapy

Rong Xiang, Holger N. Lode, Carrie S. Dolman, Torsten Dreier, Nissi M. Varki, Xiuqi Qian, Kin-Ming Lo, Yan Lan, Michael Super, Stephen D. Gillies, Ralph A. Reisfeld
Journal: Cancer Research
Cancer Res (1997) 57 (21): 4948–4955.
Published: 01 November 1997
View article titled, Elimination of Established Murine Colon Carcinoma Metastases by Antibody- Interleukin 2 Fusion Protein Therapy
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Journal Articles

Involvement of B Lymphocytes in the Growth Inhibition of Human Pulmonary Melanoma Metastases in Athymic nu/nu Mice by an Antibody-Lymphotoxin Fusion Protein

Ralph A. Reisfeld, Stephen D. Gillies, John Mendelsohn, Nissi M. Varki, Jürgen C. Becker
Journal: Cancer Research
Cancer Res (1996) 56 (8): 1707–1712.
Published: 01 April 1996
View article titled, Involvement of B Lymphocytes in the Growth Inhibition of Human Pulmonary Melanoma Metastases in Athymic <em>nu/nu</em> Mice by an Antibody-Lymphotoxin Fusion Protein
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