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Stephen B. Baylin
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Journal Articles

Abstract IA007: Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs

Shi B. Chia, Bryan J. Johnson, Junxiao Hu, Roel Vermeulen, Marc Chadeau-Hyam, Fernando Guntoro, Hugh Montgomery, Meher Boorgula, Varsha Sreekanth, Andrew Goodspeed, Bennett Davenport, Felipe Valenca-Pereira, Vadym Zaberezhnyy, Wolfgang E Schleicher, Dexiang Gao, Andreia N. Cadar, Michael Papanicolaou, Afshin Beheshti, Stephen B. Baylin, James Costello, Jenna M. Bartley, Thomas E. Morrison, Julio A. Aguirre-Ghiso, Mercedes Rincon, James DeGregori
Journal: Cancer Research
Cancer Res (2024) 84 (22_Supplement): IA007.
https://doi.org/10.1158/1538-7445.TUMBODY-IA007
Published: 17 November 2024
View article titled, Abstract IA007: Respiratory viral infection promotes the awakening and outgrowth of dormant metastatic breast cancer cells in lungs
Journal Articles

Abstract 1463: Characterizing inflammation-induced epigenetic and transcriptomic alterations driving NSCLC using lung organoid models

Na Wang, Kara Lombardo, Raksha Padaki, Ray-Whay Chiu Yen, Malcolm V. Brock, Leslie Cope, Hariharan Easwaran, Stephen B. Baylin, Michelle Vaz
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 1463.
https://doi.org/10.1158/1538-7445.AM2024-1463
Published: 22 March 2024
View article titled, Abstract 1463: Characterizing inflammation-induced epigenetic and transcriptomic alterations driving NSCLC using lung organoid models
Journal Articles

Abstract PR-005: ZNFX1 is a master regulator for epigenetic reprograming of mitochondrial inflammasome signaling and pathogen mimicry in cancer cells

Lora Stojanovic, Rachel Abbotts, Kaushlendra Tripathi, Collin M. Coon, Sheng Liu, Jun Wan, Michael J. Topper, Kenneth P. Nephew, Stephen B. Baylin, Feyruz V. Rassool
Journal: Cancer Research
Cancer Res (2024) 84 (5_Supplement_2): PR-005.
https://doi.org/10.1158/1538-7445.OVARIAN23-PR-005
Published: 04 March 2024
View article titled, Abstract PR-005: ZNFX1 is a master regulator for epigenetic reprograming of mitochondrial inflammasome signaling and pathogen mimicry in cancer cells
Journal Articles

Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci

Tomas Kanholm, Uzma Rentia, Melissa Hadley, Jennifer A. Karlow, Olivia L. Cox, Noor Diab, Matthew L. Bendall, Tyson Dawson, James I. McDonald, Wenbing Xie, Keith A. Crandall, Kathleen H. Burns, Stephen B. Baylin, Hari Easwaran, Katherine B. Chiappinelli
Journal: Cancer Research
Cancer Res (2023) 83 (15): 2584–2599.
https://doi.org/10.1158/0008-5472.CAN-22-3485
Published: 01 August 2023
View article titled, Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci
Open the PDF for Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci in another window
Includes: Supplementary data
Journal Articles

Abstract LB046: Characterizing the role of inflammation-induced epigenetic alterations in modulating the immune microenvironment during lung cancer initiation

Na Wang, Ray-Whay Chiu Yen, Hamza Khan, Malcolm V. Brock, Hariharan Easwaran, Stephen B. Baylin, Michelle Vaz
Journal: Cancer Research
Cancer Res (2023) 83 (8_Supplement): LB046.
https://doi.org/10.1158/1538-7445.AM2023-LB046
Published: 14 April 2023
View article titled, Abstract LB046: Characterizing the role of inflammation-induced epigenetic alterations in modulating the immune microenvironment during lung cancer initiation
Journal Articles

Abstract 6256: Inhibition of class IIa HDACs potentiates MYC inhibitor-driven cytotoxicity by inducing MYC depletion and oxidative stress in non-small cell lung cancer

Jina Park, Ying-Yu Chen, Jennie Cao, Michelle Vaz, Ray-Whay C. Yen, Stephen B. Baylin, Michael J. Topper
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 6256.
https://doi.org/10.1158/1538-7445.AM2023-6256
Published: 04 April 2023
View article titled, Abstract 6256: Inhibition of class IIa HDACs potentiates MYC inhibitor-driven cytotoxicity by inducing MYC depletion and oxidative stress in non-small cell lung cancer
Journal Articles

Abstract 773: Early detection of ovarian cancer using cell-free DNA fragmentomes

Akshaya V. Annapragada, Jamie E. Medina, Pien Lof, Dimitrios Mathios, Zachariah H. Foda, Michaël Noë, Sarah Short, Adrianna Bartolomucci, Daniel C. Bruhm, Euihye Jung, Jenna Canzoniero, Noushin Niknafs, Stephen Cristiano, Vilmos Adleff, Heather Symecko, Daan van de Broek, Stephen B. Baylin, Michael F. Press, Dennis Slamon, Gottfried Konecny, Susan Domchek, Ronny Drapkin, Jillian Phallen, Robert B. Scharpf, Christianne Lok, Victor E. Velculescu
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 773.
https://doi.org/10.1158/1538-7445.AM2023-773
Published: 04 April 2023
View article titled, Abstract 773: Early detection of ovarian cancer using cell-free DNA fragmentomes
Journal Articles

Abstract B016: Aberrant age-related methylation leads to tumor predisposition in colorectal organoids

Daniel A. Petkovich, Rachael Powers, Yong Tao, Byunghak Kang, Nibedita Patel, Kathy Gabrielson, Rafael de Cabo, Stephen B. Baylin, Hariharan P. Easwaran
Journal: Cancer Research
Cancer Res (2023) 83 (2_Supplement_1): B016.
https://doi.org/10.1158/1538-7445.AGCA22-B016
Published: 15 January 2023
View article titled, Abstract B016: Aberrant age-related methylation leads to tumor predisposition in colorectal organoids
Journal Articles

Abstract A012: Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers

Yuba R. Bhandari, Vinod Krishna, Rachael Powers, Sehej Parmar, Sara-Jayne Thursby, Ekta Gupta, Ozlem Kulak, Prashanth Gokare, Joke Reumers, Liesbeth Van Wesenbeeck, Kurtis E. Bachman, Stephen B. Baylin, Hariharan Easwaran
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): A012.
https://doi.org/10.1158/1538-7445.CancEpi22-A012
Published: 01 December 2022
View article titled, Abstract A012: Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers
Journal Articles

Abstract A029: Transposable elements exhibit loss of DNA methylation and increases in transcription in a model of tumorigenesis

Tomas Kanholm, Uzma Rentia, Melissa Hadley Beaty, James I. McDonald, Wenbing Xie, Stephen B. Baylin, Kathleen H. Burns, Hari Easwaran, Katherine B. Chiappinelli
Journal: Cancer Research
Cancer Res (2022) 82 (23_Supplement_2): A029.
https://doi.org/10.1158/1538-7445.CancEpi22-A029
Published: 01 December 2022
View article titled, Abstract A029: Transposable elements exhibit loss of DNA methylation and increases in transcription in a model of tumorigenesis
Journal Articles

Abstract 3278: Identification of epigenetic therapy induced tumor antigens to promote proliferation and infiltration of antigen specific T cells in non-small cell lung cancer

Julia An, Valsamo Anagnostou, Kristen A. Marrone, Victor E. Velculescu, Julie R. Brahmer, Stephen B. Baylin, Michael J. Topper
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3278.
https://doi.org/10.1158/1538-7445.AM2022-3278
Published: 15 June 2022
View article titled, Abstract 3278: Identification of epigenetic therapy induced tumor antigens to promote proliferation and infiltration of antigen specific T cells in non-small cell lung cancer
Journal Articles

Abstract 5593: DNMT inhibitor induces NSCLC inflammasome signaling and mitochondrial dysfunction, producing to DSB repair defects and PARP inhibitor sensitivity

Rachel Abbotts, Lora Stojanovic, Michael J. Topper, Brian M. Polster, Stephen B. Baylin, Feyruz V. Rassool
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5593.
https://doi.org/10.1158/1538-7445.AM2022-5593
Published: 15 June 2022
View article titled, Abstract 5593: DNMT inhibitor induces NSCLC inflammasome signaling and mitochondrial dysfunction, producing to DSB repair defects and PARP inhibitor sensitivity
Journal Articles

Abstract 3280: Combination of MYC and class IIa HDAC inhibition potentiates anti-tumor efficacy in non-small cell lung cancer

Jina Park, Michelle Vaz, Ray-Whay C. Yen, Stephen B. Baylin, Michael J. Topper
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 3280.
https://doi.org/10.1158/1538-7445.AM2022-3280
Published: 15 June 2022
View article titled, Abstract 3280: Combination of MYC and class IIa HDAC inhibition potentiates anti-tumor efficacy in non-small cell lung cancer
Journal Articles

Abstract 6301: DNA methyltransferase inhibitors increase ERV reactivation and STING-dependent interferon/inflammasome signaling in TP53 mutant AML

Aksinija A. Kogan, Michael J. Topper, Lora Stojanovic, Lena J. McLaughlin, Tammy J. Kingsbury, Maria R. Baer, Michael Kessler, Stephen B. Baylin, Feyruz V. Rassool
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6301.
https://doi.org/10.1158/1538-7445.AM2022-6301
Published: 15 June 2022
View article titled, Abstract 6301: DNA methyltransferase inhibitors increase ERV reactivation and STING-dependent interferon/inflammasome signaling in TP53 mutant AML
Journal Articles

Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner

James I. McDonald, Noor Diab, Elisa Arthofer, Melissa Hadley, Tomas Kanholm, Uzma Rentia, Stephanie Gomez, Angela Yu, Erin E. Grundy, Olivia Cox, Michael J. Topper, Xiaoyun Xing, Pamela L. Strissel, Reiner Strick, Ting Wang, Stephen B. Baylin, Katherine B. Chiappinelli
Journal: Cancer Research
Cancer Res (2021) 81 (20): 5176–5189.
https://doi.org/10.1158/0008-5472.CAN-20-4243
Published: 17 October 2021
View article titled, Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <em>TP53</em>-Dependent Manner
Open the PDF for Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <em>TP53</em>-Dependent Manner in another window
Includes: Supplementary data
Journal Articles

Abstract CT121: A Phase II trial of guadecitabine (G) plus atezolizumab (A) in patients with metastatic urothelial carcinoma (UC) progressing after initial checkpoint inhibitor therapy

Elizabeth R. Plimack, Kerry Campbell, Jean-Pierre J. Issa, Noah M. Hahn, David I. Quinn, Hyo Sik Jang, Galen Hostetter, Peter W. Nichols, Woonbok Chung, Jozef Madzo, Hitoshi Ohtani, Hui Shen, Toshinori Hinoue, Stephen B. Baylin, Peter A. Jones
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): CT121.
https://doi.org/10.1158/1538-7445.AM2021-CT121
Published: 01 July 2021
View article titled, Abstract CT121: A Phase II trial of guadecitabine (G) plus atezolizumab (A) in patients with metastatic urothelial carcinoma (UC) progressing after initial checkpoint inhibitor therapy
Journal Articles

Abstract 969: Pharmacologic induction of innate immune signaling via STING directly drives homologous recombination deficiency

Lena J. McLaughlin, Aksinija A. Kogan, Stephen B. Baylin, Michael J. Topper, Feyruz V. Rassool
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 969.
https://doi.org/10.1158/1538-7445.AM2020-969
Published: 15 August 2020
View article titled, Abstract 969: Pharmacologic induction of innate immune signaling via STING directly drives homologous recombination deficiency
Journal Articles

DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer

Meghan Travers, Stephen M. Brown, Matthew Dunworth, Cassandra E. Holbert, Karla R. Wiehagen, Kurtis E. Bachman, Jackson R. Foley, Meredith L. Stone, Stephen B. Baylin, Robert A. Casero, Jr., Cynthia A. Zahnow
Journal: Cancer Research
Cancer Res (2019) 79 (13): 3445–3454.
https://doi.org/10.1158/0008-5472.CAN-18-4018
Published: 01 July 2019
View article titled, DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer
Open the PDF for DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity

Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Yong Tao, Ray-Whay Chiu Yen, Hariharan Easwaran, Michael J. Topper, Scott B. Rothbart, Limin Xia, Stephen B. Baylin
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 947.
https://doi.org/10.1158/1538-7445.AM2019-947
Published: 01 July 2019
View article titled, Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity
Journal Articles

Abstract 4473: DNMT and PARP inhibitor combination therapy induces an interferon-driven homologous recombination defect in triple-negative breast cancers and acute myeloid leukemia

Lena J. McLaughlin, Aksinija A. Kogan, Eun Yong Choi, Rena S. Lapidus, Ying Zou, Huili Li, Stephen B. Baylin, Michael J. Topper, Feyruz V. Rassool
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 4473.
https://doi.org/10.1158/1538-7445.AM2019-4473
Published: 01 July 2019
View article titled, Abstract 4473: DNMT and PARP inhibitor combination therapy induces an interferon-driven homologous recombination defect in triple-negative breast cancers and acute myeloid leukemia