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Journal Articles

Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci

Tomas Kanholm, Uzma Rentia, Melissa Hadley, Jennifer A. Karlow, Olivia L. Cox, Noor Diab, Matthew L. Bendall, Tyson Dawson, James I. McDonald, Wenbing Xie, Keith A. Crandall, Kathleen H. Burns, Stephen B. Baylin, Hari Easwaran, Katherine B. Chiappinelli

Cancer Res (2023) 83 (15): 2584–2599.

https://doi.org/10.1158/0008-5472.CAN-22-3485

Published: 01 August 2023

View article titled, Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci

Includes: Supplementary data

Journal Articles

Abstract LB046: Characterizing the role of inflammation-induced epigenetic alterations in modulating the immune microenvironment during lung cancer initiation

Na Wang, Ray-Whay Chiu Yen, Hamza Khan, Malcolm V. Brock, Hariharan Easwaran, Stephen B. Baylin, Michelle Vaz

Cancer Res (2023) 83 (8_Supplement): LB046.

https://doi.org/10.1158/1538-7445.AM2023-LB046

Published: 14 April 2023

View article titled, Abstract LB046: Characterizing the role of inflammation-induced epigenetic alterations in modulating the immune microenvironment during lung cancer initiation

Journal Articles

Abstract 6256: Inhibition of class IIa HDACs potentiates MYC inhibitor-driven cytotoxicity by inducing MYC depletion and oxidative stress in non-small cell lung cancer

Jina Park, Ying-Yu Chen, Jennie Cao, Michelle Vaz, Ray-Whay C. Yen, Stephen B. Baylin, Michael J. Topper

Cancer Res (2023) 83 (7_Supplement): 6256.

https://doi.org/10.1158/1538-7445.AM2023-6256

Published: 04 April 2023

View article titled, Abstract 6256: Inhibition of class IIa HDACs potentiates MYC inhibitor-driven cytotoxicity by inducing MYC depletion and oxidative stress in non-small cell lung cancer

Journal Articles

Abstract 773: Early detection of ovarian cancer using cell-free DNA fragmentomes

Cancer Res (2023) 83 (7_Supplement): 773.

https://doi.org/10.1158/1538-7445.AM2023-773

Published: 04 April 2023

View article titled, Abstract 773: Early detection of ovarian cancer using cell-free DNA fragmentomes

Journal Articles

Abstract B016: Aberrant age-related methylation leads to tumor predisposition in colorectal organoids

Daniel A. Petkovich, Rachael Powers, Yong Tao, Byunghak Kang, Nibedita Patel, Kathy Gabrielson, Rafael de Cabo, Stephen B. Baylin, Hariharan P. Easwaran

Cancer Res (2023) 83 (2_Supplement_1): B016.

https://doi.org/10.1158/1538-7445.AGCA22-B016

Published: 15 January 2023

View article titled, Abstract B016: Aberrant age-related methylation leads to tumor predisposition in colorectal organoids

Journal Articles

Abstract A012: Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers

Yuba R. Bhandari, Vinod Krishna, Rachael Powers, Sehej Parmar, Sara-Jayne Thursby, Ekta Gupta, Ozlem Kulak, Prashanth Gokare, Joke Reumers, Liesbeth Van Wesenbeeck, Kurtis E. Bachman, Stephen B. Baylin, Hariharan Easwaran

Cancer Res (2022) 82 (23_Supplement_2): A012.

https://doi.org/10.1158/1538-7445.CancEpi22-A012

Published: 01 December 2022

View article titled, Abstract A012: Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers

Journal Articles

Abstract A029: Transposable elements exhibit loss of DNA methylation and increases in transcription in a model of tumorigenesis

Tomas Kanholm, Uzma Rentia, Melissa Hadley Beaty, James I. McDonald, Wenbing Xie, Stephen B. Baylin, Kathleen H. Burns, Hari Easwaran, Katherine B. Chiappinelli

Cancer Res (2022) 82 (23_Supplement_2): A029.

https://doi.org/10.1158/1538-7445.CancEpi22-A029

Published: 01 December 2022

View article titled, Abstract A029: Transposable elements exhibit loss of DNA methylation and increases in transcription in a model of tumorigenesis

Journal Articles

Abstract 6301: DNA methyltransferase inhibitors increase ERV reactivation and STING-dependent interferon/inflammasome signaling in TP53 mutant AML

Aksinija A. Kogan, Michael J. Topper, Lora Stojanovic, Lena J. McLaughlin, Tammy J. Kingsbury, Maria R. Baer, Michael Kessler, Stephen B. Baylin, Feyruz V. Rassool

Cancer Res (2022) 82 (12_Supplement): 6301.

https://doi.org/10.1158/1538-7445.AM2022-6301

Published: 15 June 2022

View article titled, Abstract 6301: DNA methyltransferase inhibitors increase ERV reactivation and STING-dependent interferon/inflammasome signaling in TP53 mutant AML

Journal Articles

Abstract 5593: DNMT inhibitor induces NSCLC inflammasome signaling and mitochondrial dysfunction, producing to DSB repair defects and PARP inhibitor sensitivity

Rachel Abbotts, Lora Stojanovic, Michael J. Topper, Brian M. Polster, Stephen B. Baylin, Feyruz V. Rassool

Cancer Res (2022) 82 (12_Supplement): 5593.

https://doi.org/10.1158/1538-7445.AM2022-5593

Published: 15 June 2022

View article titled, Abstract 5593: DNMT inhibitor induces NSCLC inflammasome signaling and mitochondrial dysfunction, producing to DSB repair defects and PARP inhibitor sensitivity

Journal Articles

Abstract 3280: Combination of MYC and class IIa HDAC inhibition potentiates anti-tumor efficacy in non-small cell lung cancer

Jina Park, Michelle Vaz, Ray-Whay C. Yen, Stephen B. Baylin, Michael J. Topper

Cancer Res (2022) 82 (12_Supplement): 3280.

https://doi.org/10.1158/1538-7445.AM2022-3280

Published: 15 June 2022

View article titled, Abstract 3280: Combination of MYC and class IIa HDAC inhibition potentiates anti-tumor efficacy in non-small cell lung cancer

Journal Articles

Abstract 3278: Identification of epigenetic therapy induced tumor antigens to promote proliferation and infiltration of antigen specific T cells in non-small cell lung cancer

Julia An, Valsamo Anagnostou, Kristen A. Marrone, Victor E. Velculescu, Julie R. Brahmer, Stephen B. Baylin, Michael J. Topper

Cancer Res (2022) 82 (12_Supplement): 3278.

https://doi.org/10.1158/1538-7445.AM2022-3278

Published: 15 June 2022

View article titled, Abstract 3278: Identification of epigenetic therapy induced tumor antigens to promote proliferation and infiltration of antigen specific T cells in non-small cell lung cancer

Journal Articles

Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner

James I. McDonald, Noor Diab, Elisa Arthofer, Melissa Hadley, Tomas Kanholm, Uzma Rentia, Stephanie Gomez, Angela Yu, Erin E. Grundy, Olivia Cox, Michael J. Topper, Xiaoyun Xing, Pamela L. Strissel, Reiner Strick, Ting Wang, Stephen B. Baylin, Katherine B. Chiappinelli

Cancer Res (2021) 81 (20): 5176–5189.

https://doi.org/10.1158/0008-5472.CAN-20-4243

Published: 17 October 2021

View article titled, Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a <em>TP53</em>-Dependent Manner

Includes: Supplementary data

Journal Articles

Abstract CT121: A Phase II trial of guadecitabine (G) plus atezolizumab (A) in patients with metastatic urothelial carcinoma (UC) progressing after initial checkpoint inhibitor therapy

Elizabeth R. Plimack, Kerry Campbell, Jean-Pierre J. Issa, Noah M. Hahn, David I. Quinn, Hyo Sik Jang, Galen Hostetter, Peter W. Nichols, Woonbok Chung, Jozef Madzo, Hitoshi Ohtani, Hui Shen, Toshinori Hinoue, Stephen B. Baylin, Peter A. Jones

Cancer Res (2021) 81 (13_Supplement): CT121.

https://doi.org/10.1158/1538-7445.AM2021-CT121

Published: 01 July 2021

View article titled, Abstract CT121: A Phase II trial of guadecitabine (G) plus atezolizumab (A) in patients with metastatic urothelial carcinoma (UC) progressing after initial checkpoint inhibitor therapy

Journal Articles

Abstract 969: Pharmacologic induction of innate immune signaling via STING directly drives homologous recombination deficiency

Lena J. McLaughlin, Aksinija A. Kogan, Stephen B. Baylin, Michael J. Topper, Feyruz V. Rassool

Cancer Res (2020) 80 (16_Supplement): 969.

https://doi.org/10.1158/1538-7445.AM2020-969

Published: 15 August 2020

View article titled, Abstract 969: Pharmacologic induction of innate immune signaling via STING directly drives homologous recombination deficiency

Journal Articles

Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity

Xiangqian Kong, Jie Chen, Wenbing Xie, Stephen M. Brown, Yi Cai, Kaichun Wu, Daiming Fan, Yongzhan Nie, Yong Tao, Ray-Whay Chiu Yen, Hariharan Easwaran, Michael J. Topper, Scott B. Rothbart, Limin Xia, Stephen B. Baylin

Cancer Res (2019) 79 (13_Supplement): 947.

https://doi.org/10.1158/1538-7445.AM2019-947

Published: 01 July 2019

View article titled, Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity

Journal Articles

Abstract 4473: DNMT and PARP inhibitor combination therapy induces an interferon-driven homologous recombination defect in triple-negative breast cancers and acute myeloid leukemia

Lena J. McLaughlin, Aksinija A. Kogan, Eun Yong Choi, Rena S. Lapidus, Ying Zou, Huili Li, Stephen B. Baylin, Michael J. Topper, Feyruz V. Rassool

Cancer Res (2019) 79 (13_Supplement): 4473.

https://doi.org/10.1158/1538-7445.AM2019-4473

Published: 01 July 2019

View article titled, Abstract 4473: DNMT and PARP inhibitor combination therapy induces an interferon-driven homologous recombination defect in triple-negative breast cancers and acute myeloid leukemia

Journal Articles

DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer

Meghan Travers, Stephen M. Brown, Matthew Dunworth, Cassandra E. Holbert, Karla R. Wiehagen, Kurtis E. Bachman, Jackson R. Foley, Meredith L. Stone, Stephen B. Baylin, Robert A. Casero, Jr., Cynthia A. Zahnow

Cancer Res (2019) 79 (13): 3445–3454.

https://doi.org/10.1158/0008-5472.CAN-18-4018

Published: 01 July 2019

View article titled, DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer

Includes: Supplementary data

Journal Articles

Dual Inhibition of DNA and Histone Methyltransferases Increases Viral Mimicry in Ovarian Cancer Cells

Minmin Liu, Stacey L. Thomas, Ashley K. DeWitt, Wanding Zhou, Zachary B. Madaj, Hitoshi Ohtani, Stephen B. Baylin, Gangning Liang, Peter A. Jones

Cancer Res (2018) 78 (20): 5754–5766.

https://doi.org/10.1158/0008-5472.CAN-17-3953

Published: 15 October 2018

View article titled, Dual Inhibition of DNA and Histone Methyltransferases Increases Viral Mimicry in Ovarian Cancer Cells

Includes: Supplementary data

Journal Articles

Abstract 2952: Targeting CDK9 reactivates epigenetically silenced genes in cancer

Cancer Res (2018) 78 (13_Supplement): 2952.

https://doi.org/10.1158/1538-7445.AM2018-2952

Published: 01 July 2018

View article titled, Abstract 2952: Targeting CDK9 reactivates epigenetically silenced genes in cancer

Journal Articles

A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine

Benjamin R. Leadem, Ioannis Kagiampakis, Catherine Wilson, Tommy K. Cheung, David Arnott, Patrick Trojer, Marie Classon, Hariharan Easwaran, Stephen B. Baylin

Cancer Res (2018) 78 (5): 1127–1139.

https://doi.org/10.1158/0008-5472.CAN-17-1453

Published: 28 February 2018

View article titled, A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine

Includes: Supplementary data

NARROW

Oncogenic Transformation Drives DNA Methylation Loss and Transcriptional Activation at Transposable Element Loci

Abstract LB046: Characterizing the role of inflammation-induced epigenetic alterations in modulating the immune microenvironment during lung cancer initiation

Abstract 6256: Inhibition of class IIa HDACs potentiates MYC inhibitor-driven cytotoxicity by inducing MYC depletion and oxidative stress in non-small cell lung cancer

Abstract 773: Early detection of ovarian cancer using cell-free DNA fragmentomes

Abstract B016: Aberrant age-related methylation leads to tumor predisposition in colorectal organoids

Abstract A012: Transcription factor expression repertoire basis for epigenetic and transcriptional subtypes of colorectal cancers

Abstract A029: Transposable elements exhibit loss of DNA methylation and increases in transcription in a model of tumorigenesis

Abstract 6301: DNA methyltransferase inhibitors increase ERV reactivation and STING-dependent interferon/inflammasome signaling in TP53 mutant AML

Abstract 5593: DNMT inhibitor induces NSCLC inflammasome signaling and mitochondrial dysfunction, producing to DSB repair defects and PARP inhibitor sensitivity

Abstract 3280: Combination of MYC and class IIa HDAC inhibition potentiates anti-tumor efficacy in non-small cell lung cancer

Abstract 3278: Identification of epigenetic therapy induced tumor antigens to promote proliferation and infiltration of antigen specific T cells in non-small cell lung cancer

Epigenetic Therapies in Ovarian Cancer Alter Repetitive Element Expression in a TP53-Dependent Manner

Abstract CT121: A Phase II trial of guadecitabine (G) plus atezolizumab (A) in patients with metastatic urothelial carcinoma (UC) progressing after initial checkpoint inhibitor therapy

Abstract 969: Pharmacologic induction of innate immune signaling via STING directly drives homologous recombination deficiency

Abstract 947: Defining UHRF1 domains that support maintenance of human colon cancer DNA methylation and tumorigenicity

Abstract 4473: DNMT and PARP inhibitor combination therapy induces an interferon-driven homologous recombination defect in triple-negative breast cancers and acute myeloid leukemia

DFMO and 5-Azacytidine Increase M1 Macrophages in the Tumor Microenvironment of Murine Ovarian Cancer

Dual Inhibition of DNA and Histone Methyltransferases Increases Viral Mimicry in Ovarian Cancer Cells

Abstract 2952: Targeting CDK9 reactivates epigenetically silenced genes in cancer

A KDM5 Inhibitor Increases Global H3K4 Trimethylation Occupancy and Enhances the Biological Efficacy of 5-Aza-2′-Deoxycytidine

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