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Stephan A. Grupp
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Journal Articles

Abstract 909: Single-cell multi-omics reveals type-2 function and metabolic fitness in maintaining CAR T cell longevity associated with 8-year leukemia remission

Zhiliang Bai, J. Joseph Melenhorst, Stephan A. Grupp, Rong Fan
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 909.
https://doi.org/10.1158/1538-7445.AM2023-909
Published: 04 April 2023
View article titled, Abstract 909: Single-cell multi-omics reveals type-2 function and metabolic fitness in maintaining CAR T cell longevity associated with 8-year leukemia remission
Journal Articles

Abstract 510: Impact of tisagenlecleucel product attributes on clinical outcomes in pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia (r/r ALL)

Irina Gershgorin, Edward R. Waldron, Stephan A. Grupp, John E. Levine, Michael A. Pulsipher, Stella M. Davies, G. Doug Myers, Margit Jeschke, Boris Engels, Chris del Corral, Andre Baruchel
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 510.
https://doi.org/10.1158/1538-7445.AM2021-510
Published: 01 July 2021
View article titled, Abstract 510: Impact of tisagenlecleucel product attributes on clinical outcomes in pediatric and young adult patients with relapsed or refractory acute lymphoblastic leukemia (r/r ALL)
Journal Articles

Abstract CT077: Potential utility of minimal residual disease (MRD) to identify relapse in pediatric and young adult (AYA) B-cell acute lymphoblastic leukemia (B-ALL) patients treated with tisagenlecleucel

Michael A. Pulsipher, Xia Han, Máire Quigley, Gabor Kari, Susana Rives, Theodore W. Laetsch, Gary D. Myers, Hidefumi Hiramatsu, Gregory A. Yanik, Muna Qayed, Timothy Driscoll, Michael W. Boyer, Heather Stefanski, Jochen Buchner, Andre Baruchel, Peter Bader, Lan Yi, Creton Kalfoglou, Harlan Robins, Erik Yusko, Gullu Gorgun, Eric Bleickardt, Stephane Wong, Stephan A. Grupp
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): CT077.
https://doi.org/10.1158/1538-7445.AM2019-CT077
Published: 01 July 2019
View article titled, Abstract CT077: Potential utility of minimal residual disease (MRD) to identify relapse in pediatric and young adult (AYA) B-cell acute lymphoblastic leukemia (B-ALL) patients treated with tisagenlecleucel
Journal Articles

Abstract 1537: Anti-CD19 ARTEMIS™ T cells prevent excessive inflammatory cytokine release, including IL-6, in a co-culture model of CRS

Hong Liu, Lucas H. Horan, Stephan A. Grupp, David M. Barrett, Cheng Liu
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1537.
https://doi.org/10.1158/1538-7445.AM2018-1537
Published: 01 July 2018
View article titled, Abstract 1537: Anti-CD19 ARTEMIS™ T cells prevent excessive inflammatory cytokine release, including IL-6, in a co-culture model of CRS
Journal Articles

Abstract 2642: Preclinical efficacy of daratumumab in acute lymphoblastic leukemia

Karen Lee Bride, Tiffaney Vincent, Soo-Yeon L. Im, Tori Fuller, Theresa Ryan, David M. Barrett, Shannon L. Maude, Mignon L. Loh, Michelle L. Hermiston, Stephan A. Grupp, Brent L. Wood, David T. Teachey
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2642.
https://doi.org/10.1158/1538-7445.AM2017-2642
Published: 01 July 2017
View article titled, Abstract 2642: Preclinical efficacy of daratumumab in acute lymphoblastic leukemia
Journal Articles

Abstract 1309: Fitness of T cells for use in cellular therapy of pediatric malignancies

Nathan Singh, Jessica Hulitt, Stephan A. Grupp, David M. Barrett
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 1309.
https://doi.org/10.1158/1538-7445.AM2015-1309
Published: 01 August 2015
View article titled, Abstract 1309: Fitness of T cells for use in cellular therapy of pediatric malignancies
Journal Articles

Abstract B20: Innate and adaptive immune control of neoantigen-bearing acute lymphoblastic leukemia (ALL) enhanced by epitope spread

Alix E. Seif, David M. Barrett, Stephan A. Grupp, Gregor SD Reid
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): B20.
https://doi.org/10.1158/1538-7445.PEDCAN-B20
Published: 09 October 2014
View article titled, Abstract B20: Innate and adaptive immune control of neoantigen-bearing acute lymphoblastic leukemia (ALL) enhanced by epitope spread
Journal Articles

Abstract PR06: T cells engineered with a chimeric antigen receptor (CAR) targeting CD19 (CTL019) produce complete responses and long-term persistence without GVHD in children with relapsed, refractory ALL

Stephan A. Grupp, Shannon Maude, Richard Aplenc, David M. Barrett, Michael Kalos, Bruce Levine, Manuel Lichtman, Susan Rheingold, Angela Shen, Christine Strait, David Teachey, Patricia A. Wood, Carl June
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): PR06.
https://doi.org/10.1158/1538-7445.PEDCAN-PR06
Published: 09 October 2014
View article titled, Abstract PR06: T cells engineered with a chimeric antigen receptor (CAR) targeting CD19 (CTL019) produce complete responses and long-term persistence without GVHD in children with relapsed, refractory ALL
Journal Articles

Abstract B33: Toll-like receptor ligands delay acute lymphoblastic leukemia onset via depletion of pre-leukemic cells

Mario Fidanza, Sumin Jo, Arnawaz Bashir, Stephan A. Grupp, Alix E. Seif, Gregor S. Reid
Journal: Cancer Research
Cancer Res (2014) 74 (20_Supplement): B33.
https://doi.org/10.1158/1538-7445.PEDCAN-B33
Published: 09 October 2014
View article titled, Abstract B33: Toll-like receptor ligands delay acute lymphoblastic leukemia onset via depletion of pre-leukemic cells
Journal Articles

Abstract 997: Targeting the Jak/Stat signaling pathway is highly effective in xenograft models of early T cell precursor (ETP) acute lymphoblastic leukemia (ALL)

Shannon L. Maude, Sibasish Dolai, Cristina Delagdo-Martin, Tiffaney Vincent, Alissa Robbins, Arthavan Selvanathan, Theresa Ryan, Stephen P. Hunger, Mignon L. Loh, Charles G. Mullighan, Brent L. Wood, Michelle L. Hermiston, Stephan A. Grupp, Richard B. Lock, David T. Teachey
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 997.
https://doi.org/10.1158/1538-7445.AM2014-997
Published: 01 October 2014
View article titled, Abstract 997: Targeting the Jak/Stat signaling pathway is highly effective in xenograft models of early T cell precursor (ETP) acute lymphoblastic leukemia (ALL)
Journal Articles

Abstract 2790: The monocyte lineage is required for production of clinically relevant interleukin-6 (IL-6) during chimeric antigen receptor (CAR) T cell cytotoxicity

David M. Barrett, Nathan Singh, Bruce Levine, Stephan A. Grupp
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 2790.
https://doi.org/10.1158/1538-7445.AM2014-2790
Published: 01 October 2014
View article titled, Abstract 2790: The monocyte lineage is required for production of clinically relevant interleukin-6 (IL-6) during chimeric antigen receptor (CAR) T cell cytotoxicity
Journal Articles

Abstract 4574: Use of CD19-targeted Chimeric Antigen Receptor-modified T (CART19) cells in ALL and CLL produce transient cytokine release syndrome (CRS), macrophage activation syndrome (MAS) and durable responses.

Stephan A. Grupp, Michael Kalos, David M. Barrett, David T. Teachey, Bruce Levine, Michael Milone, David Porter, Carl H. June
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 4574.
https://doi.org/10.1158/1538-7445.AM2013-4574
Published: 15 April 2013
View article titled, Abstract 4574: Use of CD19-targeted Chimeric Antigen Receptor-modified T (CART19) cells in ALL and CLL produce transient cytokine release syndrome (CRS), macrophage activation syndrome (MAS) and durable responses.
Journal Articles

Abstract 3972: Carpet bombing with CARs: Influence of dose, timing, lymphodepletion and costimulatory domain on efficacy of mRNA engineered anti-CD19 Chimeric Antigen Receptor T cells in preclinical xenograft models.

David M. Barrett, Yangbing Zhao, Xiaojun Liu, Shuguang Jiang, Gregor S D Reid, Alix E. Seif, Carl H. June, Stephan A. Grupp
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 3972.
https://doi.org/10.1158/1538-7445.AM2013-3972
Published: 15 April 2013
View article titled, Abstract 3972: Carpet bombing with CARs: Influence of dose, timing, lymphodepletion and costimulatory domain on efficacy of mRNA engineered anti-CD19 Chimeric Antigen Receptor T cells in preclinical xenograft models.
Journal Articles

Abstract 3505: Preclinical testing of mRNA engineered chimeric antigen receptor T cells: Comparison of a multi-infusion protocol to a single injection of stably expressed CARs in ALL xenograft models

David M. Barrett, Yangbing Zhao, Xiaojun Liu, Shuguang Jiang, Alix E. Seif, Gregor S.D. Reid, Carl H. June, Stephan A. Grupp
Journal: Cancer Research
Cancer Res (2012) 72 (8_Supplement): 3505.
https://doi.org/10.1158/1538-7445.AM2012-3505
Published: 15 April 2012
View article titled, Abstract 3505: Preclinical testing of mRNA engineered chimeric antigen receptor T cells: Comparison of a multi-infusion protocol to a single injection of stably expressed CARs in ALL xenograft models
Journal Articles

Abstract 2933: Pre-clinical model of eradication of B cell leukemia with lentiviral transduced anti-CD19 chimeric immunoreceptor-modified T cells

David M. Barrett, Carmine Carpenito, Yang Bing Zhao, Michael Kalos, Carl H. June, Stephan A. Grupp
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 2933.
https://doi.org/10.1158/1538-7445.AM10-2933
Published: 15 April 2010
View article titled, Abstract 2933: Pre-clinical model of eradication of B cell leukemia with lentiviral transduced anti-CD19 chimeric immunoreceptor-modified T cells
Journal Articles

Thymic Stromal-Derived Lymphopoietin Induces Proliferation of Pre-B Leukemia and Antagonizes mTOR Inhibitors, Suggesting a Role for Interleukin-7Rα Signaling

Valerie I. Brown, Jessica Hulitt, Jonathan Fish, Cecilia Sheen, Marlo Bruno, Qing Xu, Martin Carroll, Junjie Fang, David Teachey, Stephan A. Grupp
Journal: Cancer Research
Cancer Res (2007) 67 (20): 9963–9970.
https://doi.org/10.1158/0008-5472.CAN-06-4704
Published: 17 October 2007
View article titled, Thymic Stromal-Derived Lymphopoietin Induces Proliferation of Pre-B Leukemia and Antagonizes mTOR Inhibitors, Suggesting a Role for Interleukin-7Rα Signaling
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Journal Articles

Survivin-specific T cell immunity and immunosurveillance in high-risk neuroblastoma

Christina M. Coughlin, Mark D. Fleming, Richard G. Carroll, Bruce R. Pawel, Michael D. Hogarty, Xiaochuan Shan, Barbara A. Vance, Leonard H. Wexler, Carol J. Thiele, Gwenn-Aël H. Danet-Desnoyers, Jack L. Pinkus, Geraldine S. Pinkus, John M. Maris, Stephan A. Grupp, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2006) 66 (8_Supplement): 530.
Published: 15 April 2006
View article titled, Survivin-specific T cell immunity and immunosurveillance in high-risk neuroblastoma
Journal Articles

IL-7 and Thymic stromal lymphopoietin (TSLP) are growth factors for ALL cells, reverse the effect of rapamycin, and reveal a role for IL-7Rα

Valerie I. Brown, David Teachey, Junjie Fang, Stephan A. Grupp
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1077–1078.
Published: 01 April 2004
View article titled, IL-7 and Thymic stromal lymphopoietin (TSLP) are growth factors for ALL cells, reverse the effect of rapamycin, and reveal a role for IL-7Rα
Journal Articles

High risk neuroblastoma patients harbor survivin-specific cytotoxic T cells at diagnosis that lyse tumor cells in an MHC-restricted fashion

Christina M. Coughlin, Barbara A. Vance, Stephan A. Grupp, Robert H. Vonderheide
Journal: Cancer Research
Cancer Res (2004) 64 (7_Supplement): 1120.
Published: 01 April 2004
View article titled, High risk neuroblastoma patients harbor survivin-specific cytotoxic T cells at diagnosis that lyse tumor cells in an MHC-restricted fashion
Journal Articles

Cytoplasmic μ Heavy Chain Confers Sensitivity to Dexamethasone-induced Apoptosis in Early B-lineage Acute Lymphoblastic Leukemia

Jenny M. Kim, Junjie Fang, Susan Rheingold, Richard Aplenc, Robert Wasserman, Stephan A. Grupp
Journal: Cancer Research
Cancer Res (2002) 62 (15): 4212–4216.
Published: 01 August 2002
View article titled, Cytoplasmic μ Heavy Chain Confers Sensitivity to Dexamethasone-induced Apoptosis in Early B-lineage Acute Lymphoblastic Leukemia
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