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Stefania Orecchioni
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Journal Articles

Abstract 288: Middle-aged murine models of triple negative breast cancer (TNBC) show significant differences in tumor immune and stromal environments when compared to classic 6-8 week old models; Challenges and opportunities for preclinical efficacy studies

Paolo Falvo, Stephan Gruener, Stefania Orecchioni, Giovanna Talarico, Giulia Bravetti, Giulia Mitola, Federica Pisati, Iros Barozzi, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 288.
https://doi.org/10.1158/1538-7445.AM2024-288
Published: 22 March 2024
View article titled, Abstract 288: Middle-aged murine models of triple negative breast cancer (TNBC) show significant differences in tumor immune and stromal environments when compared to classic 6-8 week old models; Challenges and opportunities for preclinical efficacy studies
Journal Articles

Abstract 1712: A single-cell RNA atlas of innate and adaptive intratumoral immunity in triple negative breast cancer during chemo- and immunotherapies

Laura Carpen, Paolo Falvo, Stefania Orecchioni, Giulia Mitola, Roman Hillje, Saveria Mazzara, Patrizia Mancuso, Stefano Pileri, Alessandro Raveane, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 1712.
https://doi.org/10.1158/1538-7445.AM2022-1712
Published: 15 June 2022
View article titled, Abstract 1712: A single-cell RNA atlas of innate and adaptive intratumoral immunity in triple negative breast cancer during chemo- and immunotherapies
Journal Articles

Abstract 1653: A single-cell atlas of the effect of chemotherapeutics over intratumoral immune cells reveals that combining an alkylating agent and a vinca alkaloid can activate antigen presenting cells and increase tcf1+ stem-like CD8+ T-cells, thus improving anti-PD-1 efficacy in triple negative breast cancer and lymphoma

Paolo Falvo, Stefania Orecchioni, Roman Hillje, Alessandro Raveane, Giulia Mitola, Patrizia Mancuso, Chiara Camisaschi, Lucilla Luzi, PierGiuseppe Pelicci, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 1653.
https://doi.org/10.1158/1538-7445.AM2021-1653
Published: 01 July 2021
View article titled, Abstract 1653: A single-cell atlas of the effect of chemotherapeutics over intratumoral immune cells reveals that combining an alkylating agent and a vinca alkaloid can activate antigen presenting cells and increase tcf1+ stem-like CD8+ T-cells, thus improving anti-PD-1 efficacy in triple negative breast cancer and lymphoma
Journal Articles

Cyclophosphamide and Vinorelbine Activate Stem-Like CD8+ T Cells and Improve Anti-PD-1 Efficacy in Triple-Negative Breast Cancer

Paolo Falvo, Stefania Orecchioni, Roman Hillje, Alessandro Raveane, Patrizia Mancuso, Chiara Camisaschi, Lucilla Luzi, PierGiuseppe Pelicci, Francesco Bertolini
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (3): 685–697.
https://doi.org/10.1158/0008-5472.CAN-20-1818
Published: 01 February 2021
View article titled, Cyclophosphamide and Vinorelbine Activate Stem-Like CD8<sup>+</sup> T Cells and Improve Anti-PD-1 Efficacy in Triple-Negative Breast Cancer
Open the PDF for Cyclophosphamide and Vinorelbine Activate Stem-Like CD8<sup>+</sup> T Cells and Improve Anti-PD-1 Efficacy in Triple-Negative Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 4946: Bitter taste receptors system is expressed and functional in both HSCs and leukemic cells

Valentina Salvestrini, Valentina Pensato, Marilena Ciciarello, Giorgia Simonetti, Samantha Bruno, Martina Pazzaglia, Elena De Marchi, Dorian Forte, Stefania Orecchioni, Giovanni Martinelli, Francesco Bertolini, Simon Mendez-Ferrer, Elena Adinolfi, Michele Cavo, Antonio Curti
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 4946.
https://doi.org/10.1158/1538-7445.AM2020-4946
Published: 15 August 2020
View article titled, Abstract 4946: Bitter taste receptors system is expressed and functional in both HSCs and leukemic cells
Journal Articles

Abstract 900: Intermittent cyclophosphamide and vinorelbine reshape the immune cell environment, induce T cell clonal replacement and increase the efficacy of PD-1 inhibition in models of triple negative breast cancer

Paolo Falvo, Stefania Orecchioni, Roman Hillje, Alessandro Raveane, Patrizia Mancuso, Chiara Camisaschi, Lucilla Luzi, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 900.
https://doi.org/10.1158/1538-7445.AM2020-900
Published: 15 August 2020
View article titled, Abstract 900: Intermittent cyclophosphamide and vinorelbine reshape the immune cell environment, induce T cell clonal replacement and increase the efficacy of PD-1 inhibition in models of triple negative breast cancer
Journal Articles

Abstract 3948: The sequential administration of vinca alkaloids and intermittent cyclophosphamide primes antigen-presenting and NK cells and significantly improves in vivo efficacy of anti-PD-L1 in triple-negative breast cancer models

Stefania Orecchioni, Loredana Vecchi, Paolo Falvo, Lucilla Luzi, Patrizia Mancuso, Chiara Camisaschi, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3948.
https://doi.org/10.1158/1538-7445.AM2019-3948
Published: 01 July 2019
View article titled, Abstract 3948: The sequential administration of vinca alkaloids and intermittent cyclophosphamide primes antigen-presenting and NK cells and significantly improves in vivo efficacy of anti-PD-L1 in triple-negative breast cancer models
Journal Articles

Abstract 1017: Vinorelbine, cyclophosphamide, and 5-FU effects on the circulating and intratumoral landscape of immune cells improve anti-PD-L1 efficacy in preclinical models of breast cancer and lymphoma

Stefania Orecchioni, Giovanna Talarico, Valentina Labanca, Patrizia Mancuso, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 1017.
https://doi.org/10.1158/1538-7445.AM2018-1017
Published: 01 July 2018
View article titled, Abstract 1017: Vinorelbine, cyclophosphamide, and 5-FU effects on the circulating and intratumoral landscape of immune cells improve anti-PD-L1 efficacy in preclinical models of breast cancer and lymphoma
Journal Articles

Abstract 793: The novel Bruton's tyrosine kinase inhibitor ARQ531 disrupts survival signaling and triggers apoptosis in AML cells

soncini debora, stefania orecchioni, antonia cagnetta, veronica retali, samantha ruberti, paola minetto, paola contini, alessio nencioni, fiammetta monacelli, Terence Hall, marco gobbi, sudharshan eathiraj, briam schwartz, francesco bertolini, roberto lemoli, michele cea
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 793.
https://doi.org/10.1158/1538-7445.AM2018-793
Published: 01 July 2018
View article titled, Abstract 793: The novel Bruton's tyrosine kinase inhibitor ARQ531 disrupts survival signaling and triggers apoptosis in AML cells
Journal Articles

Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression

Francesca Reggiani, Valentina Labanca, Patrizia Mancuso, Cristina Rabascio, Giovanna Talarico, Stefania Orecchioni, Andrea Manconi, Francesco Bertolini
Journal: Cancer Research
Series: Author Choice
Cancer Res (2017) 77 (18): 5169–5182.
https://doi.org/10.1158/0008-5472.CAN-17-0914
Published: 14 September 2017
View article titled, Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression
Open the PDF for Adipose Progenitor Cell Secretion of GM-CSF and MMP9 Promotes a Stromal and Immunological Microenvironment That Supports Breast Cancer Progression in another window
Includes: Supplementary data
Journal Articles

Abstract 2620: Selecting the right chemotherapy partner for checkpoint inhibitors: an in vivo comparison of different drugs and dosages

Stefania Orecchioni, Giovanna Talarico, Valentina Labanca, Patrizia Mancuso, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): 2620.
https://doi.org/10.1158/1538-7445.AM2017-2620
Published: 01 July 2017
View article titled, Abstract 2620: Selecting the right chemotherapy partner for checkpoint inhibitors: an <em>in vivo</em> comparison of different drugs and dosages
Journal Articles

Abstract 4003: Metformin reduces intratumoral CD8+PD-1+ and Treg lymphocytes in orthotopic models of breast cancer and lymphoma, and has paradoxic effects on anti-PD-L1 treatment

Stefania Orecchioni, Giovanna Talarico, Patrizia Mancuso, Valentina Labanca, Francesca Reggiani, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4003.
https://doi.org/10.1158/1538-7445.AM2016-4003
Published: 15 July 2016
View article titled, Abstract 4003: Metformin reduces intratumoral CD8+PD-1+ and Treg lymphocytes in orthotopic models of breast cancer and lymphoma, and has paradoxic effects on anti-PD-L1 treatment
Journal Articles

Abstract 3374: GM-CSF and MMP9 are key regulators of the effect of adipose progenitor cells over breast cancer onset and metastatic progression in obesity

Francesca Reggiani, Valentina Labanca, Giovanna Talarico, Stefania Orecchioni, Patrizia Mancuso, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 3374.
https://doi.org/10.1158/1538-7445.AM2016-3374
Published: 15 July 2016
View article titled, Abstract 3374: GM-CSF and MMP9 are key regulators of the effect of adipose progenitor cells over breast cancer onset and metastatic progression in obesity
Journal Articles

Abstract 5214: Synergistic activity of aspirin, atenolol and metformin in the inhibition of angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells

Giovanna Talarico, Francesca Reggiani, Stefania Orecchioni, Patrizia Mancuso, Angelica Calleri, Giuliana Gregato, Valentina Labanca, Douglas M. Noonan, Katiuscia Dallaglio, Adriana Albini, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5214.
https://doi.org/10.1158/1538-7445.AM2015-5214
Published: 01 August 2015
View article titled, Abstract 5214: Synergistic activity of aspirin, atenolol and metformin in the inhibition of angiogenesis, local and metastatic growth of breast cancer by targeting both neoplastic and microenvironment cells
Journal Articles

Abstract 5212: GM-CSF and MMP9, targets of metformin, are crucial mediators of the tumor-promoting role of adipose tissue cells in breast cancer

Francesca Reggiani, Patrizia Mancuso, Cristina Rabascio, Stefania Orecchioni, Giovanna Talarico, Cinzia Massaro, Valentina Labanca, Angelica Calleri, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 5212.
https://doi.org/10.1158/1538-7445.AM2015-5212
Published: 01 August 2015
View article titled, Abstract 5212: GM-CSF and MMP9, targets of metformin, are crucial mediators of the tumor-promoting role of adipose tissue cells in breast cancer
Journal Articles

Abstract 2282: K-RasV12 bone marrow cell reconstitution causes lung cancer in wild type mice

Elena Belloni, Ines Martin-Padura, Elvira Gerbino, Stefania Orecchioni, Fulvia Fusar-Imperatore, Paola Marighetti, Giovanni Bertalot, Pier Giuseppe Pelicci, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 2282.
https://doi.org/10.1158/1538-7445.AM2015-2282
Published: 01 August 2015
View article titled, Abstract 2282: K-RasV12 bone marrow cell reconstitution causes lung cancer in wild type mice
Journal Articles

Abstract 1010: Paradoxic effects of metformin on endothelial cells and angiogenesis

Antonino Bruno, Katiuscia Dallaglio, Anna Rita Cantelmo, Alessia I. Esposito, Luca Ruggiero, Stefania Orecchioni, Angelica Callieri, Francesco Bertolini, Ulrich Pfeffer, Douglas M. Noonan, Adriana Albini
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1010.
https://doi.org/10.1158/1538-7445.AM2014-1010
Published: 01 October 2014
View article titled, Abstract 1010: Paradoxic effects of metformin on endothelial cells and angiogenesis
Journal Articles

Abstract 1011: Metformin inhibits angiogenesis, local and metastatic growth of triple-negative breast cancer by targeting two classes of adipose tissue progenitors

Stefania Orecchioni, Giuliana Gregato, Francesca Reggiani, Patrizia Mancuso, Angelica Calleri, Giovanna Talarico, Valentina Labanca, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 1011.
https://doi.org/10.1158/1538-7445.AM2014-1011
Published: 01 October 2014
View article titled, Abstract 1011: Metformin inhibits angiogenesis, local and metastatic growth of triple-negative breast cancer by targeting two classes of adipose tissue progenitors
Journal Articles

Complementary Populations of Human Adipose CD34+ Progenitor Cells Promote Growth, Angiogenesis, and Metastasis of Breast Cancer

Stefania Orecchioni, Giuliana Gregato, Ines Martin-Padura, Francesca Reggiani, Paola Braidotti, Patrizia Mancuso, Angelica Calleri, Jessica Quarna, Paola Marighetti, Chiara Aldeni, Giancarlo Pruneri, Stefano Martella, Andrea Manconi, Jean-Yves Petit, Mario Rietjens, Francesco Bertolini
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (19): 5880–5891.
https://doi.org/10.1158/0008-5472.CAN-13-0821
Published: 01 October 2013
View article titled, Complementary Populations of Human Adipose CD34<sup>+</sup> Progenitor Cells Promote Growth, Angiogenesis, and Metastasis of Breast Cancer
Open the PDF for Complementary Populations of Human Adipose CD34<sup>+</sup> Progenitor Cells Promote Growth, Angiogenesis, and Metastasis of Breast Cancer in another window
Includes: Supplementary data
Journal Articles

Abstract 2311: Two complementary populations of human adipose tissue CD34+ progenitors promote breast cancer angiogenesis, growth, and metastases.

Stefania Orecchioni, Giuliana Gregato, Ines Martin-Padura, Patrizia Mancuso, Angelica Calleri, Chiara Corsini, Stefano Martella, Jean-Yves Petit, Francesco Bertolini
Journal: Cancer Research
Cancer Res (2013) 73 (8_Supplement): 2311.
https://doi.org/10.1158/1538-7445.AM2013-2311
Published: 15 April 2013
View article titled, Abstract 2311: Two complementary populations of human adipose tissue CD34+ progenitors promote breast cancer angiogenesis, growth, and metastases.