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Stefan Knapp
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Journal Articles

Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers

Free
Adam J. Wolpaw, Richard Bayliss, Gabriele Büchel, Chi V. Dang, Martin Eilers, W. Clay Gustafson, Gwenn H. Hansen, Natalia Jura, Stefan Knapp, Mark A. Lemmon, David Levens, John M. Maris, Ronen Marmorstein, Steven J. Metallo, Julie R. Park, Linda Z. Penn, Michael Rape, Martine F. Roussel, Kevan M. Shokat, William P. Tansey, Kliment A. Verba, Seychelle M. Vos, William A. Weiss, Elmar Wolf, Yaël P. Mossé
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (7): 1627–1632.
https://doi.org/10.1158/0008-5472.CAN-20-3108
Published: 01 April 2021
View articletitled, Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers
Open the PDF for Drugging the “Undruggable” MYCN Oncogenic Transcription Factor: Overcoming Previous Obstacles to Impact Childhood Cancers in another window
Journal Articles

Abstract 1762: Dual HDAC-BET proteins inhibition by TW9 hold promise for breast cancer

Free
Pedro Luiz P. Xavier, Romain Lucas, Tim Weiser, Stefan Knapp, Heidge Fukumasu, Susanne Müller
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1762.
https://doi.org/10.1158/1538-7445.AM2020-1762
Published: 15 August 2020
View articletitled, Abstract 1762: Dual HDAC-BET proteins inhibition by TW9 hold promise for breast cancer
Journal Articles

Abstract 4691: Identification and characterization of BRPF1 bromodomain inhibitors

Free
Bernard Haendler, Léa Bouché, Stephan Siegel, Amaury E. Fernandez-Montalvan, Tatsuo Sugawara, Julia Meier, Stefan Knapp, Vicki Gamble
Journal: Cancer Research
Cancer Res (2016) 76 (14_Supplement): 4691.
https://doi.org/10.1158/1538-7445.AM2016-4691
Published: 15 July 2016
View articletitled, Abstract 4691: Identification and characterization of BRPF1 bromodomain inhibitors
Journal Articles

Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy

Free
Sarah Picaud, Oleg Fedorov, Angeliki Thanasopoulou, Katharina Leonards, Katherine Jones, Julia Meier, Heidi Olzscha, Octovia Monteiro, Sarah Martin, Martin Philpott, Anthony Tumber, Panagis Filippakopoulos, Clarence Yapp, Christopher Wells, Ka Hing Che, Andrew Bannister, Samuel Robson, Umesh Kumar, Nigel Parr, Kevin Lee, Dave Lugo, Philip Jeffrey, Simon Taylor, Matteo L. Vecellio, Chas Bountra, Paul E. Brennan, Alison O'Mahony, Sharlene Velichko, Susanne Müller, Duncan Hay, Danette L. Daniels, Marjeta Urh, Nicholas B. La Thangue, Tony Kouzarides, Rab Prinjha, Jürg Schwaller, Stefan Knapp
Journal: Cancer Research
Series: Author Choice
Cancer Res (2015) 75 (23): 5106–5119.
https://doi.org/10.1158/0008-5472.CAN-15-0236
Published: 30 November 2015
View articletitled, Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy
Open the PDF for Generation of a Selective Small Molecule Inhibitor of the CBP/p300 Bromodomain for Leukemia Therapy in another window
Includes: Supplementary data
Journal Articles

Abstract 4111: The salt inducible kinase 2 (SIK2) links lipid metabolism to survival of ovarian cancer metastasis

Free
Fabrizio Miranda, Shujuan Liu, Sandra Herrero-Gonzalez, David Mannion, Stefan Knapp, Ahmed A. Ahmed
Journal: Cancer Research
Cancer Res (2015) 75 (15_Supplement): 4111.
https://doi.org/10.1158/1538-7445.AM2015-4111
Published: 01 August 2015
View articletitled, Abstract 4111: The salt inducible kinase 2 (SIK2) links lipid metabolism to survival of ovarian cancer metastasis
Journal Articles

Abstract 4427: Copper is required for oncogenic BRAF signaling and tumorigenesis

Free
Donita C. Brady, Matthew S. Crowe, Michelle L. Turski, G Aaron Hobbs, Apirat Chaikuad, Stefan Knapp, Sharon L. Campbell, Dennis J. Thiele, Christopher M. Counter
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 4427.
https://doi.org/10.1158/1538-7445.AM2014-4427
Published: 01 October 2014
View articletitled, Abstract 4427: Copper is required for oncogenic BRAF signaling and tumorigenesis
Journal Articles

Abstract 5387: Dual kinase/bromodomain inhibitors for rationally designed polypharmacology

Free
Elizabeth R. Quinn, Pietro Ciceri, Susanne Müller-Knapp, Alison O'Mahony, Oleg Fedorov, Panagis Filippakopoulos, Jeremy P. Hunt, Elisabeth A. Lasater, Gabriel Pallares, Sarah Picaud, Christopher Wells, Lisa M. Wodicka, Neil P. Shah, Stefan Knapp, Daniel K. Treiber
Journal: Cancer Research
Cancer Res (2014) 74 (19_Supplement): 5387.
https://doi.org/10.1158/1538-7445.AM2014-5387
Published: 01 October 2014
View articletitled, Abstract 5387: Dual kinase/bromodomain inhibitors for rationally designed polypharmacology
Journal Articles

The Structural Basis of PI3K Cancer Mutations: From Mechanism to Therapy

Free
Shujuan Liu, Stefan Knapp, Ahmed Ashour Ahmed
Journal: Cancer Research
Cancer Res (2014) 74 (3): 641–646.
https://doi.org/10.1158/0008-5472.CAN-13-2319
Published: 02 February 2014
View articletitled, The Structural Basis of PI3K Cancer Mutations: From Mechanism to Therapy
Open the PDF for The Structural Basis of PI3K Cancer Mutations: From Mechanism to Therapy in another window
Journal Articles

PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains

Free
Sarah Picaud, David Da Costa, Angeliki Thanasopoulou, Panagis Filippakopoulos, Paul V. Fish, Martin Philpott, Oleg Fedorov, Paul Brennan, Mark E. Bunnage, Dafydd R. Owen, James E. Bradner, Philippe Taniere, Brendan O'Sullivan, Susanne Müller, Juerg Schwaller, Tatjana Stankovic, Stefan Knapp
Journal: Cancer Research
Series: Author Choice
Cancer Res (2013) 73 (11): 3336–3346.
https://doi.org/10.1158/0008-5472.CAN-12-3292
Published: 30 May 2013
View articletitled, PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains
Open the PDF for PFI-1, a Highly Selective Protein Interaction Inhibitor, Targeting BET Bromodomains in another window
Includes: Supplementary data
Journal Articles

Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth

Free
Renaud Prudent, Emilie Vassal-Stermann, Chi-Hung Nguyen, Catherine Pillet, Anne Martinez, Chloé Prunier, Caroline Barette, Emmanuelle Soleilhac, Odile Filhol, Anne Beghin, Glaucio Valdameri, Stéphane Honoré, Samia Aci-Sèche, David Grierson, Juliana Antonipillai, Rong Li, Attilio Di Pietro, Charles Dumontet, Diane Braguer, Jean-Claude Florent, Stefan Knapp, Ora Bernard, Laurence Lafanechère
Journal: Cancer Research
Cancer Res (2012) 72 (17): 4429–4439.
https://doi.org/10.1158/0008-5472.CAN-11-3342
Published: 30 August 2012
View articletitled, Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth
Open the PDF for Pharmacological Inhibition of LIM Kinase Stabilizes Microtubules and Inhibits Neoplastic Growth in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract 2318: BET bromodomain inhibitors for cancer therapy

Free
Jun Qi, Panagis Filippakopoulos, Michael McKeown, Katharin L. Shaw, William B. Smith, Christopher A. French, Andrew L. Kung, Stefan Knapp, James E. Bradner
Journal: Cancer Research
Cancer Res (2011) 71 (8_Supplement): 2318.
https://doi.org/10.1158/1538-7445.AM2011-2318
Published: 15 April 2011
View articletitled, Abstract 2318: BET bromodomain inhibitors for cancer therapy
Journal Articles

Abstract 3683: Small molecule inhibitors of the Fes non-receptor tyrosine kinase

Free
Sabine Hellwig, Jianming Zhang, Panagis Filippakopoulos, Eidarus Salah, Stefan Knapp, Nathanael S. Gray, Thomas E. Smithgall
Journal: Cancer Research
Cancer Res (2010) 70 (8_Supplement): 3683.
https://doi.org/10.1158/1538-7445.AM10-3683
Published: 15 April 2010
View articletitled, Abstract 3683: Small molecule inhibitors of the Fes non-receptor tyrosine kinase
Journal Articles

Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity

Free
Vanda Pogacic, Alex N. Bullock, Oleg Fedorov, Panagis Filippakopoulos, Christelle Gasser, Andrea Biondi, Sandrine Meyer-Monard, Stefan Knapp, Juerg Schwaller
Journal: Cancer Research
Cancer Res (2007) 67 (14): 6916–6924.
https://doi.org/10.1158/0008-5472.CAN-07-0320
Published: 17 July 2007
View articletitled, Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity
Open the PDF for Structural Analysis Identifies Imidazo[1,2-b]Pyridazines as PIM Kinase Inhibitors with In vitro Antileukemic Activity in another window
Includes: Supplementary data