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Stefan Fröhling
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Journal Articles

Abstract 4255: A systematic framework for efficient generation of expandable patient-derived 3D sarcoma models

Claudia Dagostino, Waqar Hussain, Jasmina Paluncic, Marcelo Zoccoler, Jessica Pablik, Daniela Richter, Lisanne Knol, Ana Banito, Johanna Wagner, Ivona Mateska, Daniel E. Stange, Ina Oehme, Stephan Richter, Stefan M. Pfister, Stefan Fröhling, Claudia Scholl, Jürgen Weitz, Klaus-Dieter Schaser, Christoph Heining, Hanno Glimm, Claudia R. Ball
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 4255.
https://doi.org/10.1158/1538-7445.AM2024-4255
Published: 22 March 2024
View article titled, Abstract 4255: A systematic framework for efficient generation of expandable patient-derived 3D sarcoma models
Journal Articles

Abstract 5631: YAP1 is a critical factor for FUS::DDIT3/BAF/c-Jun complex assembly in myxoid liposarcoma

Ruth Berthold, Ilka Isfort, Lorena Heinst, Eva Wardelmann, Pierre Åman, Claudia Scholl, Marcel Trautmann, Stefan Fröhling, Wolfgang Hartmann
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 5631.
https://doi.org/10.1158/1538-7445.AM2024-5631
Published: 22 March 2024
View article titled, Abstract 5631: YAP1 is a critical factor for FUS::DDIT3/BAF/c-Jun complex assembly in myxoid liposarcoma
Journal Articles

Abstract 3040: Tumor-specific super-enhancer drives overexpression of EVI1 in ovarian cancer

Leonie Smeenk, Sabrina Kruse, Roger Mulet-Lazaro, Ingrid Boere, John Martens, Stefan Gröschel, Claudia Scholl, Stefan Fröhling, Ruud Delwel
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 3040.
https://doi.org/10.1158/1538-7445.AM2024-3040
Published: 22 March 2024
View article titled, Abstract 3040: Tumor-specific super-enhancer drives overexpression of <em>EVI1</em> in ovarian cancer
Journal Articles

Abstract 4544: Genomic, transcriptomic, functional, and mechanistic characterization of rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusions

Julia Schoepf, Sebastian Uhrig, Christoph E. Heilig, Kwang-Seok Lee, Tatjana Walther, Alexander Carazzato, Anna Maria Dobberkau, Dieter Weichenhan, Christoph Plass, Mark Hartmann, Gaurav Diwan, Zunamys Carrero, Claudia R. Ball, Tobias Hohl, Thomas Kindler, Patricia Rudolph-Hähnel, Anna Nilsson, Ingrid Øra, Roland Imle, Ana Banito, Robert Russell, Barbara C. Jones, Daniel B. Lipka, Hanno Glimm, Daniel Hübschmann, Wolfgang Hartmann, Stefan Fröhling, Claudia Scholl
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 4544.
https://doi.org/10.1158/1538-7445.AM2023-4544
Published: 04 April 2023
View article titled, Abstract 4544: Genomic, transcriptomic, functional, and mechanistic characterization of rhabdomyosarcoma with FUS-TFCP2 or EWSR1-TFCP2 fusions
Journal Articles

Abstract 926: Genomics-based personalized oncology of advanced thymic epithelial tumors

Lino Möhrmann, Lysann Rostock, Małgorzata Oleś, Arne Jahn, Marie Arlt, Nagarajan Paramasivam, Korinna Jöhrens, Luise Rupp, Marc Schmitz, Daniela Richter, Sebastian Uhrig, Martina Fröhlich, Barbara Hutter, Jennifer Hüllein, Elena E. Wolf, Dorothea Hanf, Laura Gieldon, Simon Kreutzfeldt, Christoph E. Heilig, Veronica Teleanu, Daniel B. Lipka, Andreas Mock, Ivan Jelas, Damian T. Rieke, Marcel Wiesweg, Melanie Boerries, Anna L. Illert, Alexander Desuki, Thomas Kindler, Angela M. Krackhardt, C. Benedikt Westphalen, Heidrun Grosch, Leonidas Apostolidis, Albrecht Stenzinger, Irina A. Kerle, Christoph Heining, Daniel Hübschmann, Evelin Schröck, Stefan Fröhling, Hanno Glimm
Journal: Cancer Research
Cancer Res (2023) 83 (7_Supplement): 926.
https://doi.org/10.1158/1538-7445.AM2023-926
Published: 04 April 2023
View article titled, Abstract 926: Genomics-based personalized oncology of advanced thymic epithelial tumors
Journal Articles

Abstract 2005: First results of the EORTC-SPECTA project on comprehensive molecular profiling of adolescent and young adult sarcoma patients

Marie Morfouace, Peter Horak, Simon Kreutzfeldt, Patrick Shenjere, Eva Wardelmann, Evgeniya Denisova, Aleksandra Stevovic, Francisco J. Bautista, Julio Oliveira, Winette van der Graaf, Stefan Fröhling, Martin G. McCabe
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 2005.
https://doi.org/10.1158/1538-7445.AM2022-2005
Published: 15 June 2022
View article titled, Abstract 2005: First results of the EORTC-SPECTA project on comprehensive molecular profiling of adolescent and young adult sarcoma patients
Journal Articles

Abstract 4110: Pathway activation driven miRNA depletion highlights cancer signaling vulnerabilities and targeted therapy sensitivity

Alexander A. Wurm, Silke Brilloff, Zunamys I. Carrero, Stephan Drukewitz, Alexander Krüger, Sandra Oster, Sofia Kolovich, Melanie Hüther, Sebastian Uhrig, Dana Westphal, Friedegund Meier, Katrin Pfütze, Daniel Hübschmann, Peter Horak, Simon Kreutzfeldt, Christoph Heining, Daniela Richter, Stefan Fröhling, Claudia R. Ball, Hanno Glimm
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 4110.
https://doi.org/10.1158/1538-7445.AM2022-4110
Published: 15 June 2022
View article titled, Abstract 4110: Pathway activation driven miRNA depletion highlights cancer signaling vulnerabilities and targeted therapy sensitivity
Journal Articles

Abstract 2003: Oncogenic interplay of FUS-DDIT3 and YAP1 in myxoid liposarcoma

Ruth Berthold, Ilka Isfort, Jonas Breuer, Lorena Heinst, Thomas Kindler, Pierre Åman, Inga Grünewald, Eva Wardelmann, Thomas G. Grünewald, Florencia Cidre-Aranaz, Claudia Scholl, Stefan Fröhling, Marcel Trautmann, Wolfgang Hartmann
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 2003.
https://doi.org/10.1158/1538-7445.AM2021-2003
Published: 01 July 2021
View article titled, Abstract 2003: Oncogenic interplay of FUS-DDIT3 and YAP1 in myxoid liposarcoma
Journal Articles

Abstract 820: Genomics based personalized oncology of cancer of unknown primary

Maximilian Werner, Lino Möhrmann, Małgorzata Oleś, Andreas Mock, Arne Jahn, Simon Kreutzfeldt, Sebastian Uhrig, Martina Fröhlich, Barbara Hutter, Daniela Richter, Gina Rüter, Ivan Jelas, Rainer Hamacher, Johanna Falkenhorst, Sebastian Wagner, Christian Brandts, Melanie Börries, Anna Illert, Klaus Metzeler, Benedikt Westphalen, Alexander Desuki, Thomas Kindler, Albrecht Stenzinger, Evelin Schröck, Benedikt Brors, Peter Horak, Christoph Heining, Stefan Fröhling, Hanno Glimm
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 820.
https://doi.org/10.1158/1538-7445.AM2020-820
Published: 15 August 2020
View article titled, Abstract 820: Genomics based personalized oncology of cancer of unknown primary
Journal Articles

Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium

Peter Horak, Christoph Heining, Andreas Mock, Simon Kreutzfeldt, Andreas Lassmann, Lino Möhrmann, Jennifer Hüllein, Dorothea Hanf, Arne Jahn, Leo Ruhnke, Laura Gieldon, Christoph E. Heilig, Veronica Teleanu, Martina Fröhlich, Sebastian Uhrig, Katja Beck, Daniela Richter, Stephan Wolf, Katrin Pfütze, Christina Geörg, Bettina Meissburger, Frederick Klauschen, Ulrich Keilholz, Sebastian Ochsenreither, Gunnar Folprecht, Jens Siveke, Sebastian Bauer, Thomas Kindler, Christian Brandts, Melanie Boerries, Anna L. Illert, Nikolas von Bubnoff, Karsten Spiekermann, Philipp J. Jost, Klaus Schulze-Osthoff, Michael Bitzer, Peter Schirmacher, Christof von Kalle, Richard F. Schlenk, Barbara Klink, Barbara Hutter, Daniel Hübschmann, Albrecht Stenzinger, Wilko Weichert, Evelin Schröck, Benedikt Brors, Hanno Glimm, Stefan Fröhling, German Cancer Consortium (DKTK)
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 821.
https://doi.org/10.1158/1538-7445.AM2020-821
Published: 15 August 2020
View article titled, Abstract 821: Comprehensive genomic analysis of rare cancers: Results of the MASTER precision oncology trial of the German Cancer Consortium
Journal Articles

Abstract 1796: Requirement for LIM kinases in acute myeloid leukemia

Patrizia Jensen, Michela Carlet, Jana Kress, Andrea Weber, Ines Brunner, Mikolaj Slabicki, Gregor Grill, Simon Weisemann, Ya-Yun Cheng, Irmela Jeremias, Claudia Scholl, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 1796.
https://doi.org/10.1158/1538-7445.AM2020-1796
Published: 15 August 2020
View article titled, Abstract 1796: Requirement for LIM kinases in acute myeloid leukemia
Journal Articles

Abstract 3093: Quantifying the confounders of panel-based tumor mutational burden (TMB) measurement

Jan Budczies, Daniel Kazdal, Michael Allgäuer, Petros Christopoulos, Eugen Rempel, Nicole Pfarr, Wilko Weichert, Stefan Fröhling, Michael Thomas, Solange Peters, Volker Endris, Peter Schirmacher, Albrecht Stenzinger
Journal: Cancer Research
Cancer Res (2020) 80 (16_Supplement): 3093.
https://doi.org/10.1158/1538-7445.AM2020-3093
Published: 15 August 2020
View article titled, Abstract 3093: Quantifying the confounders of panel-based tumor mutational burden (TMB) measurement
Journal Articles

Abstract 2723: Defective homologous recombination DNA repair as therapeutic target in advanced chordoma

Stefan Gröschel, Daniel Hübschmann, Francesco Raimondi, Peter Horak, Gregor Warsow, Martina Fröhlich, Barbara Klink, Laura Gieldon, Barbara Hutter, Kortine Kleinhenz, David Bonekamp, Oliver Marschal, Priya Chudasama, Jagoda Mika, Marie Groth, Sebastian Uhrig, Stephen Krämer, Christoph Heining, Christoph Heilig, Daniela Richter, Eva Reisinger, Katrin Pfütze, Roland Eils, Stephan Wolf, Christof von Kalle, Christian Brandts, Claudia Scholl, Wilko Weichert, Stephan Richter, Sebastian Bauer, Roland Penzel, Evelin Schröck, Albrecht Stenzinger, Richard Schlenk, Benedikt Brors, Robert Russell, Hanno Glimm, Matthias Schlesner, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2723.
https://doi.org/10.1158/1538-7445.AM2019-2723
Published: 01 July 2019
View article titled, Abstract 2723: Defective homologous recombination DNA repair as therapeutic target in advanced chordoma
Journal Articles

Abstract 468: Clinical relevance of comprehensive genomic analysis in advanced-stage cancers and rare malignancies: Results from the MASTER trial of the German Cancer Consortium

Peter Horak, Christoph Heining, Simon Kreutzfeldt, Christoph E. Heilig, Lino Möhrmann, Laura Gieldon, Martina Fröhlich, Sebastian Uhrig, Daniel Hübschmann, Katja Beck, Daniela Richter, Stephan Wolf, Katrin Pfütze, Christina Geörg, Bettina Meißburger, Frederick Klauschen, Sebastian Ochsenreither, Gunnar Folprecht, Jens Siveke, Sebastian Bauer, Thomas Kindler, Christian Brandts, Melanie Börries, Nikolas von Bubnoff, Karsten Spiekermann, Philipp J. Jost, Klaus Schulze-Osthoff, Michael Bitzer, Peter Schirmacher, Christof von Kalle, Richard Schlenk, Barbara Klink, Barbara Hutter, Wilko Weichert, Albrecht Stenzinger, Evelin Schröck, Benedikt Brors, Hanno Glimm, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 468.
https://doi.org/10.1158/1538-7445.AM2019-468
Published: 01 July 2019
View article titled, Abstract 468: Clinical relevance of comprehensive genomic analysis in advanced-stage cancers and rare malignancies: Results from the MASTER trial of the German Cancer Consortium
Journal Articles

Abstract 919: Clinical relevance of comprehensive genomic analysis in patients with advanced-stage neuroendocrine neoplasms: Results from the MASTER trial of the German Cancer Consortium

Simon Kreutzfeldt, Leonidas Apostolidis, Malgorzata Oles, Peter Horak, Christoph E. Heilig, Christoph Heining, Barbara Hutter, Laura Gieldon, Barbara Klink, Mario Lamping, Damian T. Rieke, Sebastian Uhrig, Henning Jann, Ulrich F. Pape, Albrecht Stenzinger, Eva C. Winkler, Bertram Wiedenmann, Dirk Jäger, Benedikt Brors, Evelin Schröck, Ulrich Keilholz, Marianne Pavel, Hanno Glimm, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 919.
https://doi.org/10.1158/1538-7445.AM2019-919
Published: 01 July 2019
View article titled, Abstract 919: Clinical relevance of comprehensive genomic analysis in patients with advanced-stage neuroendocrine neoplasms: Results from the MASTER trial of the German Cancer Consortium
Journal Articles

Abstract 3437: Requirement for YAP1 signaling in myxoid liposarcoma

Marcel Trautmann, Ya-Yun Cheng, Patrizia Jensen, Ninel Azoitei, Ines Brunner, Jennifer Hüllein, Mikolaj Slabicki, Ilka Isfort, Magdalene Cyra, Eva Wardelmann, Sebastian Huss, Bianca Altvater, Claudia Rossig, Susanne Hafner, Thomas Simmet, Anders Ståhlberg, Pierre Åman, Thorsten Zenz, Undine Lange, Thomas Kindler, Claudia Scholl, Wolfgang Hartmann, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 3437.
https://doi.org/10.1158/1538-7445.AM2019-3437
Published: 01 July 2019
View article titled, Abstract 3437: Requirement for YAP1 signaling in myxoid liposarcoma
Journal Articles

Abstract 1686: Comprehensive genomic and transcriptomic profiling of gastrointestinal stromal tumors

Peter Horak, Matea Hajnic, Laura Gieldon, Mario Hlevnjak, Susan Richter, Barbara Hutter, Johanna Falkenhorst, Sebastian Uhrig, Gregor Warsow, Nagarajan Paramasivam, Stefan Gröschel, Barbara Klink, Simon Kreutzfeldt, Christoph Heining, Christoph E. Heilig, Martina Fröhlich, Stephan Richter, Christian Brandts, Wilko Weichert, Philipp Jost, Olaf Neumann, Marc Zapatka, Albrecht Stenzinger, Alexander Marx, Benedikt Brors, Evelin Schröck, Sebastian Bauer, Peter Hohenberger, Hanno Glimm, Claudia Scholl, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 1686.
https://doi.org/10.1158/1538-7445.AM2019-1686
Published: 01 July 2019
View article titled, Abstract 1686: Comprehensive genomic and transcriptomic profiling of gastrointestinal stromal tumors
Journal Articles

Abstract 2126: Development of a precision chordoma research program

Marie Groth, Jana Kress, Matea Hajnic, Joana Marinho, Kevin Mellert, Thomas F. Barth, Peter Möller, Birgit Dreier, Andreas Plückthun, Claudia Scholl, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2019) 79 (13_Supplement): 2126.
https://doi.org/10.1158/1538-7445.AM2019-2126
Published: 01 July 2019
View article titled, Abstract 2126: Development of a precision chordoma research program
Journal Articles

Abstract 4336: Integrative genomic and transcriptomic analysis of leiomyosarcoma

Priya Chudasama, Sadaf Mughal, Mathijs Sanders, Daniel Hübschmann, Inn Chung, Aurélie Ernst, Bernd Kasper, Hans-Georg Kopp, Sebastian Bauer, Karsten Rippe, Benedikt Brors, Marcus Renner, Peter Hohenberger, Claudia Scholl, Stefan Fröhling
Journal: Cancer Research
Cancer Res (2018) 78 (13_Supplement): 4336.
https://doi.org/10.1158/1538-7445.AM2018-4336
Published: 01 July 2018
View article titled, Abstract 4336: Integrative genomic and transcriptomic analysis of leiomyosarcoma
Journal Articles

Abstract LB-287: Identification of patients at risk for tumor predisposition syndromes based on the evaluation of sporadic cancer exome sequencing data: experiences from the NCT/DKTK MASTER program

Evelin Schrock, Barbara Hutter, Martina Fröhlich, Falk Zakrzewski, Sebastian Uhrig, Andreas Rump, Karl Hackmann, Joseph Porrmann, Laura Gieldon, Daniela Richter, Albrecht Stenzinger, Thomas Kindler, Wilko Weichert, Philipp J. Jost, Christian Brandts, Klaus Schulze-Osthoff, Johanna Falkenhorst, Sebastian Bauer, Frederick Klauschen, Konrad Klinghammer, Gunnar Folprecht, Martin Wermke, Karsten Spiekermann, Benedikt Brors, Stefan Gröschel, Christoph Heining, Peter Horak, Hanno Glimm, Stefan Fröhling, Barbara Klink
Journal: Cancer Research
Cancer Res (2017) 77 (13_Supplement): LB-287.
https://doi.org/10.1158/1538-7445.AM2017-LB-287
Published: 01 July 2017
View article titled, Abstract LB-287: Identification of patients at risk for tumor predisposition syndromes based on the evaluation of sporadic cancer exome sequencing data: experiences from the NCT/DKTK MASTER program