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Abstract 1011: Tank binding kinase (TBK1) inhibitor BX795 impairs anti-tumor efficacy of T cells by abrogating granzyme and perforin mobilization

Fatema Khambati, Jaya Padmanabhan, SriKumar Chellappan

Cancer Res (2020) 80 (16_Supplement): 1011.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1011

Published: 15 August 2020

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Journal Articles

Abstract 1523: Novel role of TBK1 in breast cancer EMT

Meenu Maan, Mainak Dutta, Neha Jaiswal, Harold Saavedra, Srikumar Chellappan

Cancer Res (2020) 80 (16_Supplement): 1523.

DOI: https://doi.org/10.1158/1538-7445.AM2020-1523

Published: 15 August 2020

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Journal Articles

Abstract 4394: Molecular interplay between Tank-binding kinase (TBK1) and Yes-associated protein (YAP1) in KRAS mutant NSCLC

Biswarup Saha, Neha Jaiswal, Namrata Bora-Singhal, Srikumar Chellappan

Cancer Res (2019) 79 (13_Supplement): 4394.

DOI: https://doi.org/10.1158/1538-7445.AM2019-4394

Published: 01 July 2019

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Journal Articles

Abstract 378: HDAC inhibition enhances MEK antagonist therapy in uveal melanoma through combined blockade of YAP, AKT and RTK signaling

Fernanda Faiao-Flores, Michael Emmons, Michael Durante, Biswarup Saha, Bin Fang, John Koomen, Srikumar Chellappan, Silvya Maria-Engler, Jonathan Licht, William Harbour, Keiran Smalley

Cancer Res (2019) 79 (13_Supplement): 378.

DOI: https://doi.org/10.1158/1538-7445.AM2019-378

Published: 01 July 2019

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Journal Articles

Abstract 2310: Targeting transcription-associated CDKs is an effective way to combat glioblastoma and medulloblastoma with minimal effect on primary neurons

Isha Bhutada, Srikumar Chellappan, Jaya Padmanabhan

Cancer Res (2018) 78 (13_Supplement): 2310.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2310

Published: 01 July 2018

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Journal Articles

Abstract 1998: Novel interplay between TANK-binding kinase (TBK1) and Yes-associated protein (YAP1) in KRAS mutant NSCLC

Biswarup Saha, Neha Jaiswal, Namrata Bora-Singhal, Srikumar Chellappan

Cancer Res (2018) 78 (13_Supplement): 1998.

DOI: https://doi.org/10.1158/1538-7445.AM2018-1998

Published: 01 July 2018

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Journal Articles

Abstract 2052: A novel PHD2/VHL- mediated regulation of YAP1 and its role in vascular mimicry and tumor angiogenesis

Namrata Bora Singhal, Biswarup Saha, Srikumar Chellappan

Cancer Res (2018) 78 (13_Supplement): 2052.

DOI: https://doi.org/10.1158/1538-7445.AM2018-2052

Published: 01 July 2018

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Journal Articles

Abstract 5063: Beta-arrestin-1 function in CAFs is necessary for enhancement of self-renewal of NSCLC stem-like cells

Mohan Kumar Durai Raj, Namrata Bora-Singhal, Srikumar Chellappan

Cancer Res (2018) 78 (13_Supplement): 5063.

DOI: https://doi.org/10.1158/1538-7445.AM2018-5063

Published: 01 July 2018

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Journal Articles

Abstract 4701: Verteporfin inhibits surface PD-L1 expression in triple-negative breast cancer (TNBC) cells

Fatema Khambati, Neha Jaiswal, Srikumar Chellappan, Hatem Soliman

Cancer Res (2018) 78 (13_Supplement): 4701.

DOI: https://doi.org/10.1158/1538-7445.AM2018-4701

Published: 01 July 2018

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Journal Articles

Abstract 365: Cross-talk between BRAF and Hippo/YAP1 signaling in melanoma

Mohan Kumar Durai Raj, Jonathan Nguyen, Namrata Bora-singhal, Jane Messina, Geoffrey Gibney, Srikumar Chellappan

Cancer Res (2017) 77 (13_Supplement): 365.

DOI: https://doi.org/10.1158/1538-7445.AM2017-365

Published: 01 July 2017

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Journal Articles

Abstract 3460: TBK1 regulates mitotic progression by modulating spindle assembly checkpoint in cancer cells

Neha Jaiswal, Smitha Pillai, Namrata BoraSinghal, Srikumar Chellappan

Cancer Res (2017) 77 (13_Supplement): 3460.

DOI: https://doi.org/10.1158/1538-7445.AM2017-3460

Published: 01 July 2017

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Journal Articles

Abstract 2145: Regulation of YAP1 during hypoxia and its novel role in vascular mimicry and angiogenesis

Namrata Bora Singhal, Srikumar Chellappan

Cancer Res (2017) 77 (13_Supplement): 2145.

DOI: https://doi.org/10.1158/1538-7445.AM2017-2145

Published: 01 July 2017

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Journal Articles

Abstract 2496: Novel role of YAP1 in tumor angiogenesis and vascular mimicry

Namrata Bora Singhal, Srikumar Chellappan

Cancer Res (2016) 76 (14_Supplement): 2496.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2496

Published: 15 July 2016

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Journal Articles

Abstract 2487: Nicotine-mediated regulation of Sox2 and stemness in non-small cell lung cancer

Courtney Schaal, Srikumar Chellappan

Cancer Res (2016) 76 (14_Supplement): 2487.

DOI: https://doi.org/10.1158/1538-7445.AM2016-2487

Published: 15 July 2016

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Journal Articles

Abstract 1516: YAP1 regulates Oct4 activity and Sox2 expression, facilitating self-renewal and vascular mimicry of stem-like cells

Namrata Bora Singhal, Jonathan Nguyen, Courtney Schaal, Deepak Perumal, Sandeep Singh, Domenico Coppola, Srikumar Chellappan

Cancer Res (2015) 75 (15_Supplement): 1516.

DOI: https://doi.org/10.1158/1538-7445.AM2015-1516

Published: 01 August 2015

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Journal Articles

Abstract 2085: Nicotine-mediated regulation of Sox2 and its implications in the biology of non-small cell lung adenocarcinoma stem-like cells

Courtney Schaal, Namrata Bora Singhal, Smitha Pillai, Jonathan Nguyen, Srikumar Chellappan

Cancer Res (2015) 75 (15_Supplement): 2085.

DOI: https://doi.org/10.1158/1538-7445.AM2015-2085

Published: 01 August 2015

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Journal Articles

Abstract 3771: Tank-binding kinase 1 associates with centrosomes and regulates microtubule dynamics and mitosis

Smitha R. Pillai, Jonathan Nguyen, Joseph Johnson, Eric Haura, Domenico Coppola, Srikumar Chellappan

Cancer Res (2015) 75 (15_Supplement): 3771.

DOI: https://doi.org/10.1158/1538-7445.AM2015-3771

Published: 01 August 2015

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Journal Articles

β-Arrestin-1 Mediates Nicotine-Induced Metastasis through E2F1 Target Genes That Modulate Epithelial–Mesenchymal Transition

Smitha Pillai, Jose Trevino, Bhupendra Rawal, Sandeep Singh, Michelle Kovacs, Xueli Li, Michael Schell, Eric Haura, Gerold Bepler, Srikumar Chellappan

Cancer Res (2015) 75 (6): 1009–1020.

DOI: https://doi.org/10.1158/0008-5472.CAN-14-0681

Published: 12 March 2015

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Includes: Supplementary data

Journal Articles

Abstract 5001: GATA3 abrogates TGFbeta-mediated breast cancer invasion and metastasis

Jianwei Sun, Huifang He, Smitha Pillai, Srikumar Chellappan, Shengyu Yang

Cancer Res (2014) 74 (19_Supplement): 5001.

DOI: https://doi.org/10.1158/1538-7445.AM2014-5001

Published: 01 October 2014

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Journal Articles

Abstract 5446: Nicotinic acetylcholine receptors activate TBK1 in a β-arrestin-1 dependent manner to promote NSCLC growth.

Smitha Pillai, Jonathan Nguyen, Eric Haura, Domenico Coppola, Srikumar Chellappan

Cancer Res (2013) 73 (8_Supplement): 5446.

DOI: https://doi.org/10.1158/1538-7445.AM2013-5446

Published: 15 April 2013

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NARROW

Abstract 1011: Tank binding kinase (TBK1) inhibitor BX795 impairs anti-tumor efficacy of T cells by abrogating granzyme and perforin mobilization

Abstract 1523: Novel role of TBK1 in breast cancer EMT

Abstract 4394: Molecular interplay between Tank-binding kinase (TBK1) and Yes-associated protein (YAP1) in KRAS mutant NSCLC

Abstract 378: HDAC inhibition enhances MEK antagonist therapy in uveal melanoma through combined blockade of YAP, AKT and RTK signaling

Abstract 2310: Targeting transcription-associated CDKs is an effective way to combat glioblastoma and medulloblastoma with minimal effect on primary neurons

Abstract 1998: Novel interplay between TANK-binding kinase (TBK1) and Yes-associated protein (YAP1) in KRAS mutant NSCLC

Abstract 2052: A novel PHD2/VHL- mediated regulation of YAP1 and its role in vascular mimicry and tumor angiogenesis

Abstract 5063: Beta-arrestin-1 function in CAFs is necessary for enhancement of self-renewal of NSCLC stem-like cells

Abstract 4701: Verteporfin inhibits surface PD-L1 expression in triple-negative breast cancer (TNBC) cells

Abstract 365: Cross-talk between BRAF and Hippo/YAP1 signaling in melanoma

Abstract 3460: TBK1 regulates mitotic progression by modulating spindle assembly checkpoint in cancer cells

Abstract 2145: Regulation of YAP1 during hypoxia and its novel role in vascular mimicry and angiogenesis

Abstract 2496: Novel role of YAP1 in tumor angiogenesis and vascular mimicry

Abstract 2487: Nicotine-mediated regulation of Sox2 and stemness in non-small cell lung cancer

Abstract 1516: YAP1 regulates Oct4 activity and Sox2 expression, facilitating self-renewal and vascular mimicry of stem-like cells

Abstract 2085: Nicotine-mediated regulation of Sox2 and its implications in the biology of non-small cell lung adenocarcinoma stem-like cells

Abstract 3771: Tank-binding kinase 1 associates with centrosomes and regulates microtubule dynamics and mitosis

β-Arrestin-1 Mediates Nicotine-Induced Metastasis through E2F1 Target Genes That Modulate Epithelial–Mesenchymal Transition

Abstract 5001: GATA3 abrogates TGFbeta-mediated breast cancer invasion and metastasis

Abstract 5446: Nicotinic acetylcholine receptors activate TBK1 in a β-arrestin-1 dependent manner to promote NSCLC growth.

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