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Sophie Postel-Vinay
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Journal Articles

Abstract CT089: Clinical and translational results of the academic ARIANES Phase 2 basket study: Longitudinal bulk and single-cell RNAseq analyses of patient tumors identify biological correlates of response to PARP inhibitors and anti-PD-L1 therapy

Free
Thibault Thomas-Bonafos, Julien Vibert, Arnaud Pagès, Léo Colmet-Daage, Roman Chabanon, Aurore Jeanson, Lambros Tselikas, Marlène Garrido, Clémence Hénon, Aurélien Parpaleix, Marianne Chasseriaud, Alice Bernard-Tessier, Nicolas Dorvault, Baptiste Bonnet, Clémence Astier, Anas Gazzah, Ronan Flippot, Natacha Naoun, Anna Patrikidou, Pernelle Lavaud, Aline Fuerea, Laurence Albiges, Yohann Loriot, Stéphane Champiat, Capucine Baldini, Fanny Bouquet, Nathalie Droin, Karim Fizazi, Damien Vasseur, Christophe Massard, Etienne Rouleau, Patricia Martin-Romano, Kaissa Ouali, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT089.
https://doi.org/10.1158/1538-7445.AM2025-CT089
Published: 25 April 2025
View articletitled, Abstract CT089: Clinical and translational results of the academic ARIANES Phase 2 basket study: Longitudinal bulk and single-cell RNAseq analyses of patient tumors identify biological correlates of response to PARP inhibitors and anti-PD-L1 therapy
Journal Articles

Abstract CT016: First-in-human (FIH) phase 1 trial of the oral first-in-class covalent Werner helicase (WRN) inhibitor RO7589831 in patients with microsatellite instable (MSI) and/or mismatch repair deficient (dMMR) advanced solid tumors

Free
Timothy A. Yap, Natalie Cook, Elisa Fontana, Erica S. Tsang, Oliver Bechter, Marwan Fakih, Kristoffer S. Rohrberg, Emiliano Calvo, Elena M. Elez, Meredith Pelster, John H. Strickler, Ignacio Matos, Adam Sharp, Sophia Blake, David Dejardin, Stephen Fowler, Nina Henkel, Michael Hettich, Angelika Lahr, Ting Liu, Christophe Meille, Piergiorgio Pettazzoni, Denise Reeves, Barbara Romagnoli, Sotirios Sotiriou, Daniel Waterkamp, Yali Fu, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT016.
https://doi.org/10.1158/1538-7445.AM2025-CT016
Published: 25 April 2025
View articletitled, Abstract CT016: First-in-human (FIH) phase 1 trial of the oral first-in-class covalent Werner helicase (WRN) inhibitor RO7589831 in patients with microsatellite instable (MSI) and/or mismatch repair deficient (dMMR) advanced solid tumors
Journal Articles

Abstract CT193: Trial in progress: A first-in-human phase 1a/b study of BGB-58067, an MTA-cooperative PRMT5 inhibitor, in patients with advanced solid tumors and MTAP deficiency

Free
Brian A. Van Tine, Timothy Humphries, Sophie Postel-Vinay, Hui Gan, Ugonma Chuwueke, Tai Qin, Hayden Huang, Chunyu Wang, Yan Dong, Caicun Zhou
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_2): CT193.
https://doi.org/10.1158/1538-7445.AM2025-CT193
Published: 25 April 2025
View articletitled, Abstract CT193: Trial in progress: A first-in-human phase 1a/b study of BGB-58067, an MTA-cooperative PRMT5 inhibitor, in patients with advanced solid tumors and MTAP deficiency
Journal Articles

Abstract 1168: ADAR1 synthetic lethality in BRCA1/2-mutant tumors defines autocrine interferon poisoning as a targetable vulnerability of cancer cells

Free
Roman M. Chabanon, Liudmila Shcherbakova, Magali Lacroix-Triki, Marine Aglave, Marlène Garrido, Jean Zeghondy, Victor Kriaa, Antoine Gougé, Elodie Edmond, Andrew N. Tutt, Fabrice Barlesi, Yohann Loriot, Suzette Delaloge, Marcel Tawk, Cindy Degerny, Yea-Lih Lin, Barbara Pistilli, Philippe Pasero, Christopher J. Lord, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 1168.
https://doi.org/10.1158/1538-7445.AM2025-1168
Published: 21 April 2025
View articletitled, Abstract 1168: ADAR1 synthetic lethality in BRCA1/2-mutant tumors defines autocrine interferon poisoning as a targetable vulnerability of cancer cells
Journal Articles

Abstract 5980: Leveraging large-scale PDO-based assays to optimize antibody-drug conjugate efficacy in digestive cancer

Free
Lélia Polit, Gizem Altay, Mia Cabantous, Anna-Rose Gryspeert, Jérome Cartry, Jacques RR. Mathieu, Sabrina Bedja, Alice Boileve, Michel Ducreux, Sophie Postel-Vinay, Fanny Jaulin, Gustave Ronteix
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 5980.
https://doi.org/10.1158/1538-7445.AM2025-5980
Published: 21 April 2025
View articletitled, Abstract 5980: Leveraging large-scale PDO-based assays to optimize antibody-drug conjugate efficacy in digestive cancer
Journal Articles

Abstract 4710: Heterogeneous efficacy patterns of KRAS inhibitors in digestive cancers

Free
Gustave Ronteix, Jérôme Caron, Rafal Pietrzak, Gizem Altay, Fabiana Graziosi, Lélia Polit, Anna-Rose Gryspeert, Jacques RR Mathieu, Jérôme Cartry, Sabrina Bedja, Alice Boilève, Michel Ducreux, Sophie Postel-Vinay, Fanny Jaulin
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 4710.
https://doi.org/10.1158/1538-7445.AM2025-4710
Published: 21 April 2025
View articletitled, Abstract 4710: Heterogeneous efficacy patterns of KRAS inhibitors in digestive cancers
Journal Articles

Abstract 2677: Multi-omics profiling identifies two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics

Free
Carine Ngo, Leo Colmet-Daage, Julien Vibert, Clémence Henon, Riwan Brillet, Jia Xiang Jin, Daniel Pissaloux, Clémence Astier, Jean-Yves Blay, Axel Le Cesne, Charles Honore, Matthieu Faron, Thomas Grünewald, Franck Bourdeaut, Franck Tirode, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2025) 85 (8_Supplement_1): 2677.
https://doi.org/10.1158/1538-7445.AM2025-2677
Published: 21 April 2025
View articletitled, Abstract 2677: Multi-omics profiling identifies two epithelioid sarcoma molecular subtypes with distinct signaling and immune characteristics
Journal Articles

Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors

Open Access
Asuka Kawai-Kawachi, Madison M. Lenormand, Clémence Astier, Noé Herbel, Meritxell B. Cutrona, Carine Ngo, Marlène Garrido, Thomas Eychenne, Nicolas Dorvault, Laetitia Bordelet, Feifei Song, Ryme Bouyakoub, Anastasia Loktev, Antonio Romo-Morales, Clémence Henon, Léo Colmet-Daage, Julien Vibert, Marjorie Drac, Rachel Brough, Etienne Schwob, Oliviano Martella, Guillaume Pinna, Janet M. Shipley, Sibylle Mittnacht, Astrid Zimmermann, Aditi Gulati, Olivier Mir, Axel Le Cesne, Matthieu Faron, Charles Honoré, Christopher J. Lord, Roman M. Chabanon, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2025) 85 (1): 154–170.
https://doi.org/10.1158/0008-5472.CAN-23-3603
Published: 02 January 2025
View articletitled, Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors
Open the PDF for Replication Stress Is an Actionable Genetic Vulnerability in Desmoplastic Small Round Cell Tumors in another window
Includes: Supplementary data
Journal Articles

Abstract CT222: Efficacy and safety of ceralasertib in the PLANETTE study in patients (pts) with ATM-altered advanced solid tumors (ASTs) or metastatic castration-resistant prostate cancer (mCRPC)

Free
Rahul Aggarwal, Antoine Italiano, Susan Domchek, Oscar Goodman, Sophie Postel-Vinay, Jesus Garcia-Donas, Tanya Dorff, Zachery Reichert, Philippe Cassier, Neal Shore, Catherine Marshall, Graeme Parr, Itziar Irurzun-Arana, Neel Shah, Natalia Lukashchuk, Olga Murina, Daniel Slade, Bienvenu Loembé, Emma Dean, Elhan Sanai, Wassim Abida
Journal: Cancer Research
Cancer Res (2024) 84 (7_Supplement): CT222.
https://doi.org/10.1158/1538-7445.AM2024-CT222
Published: 05 April 2024
View articletitled, Abstract CT222: Efficacy and safety of ceralasertib in the PLANETTE study in patients (pts) with ATM-altered advanced solid tumors (ASTs) or metastatic castration-resistant prostate cancer (mCRPC)
Journal Articles

Abstract 6932: Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in desmoplastic small round cell tumors

Free
Clémence Henon, Julien Vibert, Thomas Eychenne, Nadège Gruel, Léo Colmet-Daage, Carine Ngo, Marlène Garrido, Nicolas Dorvault, Maria Eugenia Marques Da Costa, Antonin Marchais, Asuka Kawachi, Madison Lenormand, Clémence Astier, Roman Chabanon, Benjamin Verret, Rastislav Bahleda, Axel Le Cesne, Fatima Mechta-Grigoriou, Charles Honoré, Matthieu Faron, Olivier Delattre, Joshua J Waterfall, Sarah Watson, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6932.
https://doi.org/10.1158/1538-7445.AM2024-6932
Published: 22 March 2024
View articletitled, Abstract 6932: Single-cell multiomics profiling reveals heterogeneous transcriptional programs and microenvironment in desmoplastic small round cell tumors
Journal Articles

Abstract 6406: Clinical and translational results of the academic ARIANES Phase 2 basket study: Longitudinal single-cell analysis of patient tumors identifies biological correlates of response to PARP inhibitors and anti-PD-L1 therapy

Free
Julien Vibert, Clémence Hénon, Lambros Tselikas, Baptiste Bonnet, Arnaud Pagès, Alice Bernard-Tessier, Léo Colmet-Daage, Roman Chabanon, Nicolas Dorvault, Clémence Astier, Anas Gazzah, Aurore Jeanson, Aurélien Parpaleix, Ronan Flippot, Natacha Naoun, Anna Patrikidou, Pernelle Lavaud, Giulia Baciarello, Emeline Colomba, Alina Fuerea, Laurence Albiges, Christophe Massard, Santiago Ponce, Yohann Loriot, Stéphane Champiat, Capucine Baldini, Fanny Bouquet, Nathalie Droin, Karim Fizazi, Damien Vasseur, Patricia Martin-Romano, Etienne Rouleau, Kaïssa Ouali, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2024) 84 (6_Supplement): 6406.
https://doi.org/10.1158/1538-7445.AM2024-6406
Published: 22 March 2024
View articletitled, Abstract 6406: Clinical and translational results of the academic ARIANES Phase 2 basket study: Longitudinal single-cell analysis of patient tumors identifies biological correlates of response to PARP inhibitors and anti-PD-L1 therapy
Journal Articles

Abstract P2-13-02: COBRA: Characteristics and Outcomes of patients with BReast cancer in phAse I trials at Gustave Roussy Cancer center

Free
Lauren Seknazi, Arthur Geraud, Vincent Goldschmidt, Capucine Baldini, Stéphane Champiat, Christophe Massard, Sophie Postel-Vinay, Aurelien Marabelle, Rastilav Bahleda, Antoine Hollebecque, Cristina Smolenschi, Anas Gazzah, Jean-Marie Michot, Patricia Martin-Romano, Aurore Vozy, Perrine Vuagnat, François-Xavier Danlos, Arnaud Bayle, Linda Mahjoubi, Barbara Pistilli, Yohann Loriot, Santiago Ponce-Aix, Kaissa Ouali
Journal: Cancer Research
Cancer Res (2023) 83 (5_Supplement): P2-13-02.
https://doi.org/10.1158/1538-7445.SABCS22-P2-13-02
Published: 01 March 2023
View articletitled, Abstract P2-13-02: COBRA: Characteristics and Outcomes of patients with BReast cancer in phAse I trials at Gustave Roussy Cancer center
Journal Articles

Abstract 5714: Characterization of SWI/SNF complex gene mutations, protein expression and tumor immune microenvironment in cholangiocarcinoma

Free
Clémence Astier, Jean-Yves Scoazec, Virginie Marty, Olivia Bawa, Nicolas Signolle, Carine Ngo, Francesco Facchinetti, Antoine Hollebecque, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 5714.
https://doi.org/10.1158/1538-7445.AM2022-5714
Published: 15 June 2022
View articletitled, Abstract 5714: Characterization of SWI/SNF complex gene mutations, protein expression and tumor immune microenvironment in cholangiocarcinoma
Journal Articles

Abstract 6277: Identification of ATR inhibitors as therapeutic opportunities in Desmoplastic small round cell tumors

Free
Asuka KAWAI-KAWACHI, Madison LENORMAND, Clémence HENON, Thomas EYCHENNE, Leo COLMET-DAAGE, Nicolas DORVAULT, Marlene GARRIDO, Clémence ASTIER, Carine NGO, Helen PEMBERTON, Aditi GULATI, Stephen PETTITT, Roman CHABANON, Christopher J LORD, Sophie POSTEL-VINAY
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): 6277.
https://doi.org/10.1158/1538-7445.AM2022-6277
Published: 15 June 2022
View articletitled, Abstract 6277: Identification of ATR inhibitors as therapeutic opportunities in Desmoplastic small round cell tumors
Journal Articles

Abstract CT201: Ceralasertib and olaparib in the treatment of homologous recombination repair (HRR)-deficient platinum-sensitive ovarian cancer after progression on PARP inhibitors

Free
Geoffrey I. Shapiro, Bristi Basu, Anthony El-Khoueiry, Sophie Postel-Vinay, Seock-Ah Im, Sun Young Rha, Claire F. Friedman, Antoine Italiano, Yong Man Kim, Myong Cheol Lim, Rene Roux, Joyce F. Liu, Elhan Sanai, Simon A. Smith, Claire Smith, Sarah El Farhi, Alan Lau, Natalia Lukashchuk, Emma Dean, Matthew G. Krebs
Journal: Cancer Research
Cancer Res (2022) 82 (12_Supplement): CT201.
https://doi.org/10.1158/1538-7445.AM2022-CT201
Published: 15 June 2022
View articletitled, Abstract CT201: Ceralasertib and olaparib in the treatment of homologous recombination repair (HRR)-deficient platinum-sensitive ovarian cancer after progression on PARP inhibitors
Journal Articles

A Novel Synthetic Lethal Approach to Target MYC-Driven Cancers

Available to Purchase
Roman M. Chabanon, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2022) 82 (6): 969–971.
https://doi.org/10.1158/0008-5472.CAN-22-0302
Published: 15 March 2022
View articletitled, A Novel Synthetic Lethal Approach to Target MYC-Driven Cancers
Open the PDF for A Novel Synthetic Lethal Approach to Target MYC-Driven Cancers in another window
Journal Articles

Abstract 448: High prevalence of pathogenic germline variants in patients with oncogene-driven non-small cell lung cancer

Free
Laura Mezquita, Andrei Iurchenko, Jose Carlos Benitez, Maria Baz, Sergey Nikolaev, David Planchard, Felix Blanc-Durand, Mihaela Aldea, Patricia Martín-Romano, Yohann Loriot, Claudio Nicotra, Maud Ngocamus, Jean-Yves Scoazec, Stefan Michiels, Sophie Postel-Vinay, Julien Viot, Luc Friboulet, Antoine Italiano, Fabrice Andre, Christophe Massard, Jean-Charles Soria, Etienne Rouleau, Daniel Gautheret, Benjamin Besse
Journal: Cancer Research
Cancer Res (2021) 81 (13_Supplement): 448.
https://doi.org/10.1158/1538-7445.AM2021-448
Published: 01 July 2021
View articletitled, Abstract 448: High prevalence of pathogenic germline variants in patients with oncogene-driven non-small cell lung cancer
Journal Articles

PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer

Available to Purchase
Roman M. Chabanon, Daphné Morel, Thomas Eychenne, Léo Colmet-Daage, Ilirjana Bajrami, Nicolas Dorvault, Marlène Garrido, Cornelia Meisenberg, Andrew Lamb, Carine Ngo, Suzanna R. Hopkins, Theodoros I. Roumeliotis, Samuel Jouny, Clémence Hénon, Asuka Kawai-Kawachi, Clémence Astier, Asha Konde, Elaine Del Nery, Christophe Massard, Stephen J. Pettitt, Raphaël Margueron, Jyoti S. Choudhary, Geneviève Almouzni, Jean-Charles Soria, Eric Deutsch, Jessica A. Downs, Christopher J. Lord, Sophie Postel-Vinay
Journal: Cancer Research
Cancer Res (2021) 81 (11): 2888–2902.
https://doi.org/10.1158/0008-5472.CAN-21-0628
Published: 01 June 2021
View articletitled, PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer
Open the PDF for PBRM1 Deficiency Confers Synthetic Lethality to DNA Repair Inhibitors in Cancer in another window
Includes: Multimedia, Supplementary data
Journal Articles

Abstract PS11-18: Ceralasertib (cer) in combination with olaparib (ola) in patients (pts) with advanced breast cancer (BC): Results of phase I expansion cohorts

Free
Emma Dean, Matthew G Krebs, Seock-Ah Im, Mario Campone, Sophie Postel-Vinay, Tobias Arkenau, Juanita Lopez, Wassim Abida, Duncan Jodrell, Keun-Wook Lee, SunYoung Rha, Irene Kang, Rebecca Roylance, Graeme Parr, Claire Smith, Andrew Goldwin, Elhan Sanay, Natasha Lukashchuk, Alan Lau, Andrew Pierce, Bienvenu Loembe
Journal: Cancer Research
Cancer Res (2021) 81 (4_Supplement): PS11-18.
https://doi.org/10.1158/1538-7445.SABCS20-PS11-18
Published: 15 February 2021
View articletitled, Abstract PS11-18: Ceralasertib (cer) in combination with olaparib (ola) in patients (pts) with advanced breast cancer (BC): Results of phase I expansion cohorts
Journal Articles

3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer

Free
Barrie Peck, Philip Bland, Ioanna Mavrommati, Gareth Muirhead, Hannah Cottom, Patty T. Wai, Sarah L. Maguire, Holly E. Barker, Eamonn Morrison, Divya Kriplani, Lu Yu, Amy Gibson, Giulia Falgari, Keith Brennan, Gillian Farnie, Richard Buus, Rebecca Marlow, Daniela Novo, Eleanor Knight, Naomi Guppy, Daniela Kolarevic, Snezana Susnjar, Natasa Medic Milijic, Kalnisha Naidoo, Patrycja Gazinska, Ioannis Roxanis, Sunil Pancholi, Lesley-Ann Martin, Erle M. Holgersen, Maggie C.U. Cheang, Farzana Noor, Sophie Postel-Vinay, Gerard Quinn, Simon McDade, Lukas Krasny, Paul Huang, Frances Daley, Fredrik Wallberg, Jyoti S. Choudhary, Syed Haider, Andrew N. Tutt, Rachael Natrajan
Journal: Cancer Research
Series: Author Choice
Cancer Res (2021) 81 (4): 847–859.
https://doi.org/10.1158/0008-5472.CAN-20-1822
Published: 15 February 2021
View articletitled, 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer
Open the PDF for 3D Functional Genomics Screens Identify CREBBP as a Targetable Driver in Aggressive Triple-Negative Breast Cancer in another window
Includes: Supplementary data